Nicorandil Prevents Gαq-Induced Progressive Heart Failure and Ventricular Arrhythmias in Transgenic Mice

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Hirose, Masamichi ^a   Takeishi, Yasuchika ^b   Nakada, Tsutomu ^c   Shimojo, Hisashi ^c   Kashihara, Toshihide ^c   Nishio, Ayako ^d   Suzuki, Satoshi ^b   Mende, Ulrike ^e   Matsumoto, Kiyoshi ^d   Matsushita, Naoko ^a   Taira, Eiichi ^a   Sato, Fumika ^a   Yamada, Mitsuhiko ^c  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^c SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d SHINSHU UNIVERSITY   (Japan)

^e BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CLAMIKALANT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; NICORANDIL; PROTEIN G ALPHA Q; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; FEMALE; GENE; GENE EXPRESSION; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE FIBROSIS; HEART MUSCLE POTENTIAL; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; ISOLATED HEART; MOUSE; NONHUMAN; PROTEIN EXPRESSION; QT INTERVAL; SERCA2 GENE; SIGNAL TRANSDUCTION; SUR 2B GENE; TRANSGENIC MOUSE;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; CARDIOMEGALY; ELECTROCARDIOGRAPHY; FEMALE; FIBROSIS; GENE EXPRESSION REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEART FAILURE; KATP CHANNELS; MICE; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCARDIUM; NICORANDIL; NITRIC OXIDE SYNTHASE; RNA, MESSENGER; TRPC CATION CHANNELS; VENTRICULAR PREMATURE COMPLEXES;

MUS; MUS MUSCULUS;

EID: 84871453997     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052667     Document Type: Article

References (32)

1. Lefer DJ, Lefer AM, (1988) Studies on the mechanism of the vasodilator action of nicorandil. Life Sci 42: 1907-1914.
2. Holzmann S, (1983) Cyclic GMP as possible mediator of coronary arterial relaxation by nicorandil. J Cardiovasc Pharmacol 5: 364-370.
3. Noguchi K, Matsuzaki T, Ojiri Y, Koyama T, Nakasone J, et al. (1998) Beneficial hemodynamic effects of nicorandil in a canine model of acute congestive heart failure: comparison with nitroglycerin and cromakalim. Fundam Clin Pharmacol 12: 270-278.
4. Izawa H, Iwase M, Takeichi Y, Somura F, Nagata K, et al. (2003) Effect of nicorandil on left ventricular end-diastolic pressure during exercise in patients with hypertrophic cardiomyopathy. Eur Heart J 24: 1340-1348.
5. Xu J, Nagata K, Obata K, Ichihara S, Izawa H, et al. (2005) Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats. Hypertension 46: 719-724.
6. Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, et al. (2008) Mechanisms of preventive effect of nicorandil on ischemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges. Basic & Clinical Pharmacol Toxicol 102: 504-514.
7. Bogoyevitch MA, Sugden PH, (1996) The role of protein kinases in adaptational growth of the heart. Int J Biochem Cell Biol 28: 1-12.
8. Hunter JJ, Chien KR, (1999) Signaling pathways for cardiac hypertrophy and failure. N Engl J Med 341: 1276-1283.
9. Takeishi Y, Jalili T, Ball NA, Walsh RA, (1999) Responses of cardiac protein kinase C isoforms to distinct pathological stimuli are differentially regulated. Circ Res 85: 264-271.
10. Niizeki T, Takeishi Y, Kitahara T, Arimoto T, Koyama Y, et al. (2008) Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice. Circ J 72: 309-317.
11. Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, et al. (2011) Diacylglycerol kinase z inhibits ventricular tachyarrhythmias in a mouse model of heart failure: Roles of canonical transient receptor potential (TRPC) channels. Circ J 75: 2333-2342.
12. Mende U, Kagen A, Cohen A, Aramburu J, Schoen FJ, et al. (1998) Transient cardiac expression of constitutively active Gaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proc Natl Acad Sci USA 95: 13893-13898.
13. Kamiyoshi Y, Takahashi M, Yokoseki O, Yazaki Y, Hirose S, et al. (2005) Mycophenolate mofetil prevents the development of experimental autoimmune myocarditis. J Mol Cell Cardiol 39: 467-477.
14. Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, et al. (2009) Diacylglycerol kinase ζ inhibits Gαq-induced atrial remodeling in transgenic mice. Heart Rhythm 6: 78-84.
15. Niizeki T, Takeishi Y, Kitahara T, Arimoto T, Ishino M, et al. (2008) Diacylglycerol kinase-ε restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Gαq signaling cascade. Am J Physiol 295: H245-H255.
16. Onohara N, Nishida M, Inoue R, Kobayashi H, Sumimoto H, et al. (2006) TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J 25: 5305-5316.
17. Horinaka S, Kobayashi N, Higashi T, Hara K, Hara S, et al. (2001) Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. J Cardiovasc Pharmacol 38: 200-210.
18. Treasure CB, Vita JA, Cox DA, Fish RD, Gordon JB, et al. (1990) Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy. Circulation 81: 772-779.
19. Coma-Canella I, García-Velloso MJ, Macías A, Villar L, Cosín-Sales J, et al. (2003) Impaired coronary flow reserve in patients with non-ischemic heart failure. Rev Esp Cardiol 56: 354-360.
20. Canetti M, Akhter MW, Lerman A, Karaalp IS, Zell JA, et al. (2003) Evaluation of myocardial blood flow reserve in patients with congestive heart failure due to idiopathic dilated cardiomyopathy. Am J Cardiol 92: 1246-1249.
21. Seino S, (1999) ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies. Annu Rev Physiol 61: 337-362.
22. Date T, Taniguchi I, Inada K, Matsuo S, Miyanaga S, et al. (2005) Nicorandil inhibits serum starvation induced apoptosis in vascular endothelial cells. J Cardiovasc Pharmacol 46: 721-726.
23. Hongo M, Mawatari E, Sakai A, Ruan Z, Koizumi T, et al. (2005) Effects of nicorandil on monocrotalineinduced pulmonary arterial hypertension in rats. J Cardiovasc Pharmacol 46: 452-458.
24. Teshima Y, Akao M, Baumgartner WA, Marbán E, (2003) Nicorandil prevents oxidative stress-induced apoptosis in neurons by activating mitochondrial ATP-sensitive potassium channels. Brain Res 990: 45-50.
25. Zhao X, Lu X, Feng Q, (2002) Deficiency in endothelial nitric oxide synthase impairs myocardial angiogenesis. Am J Physiol 283: H2371-H2378.
26. Koitabashi N, Arai M, Tomaru K, Takizawa T, Watanabe A, et al. (2005) Carvedilol effectively blocks oxidative stress-mediated downregulation of sarcoplasmic reticulum Ca2+-ATPase 2 gene transcription through modification of Sp1 binding. Biochem Biophys Res Commun 328: 116-124.
27. Liou JY, Hong HJ, Sung LC, Chao HH, Chen PY, et al. (2011) Nicorandil inhibits angiotensin-II-induced proliferation of cultured rat cardiac fibroblasts. Pharmacology 87: 144-151.
28. Zhou M, He HJ, Suzuki R, Liu KX, Tanaka O, et al. (2007) Localization of sulfonylurea receptor subunits, SUR2A and SUR2B, in rat heart. J Histochem Cytochem 55: 795-804.
29. Kaab S, Nuss HB, Chiamvimonvat N, O'Rourke B, Pak PH, et al. (1996) Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res 78: 262-273.
30. Yamada M, Kurachi Y, (2004) The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Mol. Pharmacol 65: 1198-1207.
31. Lee TM, Lin MS, Chang NC, (2008) Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts. J Am Coll Cardiol 51: 1309-1318.
32. Hwang GS, Oh KS, Koo HN, Seo HW, You KH, et al. (2006) Effects of KR-31378, a novel ATP-sensitive potassium channel activator, on hypertrophy of H9c2 cells and on cardiac dysfunction in rats with congestive heart failure. Eur J Pharmacol 540: 131-138.