Interleukin-17 expression and significance in normal lung function smokers and chronic obstructive pulmonary disease patients

National Medical Journal of China

Volumn 90, Issue 20, 2010, Pages 1431-1436

  Zhang, Jian Quan ^a   Lao, Qi Fang ^a   Chu, Shu Yuan ^a   Bai, Jing ^a   Zhong, Xiao Ning ^a  

^a FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Inflammation; Interleukin 17; Pulmonary disease, chronic obstructive; Smoking

Indexed keywords

EOSIN; HEMATOXYLIN; INTERLEUKIN 17;

ARTERIAL WALL THICKNESS; ARTERY RECONSTRUCTION; ARTICLE; CANCER PATIENT; CANCER SURGERY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LUNG ALVEOLUS; LUNG CANCER; LUNG FUNCTION; LUNG INFILTRATE; LUNG PARENCHYMA; PREDICTIVE VALUE; PROTEIN EXPRESSION; PULMONARY ARTERY; SMALL AIRWAY DISEASE; SMOKING; UPREGULATION; ADULT; AGED; CASE CONTROL STUDY; FEMALE; INFLAMMATION; LUNG; LUNG FUNCTION TEST; MALE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY;

ADULT; AGED; CASE-CONTROL STUDIES; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-17; LUNG; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY FUNCTION TESTS; SMOKING;

EID: 84871441857     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2010.20.018     Document Type: Article

References (12)

1. Cosio M G, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med, 2009, 360:2445-2454.
2. Barnes P J. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol, 2008, 8:183-192.
3. Di Stefano A, Caramori G, Gnemmi I. T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin Exp Immunol, 2009, 157:316-324.
4. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease (Updated 2005) (EB/OL). (2005-08-23) [2006-04-12]. http://www.goldcopd.com/Guidelineitem.asp?11 =2&12=1&intId=1662.
5. 2006, 29: 435-439.
6. Saetta M, Baraldo S, Corbino L, et al. CD8+ ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 1999, 160:711-717.
7. Harrisona O J, Foley J, Bolognesea B J. Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunology Letters, 2008, 121:13-21.
8. Kawaguchi M, Adachi M, Oda N, et al. IL-17 cytokine family. J. Allergy Clin. Immunol, 2004, 114:1265-1273.
9. Zhou L, Ivanov I I, Spolski R, et al. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol, 2007, 8:967-974.
10. Korn T, Bettelli E, Gao W, et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H) 17 cells. Nature, 2007, 448:484-487.
11. Elsaesser H, Sauer K, Brooks D G. IL-21 is required to control chronic viral infection. Science, 2009, 324: 1569-1572.
12. Maeno T, Houghton A M, Quintero P A, et al. CD8 + T cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol, 2007, 178:8090-8096.