메뉴 건너뛰기




Volumn 7, Issue 12, 2012, Pages

DNA Methylation in Multiple Myeloma Is Weakly Associated with Gene Transcription

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONTROLLED STUDY; CPG ISLAND; DLC1 GENE; DNA METHYLATION; GENE; GENE CONTROL; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; IGF1R GENE; IL17RB GENE; MAJOR CLINICAL STUDY; MULTIPLE MYELOMA; PYROSEQUENCING; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; VALIDATION STUDY;

EID: 84871437541     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052626     Document Type: Article
Times cited : (19)

References (37)
  • 1
    • 74049162897 scopus 로고    scopus 로고
    • International Myeloma Working Group molecular classification of multiple myeloma: spotlight review
    • Fonseca R, Bergsagel PL, Drach J, Shaughnessy J, Gutierrez N, et al. (2009) International Myeloma Working Group molecular classification of multiple myeloma: spotlight review. Leukemia 23: 2210-2221.
    • (2009) Leukemia , vol.23 , pp. 2210-2221
    • Fonseca, R.1    Bergsagel, P.L.2    Drach, J.3    Shaughnessy, J.4    Gutierrez, N.5
  • 4
    • 27244445489 scopus 로고    scopus 로고
    • Molecular pathogenesis and a consequent classification of multiple myeloma
    • Bergsagel PL, Kuehl WM, (2005) Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol 23: 6333-6338.
    • (2005) J Clin Oncol , vol.23 , pp. 6333-6338
    • Bergsagel, P.L.1    Kuehl, W.M.2
  • 6
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M, (2008) Epigenetics in cancer. N Engl J Med 358: 1148-1159.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 7
    • 77950678085 scopus 로고    scopus 로고
    • Coordinated chromatin control: structural and functional linkage of DNA and histone methylation
    • Cheng X, Blumenthal RM, (2010) Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry 49: 2999-3008.
    • (2010) Biochemistry , vol.49 , pp. 2999-3008
    • Cheng, X.1    Blumenthal, R.M.2
  • 8
    • 0141645511 scopus 로고    scopus 로고
    • Cancer epigenetics: DNA methylation and chromatin alterations in human cancer
    • Esteller M, (2003) Cancer epigenetics: DNA methylation and chromatin alterations in human cancer. Adv Exp Med Biol 532: 39-49.
    • (2003) Adv Exp Med Biol , vol.532 , pp. 39-49
    • Esteller, M.1
  • 9
    • 0022000776 scopus 로고
    • A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA
    • Bird A, Taggart M, Frommer M, Miller OJ, Macleod D, (1985) A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA. Cell 40: 91-99.
    • (1985) Cell , vol.40 , pp. 91-99
    • Bird, A.1    Taggart, M.2    Frommer, M.3    Miller, O.J.4    Macleod, D.5
  • 11
    • 80054880084 scopus 로고    scopus 로고
    • DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter
    • Han H, Cortez CC, Yang X, Nichols PW, Jones PA, et al. (2011) DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter. Human molecular genetics 20: 4299-4310.
    • (2011) Human Molecular Genetics , vol.20 , pp. 4299-4310
    • Han, H.1    Cortez, C.C.2    Yang, X.3    Nichols, P.W.4    Jones, P.A.5
  • 12
    • 79956330964 scopus 로고    scopus 로고
    • CpG islands and the regulation of transcription
    • Deaton AM, Bird A, (2011) CpG islands and the regulation of transcription. Genes & development 25: 1010-1022.
    • (2011) Genes & Development , vol.25 , pp. 1010-1022
    • Deaton, A.M.1    Bird, A.2
  • 13
    • 77956288766 scopus 로고    scopus 로고
    • DNA methylation analysis determines the high frequency of genic hypomethylation and low frequency of hypermethylation events in plasma cell tumors
    • Salhia B, Baker A, Ahmann G, Auclair D, Fonseca R, et al. (2010) DNA methylation analysis determines the high frequency of genic hypomethylation and low frequency of hypermethylation events in plasma cell tumors. Cancer Res 70: 6934-6944.
    • (2010) Cancer Res , vol.70 , pp. 6934-6944
    • Salhia, B.1    Baker, A.2    Ahmann, G.3    Auclair, D.4    Fonseca, R.5
  • 14
    • 64349091471 scopus 로고    scopus 로고
    • Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells
    • Ball MP, Li JB, Gao Y, Lee JH, LeProust EM, et al. (2009) Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nature biotechnology 27: 361-368.
    • (2009) Nature Biotechnology , vol.27 , pp. 361-368
    • Ball, M.P.1    Li, J.B.2    Gao, Y.3    Lee, J.H.4    LeProust, E.M.5
  • 15
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, et al. (2009) The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nature genetics 41: 178-186.
    • (2009) Nature Genetics , vol.41 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3    Wu, Z.4    Montano, C.5
  • 17
    • 22044440425 scopus 로고    scopus 로고
    • Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma
    • Bergsagel PL, Kuehl WM, Zhan F, Sawyer J, Barlogie B, et al. (2005) Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood 106: 296-303.
    • (2005) Blood , vol.106 , pp. 296-303
    • Bergsagel, P.L.1    Kuehl, W.M.2    Zhan, F.3    Sawyer, J.4    Barlogie, B.5
  • 18
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: islands, start sites, gene bodies and beyond
    • Jones PA, (2012) Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nature reviews Genetics 13: 484-492.
    • (2012) Nature Reviews Genetics , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 19
    • 0027849602 scopus 로고
    • Hypomethylation of DNA: a possible nongenotoxic mechanism underlying the role of cell proliferation in carcinogenesis
    • Goodman JI, Counts JL, (1993) Hypomethylation of DNA: a possible nongenotoxic mechanism underlying the role of cell proliferation in carcinogenesis. Environmental health perspectives 101Suppl 5: 169-172.
    • (1993) Environmental Health Perspectives , vol.101 , pp. 169-172
    • Goodman, J.I.1    Counts, J.L.2
  • 20
    • 77649267695 scopus 로고    scopus 로고
    • Dynamic changes in the human methylome during differentiation
    • Laurent L, Wong E, Li G, Huynh T, Tsirigos A, et al. (2010) Dynamic changes in the human methylome during differentiation. Genome research 20: 320-331.
    • (2010) Genome Research , vol.20 , pp. 320-331
    • Laurent, L.1    Wong, E.2    Li, G.3    Huynh, T.4    Tsirigos, A.5
  • 21
    • 84860389965 scopus 로고    scopus 로고
    • Genome-wide profiling of DNA methylation in human cancer cells
    • Ogoshi K, Hashimoto S, Nakatani Y, Qu W, Oshima K, et al. (2011) Genome-wide profiling of DNA methylation in human cancer cells. Genomics 98: 280-287.
    • (2011) Genomics , vol.98 , pp. 280-287
    • Ogoshi, K.1    Hashimoto, S.2    Nakatani, Y.3    Qu, W.4    Oshima, K.5
  • 22
    • 33748861305 scopus 로고    scopus 로고
    • High-frequency promoter hypermethylation of the deleted in liver cancer-1 gene in multiple myeloma
    • Song YF, Xu R, Zhang XH, Chen BB, Chen Q, et al. (2006) High-frequency promoter hypermethylation of the deleted in liver cancer-1 gene in multiple myeloma. J Clin Pathol 59: 947-951.
    • (2006) J Clin Pathol , vol.59 , pp. 947-951
    • Song, Y.F.1    Xu, R.2    Zhang, X.H.3    Chen, B.B.4    Chen, Q.5
  • 23
    • 60149086463 scopus 로고    scopus 로고
    • DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway
    • Ullmannova-Benson V, Guan M, Zhou X, Tripathi V, Yang XY, et al. (2009) DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway. Leukemia 23: 383-390.
    • (2009) Leukemia , vol.23 , pp. 383-390
    • Ullmannova-Benson, V.1    Guan, M.2    Zhou, X.3    Tripathi, V.4    Yang, X.Y.5
  • 24
    • 0347955433 scopus 로고    scopus 로고
    • Methylation of p16 and p15 genes in multiple myeloma
    • Chen W, Wu Y, Zhu J, Liu J, Tan S, et al. (2002) Methylation of p16 and p15 genes in multiple myeloma. Chin Med Sci J 17: 101-105.
    • (2002) Chin Med Sci J , vol.17 , pp. 101-105
    • Chen, W.1    Wu, Y.2    Zhu, J.3    Liu, J.4    Tan, S.5
  • 25
    • 33846852215 scopus 로고    scopus 로고
    • Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implications
    • Gonzalez-Paz N, Chng WJ, McClure RF, Blood E, Oken MM, et al. (2007) Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implications. Blood 109: 1228-1232.
    • (2007) Blood , vol.109 , pp. 1228-1232
    • Gonzalez-Paz, N.1    Chng, W.J.2    McClure, R.F.3    Blood, E.4    Oken, M.M.5
  • 26
    • 0037697734 scopus 로고    scopus 로고
    • Different prognostic values of p15(INK4b) and p16(INK4a) gene methylations in multiple myeloma
    • Guillerm G, Depil S, Wolowiec D, Quesnel B, (2003) Different prognostic values of p15(INK4b) and p16(INK4a) gene methylations in multiple myeloma. Haematologica 88: 476-478.
    • (2003) Haematologica , vol.88 , pp. 476-478
    • Guillerm, G.1    Depil, S.2    Wolowiec, D.3    Quesnel, B.4
  • 27
    • 18544379572 scopus 로고    scopus 로고
    • Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival
    • Mateos MV, Garcia-Sanz R, Lopez-Perez R, Moro MJ, Ocio E, et al. (2002) Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival. Br J Haematol 118: 1034-1040.
    • (2002) Br J Haematol , vol.118 , pp. 1034-1040
    • Mateos, M.V.1    Garcia-Sanz, R.2    Lopez-Perez, R.3    Moro, M.J.4    Ocio, E.5
  • 28
    • 76449084073 scopus 로고    scopus 로고
    • Detecting methylation patterns of p16, MGMT, DAPK and E-cadherin genes in multiple myeloma patients
    • Yuregir OO, Yurtcu E, Kizilkilic E, Kocer NE, Ozdogu H, et al. (2009) Detecting methylation patterns of p16, MGMT, DAPK and E-cadherin genes in multiple myeloma patients. Int J Lab Hematol.
    • (2009) Int J Lab Hematol.
    • Yuregir, O.O.1    Yurtcu, E.2    Kizilkilic, E.3    Kocer, N.E.4    Ozdogu, H.5
  • 29
    • 53449089919 scopus 로고    scopus 로고
    • Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma
    • Dhodapkar KM, Barbuto S, Matthews P, Kukreja A, Mazumder A, et al. (2008) Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood 112: 2878-2885.
    • (2008) Blood , vol.112 , pp. 2878-2885
    • Dhodapkar, K.M.1    Barbuto, S.2    Matthews, P.3    Kukreja, A.4    Mazumder, A.5
  • 30
    • 33644976163 scopus 로고    scopus 로고
    • IGF-1R is overexpressed in poor-prognostic subtypes of multiple myeloma
    • Chng WJ, Gualberto A, Fonseca R, (2006) IGF-1R is overexpressed in poor-prognostic subtypes of multiple myeloma. Leukemia 20: 174-176.
    • (2006) Leukemia , vol.20 , pp. 174-176
    • Chng, W.J.1    Gualberto, A.2    Fonseca, R.3
  • 33
    • 66549106493 scopus 로고    scopus 로고
    • The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor
    • Sprynski AC, Hose D, Caillot L, Reme T, Shaughnessy JD Jr, et al. (2009) The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. Blood 113: 4614-4626.
    • (2009) Blood , vol.113 , pp. 4614-4626
    • Sprynski, A.C.1    Hose, D.2    Caillot, L.3    Reme, T.4    Shaughnessy Jr., J.D.5
  • 34
    • 58749086023 scopus 로고    scopus 로고
    • A humanised anti-IGF-1R monoclonal antibody (AVE1642) enhances Bortezomib-induced apoptosis in myeloma cells lacking CD45
    • Descamps G, Gomez-Bougie P, Venot C, Moreau P, Bataille R, et al. (2009) A humanised anti-IGF-1R monoclonal antibody (AVE1642) enhances Bortezomib-induced apoptosis in myeloma cells lacking CD45. British journal of cancer 100: 366-369.
    • (2009) British Journal of Cancer , vol.100 , pp. 366-369
    • Descamps, G.1    Gomez-Bougie, P.2    Venot, C.3    Moreau, P.4    Bataille, R.5
  • 35
    • 63449109698 scopus 로고    scopus 로고
    • Myeloma cell growth inhibition is augmented by synchronous inhibition of the insulin-like growth factor-1 receptor by NVP-AEW541 and inhibition of mammalian target of rapamycin by Rad001
    • Baumann P, Hagemeier H, Mandl-Weber S, Franke D, Schmidmaier R, (2009) Myeloma cell growth inhibition is augmented by synchronous inhibition of the insulin-like growth factor-1 receptor by NVP-AEW541 and inhibition of mammalian target of rapamycin by Rad001. Anti-cancer drugs 20: 259-266.
    • (2009) Anti-Cancer Drugs , vol.20 , pp. 259-266
    • Baumann, P.1    Hagemeier, H.2    Mandl-Weber, S.3    Franke, D.4    Schmidmaier, R.5
  • 37
    • 79955805214 scopus 로고    scopus 로고
    • Phase I study of the anti insulin-like growth factor 1 receptor (IGF-1R) monoclonal antibody, AVE1642, as single agent and in combination with bortezomib in patients with relapsed multiple myeloma
    • Moreau P, Cavallo F, Leleu X, Hulin C, Amiot M, et al. (2011) Phase I study of the anti insulin-like growth factor 1 receptor (IGF-1R) monoclonal antibody, AVE1642, as single agent and in combination with bortezomib in patients with relapsed multiple myeloma. Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, UK 25: 872-874.
    • (2011) Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, UK , vol.25 , pp. 872-874
    • Moreau, P.1    Cavallo, F.2    Leleu, X.3    Hulin, C.4    Amiot, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.