메뉴 건너뛰기




Volumn 9, Issue 1, 2012, Pages

Treatment for uterine fibroids: Searching for effective drug therapies

Author keywords

[No Author keywords available]

Indexed keywords

ACOLBIFENE; ANASTROZOLE; AROMATASE INHIBITOR; ARZOXIFENE; ASOPRISNIL; BUSERELIN; CLOSTRIDIOPEPTIDASE A; GESTAGEN; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; GOSERELIN; HALOFUGINONE; HISTRELIN; LETROZOLE; LEUPRORELIN; LEVONORGESTREL; MIFEPRISTONE; NAFARELIN; NANOCARRIER; ORAL CONTRACEPTIVE AGENT; PIRFENIDONE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR MODULATOR; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TRIPTORELIN; ULIPRISTAL;

EID: 84871433297     PISSN: None     EISSN: 17406773     Source Type: Journal    
DOI: 10.1016/j.ddstr.2012.06.001     Document Type: Review
Times cited : (35)

References (48)
  • 1
    • 58149396853 scopus 로고    scopus 로고
    • Growth of uterine leiomyomata among premenopausal black and white women
    • Peddada, S.D. et al. (2008) Growth of uterine leiomyomata among premenopausal black and white women. Proc. Natl. Acad. Sci. U.S.A. 105, 19887-19892
    • (2008) Proc. Natl. Acad. Sci. U.S.A , vol.105 , pp. 19887-19892
    • Peddada, S.D.1
  • 2
    • 33746522802 scopus 로고    scopus 로고
    • A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays
    • DOI 10.1016/j.ajog.2005.12.059, PII S0002937806000068
    • Leppert, P.C. et al. (2006) A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays. Am. J. Obstet. Gynecol. 195, 415-420 (Pubitemid 44142369)
    • (2006) American Journal of Obstetrics and Gynecology , vol.195 , Issue.2 , pp. 415-420
    • Leppert, P.C.1    Catherino, W.H.2    Segars, J.H.3
  • 4
    • 84859114099 scopus 로고    scopus 로고
    • Proteoglycans of uterine fibroids and keloid scars: Similarity in their proteoglycan composition
    • Carrino, D.A. et al. (2012) Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. Biochem. J. 443, 361-368. This report presents evidence that uterine fibroids are characterized by disarrayed collagen fibrils strikingly similar to those of keloid scars. The authors find that keloids are a form of excessive dermal fibrosis demonstrating abnormal wound-healing response in certain individuals; they form after skin trauma such as surgery; they tend to develop during and after puberty and in women symptoms of keloids disappear after menopause; they produce high levels of collagen, and fibronectin; they are characterized as resisting apoptosis and thus continue to produce collagen.
    • (2012) Biochem. J , vol.443 , pp. 361-368
    • Carrino, D.A.1
  • 5
    • 77957678197 scopus 로고    scopus 로고
    • The impact of uterine leiomyomas on reproductive outcomes
    • Cook, H. et al. (2010) The impact of uterine leiomyomas on reproductive outcomes. Minerva Ginecol. 62, 225-236
    • (2010) Minerva Ginecol , vol.62 , pp. 225-236
    • Cook, H.1
  • 6
    • 80052267728 scopus 로고    scopus 로고
    • Comparing focused ultrasound and uterine artery embolization for uterine fibroids-rationale and design of the fibroid interventions: Reducing symptoms today and tomorrow (firstt) trial
    • Bouwsma, E.V. et al. (2011) Comparing focused ultrasound and uterine artery embolization for uterine fibroids-rationale and design of the fibroid interventions: reducing symptoms today and tomorrow (firstt) trial. Fertil. Steril. 96, 704-710
    • (2011) Fertil. Steril , Issue.96 , pp. 704-710
    • Bouwsma, E.V.1
  • 7
    • 84885392005 scopus 로고    scopus 로고
    • Medical management of uterine fibroids
    • Parsanezhad, M. et al. (2012) Medical management of uterine fibroids. Curr. Obstet. Gynecol. Rep. 1-8
    • (2012) Curr. Obstet. Gynecol. Rep , pp. 1-8
    • Parsanezhad, M.1
  • 8
    • 84871457988 scopus 로고    scopus 로고
    • The estimated annual cost of uterine leiomyomata in the united states
    • Cardozo, E.R. et al. (2011) The estimated annual cost of uterine leiomyomata in the united states. Am. J. Obstet. Gynecol. . The article reports than annual societal costs for uterine fibroid therapy approach $34.4 billion not accounting for those women with symptomatic fibroids and no access to medical care. The authors use pooled odds ratios when possible and reflect a large number of studies, to arrive at numbers for direct, indirect, and associated pregnancy and obstetrical related costs in the assessment of cost of uterine fibroids.
    • (2011) Am. J. Obstet. Gynecol
    • Cardozo, E.R.1
  • 9
    • 79957449072 scopus 로고    scopus 로고
    • A randomized controlled study comparing pain experience between a newly designed needle with a thin tip and a standard needle for oocyte aspiration
    • Wikland, M. et al. (2011) A randomized controlled study comparing pain experience between a newly designed needle with a thin tip and a standard needle for oocyte aspiration. Hum. Reprod. 26, 1377-1383
    • (2011) Hum. Reprod , vol.26 , pp. 1377-1383
    • Wikland, M.1
  • 10
    • 84876261558 scopus 로고    scopus 로고
    • Situ forming systems (depots)
    • (Wright, J.C. and Burgess, D.J., eds) Springer
    • Wright, J.C. et al. (2012) In situ forming systems (depots). In Long acting injections and implants (Wright, J.C. and Burgess, D.J., eds), pp. 153-166, Springer
    • (2012) Long Acting Injections and Implants , pp. 153-166
    • Wright, J.C.1
  • 11
    • 85065220396 scopus 로고    scopus 로고
    • Temperature-responsive biocompatible copolymers incorporating hyperbranched polyglycerols for adjustable functionality
    • Taylor, D.K. et al. (2011) Temperature-responsive biocompatible copolymers incorporating hyperbranched polyglycerols for adjustable functionality. J. Funct. Biomater. 2, 173-194. The authors describe the design, synthesis, and characterization of a four component copolymer that responds to elevation in temperature by undergoing a phase transition from liquid to solid. This is the first thermoresponsive injectable that has the potential to deliver multiple drugs by mechanistically different approaches: covalent attachment of drug and physical entrapment of drug.
    • (2011) J. Funct. Biomater , Issue.2 , pp. 173-194
    • Taylor, D.K.1
  • 12
    • 79960545091 scopus 로고    scopus 로고
    • Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer
    • del Mastro, L. et al. (2011) Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer. J. Am. Med. Assoc. 306, 269-276
    • (2011) J. Am. Med. Assoc , vol.306 , pp. 269-276
    • Del Mastro, L.1
  • 13
    • 84865173010 scopus 로고    scopus 로고
    • Innovative oral treatments of uterine leiomyoma
    • Sabry, M. and Al-Hendy, A. (2012) Innovative oral treatments of uterine leiomyoma. Obstet. Gynecol. Int. http://dx.doi.org/10.1155/2012/943635. This review of drug therapies covers conventional drugs in a very succinct manner. In addition, the authors include a section on herbal therapies.
    • (2012) Obstet. Gynecol. Int
    • Sabry, M.1    Al-Hendy, A.2
  • 14
    • 76749155403 scopus 로고    scopus 로고
    • Changes in tissue inflammation, angiogenesis and apoptosis in endometriosis, adenomyosis and uterine myoma after gnrh agonist therapy
    • Khan, K.N. et al. (2010) Changes in tissue inflammation, angiogenesis and apoptosis in endometriosis, adenomyosis and uterine myoma after gnrh agonist therapy. Hum. Reprod. 25, 642-653
    • (2010) Hum. Reprod , vol.25 , pp. 642-653
    • Khan, K.N.1
  • 15
    • 79956348446 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone agonist increases expression of osmotic response genes in leiomyoma cells
    • McCarthy-Keith, D.M. et al. (2011) Gonadotropin-releasing hormone agonist increases expression of osmotic response genes in leiomyoma cells. Fertil. Steril. 95, 2383-2387. The authors characterize hyperosmolarity-responsive genes in leiomyoma cells and determine whether gonadotropin-releasing hormone (GnRH) agonist treatment altered their expression. This report is timely because it offers insight into yet another mechanism of fibroid shrinkage.
    • (2011) Fertil. Steril , vol.95 , pp. 2383-2387
    • McCarthy-Keith, D.M.1
  • 16
    • 77954735637 scopus 로고    scopus 로고
    • Novel highly potent and selective nonsteroidal aromatase inhibitors: Syn thesis, biological evaluation and structure- activity relationships investigation
    • Gobbi, S. et al. (2010) Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure- activity relationships investigation. J. Med Chem. 53, 5347-5351. This is one of a series of papers that reports on some molecules featuring different oxygenated heterocycles such as flavone, chromone, and xanthone asaromatase inhibitors. The authors are focusing on development of novel AI constructs with the aim of increasing potency and selectivity versus other CYP enzymes.
    • (2010) J. Med Chem , vol.53 , pp. 5347-5351
    • Gobbi, S.1
  • 17
    • 84871422051 scopus 로고    scopus 로고
    • Serm's in treatment of breast cancer
    • Saudagar, R.B. et al. (2011) Serm's in treatment of breast cancer. Asian J. Pharm. Res. 1, 81-86
    • (2011) Asian J. Pharm. Res , Issue.1 , pp. 81-86
    • Saudagar, R.B.1
  • 18
    • 84863011241 scopus 로고    scopus 로고
    • Selective estrogen receptor modulator: Raloxifene
    • Dai, X. and Wu, J. (2011) Selective estrogen receptor modulator: raloxifene. J. Reprod. Contracept. 22, 51-60. This paper compiles a lot of the previously reported findings on raloxifene. It also has general discussion about SERMs as a drug class.
    • (2011) J. Reprod. Contracept , Issue.22 , pp. 51-60
    • Dai, X.1    Wu, J.2
  • 19
    • 80054979226 scopus 로고    scopus 로고
    • Selective progesterone receptor modulators in reproductive medicine: Pharmacology, clinical efficacy and safety
    • This paper serves as the first recent review of SPRMs and compiles a lot of the previously reported findings for this drug class. Thus, it is a timely contribution to the field
    • Bouchard, P. et al. (2011) Selective progesterone receptor modulators in reproductive medicine: pharmacology, clinical efficacy and safety. Fertil. Steril. 96, 1175-1189. This paper serves as the first recent review of SPRMs and compiles a lot of the previously reported findings for this drug class. Thus, it is a timely contribution to the field.
    • (2011) Fertil. Steril , vol.96 , pp. 1175-1189
    • Bouchard, P.1
  • 20
    • 78650420556 scopus 로고    scopus 로고
    • Proceedings from the national institute of child health and human development conference on the uterine fibroid research update workshop
    • Catherino, W.H. et al. (2011) Proceedings from the national institute of child health and human development conference on the uterine fibroid research update workshop. Fertil. Steril. 95, 9-12
    • (2011) Fertil. Steril , vol.95 , pp. 9-12
    • Catherino, W.H.1
  • 21
    • 84864147332 scopus 로고    scopus 로고
    • Term myometrium is characterized by increased activating epigenetic modifications at the progesterone receptor-A promoter
    • Chai, S.Y. et al. (2012) Term myometrium is characterized by increased activating epigenetic modifications at the progesterone receptor-a promoter. Mol. Hum. Reprod. http://dx.doi.org/10.1093/molehr/gas012
    • (2012) Mol. Hum. Reprod
    • Chai, S.Y.1
  • 22
    • 84871434604 scopus 로고    scopus 로고
    • Mitochondrial progesterone receptor (pr-m) distribution in uterine leiomyoma and myometrium and impact on mitochondrial membrane potential (mmp) in immortilized human myometrial cells (htert-hm)
    • Crochet, J.R. et al. (2011) Mitochondrial progesterone receptor (pr-m) distribution in uterine leiomyoma and myometrium and impact on mitochondrial membrane potential (mmp) in immortilized human myometrial cells (htert-hm). Fertil. Steril. 96, S96. In providing evidence of increase PR-M expression and number of mitochondria in the fibroids edge, these authors present evidence that a non-genomic progestininduced increase in cellular respiration may be a major factor in the growth of fibroids.
    • (2011) Fertil. Steril , vol.96
    • Crochet, J.R.1
  • 23
    • 79951526115 scopus 로고    scopus 로고
    • Novel 3-aryl indoles as progesterone receptor antagonists for uterine fibroids
    • Richardson, T.I. et al. (2011) Novel 3-aryl indoles as progesterone receptor antagonists for uterine fibroids. ACS Med. Chem. Lett. 2, 148-153
    • (2011) ACS Med. Chem. Lett , Issue.2 , pp. 148-153
    • Richardson, T.I.1
  • 24
    • 77957748919 scopus 로고    scopus 로고
    • Mifepristone: Where do we come from and where are we going? Clinical development over a quarter of a century
    • Spitz, I.M. (2010) Mifepristone: where do we come from and where are we going? Clinical development over a quarter of a century Contraception 82, 442-452. This paper serves as the current review of milepristone compiling results over 25 years.
    • (2010) Contraception , vol.82 , pp. 442-452
    • Spitz, I.M.1
  • 25
    • 84858441465 scopus 로고    scopus 로고
    • Treatment of uterine myoma with 5 or 10 mg mifepristone daily during 6 months, post-treatment evolution over 12 months: Double-blind randomised clinical trial
    • Esteve, J.L.C. et al. (2012) Treatment of uterine myoma with 5 or 10 mg mifepristone daily during 6 months, post-treatment evolution over 12 months: double-blind randomised clinical trial. Eur. J. Obstet. Gynecol. Reprod. Biol. 161, 202-208
    • (2012) Eur. J. Obstet. Gynecol. Reprod. Biol , Issue.161 , pp. 202-208
    • Esteve, J.L.C.1
  • 26
    • 83455163592 scopus 로고    scopus 로고
    • Emerging indications for the levonorgestrel-releasing intrauterine system (lng-ius
    • Heikinheimo, O. and Gemzell-Danielsson, K. (2012) Emerging indications for the levonorgestrel-releasing intrauterine system (lng-ius). Acta Obstet. Gynecol. Scand. 91, 3-9
    • (2012) Acta Obstet. Gynecol. Scand , vol.91 , pp. 3-9
    • Heikinheimo, O.1    Gemzell-Danielsson, K.2
  • 27
    • 78650735049 scopus 로고    scopus 로고
    • A randomized clinical trial of a levonorgestrel-releasing intrauterine system and a low-dose combined oral contraceptive for fibroid-related menorrhagia
    • Sayed, G.H. et al. (2011) A randomized clinical trial of a levonorgestrel-releasing intrauterine system and a low-dose combined oral contraceptive for fibroid-related menorrhagia. Int. J. Gynecol. Obstet. 112, 126-130
    • (2011) Int. J. Gynecol. Obstet , vol.112 , pp. 126-130
    • Sayed, G.H.1
  • 28
    • 83055194361 scopus 로고    scopus 로고
    • Efficacy of the levonorgestrel-releasing intrauterine system in uterine leiomyoma
    • Kriplani, A. et al. (2012) Efficacy of the levonorgestrel-releasing intrauterine system in uterine leiomyoma. Int. J. Gynecol. Obstet. 116, 35-38
    • (2012) Int. J. Gynecol. Obstet , vol.116 , pp. 35-38
    • Kriplani, A.1
  • 29
    • 80555148896 scopus 로고    scopus 로고
    • Treatment of symptomatic uterine leiomyomas with selective progesterone receptor modulators
    • Stovall, D.W. and Mikdachi, H.E. (2011) Treatment of symptomatic uterine leiomyomas with selective progesterone receptor modulators. Expert Rev. Obstet. Gynecol. 6, 579-582
    • (2011) Expert Rev. Obstet. Gynecol , vol.6 , pp. 579-582
    • Stovall, D.W.1    Mikdachi, H.E.2
  • 30
    • 77951880664 scopus 로고    scopus 로고
    • Intrauterine progestins, progesterone antagonists, and receptor modulators: A review of gynecologic applications
    • Rodriguez, M.I. et al. (2010) Intrauterine progestins, progesterone antagonists, and receptor modulators: a review of gynecologic applications. Am. J. Obstet. Gynecol. 202, 420-428
    • (2010) Am. J. Obstet. Gynecol , vol.202 , pp. 420-428
    • Rodriguez, M.I.1
  • 31
    • 84856568733 scopus 로고    scopus 로고
    • Ulipristal acetate versus placebo for fibroid treatment before surgery
    • Donnez, J. et al. (2012) Ulipristal acetate versus placebo for fibroid treatment before surgery. N. Engl. J. Med. 366, 409-420
    • (2012) N. Engl. J. Med , vol.366 , pp. 409-420
    • Donnez, J.1
  • 32
    • 78751569564 scopus 로고    scopus 로고
    • Efficacy and tolerability of cdb-2914 treatment for symptomatic uterine fibroids: A randomized, double-blind, placebocontrolled, phase iib study
    • Nieman, L.K. et al. (2011) Efficacy and tolerability of cdb-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebocontrolled, phase iib study. Fertil. Steril. 95, 767-769
    • (2011) Fertil. Steril , vol.95 , pp. 767-769
    • Nieman, L.K.1
  • 33
    • 77952110601 scopus 로고    scopus 로고
    • The selective progesterone receptor modulator cdb4124 inhibits proliferation and induces apoptosis in uterine leiomyoma cells
    • Luo, X. et al. (2010) The selective progesterone receptor modulator cdb4124 inhibits proliferation and induces apoptosis in uterine leiomyoma cells. Fertil. Steril. 93, 2668-2673
    • (2010) Fertil. Steril , vol.93 , pp. 2668-2673
    • Luo, X.1
  • 34
    • 80051988006 scopus 로고    scopus 로고
    • Cdb-4124 does not cause apoptosis in cultured fibroid cells
    • Roeder, H. et al. (2011) Cdb-4124 does not cause apoptosis in cultured fibroid cells. Reprod. Sci. 18, 850-857. This report is a major finding as it corrects previous thoughts on the role of CDB-4124.
    • (2011) Reprod. Sci , vol.18 , pp. 850-857
    • Roeder, H.1
  • 35
    • 77950640187 scopus 로고    scopus 로고
    • Multimodal regulation of e2f1 gene expression by progestins
    • Wade, H.E. et al. (2010) Multimodal regulation of e2f1 gene expression by progestins. Mol. Cell. Biol. 30, 1866-1877
    • (2010) Mol. Cell. Biol , vol.30 , pp. 1866-1877
    • Wade, H.E.1
  • 36
    • 77953808712 scopus 로고    scopus 로고
    • Potential therapeutic targets for cardiac fibrosis: Tgfbeta, angiotensin, endothelin, ccn2, and pdgf, partners in fibroblast activation
    • Leask, A. (2010) Potential therapeutic targets for cardiac fibrosis: Tgfbeta, angiotensin, endothelin, ccn2, and pdgf, partners in fibroblast activation. Circ. Res. 106, 1675-1680
    • (2010) Circ. Res , vol.106 , pp. 1675-1680
    • Leask, A.1
  • 37
    • 77951528114 scopus 로고    scopus 로고
    • Why leiomyomas are called fibroids: The central role of extracellular matrix in symptomatic women
    • Malik, M. et al. (2010) Why leiomyomas are called fibroids: the central role of extracellular matrix in symptomatic women. Semin. Reprod. Med. 28, 169-179
    • (2010) Semin. Reprod. Med , vol.28 , pp. 169-179
    • Malik, M.1
  • 38
    • 84855592608 scopus 로고    scopus 로고
    • Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma
    • Norian, J.M. et al. (2012) Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma. Matrix Biol. 31, 57-65
    • (2012) Matrix Biol , vol.31 , pp. 57-65
    • Norian, J.M.1
  • 39
    • 79955027602 scopus 로고    scopus 로고
    • Increased type i and v collagen expression in uterine leiomyomas during the menstrual cycle
    • Iwahashi, M. and Muragaki, Y. (2011) Increased type i and v collagen expression in uterine leiomyomas during the menstrual cycle. Fertil. Steril. 95, 2137-2139
    • (2011) Fertil. Steril , Issue.95 , pp. 2137-2139
    • Iwahashi, M.1    Muragaki, Y.2
  • 40
    • 79961097552 scopus 로고    scopus 로고
    • Progress towards discovery of antifibrotic drugs targeting synthesis of type i collagen
    • Fritz, D. et al. (2011) Progress towards discovery of antifibrotic drugs targeting synthesis of type i collagen. Curr. Med. Chem. 18, 3410-3416. This paper serves as the first recent review of antifibrotic drugs. The authors compile a lot of the previously reported findings within this drug class.
    • (2011) Curr. Med. Chem , vol.18 , pp. 3410-3416
    • Fritz, D.1
  • 41
    • 74549117840 scopus 로고    scopus 로고
    • Pirfenidone: An anti-fibrotic therapy for progressive kidney disease
    • Cho, M.E. and Kopp, J.B. (2010) Pirfenidone: an anti-fibrotic therapy for progressive kidney disease. Expert Opin. Investig. Drugs 19, 275-283
    • (2010) Expert Opin. Investig. Drugs , vol.19 , pp. 275-283
    • Cho, M.E.1    Kopp, J.B.2
  • 42
    • 80052591439 scopus 로고    scopus 로고
    • The multifaceted role of pirfenidone and its novel targets
    • Macias-Barragan, J. et al. (2010) The multifaceted role of pirfenidone and its novel targets. Fibrogenesis Tissue Rep. 3, 16. This is concise review of the chemical and biological properties of pirfenidone. The authors have captured not only major previous reports on this drug, but in addition, given insight into what we can expect from pharmaceutical development within this drug class.
    • (2010) Fibrogenesis Tissue Rep , Issue.3 , pp. 16
    • MacIas-Barragan, J.1
  • 44
    • 77049102168 scopus 로고    scopus 로고
    • The antifibrotic drug halofuginone inhibits proliferation and collagen production by human leiomyoma and myometrial smooth muscle cells
    • Grudzien, M.M. et al. (2010) The antifibrotic drug halofuginone inhibits proliferation and collagen production by human leiomyoma and myometrial smooth muscle cells. Fertil. Steril. 93, 1290-1298
    • (2010) Fertil. Steril , vol.93 , pp. 1290-1298
    • Grudzien, M.M.1
  • 45
    • 84871404910 scopus 로고    scopus 로고
    • Non-surgical treatment options for symptomatic uterine leiomyomas
    • Tantibhedhyangkul, J.A. and Behera, M. (2010) Non-surgical treatment options for symptomatic uterine leiomyomas. Curr. Womens Health Rev. 6, 146-160
    • (2010) Curr. Womens Health Rev , Issue.6 , pp. 146-160
    • Tantibhedhyangkul, J.A.1    Behera, M.2
  • 46
    • 84555217908 scopus 로고    scopus 로고
    • Contraceptives with novel benefits
    • Su, Y. et al. (2012) Contraceptives with novel benefits. Expert Opin. Investig. Drugs 21, 83-90
    • (2012) Expert Opin. Investig. Drugs , vol.21 , pp. 83-90
    • Su, Y.1
  • 47
    • 84886197101 scopus 로고    scopus 로고
    • Introduction to traditional herbal medicines and their study
    • (Liu, W.J.H., ed.), John Wiley & Sons, Inc
    • Liu, W.J.H. (2011) Introduction to traditional herbal medicines and their study. In Traditional herbal medicine research methods (Liu, W.J.H., ed.), pp. 1-26, John Wiley & Sons, Inc
    • (2011) Traditional Herbal Medicine Research Methods , pp. 1-26
    • Liu, W.J.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.