An unusual antithrombin-binding heparin octasaccharide with an additional 3-O-sulfated glucosamine in the active pentasaccharide sequence

Biochemical Journal

Volumn 449, Issue 2, 2013, Pages 343-351

  Guerrini, Marco ^a   Elli, Stefano ^a   Mourier, Pierre ^b   Rudd, Timothy R ^a,d   Gaudesi, Davide ^a,e   Casu, Benito ^a   Boudier, Christian ^c   Torri, Giangiacomo ^a   Viskov, Christian ^b  

^a Istituto di Ricerche Chimiche e Biochimiche G Ronzoni   (Italy)

^b SANOFI   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d DIAMOND LIGHT SOURCE LTD   (United Kingdom)

^e SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

3 O sulfation; 3 O sulfotransferase (3 OST); Antithrombin; Heparin; NMR

Indexed keywords

GLUCOSAMINE DERIVATIVE; HEPARIN; PENTASACCHARIDE;

ANTICOAGULATION; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG BINDING; DRUG BINDING SITE; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SULFATION; ENZYME SPECIFICITY; EQUILIBRIUM CONSTANT; FOURIER TRANSFORMATION; HYDROGEN BOND; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; STATIC ELECTRICITY; STOICHIOMETRY; TEMPERATURE; TITRIMETRY;

ANTITHROMBINS; CARBOHYDRATE SEQUENCE; GLUCOSAMINE; HEPARIN; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OLIGOSACCHARIDES; PROTEIN BINDING; PROTEIN CONFORMATION; SULFATES; TEMPERATURE;

EID: 84871422681     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121309     Document Type: Article

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