Synthesis, crystal structure and b-glucuronidase inhibition activity of some new hydrazinecarboxamides and their 1,2,4-triazole derivatives

Medicinal Chemistry Research

Volumn 21, Issue 11, 2012, Pages 3885-3896

  Hanif, Muhammad ^a   Khan, Imtiaz ^a   Rama, Nasim Hasan ^a   Noreen, Shagufta ^b   Choudhary, Muhammad Iqbal ^b   Jones, Peter G ^d   Iqbal, Mazhar ^c  

^a QUAID I AZAM UNIVERSITY   (Pakistan)

^b UNIVERSITY OF KARACHI   (Pakistan)

^c TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^d NATIONAL INSTITUTE FOR BIOTECHNOLOGY AND GENETIC ENGINEERING NIBGE   (Pakistan)

Author keywords

1,2,4 Triazoles; B Glucuronidase inhibition; Cyclization; Heterocycles; Hydrazinecarboxamides

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 3 (2 METHOXYBENZYL) 4 (2 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 5(4H) ONE; 3 (2 METHOXYBENZYL) 4 (3 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 5(4H) ONE; 3 (2 METHOXYPHENETHYL) 4 (2 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 5(4H) ONE; 3 (2 METHOXYPHENETHYL) 4 (3 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 5(4H) ONE; 3 (2 METHOXYPHENETHYL) 4 (4 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 5(4H) ONE; 3 (3 METHOXYBENZYL) 4 (2 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 5(4H) ONE; 3 (3 METHOXYBENZYL) 4 (3 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 5(4H) ONE; 3 (3 METHOXYPHENETHYL) 4 (2 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 5(4H) ONE; 3 (3 METHOXYPHENETHYL) 4 (3 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 5(4H) ONE; 3 (4 METHOXYBENZYL) 4 (2 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 5(4H) ONE; 3 (4 METHOXYPHENETHYL) 4 (2 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 5(4H) ONE; 3 (4 METHOXYPHENETHYL) 4 (3 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 5(4H) ONE; BETA GLUCURONIDASE; HYDRAZIDE DERIVATIVE; HYDRAZINECARBOXAMIDE DERIVATIVE; N (2 METHOXYPHENYL) 2 [2 (2 METHOXYPHENYL)ACETYL]HYDRAZINECARBOXAMIDE; N (2 METHOXYPHENYL) 2 [2 (3 METHOXYPHENYL)ACETYL]HYDRAZINECARBOXAMIDE; N (2 METHOXYPHENYL) 2 [2 (4 METHOXYPHENYL)ACETYL]HYDRAZINECARBOXAMIDE; N (2 METHOXYPHENYL) 2 [3 (2 METHOXYPHENYL)PROPANOYL]HYDRAZINECARBOXAMIDE; N (2 METHOXYPHENYL) 2 [3 (3 METHOXYPHENYL)PROPANOYL]HYDRAZINECARBOXAMIDE; N (2 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPANOYL]HYDRAZINECARBOXAMIDE; N (3 METHOXYPHENYL) 2 [2 (2 METHOXYPHENYL)ACETYL]HYDRAZINECARBOXAMIDE; N (3 METHOXYPHENYL) 2 [2 (3 METHOXYPHENYL)ACETYL]HYDRAZINECARBOXAMIDE; N (3 METHOXYPHENYL) 2 [3 (2 METHOXYPHENYL)PROPANOYL]HYDRAZINECARBOXAMIDE; N (3 METHOXYPHENYL) 2 [3 (3 METHOXYPHENYL)PROPANOYL]HYDRAZINECARBOXAMIDE; N (3 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPANOYL]HYDRAZINECARBOXAMIDE; N (4 METHOXYPHENYL) 2 [3 (2 METHOXYPHENYL)PROPANOYL]HYDRAZINECARBOXAMIDE; N (4 METHOXYPHENYL) 2 [3 (3 METHOXYPHENYL)PROPANOYL]HYDRAZINECARBOXAMIDE; N (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPANOYL]HYDRAZINECARBOXAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION;

EID: 84871418694     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-011-9929-1     Document Type: Article

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