Tissue engineering vascularized bone repairing segmental femoral bone defects in rabbits

National Medical Journal of China

Volumn 90, Issue 23, 2010, Pages 1637-1641

  Wang, Le ^a   Pei, Guo Xian ^b   Gao, Liang Bin ^a   Jiang, Shan ^c   Mu, Tian Wang ^c   Chen, Si Yuan ^c   Qin, Jun Jun ^c   Jin, Dan ^c   Lou, Ai Ju ^c   Zhao, Pei Ran ^c  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c NONE

Author keywords

Biomedical engineering; Bone defect; Endothelium, vascular

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BONE DEFECT; BONE REMODELING; CONTROLLED STUDY; FEMORAL BONE DEFECT; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; OSSIFICATION; PROTEIN EXPRESSION; RABBIT; REAL TIME POLYMERASE CHAIN REACTION; TISSUE ENGINEERING VASCULARIZED BONE REPAIR; WESTERN BLOTTING; ANGIOGENESIS; ANIMAL; BONE DEVELOPMENT; BONE MARROW CELL; BONE PROSTHESIS; CYTOLOGY; DIAPHYSIS; INJURY; METABOLISM; METHODOLOGY; TISSUE ENGINEERING; WOUND HEALING;

ANIMALS; BONE MARROW CELLS; BONE SUBSTITUTES; DIAPHYSES; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOGENESIS; RABBITS; TISSUE ENGINEERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 84871414612     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2010.23.016     Document Type: Article

References (29)

1. 2007, 34:620-622.
2. Carano R A, Filvaroff E H. Angiogenesis and bone repair. Drug Discov Today, 2003, 8:980-989.
3. 2005, 7:353-357.
4. 2006, 26:931-935.
5. 2007, 27:614-618.
6. 2003, 83: 1345-1349.
7. Ilizarov G A. The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. Clin Orthop Relat Res, 1989, 239:263.
8. Ma H Z, Zeng B F, Li X L, et al. Upregulation of VEGF in subchondral bone of necrotic femoral heads in rabbits with use of extracorporeal shock waves. Calcif Tissue Int, 2007, 81:124-131.
9. Bradford M M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 1976, 72: 248-254.
10. 2003, 83:1676-1681.
11. 2002, 82:191-193.
12. Hsiong S X, Mooney D J. Regeneration of vascularized bone. Regen Med, 2007, 2:831-837.
13. Kanczler J M, Oreffo R O. Osteogenesis and angiogenesis: the potential for engineering bone. Eur Cell Mater, 2008, 2: 100-114.
14. Kneser U, Polykandriotis E, Ohnolz J, et al. Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop. Tissue Eng, 2006, 12:1721-1731.
15. 2006, 23:1510-1512.
16. Pelissier P, Villars F, Mathoulin-Pelissier S, et al. Influences of vascularization and osteogenic cells on heterotopic bone formation within a madreporic ceramic in rats. Plast Reconstr Surg, 2003, 111:1932-1941.
17. Madeddu P. Therapeutic angiogenesis and vasculogenesis for tissue regeneration. Exp Physiol, 2005, 90:315-326.
18. Vico L. VEGF and bone formation: New perspectives. European Cells and Materials, 2007, 14:32.
19. Ferrara N, Gerber H P, LeCouter J. The biology of VEGF and its receptors. Nat Med, 2003, 9:669-676.
20. Dai J, Rabie A B. VEGF: an essential mediator of both angiogenesis and endochondral ossification. J Dent Res, 2007, 86:937-950.
21. Kaigler D, Krebsbach P H, Polverini P J, et al. Role of vascular endothelial growth factor in bone marrow stromal cell modulation of endothelial cells. Tissue Eng, 2003, 9:95-103.
22. Geiger F, Lorenz H, Xu W, et al. VEGF producing bone marrow stromal cells (BMSC) enhance vascularization and resorption of a natural coral bone substitute. Bone, 2007, 41:516-522.
23. 2005, 7:971-974.
24. Crigel M H, Balligand M. Critical size defect model on the femur in rabbits. Vet Comp Orthop traumatol, 2002, 15:158-163.
25. Concannon M J, Boschert M T, Puckett C L. Bone induction using demineralized bone in the rabbit femur: a long-term study. Plast Reconstr Surg, 1997, 99:1983-1988.
26. Alini M, Marriott A, Chen T, et al. A novel angiogenic molecule produced at the time of chondrocyte hypertrophy during endochondral bone formation. Dev Biol, 1996, 176:124-132.
27. Pufe T, Wildemann B, Petersen W, et al. Quantitative measurement of the splice variants 120 and 164 of the angiogenic peptide vascular endothelial growth factor in the time flow of fracture healing: a study in the rat. Cell Tissue Res, 2002, 309: 387-392.
28. Carano R A, Filvaroff E H. Angiogenesis and bone repair. Drug Discov Today, 2003, 8:980-989.
29. Zelzer E, McLean W, Ng Y S, et al. Skeletal defects in VEGF (120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development, 2002, 129: 1893-1904.