메뉴 건너뛰기




Volumn 4, Issue 12, 2012, Pages 962-969

Two-dimensional gas chromatography with heart-cutting for isotope ratio mass spectrometry analysis of steroids in doping control

Author keywords

GC GC; Heart cutting; IRMS; Multidimentional GC; Steroids; Testosterone

Indexed keywords

GAS CHROMATOGRAPHY; ISOTOPES; LIPIDS; MASS SPECTROMETRY; SILICONES; SPECTROMETERS;

EID: 84871394090     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.1379     Document Type: Article
Times cited : (25)

References (37)
  • 1
    • 85153153911 scopus 로고    scopus 로고
    • World Anti-Doping Agency, 2010 Adverse Analytical Findings and Atypical Findings, Reported by Accredited Laboratories. Available at: [15 November 2011].
    • World Anti-Doping Agency, 2010 Adverse Analytical Findings and Atypical Findings, Reported by Accredited Laboratories. Available at: http://www.wada-ama.org/Documents/Resources/Statistics/Laboratory_Statistics/WADA_2010_Laboratory_Statistics_Report.pdf [15 November 2011].
  • 2
    • 85153145086 scopus 로고    scopus 로고
    • World Anti-Doping Agency (WADA), Technical Document - TD2004EAAS. Available at: [27 August 2011].
    • World Anti-Doping Agency (WADA), Technical Document - TD2004EAAS. Available at: http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-IS-Laboratories/Technical_Documents/WADA_TD2004EAAS_Reporting_Evaluation_Testosterone_Epitestosterone_TE_Ratio_EN.pdf [27 August 2011].
  • 3
    • 44349157577 scopus 로고    scopus 로고
    • Pharmacology of anabolic steroids
    • A.T. Kicman Pharmacology of anabolic steroids. Brit. J. Pharmacol. 2008, 154, 502.
    • (2008) Brit. J. Pharmacol. , vol.154 , pp. 502
    • Kicman, A.T.1
  • 4
    • 0026539022 scopus 로고
    • Evaluating an abnormal urinary steroid profile
    • H. Oftebro Evaluating an abnormal urinary steroid profile. Lancet 1992, 339, 941.
    • (1992) Lancet , vol.339 , pp. 941
    • Oftebro, H.1
  • 6
    • 77953440669 scopus 로고    scopus 로고
    • Screening for testosterone abuse in male athletes using the measurement of urinary LH, a revision of the paradigm
    • C. Goebel, C.J. Howe, K.K. Ho, A. Nelson, R. Kazlauskas, G.J. Trout Screening for testosterone abuse in male athletes using the measurement of urinary LH, a revision of the paradigm. Drug Test. Anal. 2009, 1, 511.
    • (2009) Drug Test. Anal. , vol.1 , pp. 511
    • Goebel, C.1    Howe, C.J.2    Ho, K.K.3    Nelson, A.4    Kazlauskas, R.5    Trout, G.J.6
  • 8
    • 77953430016 scopus 로고    scopus 로고
    • Subject-based profiling for the detection of testosterone administration in sport
    • A.T. Kicman, D.A. Cowan Subject-based profiling for the detection of testosterone administration in sport. Drug Test. Anal. 2009, 1, 22.
    • (2009) Drug Test. Anal. , vol.1 , pp. 22
    • Kicman, A.T.1    Cowan, D.A.2
  • 9
    • 0028410574 scopus 로고
    • Gas chromatography/combustion/isotope-ratio mass spectrometry analysis of urinary steroids to detect misuse of testosterone in sport
    • M. Becchi, R. Aguilera, Y. Farizon, M.M. Flament, H. Casabianca, P. James Gas chromatography/combustion/isotope-ratio mass spectrometry analysis of urinary steroids to detect misuse of testosterone in sport. Rapid Commun. Mass Spectrom. 1994, 8, 304.
    • (1994) Rapid Commun. Mass Spectrom. , vol.8 , pp. 304
    • Becchi, M.1    Aguilera, R.2    Farizon, Y.3    Flament, M.M.4    Casabianca, H.5    James, P.6
  • 10
    • 0030934910 scopus 로고    scopus 로고
    • Confirming testosterone administration by isotope ratio mass spectrometric analysis of urinary androstanediols
    • C.H. Shackleton, A. Phillips, T. Chang, Y. Li Confirming testosterone administration by isotope ratio mass spectrometric analysis of urinary androstanediols. Steroids 1997, 62, 379.
    • (1997) Steroids , vol.62 , pp. 379
    • Shackleton, C.H.1    Phillips, A.2    Chang, T.3    Li, Y.4
  • 11
    • 85153149685 scopus 로고
    • Proceedings and Abstracts of the Second International Symposium on Applied Mass Spectrometry, Barcelona, Spain, 17-20 April
    • G. Southan, A. Mallet, J. Jumeau, S. Craig, N. Poojara, D. Mitchell, et al. In Proceedings and Abstracts of the Second International Symposium on Applied Mass Spectrometry, Barcelona, Spain, 17-20 April, 1990.
    • (1990)
    • Southan, G.1    Mallet, A.2    Jumeau, J.3    Craig, S.4    Poojara, N.5    Mitchell, D.6
  • 12
    • 0032947661 scopus 로고    scopus 로고
    • Applied gas chromatography coupled to isotope ratio mass spectrometry
    • W. Meier-Augenstein Applied gas chromatography coupled to isotope ratio mass spectrometry. J. Chromatogr. A 1999, 842, 351.
    • (1999) J. Chromatogr. A , vol.842 , pp. 351
    • Meier-Augenstein, W.1
  • 13
    • 84882887778 scopus 로고    scopus 로고
    • Isotope Ratio Studies Using Mass Spectrometry
    • (Eds: J.C. Lindon, G.E. Tranter, J.L. Holmes). Academic Press, ISBN 0-12-226680-3
    • M.E. Wieser, W.A. Brand, Isotope Ratio Studies Using Mass Spectrometry. in Encyclopedia of Spectroscopy and Spectrometry. (Eds: J.C. Lindon, G.E. Tranter, J.L. Holmes). Academic Press, ISBN 0-12-226680-3, 1999, 1072-1086.
    • (1999) Encyclopedia of Spectroscopy and Spectrometry , pp. 1072-1086
    • Wieser, M.E.1    Brand, W.A.2
  • 14
    • 0000512238 scopus 로고
    • Improvements in mass spectrometers for the measurement of small differences in isotope abundance ratios
    • C. McKinney, J. McCrea, S. Epstein, H.A. Allen, H.C. Urey Improvements in mass spectrometers for the measurement of small differences in isotope abundance ratios. Rev. Sci. Instrum. 1950, 21, 724.
    • (1950) Rev. Sci. Instrum. , vol.21 , pp. 724
    • McKinney, C.1    McCrea, J.2    Epstein, S.3    Allen, H.A.4    Urey, H.C.5
  • 15
    • 33748420058 scopus 로고    scopus 로고
    • Isotope-ratio detection for gas chromatography
    • A.L. Sessions Isotope-ratio detection for gas chromatography. J. Sep. Sci. 2006, 29, 1946.
    • (2006) J. Sep. Sci. , vol.29 , pp. 1946
    • Sessions, A.L.1
  • 16
    • 83955164394 scopus 로고    scopus 로고
    • Guidelines and recommended terms for expression of stable-isotope-ratio and gas-ratio measurement results
    • T.B. Coplen Guidelines and recommended terms for expression of stable-isotope-ratio and gas-ratio measurement results. Rapid Commun. Mass Spectrom. 2011, 25, 2538.
    • (2011) Rapid Commun. Mass Spectrom. , vol.25 , pp. 2538
    • Coplen, T.B.1
  • 17
    • 0033652152 scopus 로고    scopus 로고
    • A rapid screening assay for measuring urinary androsterone and etiocholanolone delta(13)C (per thousand) values by gas chromatography/combustion/isotope ratio mass spectrometry
    • R. Aguilera, T.E. Chapman, D.H. Catlin A rapid screening assay for measuring urinary androsterone and etiocholanolone delta(13)C (per thousand) values by gas chromatography/combustion/isotope ratio mass spectrometry. Rapid Commun. Mass Spectrom. 2000, 14, 2294.
    • (2000) Rapid Commun. Mass Spectrom. , vol.14 , pp. 2294
    • Aguilera, R.1    Chapman, T.E.2    Catlin, D.H.3
  • 18
    • 0032949912 scopus 로고    scopus 로고
    • Screening urine for exogenous testosterone by isotope ratio mass spectrometric analysis of one pregnanediol and two androstanediols
    • R. Aguilera, D.H. Catlin, M. Becchi, A. Phillips, C. Wang, R.S. Swerdloff, et al. Screening urine for exogenous testosterone by isotope ratio mass spectrometric analysis of one pregnanediol and two androstanediols. J. Chromatogr. B Biomed. Sci. Appl. 1999, 727, 95.
    • (1999) J. Chromatogr. B Biomed. Sci. Appl. , vol.727 , pp. 95
    • Aguilera, R.1    Catlin, D.H.2    Becchi, M.3    Phillips, A.4    Wang, C.5    Swerdloff, R.S.6
  • 19
    • 0030022083 scopus 로고    scopus 로고
    • Improved method of detection of testosterone abuse by gas chromatography/combustion/isotope ratio mass spectrometry analysis of urinary steroids
    • R. Aguilera, M. Becchi, H. Casabianca, C.K. Hatton, D.H. Catlin, B. Starcevic, et al. Improved method of detection of testosterone abuse by gas chromatography/combustion/isotope ratio mass spectrometry analysis of urinary steroids. J. Mass Spectrom. 1996, 31, 169.
    • (1996) J. Mass Spectrom. , vol.31 , pp. 169
    • Aguilera, R.1    Becchi, M.2    Casabianca, H.3    Hatton, C.K.4    Catlin, D.H.5    Starcevic, B.6
  • 20
    • 0035136380 scopus 로고    scopus 로고
    • Performance characteristics of a carbon isotope ratio method for detecting doping with testosterone based on urine diols: controls and athletes with elevated testosterone/epitestosterone ratios
    • R. Aguilera, T.E. Chapman, B. Starcevic, C.K. Hatton, D.H. Catlin Performance characteristics of a carbon isotope ratio method for detecting doping with testosterone based on urine diols: controls and athletes with elevated testosterone/epitestosterone ratios. Clin. Chem. 2001, 47, 292.
    • (2001) Clin. Chem. , vol.47 , pp. 292
    • Aguilera, R.1    Chapman, T.E.2    Starcevic, B.3    Hatton, C.K.4    Catlin, D.H.5
  • 21
    • 0030777089 scopus 로고    scopus 로고
    • Androstanediol and 5-androstenediol profiling for detecting exogenously administered dihydrotestosterone, epitestosterone, and dehydroepiandrosterone: potential use in gas chromatography isotope ratio mass spectrometry
    • C.H. Shackleton, E. Roitman, A. Phillips, T. Chang Androstanediol and 5-androstenediol profiling for detecting exogenously administered dihydrotestosterone, epitestosterone, and dehydroepiandrosterone: potential use in gas chromatography isotope ratio mass spectrometry. Steroids 1997, 62, 665.
    • (1997) Steroids , vol.62 , pp. 665
    • Shackleton, C.H.1    Roitman, E.2    Phillips, A.3    Chang, T.4
  • 22
    • 47749087836 scopus 로고    scopus 로고
    • The application of carbon isotope ratio mass spectrometry to doping control
    • A.T. Cawley, U. Flenker The application of carbon isotope ratio mass spectrometry to doping control. J. Mass Spectrom. 2008, 43, 854.
    • (2008) J. Mass Spectrom. , vol.43 , pp. 854
    • Cawley, A.T.1    Flenker, U.2
  • 23
    • 61349177869 scopus 로고    scopus 로고
    • Carbon isotope ratio (delta13C) values of urinary steroids for doping control in sport
    • A.T. Cawley, G.J. Trout, R. Kazlauskas, C.J. Howe, A.V. George Carbon isotope ratio (delta13C) values of urinary steroids for doping control in sport. Steroids 2009, 74, 379.
    • (2009) Steroids , vol.74 , pp. 379
    • Cawley, A.T.1    Trout, G.J.2    Kazlauskas, R.3    Howe, C.J.4    George, A.V.5
  • 24
    • 47349109119 scopus 로고    scopus 로고
    • Determination of 13C/12C ratios of endogenous urinary steroids: method validation, reference population and application to doping control purposes
    • T. Piper, U. Mareck, H. Geyer, U. Flenker, M. Thevis, P. Platen, et al. Determination of 13C/12C ratios of endogenous urinary steroids: method validation, reference population and application to doping control purposes. Rapid Commun. Mass Spectrom. 2008, 22, 2161.
    • (2008) Rapid Commun. Mass Spectrom. , vol.22 , pp. 2161
    • Piper, T.1    Mareck, U.2    Geyer, H.3    Flenker, U.4    Thevis, M.5    Platen, P.6
  • 25
    • 56449083310 scopus 로고    scopus 로고
    • Comprehensive two-dimensional gas chromatography combustion isotope ratio mass spectrometry
    • H.J. Tobias, G.L. Sacks, Y. Zhang, J.T. Brenna Comprehensive two-dimensional gas chromatography combustion isotope ratio mass spectrometry. Anal. Chem. 2008, 80, 8613.
    • (2008) Anal. Chem. , vol.80 , pp. 8613
    • Tobias, H.J.1    Sacks, G.L.2    Zhang, Y.3    Brenna, J.T.4
  • 26
    • 80052813326 scopus 로고    scopus 로고
    • Detection of synthetic testosterone use by novel comprehensive two-dimensional gas chromatography combustion-isotope ratio mass spectrometry
    • H.J. Tobias, Y. Zhang, R.J. Auchus, J.T. Brenna Detection of synthetic testosterone use by novel comprehensive two-dimensional gas chromatography combustion-isotope ratio mass spectrometry. Anal. Chem. 2011, 83, 7158.
    • (2011) Anal. Chem. , vol.83 , pp. 7158
    • Tobias, H.J.1    Zhang, Y.2    Auchus, R.J.3    Brenna, J.T.4
  • 27
    • 84985294435 scopus 로고
    • Multidimensional gas chromatography - isotope ratio mass spectrometry (MDRC-IRMS). Part a: system description and technical requirements
    • N. Nitz, B. Weinrich, F. Drawert Multidimensional gas chromatography - isotope ratio mass spectrometry (MDRC-IRMS). Part a: system description and technical requirements. J. High Resolut. Chromatogr. 1992, 15, 387.
    • (1992) J. High Resolut. Chromatogr. , vol.15 , pp. 387
    • Nitz, N.1    Weinrich, B.2    Drawert, F.3
  • 28
    • 0031696053 scopus 로고    scopus 로고
    • Multidimensional gas chromatography coupled on-line with isotope ratio mass spectrometry (MDGC-RMS)
    • D. Juchelka, T. Beck, F. Dettmar, A. Mosandl Multidimensional gas chromatography coupled on-line with isotope ratio mass spectrometry (MDGC-RMS). J. High Resolut. Chromatogr. 1998, 21, 145.
    • (1998) J. High Resolut. Chromatogr. , vol.21 , pp. 145
    • Juchelka, D.1    Beck, T.2    Dettmar, F.3    Mosandl, A.4
  • 29
    • 20044377936 scopus 로고    scopus 로고
    • Congener-specific carbon isotopic analysis of technical PCB and PCN mixtures using two-dimensional gas chromatography-isotope ratio mass spectrometry
    • Y. Horii, K. Kannan, G. Petrick, T. Gamo, J. Falandysz, N. Yamashita Congener-specific carbon isotopic analysis of technical PCB and PCN mixtures using two-dimensional gas chromatography-isotope ratio mass spectrometry. Environ. Sci. Technol. 2005, 39, 4206.
    • (2005) Environ. Sci. Technol. , vol.39 , pp. 4206
    • Horii, Y.1    Kannan, K.2    Petrick, G.3    Gamo, T.4    Falandysz, J.5    Yamashita, N.6
  • 30
    • 31044455037 scopus 로고    scopus 로고
    • Development of two-dimensional gas chromatography/isotope ratio mass spectrometry for the stable carbon isotopic analysis of C(2)-C(5) non-methane hydrocarbons emitted from biomass burning
    • H. Nara, F. Nakagawa, N. Yoshida Development of two-dimensional gas chromatography/isotope ratio mass spectrometry for the stable carbon isotopic analysis of C(2)-C(5) non-methane hydrocarbons emitted from biomass burning. Rapid Commun. Mass Spectrom. 2006, 20 241.
    • (2006) Rapid Commun. Mass Spectrom. , vol.20 , pp. 241
    • Nara, H.1    Nakagawa, F.2    Yoshida, N.3
  • 31
    • 13944252001 scopus 로고    scopus 로고
    • Comprehensive authentication of (E)-alpha(beta)-ionone from raspberries, using constant flow MDGC-C/P-IRMS and enantio-MDGC-MS
    • S. Sewenig, D. Bullinger, U. Hener, A. Mosandl Comprehensive authentication of (E)-alpha(beta)-ionone from raspberries, using constant flow MDGC-C/P-IRMS and enantio-MDGC-MS. J. Agric. Food Chem. 2005, 53, 838.
    • (2005) J. Agric. Food Chem. , vol.53 , pp. 838
    • Sewenig, S.1    Bullinger, D.2    Hener, U.3    Mosandl, A.4
  • 32
    • 3042754032 scopus 로고    scopus 로고
    • Searching for new markers of endogenous steroid administration in athletes: "looking outside the metabolic box"
    • A.T. Cawley, E.R. Hine, G.J. Trout, A.V. George, R. Kazlauskas Searching for new markers of endogenous steroid administration in athletes: "looking outside the metabolic box". Forensic Sci. Int. 2004, 143, 103.
    • (2004) Forensic Sci. Int. , vol.143 , pp. 103
    • Cawley, A.T.1    Hine, E.R.2    Trout, G.J.3    George, A.V.4    Kazlauskas, R.5
  • 33
    • 33845980567 scopus 로고    scopus 로고
    • Mass spectrometry in sports drug testing: structure characterization and analytical assays
    • M. Thevis, W. Schanzer Mass spectrometry in sports drug testing: structure characterization and analytical assays. Mass Spectrom. Rev. 2007, 26, 79.
    • (2007) Mass Spectrom. Rev. , vol.26 , pp. 79
    • Thevis, M.1    Schanzer, W.2
  • 34
    • 73249146256 scopus 로고    scopus 로고
    • Reference ranges for urinary concentrations and ratios of endogenous steroids, which can be used as markers for steroid misuse, in a Caucasian population of athletes
    • P. Van Renterghem, P. Van Eenoo, H. Geyer, W. Schanzer, F.T. Delbeke Reference ranges for urinary concentrations and ratios of endogenous steroids, which can be used as markers for steroid misuse, in a Caucasian population of athletes. Steroids 2010, 75, 154.
    • (2010) Steroids , vol.75 , pp. 154
    • Van Renterghem, P.1    Van Eenoo, P.2    Geyer, H.3    Schanzer, W.4    Delbeke, F.T.5
  • 37
    • 0030573012 scopus 로고    scopus 로고
    • Testing for natural and synthetic anabolic agents in human urine
    • C. Ayotte, D. Goudreault, A. Charlebois Testing for natural and synthetic anabolic agents in human urine. J. Chromatogr. B 1996, 687, 3.
    • (1996) J. Chromatogr. B , vol.687 , pp. 3
    • Ayotte, C.1    Goudreault, D.2    Charlebois, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.