Detection of synthetic testosterone use by novel comprehensive two-dimensional gas chromatography combustion-isotope ratio mass spectrometry

Analytical Chemistry

Volumn 83, Issue 18, 2011, Pages 7158-7165

  Tobias, Herbert J ^a   Zhang, Ying ^a   Auchus, Richard J ^b   Brenna, J Thomas ^a  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASELINE SEPARATION; CARBON ISOTOPE RATIO; CHROMATOGRAPHIC PEAKS; COMPREHENSIVE TWO-DIMENSIONAL GAS CHROMATOGRAPHY; CONCENTRATION RATIO; ETIOCHOLANOLONE; ISOTOPIC ANALYSIS; ISOTOPIC INFORMATION; LOW CONCENTRATIONS; PEAK SHAPES; REFERENCE COMPOUNDS; SAMPLE PREPARATION; SIGNAL INTENSITIES; SYNTHETIC STEROIDS; TARGET COMPOUND; TESTOSTERONE; TRACE COMPONENTS; URINE MATRIX EFFECTS; WORLD ANTI-DOPING AGENCY;

BODY FLUIDS; COMBUSTION; GELS; ISOTOPES; LIPIDS; MASS SPECTROMETRY; PETROLEUM REFINING; SEPARATION; SMOKE DETECTORS; SPECTROMETERS; TRACE ANALYSIS; TWO DIMENSIONAL;

GAS CHROMATOGRAPHY;

11 OXOETIOCHOLANOLONE; 11-KETOETIOCHOLANOLONE; CARBON; DRUG DERIVATIVE; EPITESTOSTERONE; ETIOCHOLANOLONE; TESTOSTERONE;

ARTICLE; CHEMISTRY; DOPING; HUMAN; ISOTOPE LABELING; MASS FRAGMENTOGRAPHY; METHODOLOGY; STANDARD; URINE;

CARBON ISOTOPES; DOPING IN SPORTS; EPITESTOSTERONE; ETIOCHOLANOLONE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; ISOTOPE LABELING; REFERENCE STANDARDS; TESTOSTERONE;

EID: 80052813326     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac2015849     Document Type: Article

References (44)

1. Thevis, M.; Kuuranne, T.; Geyer, H.; Schanzer, W. Drug Test. Anal. 2010, 3, 1-14
2. Walker, J.; Adams, B. Int. J. Dermatol. 2009, 48, 1044-1048
3. World Anti-Doping Agency. Coordinating Investigations and Sharing Anti-Doping Information and Evidence; Montreal, Canada, 2011.
4. Catlin, D. H.; Sekera, M. H.; Ahrens, B. D.; Starcevic, B.; Chang, Y. C.; Hatton, C. K. Rapid Commun. Mass Spectrom. 2004, 18, 1245-1249
5. Donike, M.; Barwald, K. R.; Klostermann, K.; Schanzer, W.; Zimmermann, J. Int. J. Sports Med. 1983, 4, 68-68
6. World Anti-Doping Agency. Guideline Reporting and Management of Elevated T/E Ratios; Montreal, Canada, 2006.
7. Meier-Augenstein, W. J. Chromatogr., A 1999, 842, 351-371
8. Lichtfouse, E. Rapid Commun. Mass Spectrom. 2000, 14, 1337-1344
9. Oulhote, Y.; Le Bot, B.; Deguen, S.; Glorennec, P. Trends Anal. Chem. 2011, 30, 302-312
10. Gessler, A. Progress in Botany 72; Springer-Verlag: Berlin, 2011; pp 227-248.
11. Primrose, S.; Woolfe, M.; Rollinson, S. Trends Food Sci. Technol. 2011, 21, 582-590
12. Regert, M. Mass Spectrom. Rev. 2011, 30, 177-220
13. Hoefs, J. Eur. J. Mineral. 2010, 22, 3-15
14. Hofstetter, T. B.; Berg, M. Trends Anal. Chem. 2011, 30, 618-627
15. Mladenov, N.; Alados-Arboledas, L.; Olmo, F. J.; Lyamani, H.; Delgado, A.; Molina, A.; Reche, I. Atmos. Environ. 2011, 45, 1960-1969
16. Daeid, N. N.; Buchanan, H. A. S.; Savage, K. A.; Fraser, J. G.; Cresswell, S. L. Aust. J. Chem. 2011, 63, 3-7
17. Stellaard, F.; Elzinga, H. Isot. Environ. Health Stud. 2005, 41, 345-361
18. Chang, T.-L.; Li, W.-J. Chin. Sci. Bull. 1990, 35, 290-296
19. Wieser, M. E.; Coplen, T. B. Pure Appl. Chem. 2011, 83, 359-396
20. Aguilera, R.; Catlin, D. H.; Becchi, M.; Phillips, A.; Wang, C.; Swerdloff, R. S.; Pope, H. G.; Hatton, C. K. J. Chromatogr., B 1999, 727, 95-105
21. Aguilera, R.; Chapman, T. E.; Starcevic, B.; Hatton, C. K.; Catlin, D. H. Clin. Chem. 2001, 47, 292-300
22. Aguilera, R.; Becchi, M.; Casabianca, H.; Hatton, C. K.; Catlin, D. H.; Starcevic, B.; Pope, H. G., Jr. J. Mass Spectrom. 1996, 31, 169-176
23. Piper, T.; Mareck, U.; Geyer, H.; Flenker, U.; Thevis, M.; Platen, P.; Schanzer, W. Rapid Commun. Mass Spectrom. 2008, 22, 2161-2175
24. Saudan, C.; Emery, C.; Marclay, F.; Strahm, E.; Mangin, P.; Saugy, M. J. Chromatogr., B 2009, 877, 2321-2329
25. World Anti-Doping Agency. The 2011 Prohibited List International Standard; Montreal, Canada, 2011.
26. World Anti-Doping Agency. Endogenous Anabolic Androgenic Steroids Testing, Reporting and Interpretive Guidance; Montreal, Canada, 2009.
27. Matthews, D. E.; Hayes, J. M. Anal. Chem. 1978, 50, 1465-1473
28. Tobias, H. J.; Brenna, J. T. Anal. Chem. 1997, 69, 3148-3152
29. Burgoyne, T. W.; Hayes, J. M. Anal. Chem. 1998, 70, 5136-5141
30. Merritt, D. A.; Hayes, J. M. J. Am. Soc. Mass Spectrom. 1994, 5, 387-397
31. Werner, R. A.; Kornexl, B. E.; Rossmann, A.; Schmidt, H. L. Anal. Chim. Acta 1996, 319, 159-164
32. Dias, R. F.; Freeman, K. H.; Franks, S. G. Org. Geochem. 2002, 33, 161-168
33. Corso, T. N.; Brenna, J. T. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 1049-1053
34. Sacks, G. L.; Zhang, Y.; Brenna, J. T. Anal. Chem. 2007, 79, 6348-6358
35. Tobias, H. J.; Sacks, G. L.; Zhang, Y.; Brenna, J. T. Anal. Chem. 2008, 80, 8613-8621
36. Goodman, K. J.; Brenna, J. T. Anal. Chem. 1994, 66, 1294-1301
37. Adahchour, M.; Beens, J.; Vreuls, R. J. J.; Brinkman, U. A. T. Trends Anal. Chem. 2006, 25, 540-553
38. Adahchour, M.; Beens, J.; Vreuls, R. J. J.; Brinkman, U. A. T. Trends Anal. Chem. 2006, 25, 438-454
39. Marriott, P. J.; Kinghorn, R. M. Anal. Chem. 1997, 69, 2582-2588
40. Tobias, H. J.; Brenna, J. T. Microfluid. Nanofluid. 2010, 9, 461-470
41. Zhang, Y.; Sacks, G. S.; Tobias, H. J.; Brenna, J. T. Manuscript submitted for publication.
42. Santrock, J.; Studley, S. A.; Hayes, J. M. Anal. Chem. 1985, 57, 1444-1448
43. Zhang, Y.; Tobias, H. J.; Brenna, J. T. Steroids 2009, 74, 369-378
44. Van Renterghem, P.; Van Eenoo, P.; Geyer, H.; Schänzer, W.; Delbeke, F. T. Steroids 2010, 75, 154-163