Sex-dependent differences in intestinal tumorigenesis induced in Apc1638N/+ mice by exposure to γ rays

International Journal of Radiation Oncology Biology Physics

Volumn 85, Issue 1, 2013, Pages 223-229

  Trani, Daniela ^a,b,c   Moon, Bo Hyun ^a,b   Kallakury, Bhaskar ^b   Hartmann, Dan P ^b   Datta, Kamal ^a,b   Fornace Jr , Albert J ^a,b,d  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMATOUS POLYPOSIS COLI; ESTROGEN RECEPTOR; IMMUNOHISTOCHEMISTRY; IN-VIVO; IRRADIATED ANIMALS; LARGE INTESTINE; MALE MOUSE; MUTANT MICE; PROTEIN LEVEL; RADIATION EXPOSURE; RADIATION-INDUCED; RELATIVE FREQUENCIES; TUMOR PROGRESSIONS; TUMORIGENESIS; WHOLE BODY;

MAMMALS;

TUMORS;

ESTROGEN RECEPTOR ALPHA; KI 67 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER SUSCEPTIBILITY; CARCINOGENESIS; COLON POLYPOSIS; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GAMMA RADIATION; INTESTINE CANCER; INVASIVE CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; SEX DIFFERENCE;

ADENOMA; ANIMALS; CARCINOMA; DISEASE PROGRESSION; FEMALE; GAMMA RAYS; GENES, APC; GENETIC PREDISPOSITION TO DISEASE; INTESTINAL NEOPLASMS; INTESTINE, LARGE; INTESTINE, SMALL; KI-67 ANTIGEN; MALE; MICE; MICE, INBRED C57BL; NEOPLASMS, RADIATION-INDUCED; RADIATION DOSAGE; RECEPTORS, ESTROGEN; SEX FACTORS; TUMOR BURDEN;

EID: 84871392633     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2012.02.053     Document Type: Article

References (19)

1. W.D. Newhauser, and M. Durante Assessing the risk of second malignancies after modern radiotherapy Nat Rev Cancer 11 2011 438 448
2. M. Tubiana Can we reduce the incidence of second primary malignancies occurring after radiotherapy? A critical review Radiother Oncol 91 2009 4 15 discussion 1-3
3. D.L. Friedman, J. Whitton, and W. Leisenring Subsequent neoplasms in 5-year survivors of childhood cancer: The Childhood Cancer Survivor Study J Natl Cancer Inst 102 2010 1083 1095
4. D.L. Preston, E. Ron, and S. Tokuoka Solid cancer incidence in atomic bomb survivors: 1958-1998 Radiat Res 168 2007 1 64 (Pubitemid 351292925)
5. R. Fodde, W. Edelmann, and K. Yang A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors Proc Natl Acad Sci U S A 91 1994 8969 8973
6. D. Trani, K. Datta, and K. Doiron Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimates Radiat Environ Biophys 49 2010 389 396
7. C.W. van der Houven van Oordt, R. Smits, and S.L. Williamson Intestinal and extra-intestinal tumor multiplicities in the Apc1638N mouse model after exposure to X-rays Carcinogenesis 18 1997 2197 2203 (Pubitemid 28134748)
8. T. Nakayama, K. Yamazumi, and T. Uemura X radiation up-regulates the occurrence and the multiplicity of invasive carcinomas in the intestinal tract of Apc(min/+) mice Radiat Res 168 2007 433 439 (Pubitemid 351303171)
9. A.G. Cleveland, S.I. Oikarinen, and K.K. Bynote Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice Carcinogenesis 30 2009 1581 1590
10. J.H. Koo, R.W. Leong, and J.H. Koo Sex differences in epidemiological, clinical and pathological characteristics of colorectal cancer J Gastroenterol Hepatol 25 2010 33 42
11. K.J. Lin, W.Y. Cheung, and J.Y. Lai The effect of estrogen versus combined estrogen-progestogen therapy on the risk of colorectal cancer Int J Cancer 130 2012 419 430
12. M.J. Weyant, A.M. Carothers, and N.N. Mahmoud Reciprocal expression of ERalpha and ERbeta is associated with estrogen-mediated modulation of intestinal tumorigenesis Cancer Res 61 2001 2547 2551 (Pubitemid 32685837)
13. N. Barker, M. van den Born, and N. Barker Detection of beta-catenin localization by immunohistochemistry Methods Mol Biol 468 2008 91 98
14. S. Bhatia, and Sklar Second cancers in survivors of childhood cancer Nat Rev Cancer 2 2002 124 132 (Pubitemid 37328799)
15. K.W. Kinzler, B. Vogelstein, and K.W. Kinzler Lessons from hereditary colorectal cancer Cell 87 1996 159 170 (Pubitemid 26358996)
16. J. Matthews, and J.A. Gustafsson Estrogen signaling: a subtle balance between ER alpha and ER beta Mol Interv 3 2003 281 292
17. A.M. Ferreira, H. Westers, and A. Albergaria Estrogens, MSI and Lynch syndrome-associated tumors Biochim Biophys Acta 1796 2009 194 200
18. N.C. Nussler, K. Reinbacher, and N. Shanny Sex-specific differences in the expression levels of estrogen receptor subtypes in colorectal cancer Gend Med 5 2008 209 217
19. A. Bardin, N. Boulle, and G. Lazennec Loss of ERbeta expression as a common step in estrogen-dependent tumor progression Endocr Relat Cancer 11 2004 537 551 (Pubitemid 39331282)