Ghrelin and adipokines as circulating markers of disease activity in patients with Takayasu arteritis

Arthritis Research and Therapy

Volumn 14, Issue 6, 2012, Pages

  Yilmaz, Hatice ^a   Gerdan, Vedat ^a   Kozaci, Didem ^b   Solmaz, Dilek ^a   Akar, Servet ^a   Can, Gercek ^a   Gulcu, Aytac ^a   Goktay, Yigit ^a   Sari, Ismail ^a   Birlik, Merih ^a   Akkoc, Nurullah ^a   Onen, Fatos ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

^b ADNAN MENDERES UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; AZATHIOPRINE; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CORTICOSTEROID; GHRELIN; LEFLUNOMIDE; LEPTIN; METHOTREXATE; GLUCOCORTICOID;

ACYLATION; ADULT; AORTA ARCH SYNDROME; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE ACTIVITY; DOPPLER ECHOGRAPHY; ECHOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIP CIRCUMFERENCE; HORMONE BLOOD LEVEL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LEUKOCYTE COUNT; MALE; MONOTHERAPY; NEUTROPHIL COUNT; PROTEIN BLOOD LEVEL; WAIST CIRCUMFERENCE; ARTERIAL WALL THICKNESS; BLOOD; BODY MASS; CAROTID ARTERY; MIDDLE AGED; OUTCOME ASSESSMENT; PATHOLOGY; TAKAYASU ARTERITIS; WAIST HIP RATIO;

ACYLATION; ADIPONECTIN; ADULT; BIOLOGICAL MARKERS; BODY MASS INDEX; CAROTID ARTERIES; CAROTID INTIMA-MEDIA THICKNESS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GHRELIN; GLUCOCORTICOIDS; HUMANS; LEPTIN; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); TAKAYASU ARTERITIS; WAIST CIRCUMFERENCE; WAIST-HIP RATIO;

EID: 84871370546     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4120     Document Type: Article

References (60)

1. Johnston SL, Lock RJ, Gompels MM. Takayasu arteritis: a review. J Clin Pathol 2002, 55:481-486. 10.1136/jcp.55.7.481, 1769710, 12101189.
2. Morrissey NJ, Goldman J, Fallon JT, Faries PL, Marin ML, Hollier LH. Endovascular aortic biopsy in the diagnosis of Takayasu arteritis. J Endovasc Ther 2003, 10:136-140. 10.1583/1545-1550(2003)010<0136:EABITD>2.0.CO;2, 12751945.
3. Hata A, Numano F. Magnetic resonance imaging of vascular changes in Takayasu arteritis. Int J Cardiol 1995, 52:45-52. 10.1016/0167-5273(95)02438-3, 8707435.
4. Yamada I, Numano F, Suzuki S. Takayasu arteritis: evaluation with MR imaging. Radiology 1993, 188:89-94.
5. Kissin EY, Merkel PA. Diagnostic imaging in Takayasu arteritis. Curr Opin Rheumatol 2004, 16:31-37. 10.1097/00002281-200401000-00007, 14673386.
6. Kerr GS. Takayasu's arteritis. Rheum Dis Clin North Am 1995, 21:1041-1058.
7. Kerr GS, Hallahan CW, Giordano J, Leavitt RY, Fauci AS, Rottem M, Hoffman GS. Takayasu arteritis. Ann Intern Med 1994, 120:919-929.
8. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB, Korbonits M. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002, 87:2988. 10.1210/jc.87.6.2988, 12050285.
9. Dixit VD, Schaffer EM, Pyle RS, Collins GD, Sakthivel SK, Palaniappan R, Lillard JW, Taub DD. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest 2004, 114:57-66. 437970, 15232612.
10. Baatar D, Patel K, Taub DD. The effects of ghrelin on inflammation and the immune system. Mol Cell Endocrinol 2011, 340:44-58. 10.1016/j.mce.2011.04.019, 21565248.
11. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432. 10.1038/372425a0, 7984236.
12. Brabant G, Nave H, Horn R, Anderwald C, Muller G, Roden M. In vivo and in vitro evidence for a hepatic modulation of the leptin signal in rats. Eur J Clin Invest 2004, 34:831-837. 10.1111/j.1365-2362.2004.01427.x, 15606726.
13. Faggioni R, Feingold KR, Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 2001, 15:2565-2571. 10.1096/fj.01-0431rev, 11726531.
14. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998, 394:897-901. 10.1038/29795, 9732873.
15. Palmer G, Gabay C. A role for leptin in rheumatic diseases?. Ann Rheum Dis 2003, 62:913-915. 10.1136/ard.62.10.913, 1754337, 12972464.
16. Bernotiene E, Palmer G, Gabay C. The role of leptin in innate and adaptive immune responses. Arthritis Res Ther 2006, 8:217. 10.1186/ar2004, 1779438, 16879738.
17. Brochu-Gaudreau K, Rehfeldt C, Blouin R, Bordignon V, Murphy BD, Palin MF. Adiponectin action from head to toe. Endocrine 2010, 37:11-32. 10.1007/s12020-009-9278-8, 20963555.
18. Sivakumar M, Misra RN, Bacon PA. The Indian perspective of Takayasu arteritis and development of a disease extent index (DEI.Tak) to assess Takayasu arteritis. Rheumatology 2005, 44:iii6-7.
19. Manzi S, Selzer F, Sutton-Tyrrell K, Fitzgerald SG, Rairie JE, Tracy RP, Kuller LH. Prevalence and risk factors of carotid plaque in women with systemic lupus erythematosus. Arthritis Rheum 1999, 42:51-60. 10.1002/1529-0131(199901)42:1<51::AID-ANR7>3.0.CO;2-D, 9920014.
20. Arend WP, Michel BA, Bloch DA, Hunder GG, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY, Lie JT, Lightfoot RW, et al. The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum 1990, 33:1129-1134.
21. Numano F, Kobayashi Y. Takayasu arteritis--beyond pulselessness. Intern Med 1999, 38:226-232. 10.2169/internalmedicine.38.226, 10337931.
22. Kumpers P, Horn R, Brabant G, Woywodt A, Schiffer M, Haller H, Haubitz M. Serum leptin and ghrelin correlate with disease activity in ANCA-associated vasculitis. Rheumatology (Oxford) 2008, 47:484-487.
23. Aliyazicioglu Y, Ozkaya O, Yakut H, Islek I, Alvur M. Leptin levels in Henoch-Schonlein purpura. Clin Rheumatol 2007, 26:371-375. 10.1007/s10067-006-0363-6, 16816886.
24. Yalcindag FN, Kisa U, Batioglu F, Yalcindag A, Ozdemir O, Caglayan O. Serum leptin levels in patients with ocular and nonocular Behcet's disease. Mediators Inflamm 2007, 2007:31986. 1906708, 17641728.
25. Evereklioglu C, Inaloz HS, Kirtak N, Doganay S, Bulbul M, Ozerol E, Er H, Ozbek E. Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity. Br J Dermatol 2002, 147:331-336. 10.1046/j.1365-2133.2002.04703.x, 12174107.
26. Garcia-Gonzalez A, Gonzalez-Lopez L, Valera-Gonzalez IC, Cardona-Munoz EG, Salazar-Paramo M, Gonzalez-Ortiz M, Martinez-Abundis E, Gamez-Nava JI. Serum leptin levels in women with systemic lupus erythematosus. Rheumatol Int 2002, 22:138-141. 10.1007/s00296-002-0216-9, 12172951.
27. Chung CP, Long AG, Solus JF, Rho YH, Oeser A, Raggi P, Stein CM. Adipocytokines in systemic lupus erythematosus: relationship to inflammation, insulin resistance and coronary atherosclerosis. Lupus 2009, 18:799-806. 10.1177/0961203309103582, 2707942, 19578104.
28. Sada KE, Yamasaki Y, Maruyama M, Sugiyama H, Yamamura M, Maeshima Y, Makino H. Altered levels of adipocytokines in association with insulin resistance in patients with systemic lupus erythematosus. J Rheumatol 2006, 33:1545-1552.
29. Rovin BH, Song H, Hebert LA, Nadasdy T, Nadasdy G, Birmingham DJ, Yung Yu C, Nagaraja HN. Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus. Kidney Int 2005, 68:1825-1833. 10.1111/j.1523-1755.2005.00601.x, 16164660.
30. Al M, Ng L, Tyrrell P, Bargman J, Bradley T, Silverman E. Adipokines as novel biomarkers in paediatric systemic lupus erythematosus. Rheumatology (Oxford) 2009, 48:497-501.
31. Bokarewa M, Bokarew D, Hultgren O, Tarkowski A. Leptin consumption in the inflamed joints of patients with rheumatoid arthritis. Ann Rheum Dis 2003, 62:952-956. 10.1136/ard.62.10.952, 1754314, 12972473.
32. Lee SW, Park MC, Park YB, Lee SK. Measurement of the serum leptin level could assist disease activity monitoring in rheumatoid arthritis. Rheumatol Int 2007, 27:537-540. 10.1007/s00296-006-0253-x, 17102946.
33. Targonska-Stepniak B, Majdan M, Dryglewska M. Leptin serum levels in rheumatoid arthritis patients: relation to disease duration and activity. Rheumatol Int 2008, 28:585-591. 10.1007/s00296-007-0480-9, 17968549.
34. Seven A, Guzel S, Aslan M, Hamuryudan V. Serum and synovial fluid leptin levels and markers of inflammation in rheumatoid arthritis. Rheumatol Int 2009, 29:743-747. 10.1007/s00296-008-0764-8, 19009296.
35. Otero M, Lago R, Gomez R, Lago F, Dieguez C, Gomez-Reino JJ, Gualillo O. Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis 2006, 65:1198-1201. 10.1136/ard.2005.046540, 1798289, 16414972.
36. Toussirot E, Streit G, Nguyen NU, Dumoulin G, Le Huede G, Saas P, Wendling D. Adipose tissue, serum adipokines, and ghrelin in patients with ankylosing spondylitis. Metabolism 2007, 56:1383-1389. 10.1016/j.metabol.2007.05.009, 17884449.
37. Koca SS, Ozgen M, Aydin S, Dag S, Evren B, Isik A. Ghrelin and obestatin levels in rheumatoid arthritis. Inflammation 2008, 31:329-335. 10.1007/s10753-008-9082-2, 18677577.
38. Otero M, Nogueiras R, Lago F, Dieguez C, Gomez-Reino JJ, Gualillo O. Chronic inflammation modulates ghrelin levels in humans and rats. Rheumatology (Oxford) 2004, 43:306-310.
39. Karagiozoglou-Lampoudi T, Trachana M, Agakidis C, Pratsidou-Gertsi P, Taparkou A, Lampoudi S, Kanakoudi-Tsakalidou F. Ghrelin levels in patients with juvenile idiopathic arthritis: relation to anti-tumor necrosis factor treatment and disease activity. Metabolism 2011, 60:1359-1362. 10.1016/j.metabol.2011.03.006, 21550087.
40. Ottonello L, Gnerre P, Bertolotto M, Mancini M, Dapino P, Russo R, Garibotto G, Barreca T, Dallegri F. Leptin as a uremic toxin interferes with neutrophil chemotaxis. J Am Soc Nephrol 2004, 15:2366-2372. 10.1097/01.ASN.0000139321.98029.40, 15339985.
41. Artwohl M, Roden M, Holzenbein T, Freudenthaler A, Waldhausl W, Baumgartner-Parzer SM. Modulation by leptin of proliferation and apoptosis in vascular endothelial cells. Int J Obes Relat Metab Disord 2002, 26:577-580. 10.1038/sj.ijo.0801947, 12075587.
42. Baiguera S, Conconi MT, Guidolin D, Mazzocchi G, Malendowicz LK, Parnigotto PP, Spinazzi R, Nussdorfer GG. Ghrelin inhibits in vitro angiogenic activity of rat brain microvascular endothelial cells. Int J Mol Med 2004, 14:849-854.
43. Conconi MT, Nico B, Guidolin D, Baiguera S, Spinazzi R, Rebuffat P, Malendowicz LK, Vacca A, Carraro G, Parnigotto PP, Nussdorfer GG, Ribatti D. Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo. Peptides 2004, 25:2179-2185. 10.1016/j.peptides.2004.08.011, 15572208.
44. Poykko SM, Kellokoski E, Horkko S, Kauma H, Kesaniemi YA, Ukkola O. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 2003, 52:2546-2553. 10.2337/diabetes.52.10.2546, 14514639.
45. Li ZF, Guo ZF, Yang SG, Zheng X, Cao J, Qin YW. Circulating ghrelin and ghrelin to obestatin ratio are low in patients with untreated mild-to-moderate hypertension. Regul Pept 2010, 165:206-209. 10.1016/j.regpep.2010.07.168, 20688108.
46. Otto B, Tschop M, Heldwein W, Pfeiffer AF, Diederich S. Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans. Eur J Endocrinol 2004, 151:113-117. 10.1530/eje.0.1510113, 15248830.
47. Wang YH, Huang TS, Liang HW, Su TC, Chen SY, Wang TD. Fasting serum levels of adiponectin, ghrelin, and leptin in men with spinal cord injury. Arch Phys Med Rehabil 2005, 86:1964-1968. 10.1016/j.apmr.2005.04.017, 16213239.
48. Huang TS, Wang YH, Chen SY. The relation of serum leptin to body mass index and to serum cortisol in men with spinal cord injury. Arch Phys Med Rehabil 2000, 81:1582-1586. 10.1053/apmr.2000.9173, 11128893.
49. Gomez JM, Maravall FJ, Gomez N, Navarro MA, Casamitjana R, Soler J. Interactions between serum leptin, the insulin-like growth factor-I system, and sex, age, anthropometric and body composition variables in a healthy population randomly selected. Clin Endocrinol (Oxf) 2003, 58:213-219.
50. Kozakowski J, Rabijewski M, Zgliczynski W. [Decrease in serum ghrelin levels in patients with acromegaly normalize after successful surgical treatment]. Endokrynol Pol 2005, 56:862-870.
51. Scerif M, Goldstone AP, Korbonits M. Ghrelin in obesity and endocrine diseases. Mol Cell Endocrinol 2011, 340:15-25. 10.1016/j.mce.2011.02.011, 21345363.
52. Watts R, Al-Taiar A, Mooney J, Scott D, Macgregor A. The epidemiology of Takayasu arteritis in the UK. Rheumatology (Oxford) 2009, 48:1008-1011.
53. Kucukyavas Y, Aksu K, Solmaz D, Can G, Taylan A, Akar S, Sari I, Birlik M, Onen F, Akkoc N. Prevalence of Takayasu's Arteritis in Izmir, Turkey: A Multicenter Study. Annual European Congress of Rheumatology, EULAR 2012 2012, Berlin, Germany, Abstract Book 61.
54. Salvarani C, Cantini F, Boiardi L, Hunder GG. Laboratory investigations useful in giant cell arteritis and Takayasu's arteritis. Clin Exp Rheumatol 2003, 21:S23-28.
55. Lagneau P, Michel JB, Vuong PN. Surgical treatment of Takayasu's disease. Ann Surg 1987, 205:157-166. 10.1097/00000658-198702000-00010, 1492814, 2880571.
56. Hoffman GS, Ahmed AE. Surrogate markers of disease activity in patients with Takayasu arteritis. A preliminary report from The International Network for the Study of the Systemic Vasculitides (INSSYS). Int J Cardiol 1998, 66(Suppl 1):S191-194. discussion S195.
57. Akazawa H, Ikeda U, Yamamoto K, Kuroda T, Shimada K. Hypercoagulable state in patients with Takayasu's arteritis. Thromb Haemost 1996, 75:712-716.
58. Akazawa H, Ikeda U, Kuroda T, Shimada K. Plasma endothelin-1 levels in Takayasu's arteritis. Cardiology 1996, 87:303-305. 10.1159/000177110, 8793164.
59. Dagna L, Salvo F, Tiraboschi M, Bozzolo EP, Franchini S, Doglioni C, Manfredi AA, Baldissera E, Sabbadini MG. Pentraxin-3 as a marker of disease activity in Takayasu arteritis. Ann Intern Med 2011, 155:425-433.
60. Aydin SZ, Yilmaz N, Akar S, Aksu K, Kamali S, Yucel E, Karadag O, Bicakcigil M, Ozer H, Kiraz S, Onen F, Inanc M, Keser G, Akkoc N, Direskeneli H. Assessment of disease activity and progression in Takayasu's arteritis with Disease Extent Index-Takayasu. Rheumatology (Oxford) 2010, 49:1889-1893.