Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 51, 2012, Pages 20901-20906

  Ma, Junhe ^a   Edlich, Frank ^b   Bermejo, Guillermo A ^a   Norris, Kristi L ^b   Youle, Richard J ^b   Tjandra, Nico ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CYTOCHROME C; PROTEIN BAX; UNCLASSIFIED DRUG; VIRAL MITOCHONDRIA LOCALIZED INHIBITOR OF APOPTOSIS; VIRUS PROTEIN;

ANISOTROPY; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CONFORMATIONAL TRANSITION; CYTOMEGALOVIRUS; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR INTERACTION; OLIGOMERIZATION; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN STRUCTURE; WILD TYPE;

ANISOTROPY; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL LINE; CELL LINE, TUMOR; CYTOCHROMES C; CYTOMEGALOVIRUS; HUMANS; IMMEDIATE-EARLY PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MITOCHONDRIA; MUTATION; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 84871369730     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1217094110     Document Type: Article

References (26)

1. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26(4):239-257.
2. Raff MC (1992) Social controls on cell survival and cell death. Nature 356(6368): 397-400.
3. Vaux DL, Haecker G, Strasser A (1994) An evolutionary perspective on apoptosis. Cell 76(5):777-779.
4. Thompson CB (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267(5203):1456-1462.
5. Youle RJ, Strasser A (2008) The BCL-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9(1):47-59.
6. Edlich F, et al. (2011) Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell 145(1):104-116.
7. Tschopp J, Thome M, Hofmann K, Meinl E (1998) The fight of viruses against apoptosis. Curr Opin Genet Dev 8(1):82-87.
8. Goldmacher VS (2002) vMIA, a viral inhibitor of apoptosis targeting mitochondria. Biochimie 84(2-3):177-185.
9. Goldmacher VS, et al. (1999) A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2. Proc Natl Acad Sci USA 96(22):12536-12541.
10. McCormick AL, Skaletskaya A, Barry PA, Mocarski ES, Goldmacher VS (2003) Differential function and expression of the viral inhibitor of caspase 8-induced apoptosis (vICA) and the viral mitochondria-localized inhibitor of apoptosis (vMIA) cell death suppressors conserved in primate and rodent cytomegaloviruses. Virology 316(2):221-233.
11. Arnoult D, et al. (2004) Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria. Proc Natl Acad Sci USA 101(21):7988-7993.
12. Suzuki M, Youle RJ, Tjandra N (2000) Structure of Bax: Coregulation of dimer formation and intracellular localization. Cell 103(4):645-654.
13. Gavathiotis E, et al. (2008) BAX activation is initiated at a novel interaction site. Nature 455(7216):1076-1081.
14. Poncet D, et al. (2004) An anti-apoptotic viral protein that recruits Bax to mitochondria. J Biol Chem 279(21):22605-22614.
15. (1)H transverse paramagnetic relaxation enhancement measurements on macromolecules. J Magn Reson 184(2):185-195.
16. Battiste JL, Wagner G (2000) Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data. Biochemistry 39(18):5355-5365.
17. Clore GM, Schwieters CD (2003) Docking of protein-protein complexes on the basis of highly ambiguous intermolecular distance restraints derived from 1H/15N chemical shift mapping and backbone 15N-1H residual dipolar couplings using conjoined rigid body/torsion angle dynamics. J Am Chem Soc 125(10):2902-2912.
18. Norris KL, Youle RJ (2008) Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins. J Virol 82(13):6232-6243.
19. Desagher S, et al. (1999) Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol 144(5):891-901.
20. Dewson G, et al. (2012) Bax dimerizes via a symmetric BH3:groove interface during apoptosis. Cell Death Differ 19(4):661-670.
21. Annis MG, et al. (2005) Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis. EMBO J 24(12):2096-2103.
22. Kuszewski J, Nilges M, Brünger AT (1992) Sampling and efficiency of metric matrix distance geometry: A novel partial metrization algorithm. J Biomol NMR 2(1):33-56.
23. Schwieters CD, Kuszewski JJ, Clore GM (2006) Using Xplor-NIH for NMR molecular structure determination. Prog Nucl Magn Reson Spectrosc 48(1):47-62.
24. Schwieters CD, Kuszewski JJ, Tjandra N, Clore GM (2003) The Xplor-NIH NMR molecular structure determination package. J Magn Reson 160(1):65-73.
25. Grzesiek S, et al. (1996) The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase. Nat Struct Biol 3(4):340-345.
26. Hubbard SJ, Thornton JM (1993) NACCESS Computer Program (Department of Biochemistry and Molecular Biology, Univ College London, London).