Using a single hydrophobic-interaction chromatography to purify pharmaceutical-grade supercoiled plasmid DNA from other isoforms

Pharmaceutical Biology

Volumn 51, Issue 1, 2013, Pages 42-48

  Bo, Huaben ^a,b   Wang, Jinquan ^b   Chen, Qizhu ^b   Shen, Han ^b   Wu, Fenglin ^b   Shao, Hongwei ^b   Huang, Shulin ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

DNA vaccine; Gene therapy; Non viral vectors

Indexed keywords

DNA VACCINE; ENDOTOXIN; GENOMIC DNA; GENOMIC RNA; OPEN CIRCULAR PLASMID DNA; PLASMID DNA; SUPERCOILED PLASMID DNA; UNCLASSIFIED DRUG;

ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DNA PURIFICATION; DNA TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; IN VITRO GENE TRANSFER; LARGE SCALE PRODUCTION; NONVIRAL GENE THERAPY; PROTEIN EXPRESSION; QUALITY CONTROL;

CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COST-BENEFIT ANALYSIS; DNA, SUPERHELICAL; ESCHERICHIA COLI; GENETIC THERAPY; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PLASMIDS; VACCINES, DNA;

EID: 84871364211     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2012.703678     Document Type: Article

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