The cytotoxicity mechanism of 6-shogaol-treated HeLa human cervical cancer cells revealed by label-free shotgun proteomics and bioinformatics analysis

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Liu, Qun ^a   Peng, Yong Bo ^a   Qi, Lian Wen ^a   Cheng, Xiao Lan ^a   Xu, Xiao Jun ^a   Liu, Le Le ^a   Liu, E Hu ^a   Li, Ping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

6 SHOGAOL; ANTINEOPLASTIC AGENT; PLANT EXTRACT; PROTEIN 14 3 3; UNCLASSIFIED DRUG;

ARTICLE; BIOINFORMATICS; CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; M PHASE CELL CYCLE CHECKPOINT; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; TIME OF FLIGHT MASS SPECTROMETRY; UTERINE CERVIX CANCER;

EID: 84871362104     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/278652     Document Type: Article

References (37)

1. Jemal A., Bray F., Center M. M., Ferlay J., Ward E., Forman D., Global cancer statistics. Cancer Journal for Clinicians 2011 61 2 69 90 2-s2.0-79952232216 10.3322/caac.20107
2. Ota T., Takeshima N., Tabata T., Hasumi K., Takizawa K., Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers. British Journal of Cancer 2007 97 8 1058 1062 2-s2.0-35348859537 10.1038/sj.bjc.6604005 (Pubitemid 47587017)
3. Pabla N., Dong Z., Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney International 2008 73 9 994 1007 2-s2.0-42149187768 10.1038/sj.ki.5002786 (Pubitemid 351543900)
4. Kaefer C. M., Milner J. A., The role of herbs and spices in cancer prevention. Journal of Nutritional Biochemistry 2008 19 6 347 361 2-s2.0-43749107872 10.1016/j.jnutbio.2007.11.003 (Pubitemid 351689086)
5. Dorai T., Aggarwal B. B., Role of chemopreventive agents in cancer therapy. Cancer Letters 2004 215 2 129 140 2-s2.0-5644283296 10.1016/j.canlet.2004.07.013 (Pubitemid 39370030)
6. Hung J. Y. U., Hsu Y. A. L., Li C. T., Ko Y. C., Ni W. C., Huang M. S., Kuo P. L., 6-shogaol, an active constituent of dietary ginger, induces autophagy by inhibiting the AKT/mTOR pathway in human non-small cell lung cancer A549 cells. Journal of Agricultural and Food Chemistry 2009 57 20 9809 9816 2-s2.0-70350317873 10.1021/jf902315e
7. Gan F. F., Nagle A. A., Ang X., Ho O. H., Tan S. H., Yang H., Chui W. K., Chew E. H., Shogaols at proapoptotic concentrations induce G2/M arrest and aberrant mitotic cell death associated with tubulin aggregation. Apoptosis 2011 16 8 856 867 2-s2.0-79955979482 10.1007/s10495-011-0611-3
8. Brusic V., Marina O., Wu C. J., Reinherz E. L., Proteome informatics for cancer research: from molecules to clinic. Proteomics 2007 7 6 976 991 2-s2.0-33947732714 10.1002/pmic.200600965 (Pubitemid 46506744)
9. Liao L., McClatchy D. B., Yates J. R., Shotgun proteomics in neuroscience. Neuron 2009 63 1 12 26 2-s2.0-68349123677
10. Johann D. J. Jr., McGuigan M. D., Patel A. R., Tomov S., Ross S., Conrads T. P., Veenstra T. D., Fishman D. A., Whiteley G. R., Petricoin E. F., Liotta L. A., Clinical proteomics and biomarker discovery. Annals of the New York Academy of Sciences 2004 1022 295 305 2-s2.0-3242707508 10.1196/annals.1318.045 (Pubitemid 38951617)
11. Wang W., Li C. Y., Wen X. D., Li P., Qi L. W., Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: application to pharmacokinetics. Journal of Chromatography B 2009 877 8-9 671 679 2-s2.0-61349111478 10.1016/j.jchromb.2009. 01.021
12. Wang C. Z., Zhang B., Song W. X., Wang A., Ni M., Luo X., Aung H. H., Xie J. T., Tong R., He T. C., Yuan C. S., Steamed American ginseng berry: ginsenoside analyses and anticancer activities. Journal of Agricultural and Food Chemistry 2006 54 26 9936 9942 2-s2.0-33846469565 10.1021/jf062467k (Pubitemid 46158993)
13. Nakajima H., Park H. L., Henkart P. A., Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin. Journal of Experimental Medicine 1995 181 3 1037 1046 2-s2.0-0028967988 10.1084/jem.181.3.1037
14. Nicoletti I., Migliorati G., Pagliacci M. C., Grignani F., Riccardi C., A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. Journal of Immunological Methods 1991 139 2 271 279 2-s2.0-0025726216 10.1016/0022-1759(91)90198-O
15. Gao N., Rahmani M., Shi X., Dent P., Grant S., Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress. Blood 2006 107 1 241 249 2-s2.0-30344433284 10.1182/blood-2005-06-2409 (Pubitemid 43054972)
16. Belmokhtar C. A., Híllion J., Segal-Bendirdjian E., Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms. Oncogene 2001 20 26 3354 3362 2-s2.0-0035821647 10.1038/sj.onc. 1204436 (Pubitemid 32588984)
17. Peng Y.-B., Zhou P., Chu C., Liu E. H., Wen X. D., Liu Q., Chen J., Gao N., Qi L. W., Li P., Proteomic Analysis for Malonylastragaloside I in U937 Leukemia Cells by Modified Label-free Quantitative Strategy with LC Chip Q-TOF MS/MS. Chinese Journal of Natural Medicines 2011 9 4 305 316 2-s2.0-79960408010 10.1016/S1875-5364(11)60068-X
18. Thomas P. D., Kejariwal A., Guo N., Mi H., Campbell M. J., Muruganujan A., Lazareva-Ulitsky B., Applications for protein sequence-function evolution data: mRNA/protein expression analysis and coding SNP scoring tools. Nucleic Acids Research 2006 34 W645 W650 2-s2.0-33747865461 10.1093/nar/gkl229 (Pubitemid 44529850)
19. Jensen L. J., Kuhn M., Stark M., Chaffron S., Creevey C., Muller J., Doerks T., Julien P., Roth A., Simonovic M., Bork P., von Mering C., STRING 8-a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Research 2009 37 1 D412 D416 2-s2.0-58149193234 10.1093/nar/gkn760
20. Cline M. S., Smoot M., Cerami E., Kuchinsky A., Landys N., Workman C., Christmas R., Avila-Campilo I., Creech M., Gross B., Hanspers K., Isserlin R., Kelley R., Killcoyne S., Lotia S., Maere S., Morris J., Ono K., Pavlovic V., Pico A. R., Vailaya A., Wang P. L., Adler A., Conklin B. R., Hood L., Kuiper M., Sander C., Schmulevich I., Schwikowski B., Warner G. J., Ideker T., Bader G. D., Integration of biological networks and gene expression data using Cytoscape. Nature Protocols 2007 2 10 2366 2382 2-s2.0-38449101120 10.1038/nprot.2007.324
21. Ganter B., Giroux C. N., Emerging applications of network and pathway analysis in drug discovery and development. Current Opinion in Drug Discovery and Development 2008 11 1 86 94 2-s2.0-37849009181
22. Brunelle J. K., Letai A., Control of mitochondrial apoptosis by the Bcl-2 family. Journal of Cell Science 2009 122 4 437 441 2-s2.0-64849113485 10.1242/jcs.031682
23. Riedl S. J., Salvesen G. S., The apoptosome: signalling platform of cell death. Nature Reviews Molecular Cell Biology 2007 8 5 405 413 2-s2.0-34247345833 10.1038/nrm2153 (Pubitemid 46643237)
24. Chen X., Wong J. Y. C., Wong P., Radany E. H., Low-dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53-dependent modulation of mitochondrial membrane potential and apoptosis. Molecular Cancer Research 2011 9 4 448 461 2-s2.0-79954488451 10.1158/1541-7786.MCR-10-0471
25. Cheng X. L., Liu Q., Peng Y.-B., Qi L. W., Li P., Steamed ginger (Zingiber officinale): changed chemical profile and increased anticancer potential. Food Chemistry 2011 129 4 1785 1792 2-s2.0-79960041663 10.1016/j.foodchem.2011.06.026
26. Weng C. J., Wu C. F., Huang H. W., Ho C. T., Yen G. C., Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells. Molecular Nutrition and Food Research 2010 54 11 1618 1627 2-s2.0-78349245958 10.1002/mnfr.201000108
27. Pan M. H., Hsieh M. C., Kuo J. M., Lai C. S., Wu H., Sang S., Ho C. T., 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. Molecular Nutrition and Food Research 2008 52 5 527 537 2-s2.0-48649093632 10.1002/mnfr.200700157
28. Li N., Guo R., Li W., Shao J., Li S., Zhao K., Chen X., Xu N., Liu S., Lu Y., A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide. Carcinogenesis 2006 27 6 1222 1231 2-s2.0-33745600824 10.1093/carcin/bgi306 (Pubitemid 43985437)
29. Chuthapisith S., Bean B. E., Cowley G., Eremin J. M., Samphao S., Layfield R., Kerr I. D., Wiseman J., El-Sheemy M., Sreenivasan T., Eremin O., Annexins in human breast cancer: possible predictors of pathological response to neoadjuvant chemotherapy. European Journal of Cancer 2009 45 7 1274 1281 2-s2.0-64349091540 10.1016/j.ejca.2008.12.026
30. Panicker G., Ye Y., Wang D., Unger E. R., Characterization of the human cervical mucous proteome. Clinical Proteomics 2010 6 1-2 18 28 2-s2.0-77951878032 10.1007/s12014-010-9042-3
31. Zitvogel L., Kepp O., Senovilla L., Menger L., Chaput N., Kroemer G., Immunogenic tumor cell death for optimal anticancer therapy: the calreticulin exposure pathway. Clinical Cancer Research 2010 16 12 3100 3104 2-s2.0-77953701142 10.1158/1078-0432.CCR-09-2891
32. Chang Y. I., Lin S. W., Chiou Y. Y., Sung J. S., Cheng L. C., Lu Y. L., Sun K. H., Chang K., Lin C. H., Lin W. J., Establishment of an ectopically expressed and functional PRMT1 for proteomic analysis of arginine-methylated proteins. Electrophoresis 2010 31 23-24 3834 3842 2-s2.0-78650009507 10.1002/elps.201000376
33. Morrison D. K., The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development. Trends in Cell Biology 2009 19 1 16 23 2-s2.0-58149488988 10.1016/j.tcb.2008.10.003
34. Nomura M., Shimizu S., Sugiyama T., Narita M., Ito T., Matsuda H., Tsujimoto Y., 14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax. Journal of Biological Chemistry 2003 278 3 2058 2065 2-s2.0-0037449733 10.1074/jbc.M207880200 (Pubitemid 36801450)
35. Kumagai A., Dunphy W. G., Binding of 14-3-3 proteins and nuclear export control the mtracellular localization of the mitotic inducer Cdc25. Genes and Development 1999 13 9 1067 1072 2-s2.0-0033134794 (Pubitemid 29233138)
36. Laronga C., Yang H. Y., Neal C., Lee M. H., Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression. Journal of Biological Chemistry 2000 275 30 23106 23112 2-s2.0-0034725698 10.1074/jbc.M905616199 (Pubitemid 30646202)
37. Yue Q. X., Cao Z. W., Guan S. H., Liu X. H., Tao L., Wu W. Y., Li Y. X., Yang P. Y., Liu X., Guo D. A., Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Molecular and Cellular Proteomics 2008 7 5 949 961 2-s2.0-43849085358 10.1074/mcp.M700259-MCP200 (Pubitemid 351737094)