The last piece in the vitamin B1 biosynthesis puzzle: Structural and functional insight into yeast 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthase

Journal of Biological Chemistry

Volumn 287, Issue 50, 2012, Pages 42333-42343

  Coquille, Sandrine ^a   Roux, Céline ^a   Fitzpatrick, Teresa B ^a   Thore, Stéphane ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEINS; COFACTORS; COMPLEMENTATION; CRYSTALLOGRAPHIC STRUCTURE; DNA DAMAGE RESPONSE; IRON BINDING; KEY RESIDUES; METABOLIC PATHWAYS; STRUCTURE-FUNCTION STUDIES; SYNTHASES; VITAMIN B;

BIOCHEMISTRY; BIOSYNTHESIS; ENZYMES; METHANOL;

YEAST;

4 AMINO 5 HYDROXYMETHYL 2 METHYLPYRIMIDINE PHOSPHATE SYNTHASE; FERROZINE; PERIPLASMIC BINDING PROTEIN; PYRIDOXAL 5 PHOSPHATE; SYNTHETASE; THIAMINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME SUBSTRATE; ENZYME SYNTHESIS; GENETIC COMPLEMENTATION; IRON BINDING CAPACITY; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION; VITAMIN METABOLISM;

CRYSTALLOGRAPHY, X-RAY; IRON; MUTATION; PHOSPHOTRANSFERASES (PHOSPHATE GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAMINE;

EID: 84871333510     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.397240     Document Type: Article

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