Hydrodynamics of liquid-liquid dispersion in an advanced-flow reactor

Industrial and Engineering Chemistry Research

Volumn 51, Issue 50, 2012, Pages 16251-16262

  Nieves Remacha, María José ^a   Kulkarni, Amol A ^b   Jensen, Klavs F ^a  

^a USA   (United States)

^b NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CHANGING CROSS SECTION; COMMERCIAL SYSTEMS; COMPLEX GEOMETRIES; CONTINUOUS FLOWS; DROP SIZE; DROP SIZE DISTRIBUTION; FLOW PATH; INLET COMPOSITION; LIQUID-LIQUID DISPERSIONS; LIQUID-LIQUID FLOW; LIQUID-LIQUIDS; MICRO REACTOR; MODEL SYSTEM; ORDERS OF MAGNITUDE; OVERALL MASS TRANSFER COEFFICIENT; PHASE FLOW; PRESSURE CHANGE; PRESSURE DROP MEASUREMENTS; SMALL SCALE; SPECIFIC INTERFACIAL AREA; STATIC MIXERS; STIRRED TANK REACTORS; TRANSPORT PHENOMENA; VISUALIZATION TECHNIQUE;

CHEMICAL REACTORS; FLOW RATE; FLOW VISUALIZATION; HEXANE; HYDRODYNAMICS; MASS TRANSFER;

LIQUIDS;

EID: 84871295171     PISSN: 08885885     EISSN: 15205045     Source Type: Journal    
DOI: 10.1021/ie301821k     Document Type: Article

References (57)

1. Dugger, R. W.; Ragan, J. A.; Ripin, D. H. B. Survey of GMP bulk reactions run in a research facility between 1985 and 2002 Org. Process Res. Dev. 2005, 9, 253-258
2. Carey, J. S.; Laffan, D.; Thomson, C.; Williams, M. T. Analysis of the reactions used for the preparation of drug candidate molecules Org. Biomol. Chem. 2006, 4, 2337-2347
3. Constable, D. J. C.; Dunn, P. J.; Hayler, J. D.; Humphrey, G. R.; Leazer, J. L., Jr.; Linderman, R. J.; Lorenz, K.; Manley, J.; Pearlman, B. A.; Wells, A.; Zaks, A.; Zhang, T. Y. Key green chemistry research areas-a perspective from pharmaceutical manufacturers Green Chem. 2007, 9, 411-420
4. Mckenzie, P.; Kiang, S.; Tom, J.; Rubin, A. E.; Futran, M. Can pharmaceutical process development become high tech? AIChE J. 2006, 52, 3990-3994
5. Fedoryński, M.; Jezierska-Zieba, M.; Kakol, B. Phase transfer catalysis in pharmaceutical industry-where are we? Acta Pol. Pharm. 2008, 65, 647-654
6. Ahmed-Omer, B.; Barrow, D.; Wirth, T. Biphasic reactions in microreactors. Proceedings of the 4th International Conference on Multi-Material Micro Manufacture; Dimov, S.; Menz, W., Eds.; Whittles Publishing: Dunbeath, U.K., 2008; pp 2-4.
7. Wilhite, B. A.; Jensen, K. F.; Hill, T. F.; Epstein, A. H.; Livermore, C. Design of a silicon-based microscale trickle-bed system for singlet-oxygen production AIChE J. 2008, 54, 2441-2455
8. Ajmera, S. K.; Losey, M. W.; Jensen, K. F.; Schmidt, M. A. Microfabricated packed-bed reactor for phosgene synthesis AIChE J. 2001, 47, 1639-1647
9. Zhang, X.; Stefanick, S.; Villani, F. J. Application of microreactor technology in process development Org. Process Res. Dev. 2004, 8, 455-460
10. Gavriilidis, A.; Angeli, P.; Cao, E.; Yeong, K. K.; Wan, Y. S. S. Technology and applications of microengineered reactors Trans. Inst. Chem. Eng. 2002, 80, 3-30
11. Saber, M.; Commenge, J. M.; Falk, L. Microreactor numbering-up in multi-scale networks for industrial-scale applications: Impact of flow maldistribution on the reactor performances Chem. Eng. Sci. 2010, 65, 372-379
12. Roberge, D. M.; Gottsponer, M.; Eyholzer, M.; Kockmann, N. Industrial design, scale-up, and use of microreactors Chem. Today 2009, 7, 8-11
13. Jensen, K. F. Microreaction engineering-is small better? Chem. Eng. Sci. 2001, 56, 293-303
14. Watts, P.; Haswell, S. J. The application of micro reactors for organic synthesis Chem. Soc. Rev. 2005, 34, 235-46
15. Haswell, S. J.; Middleton, R. J.; O'Sullivan, B.; Skelton, V.; Watts, P.; Styring, P. The application of micro reactors to synthetic chemistry Chem. Commun. 2001, 391-398
16. Commenge, J. M.; Falk, L.; Corriou, J. P.; Matlosz, M. Optimal design for flow uniformity in microchannel reactors AIChE J. 2002, 48, 345-358
17. Amador, C. Flow distribution in different microreactor scale-out geometries and the effect of manufacturing tolerances and channel blockage Chem. Eng. J. 2004, 101, 379-390
18. Wada, Y.; Schmidt, M. A.; Jensen, K. F. Flow distribution and ozonolysis in gas-liquid multichannel microreactors Ind. Eng. Chem. Res. 2006, 45, 8036-8042
19. Hasebe, S. Design and operation of micro-chemical plants-bridging the gap between nano, micro and macro technologies Comput. Chem. Eng. 2004, 29, 57-64
20. Iwasaki, T.; Kawano, N.; Yoshida, J. Radical polymerization using microflow system: numbering-up of microreactors and continuous operation Org. Process Res. Dev. 2006, 10, 1126-1131
21. Hornung, C. H.; Mackley, M. R.; Baxendale, I. R.; Ley, S. V. A microcapillary flow disc reactor for organic synthesis Org. Process Res. Dev. 2007, 11, 399-405
22. Schenk, R. Numbering-up of micro devices: a first liquid-flow splitting unit Chem. Eng. J. 2004, 101, 421-429
23. Calabrese, G. S.; Park, S.; Pissavini, S. From batch to continuous flow processing in chemicals manufacturing AIChE J. 2011, 57, 828-834
24. Zhao, Y.; Chen, G.; Yuan, Q. Liquid-liquid two-phase flow patterns in a rectangular microchannel AIChE J. 2006, 52, 4052-4060
25. Dessimoz, A.; Cavin, L.; Renken, A.; Kiwiminsker, L. Liquid-liquid two-phase flow patterns and mass transfer characteristics in rectangular glass microreactors Chem. Eng. Sci. 2008, 63, 4035-4044
26. Cherlo, S. K. R.; Kariveti, S.; Pushpavanam, S. Experimental and numerical investigations of two-phase (liquid-liquid) flow behavior in rectangular microchannels Ind. Eng. Chem. Res. 2010, 49, 893-899
27. Serizawa, A.; Feng, Z.; Kawara, Z. Two-phase flow in microchannels Exp. Therm. Fluid Sci. 2002, 26, 703-714
28. Kashid, M. N.; Gupta, A.; Renken, A.; Kiwi-Minsker, L. Numbering-up and mass transfer studies of liquid-liquid two-phase microstructured reactors Chem. Eng. J. 2010, 158, 233-240
29. Kashid, M. N.; Gerlach, I.; Goetz, S.; Franzke, J.; Acker, J. F.; Platte, F.; Agar, D. W.; Turek, S. Internal circulation within the liquid slugs of a liquid-liquid slug-flow capillary microreactor Ind. Eng. Chem. Res. 2005, 44, 5003-5010
30. Tice, J. D.; Song, H.; Lyon, A. D.; Ismagilov, R. F. Formation of droplets and mixing in multiphase microfluidics at low values of the Reynolds and the Capillary numbers Langmuir 2003, 19, 9127-9133
31. Song, H.; Chen, D. L.; Ismagilov, R. F. Reactions in droplets in microfluidic channels Angew. Chem., Int. Ed. 2006, 45, 7336-7356
32. Nere, N. K.; Patwardhan, A. W.; Joshi, J. B. Liquid-phase mixing in stirred vessels: turbulent flow regime Ind. Eng. Chem. Res. 2003, 42, 2661-2698
33. Mitrinovic, D. M.; Zhang, Z.; Williams, S. M.; Huang, Z.; Schlossman, M. L. X-ray reflectivity study of the water-hexane interface J. Phys. Chem. B 1999, 103, 1779-1782
34. Lockhart, R. W.; Martinelli, R. C. Proposed correlation of data for isothermal, two-phase, two-component flow in pipes Chem. Eng. Prog. 1949, 45, 39-48
35. Gennes, P. G.; Wyart, F. B.; Quere, D. Capillarity and Wetting Phenomena: Drops, Bubbles, Pearls, Waves; Springer: Berlin, 2003.
36. Tabeling, P. Investigating slippage, droplet breakup, and synthesizing microcapsules in microfluidic systems Phys. Fluids 2010, 22, 1-7
37. Clift, R.; Grace, J. R.; Weber, M. E. Bubbles, Drops and Particles; Academic Press: New York, 1978.
38. Vananroye, A.; Puyvelde, P. V.; Moldenaers, P. Morphology development during microconfined flow of viscous emulsions Appl. Rheol. 2006, 16, 242-247
39. Tsouris, C.; Lizama, H. M.; Spurrier, M. A.; Takeuchi, T. L.; Scott, T. C. Hydrodynamics of bioreactor systems for liquid-liquid contacting Appl. Biochem. Biotechnol. 1996, 57-58, 581-592
40. Jovanović, J.; Rebrov, E. V.; Nijhuis, T. A. (X.); Hessel, V.; Schouten, J. C. Phase-transfer catalysis in segmented flow in a microchannel: fluidic control of selectivity and productivity Ind. Eng. Chem. Res. 2010, 49, 2681-2687
41. Lemenand, T. Droplets formation in turbulent mixing of two immiscible fluids in a new type of static mixer Int. J. Multiphase Flow 2003, 29, 813-840
42. Calderbank, P. H.; Lochiel, A. C. Mass transfer coefficients, velocities and shapes of carbon dioxide bubbles in free rise through distilled water Chem. Eng. Sci. 1964, 19, 485-503
43. Higbie, R. The rate of absorption of a pure gas into a still liquid during short periods of exposure Trans. Am. Inst. Chem. Eng. 1935, 365-389
44. Timson, W.; Dunn, C. Mechanism of gas absorption from bubbles under shear Ind. Eng. Chem. 1960, 52, 799-802
45. Deindoerfer, F.; Humphrey, A. Mass transfer from individual gas bubbles Ind. Eng. Chem. 1961, 53, 755-759
46. Lapidus, L.; Elgin, J. C. Mechanics of vertical-moving fluidized systems AIChE J. 1957, 3, 63-68
47. Lockett, M. J.; Kirkpatrick, R. D. Ideal bubbly flow and actual flow in bubble columns Trans. Inst. Chem. Eng. 1975, 53, 267-273
48. Laurenzi, F.; Coroneo, M.; Montante, G.; Paglianti, A.; Magelli, F. Hydrodynamics of immiscible liquid-liquid dispersions in stirred vessels. Presented at the 13th European Conference on Mixing, London, April 14-17, 2009.
49. Kamienski, J.; Wojtowicz, R. Dispersion of liquid-liquid systems in a mixer with a reciprocating agitator Chem. Eng. Process. 2003, 42, 1007-1017
50. Zhou, G.; Kresta, S. M. Correlation of mean drop size and minimum drop size with the turbulence energy dissipation and the flow in an agitated tank Chem. Eng. Sci. 1998, 53, 2063-2079
51. Buchs, J.; Bernd, Z. Evaluation of maximum to specific power consumption ratio in shaking bioreactors J. Chem. Eng. Jpn. 2001, 34, 647-653
52. Kashid, M.; Agar, D. Hydrodynamics of liquid-liquid slug flow capillary microreactor: Flow regimes, slug size and pressure drop Chem. Eng. J. 2007, 131, 1-13
53. Al Taweel, A. M.; Li, C.; Gomaa, H. G.; Yuet, P. Intensifying mass transfer between immiscible liquids using screen-type static mixers Trans. Inst. Chem. Eng., Part A: Chem. Eng. Res. Des. 2007, 85, 760-765
54. Lemenand, T.; Dupont, P.; Della Valle, D.; Peerhossaini, H. Turbulent mixing of two immiscible fluids J. Fluids Eng. 2005, 127, 1132
55. Kashid, M. N.; Renken, A.; Kiwi-Minsker, L. Gas-liquid and liquid-liquid mass transfer in microstructured reactors Chem. Eng. Sci. 2011, 66, 3876-3897
56. Merchuk, J. C. Experimental study of dispersion and separation of phases in liquid-liquid extraction of copper by LIX 64N in various types of mixers Ind. Eng. Chem. Process Des. Dev. 1980, 19, 522-526
57. Su, Y.; Zhao, Y.; Chen, G.; Yuan, Q. Liquid-liquid two-phase flow and mass transfer characteristics in packed microchannels Chem. Eng. Sci. 2010, 65, 3947-3956