-
1
-
-
0032105481
-
Rapamune® (RAPA, rapamycin, sirolimus): Mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
-
DOI 10.1016/S0009-9120(98)00045-9, PII S0009912098000459
-
Sehgal SN. Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression. Clin Biochem 1998;31:335-40 (Pubitemid 28385231)
-
(1998)
Clinical Biochemistry
, vol.31
, Issue.5
, pp. 335-340
-
-
Sehgal, S.N.1
-
2
-
-
0038299000
-
Sirolimus: Its discovery, biological properties, and mechanism of action
-
DOI 10.1016/S0041-1345(03)00211-2
-
Sehgal SN. Sirolimus: its discovery, biological properties, and mechanism of action. Transplant Proc 2003;35:7S-14S (Pubitemid 36547910)
-
(2003)
Transplantation Proceedings
, vol.35
, Issue.3 SUPPL.
-
-
Sehgal, S.N.1
-
3
-
-
0031657020
-
Chemical modification of rapamycin: The discovery of SDZ RAD
-
DOI 10.1016/S0041-1345(98)00587-9, PII S0041134598005879
-
Sedrani R, Cottens S, Kallen J, Schuler W. Chemical modification of rapamycin: the discovery of SDZ RAD. Transplant Proc 1998;30:2192-4 (Pubitemid 28399473)
-
(1998)
Transplantation Proceedings
, vol.30
, Issue.5
, pp. 2192-2194
-
-
Sedrani, R.1
Cottens, S.2
Kallen, J.3
Schuler, W.4
-
4
-
-
0030832514
-
SDZ RAD, a new rapamycin derivative: Pharmacological properties in vitro and in vivo
-
DOI 10.1097/00007890-199707150-00008
-
Schuler W, Sedrani R, Cottens S, et al. SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo. Transplantation 1997;64:36-42 (Pubitemid 27327197)
-
(1997)
Transplantation
, vol.64
, Issue.1
, pp. 36-42
-
-
Schuler, W.1
Sedrani, R.2
Cottens, S.3
Haberlin, B.4
Schulz, M.5
Schuurman, H.-J.6
Zenke, G.7
Zerwes, H.-G.8
Schreier, M.H.9
-
5
-
-
0032930567
-
Absorption and intestinal metabolism of SDZ-RAD and rapamycin in rats
-
Crowe A, Bruelisauer A, Duerr L, et al. Absorption and intestinal metabolism of SDZ-RAD and rapamycin in rats. Drug Metab Dispos 1999;27:627-32 (Pubitemid 29214476)
-
(1999)
Drug Metabolism and Disposition
, vol.27
, Issue.5
, pp. 627-632
-
-
Crowe, A.1
Bruelisauer, A.2
Duerr, L.3
Guntz, P.4
Lemaire, M.5
-
9
-
-
38949125143
-
Multidisciplinary insights on clinical guidance for the use of proliferation signal inhibitors in heart transplantation
-
DOI 10.1016/j.healun.2007.08.014, PII S105324980700767X
-
Zuckermann A, Manito N, Epailly E, et al. Multidisciplinary insights on clinical guidance for the use of proliferation signal inhibitors in heart transplantation. J Heart Lung Transplant 2008;27:141-9 (Pubitemid 351221042)
-
(2008)
Journal of Heart and Lung Transplantation
, vol.27
, Issue.2
, pp. 141-149
-
-
Zuckermann, A.1
Manito, N.2
Epailly, E.3
Fiane, A.4
Bara, C.5
Delgado, J.F.6
Lehmkuhl, H.7
Ross, H.8
Eisen, H.9
Chapman, J.10
Valantine, H.11
-
10
-
-
33745393847
-
Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-Year report
-
DOI 10.1111/j.1600-6143.2006.01290.x
-
Kobashigawa JA, Miller LW, Russell SD, et al. Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report. Am J Transplant 2006;6:1377-86 (Pubitemid 44030320)
-
(2006)
American Journal of Transplantation
, vol.6
, Issue.6
, pp. 1377-1386
-
-
Kobashigawa, J.A.1
Miller, L.W.2
Russell, S.D.3
Ewald, G.A.4
Zucker, M.J.5
Goldberg, L.R.6
Eisen, H.J.7
Salm, K.8
Tolzman, D.9
Gao, J.10
Fitzsimmons, W.11
First, R.12
-
11
-
-
34249308123
-
Is there a role for proliferation signal/mTOR inhibitors in the prevention and treatment of de novo malignancies after heart transplantation? Lessons learned from renal transplantation and oncology
-
Valentine H. Is there a role for proliferation signal/mTOR inhibitors in the prevention and treatment of de novo malignancies after heart transplantation? Lessons learned from renal transplantation and oncology. J Heart Lung Transplant 2007;26:557-64
-
(2007)
J Heart Lung Transplant
, vol.26
, pp. 557-564
-
-
Valentine, H.1
-
12
-
-
27644436740
-
Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies
-
DOI 10.1097/01.TP.0000184006.43152.8D
-
Kauffman HM, Cherikh WS, Cheng Y, et al. Maintenance immunosuppression with target of rapamycin inhibitors is associated with a reduced-incidence of de novo malignancies. Transplantation 2005;80:883-9 (Pubitemid 41552882)
-
(2005)
Transplantation
, vol.80
, Issue.7
, pp. 883-889
-
-
Kauffman, H.M.1
Cherikh, W.S.2
Cheng, Y.3
Hanto, D.W.4
Kahan, B.D.5
-
13
-
-
57649186751
-
Sirolimus treatment for recurrent lymphangioleiomyomatosis after lung transplantation
-
Chen F, Omasa M, Kondo N, et al. Sirolimus treatment for recurrent lymphangioleiomyomatosis after lung transplantation. Ann Thorac Surg 2009;87:e6-7
-
(2009)
Ann Thorac Surg
, vol.87
-
-
Chen, F.1
Omasa, M.2
Kondo, N.3
-
14
-
-
40949158793
-
Regression of Pulmonary Lymphangioleiomyomatosis (PLAM)-associated Retroperitoneal Angiomyolipoma Post-Lung Transplantation With Rapamycin Treatment
-
DOI 10.1016/j.healun.2008.01.005, PII S1053249808000065
-
Morton JM, McLean C, Booth SS, et al. Regression of pulmonary lymphangioleiomyomatosis (PLAM)-associated retroperitoneal angiomyolipoma post-lung transplantation with rapamycin treatment. J Heart Lung Transplant 2008;27:462-5 (Pubitemid 351418242)
-
(2008)
Journal of Heart and Lung Transplantation
, vol.27
, Issue.4
, pp. 462-465
-
-
Morton, J.M.1
McLean, C.2
Booth, S.S.3
Snell, G.I.4
Whitford, H.M.5
-
15
-
-
76649119471
-
Cyclosporine lowering with everolimus or mycophenolate to preserve renal function in heart recipients: A randomized study
-
Potena L, Bianchi IG, Magnani G, et al. Cyclosporine lowering with everolimus or mycophenolate to preserve renal function in heart recipients: a randomized study. Transplantation 2010;89:263-5
-
(2010)
Transplantation
, vol.89
, pp. 263-265
-
-
Potena, L.1
Bianchi, I.G.2
Magnani, G.3
-
16
-
-
84861184815
-
Cyclosporine lowering with everolimus or mycophenolate mofetil in heart transplant recipients: Long-term follow-ip of the SHIRAKISS randomized, prospective study
-
Potena L, Prestinenzi P, Bianchi IG, et al. Cyclosporine lowering with everolimus or mycophenolate mofetil in heart transplant recipients: long-term follow-ip of the SHIRAKISS randomized, prospective study. J Heart Lung Transplant 2012;31:565-70
-
(2012)
J Heart Lung Transplant
, vol.31
, pp. 565-570
-
-
Potena, L.1
Prestinenzi, P.2
Bianchi, I.G.3
-
17
-
-
77950952997
-
Everolimus with reduced calcineurin inhibitor in thoracic transplant recipients with renal dysfunction: A multicenter, randomized trial
-
Gullestad L, Iversen M, Mortensen SA, et al. Everolimus with reduced calcineurin inhibitor in thoracic transplant recipients with renal dysfunction: a multicenter, randomized trial. Transplantation 2010;89:864-72
-
(2010)
Transplantation
, vol.89
, pp. 864-872
-
-
Gullestad, L.1
Iversen, M.2
Mortensen, S.A.3
-
18
-
-
84856872316
-
Improvement in renal function after everolimus introduction and calcineurin inhibitor reduction in maintenance thoracic transplant recipients: The significance of baseline glomerular filtration rate
-
Arora S, Gude E, Sigurdardottir V, et al. Improvement in renal function after everolimus introduction and calcineurin inhibitor reduction in maintenance thoracic transplant recipients: the significance of baseline glomerular filtration rate. J Heart Lung Transplant 2012;31:259-65
-
(2012)
J Heart Lung Transplant
, vol.31
, pp. 259-265
-
-
Arora, S.1
Gude, E.2
Sigurdardottir, V.3
-
19
-
-
84865582428
-
Randomized controlled trial of sirolimus conversion in cardiac transplant recipients with renal insufficiency
-
Epub ahead of print
-
Zuckermann A, Keogh A, Crespo-Leiro MG, et al. Randomized controlled trial of sirolimus conversion in cardiac transplant recipients with renal insufficiency. Am J Transplant 2012; Epub ahead of print
-
(2012)
Am J Transplant
-
-
Zuckermann, A.1
Keogh, A.2
Crespo-Leiro, M.G.3
-
20
-
-
33646138493
-
Early renal benefit of rapamycin combined with reduced calcineurin inhibitor dose in pediatric heart transplantation patients
-
Balfour IC, Srun SW, Wood EG, et al. Early renal benefit of rapamycin combined with reduced calcineurin inhibitor dose in pediatric heart transplantation patients. J Heart Lung Transplant 2006;25:518-22
-
(2006)
J Heart Lung Transplant
, vol.25
, pp. 518-522
-
-
Balfour, I.C.1
Srun, S.W.2
Wood, E.G.3
-
21
-
-
77149153725
-
Lower incidence of cytomegalovirus infection with everolimus versus mycophenolate mofetil in de novo cardiac transplant recipients: a randomized multicenter study
-
Vigano M, Dengler T, Mattei MF, et al. Lower incidence of cytomegalovirus infection with everolimus versus mycophenolate mofetil in de novo cardiac transplant recipients: a randomized multicenter study. Transpl Infect Dis 2010;12:23-30
-
(2010)
Transpl Infect Dis
, vol.12
, pp. 23-30
-
-
Vigano, M.1
Dengler, T.2
Mattei, M.F.3
-
22
-
-
33947723271
-
Cytomegalovirus in transplantation-challenging the status quo
-
Fishman JA, Emery V, Freeman R, et al. Cytomegalovirus in transplantation-challenging the status quo. Clin Transplant 2007;21:149-58
-
(2007)
Clin Transplant
, vol.21
, pp. 149-158
-
-
Fishman, J.A.1
Emery, V.2
Freeman, R.3
-
23
-
-
37349084974
-
A lower incidence of cytomegalovirus infection in de novo heart transplant recipients randomized to everolimus
-
DOI 10.1097/01.tp.0000290686.68910.bd, PII 0000789020071215000009
-
Hill JA, Hummel M, Starling RC, et al. A lower incidence of cytomegalovirus infection in de novo heart transplant recipients randomized to everolimus. Transplantation 2007;84:1436-42 (Pubitemid 350294718)
-
(2007)
Transplantation
, vol.84
, Issue.11
, pp. 1436-1442
-
-
Hill, J.A.1
Hummel, M.2
Starling, R.C.3
Kobashigawa, J.A.4
Perrone, S.V.5
Arizon, J.M.6
Simonsen, S.7
Abeywickrama, K.H.8
Bara, C.9
-
24
-
-
84885690067
-
Lower incidence of viral infections with everolimus versus MMF in de novo heart transplant recipients: 12 month analysis of a randomized multicenter study
-
Ross H, Kfoury AG, Van Balek A, et al. Lower incidence of viral infections with everolimus versus MMF in de novo heart transplant recipients: 12 month analysis of a randomized multicenter study. J Heart Lung Transplant 2011;30:171s
-
(2011)
J Heart Lung Transplant
, vol.30
-
-
Ross, H.1
Kfoury, A.G.2
Van Balek, A.3
-
25
-
-
84885682498
-
Everolimus treatment reduces the need for anti-CMV prophylaxis in de novo heart transplant recipients
-
Potena L, Bianchi IG, D'Agostino C, et al. Everolimus treatment reduces the need for anti-CMV prophylaxis in de novo heart transplant recipients. J Heart Lung Transplant 2011;30:172s
-
(2011)
J Heart Lung Transplant
, vol.30
-
-
Potena, L.1
Bianchi, I.G.2
D'Agostino, C.3
-
26
-
-
45449112352
-
Reduced risk of cytomegalovirus infection in solid organ transplant recipients treated with sirolimus: A pooled analysis of clinical trials
-
DOI 10.1016/j.transproceed.2008.03.084, PII S0041134508003023
-
Demopoulos L, Pollinsky M, Steele G, et al. Reduced risk of cytomegalovirus infection in solid organ transplant recipients treated with sirolimus: a pooled analysis of clinical trials. Transplant Proc 2008;40:1407-10 (Pubitemid 351853135)
-
(2008)
Transplantation Proceedings
, vol.40
, Issue.5
, pp. 1407-1410
-
-
Demopoulos, L.1
Polinsky, M.2
Steele, G.3
Mines, D.4
Blum, M.5
Caulfield, M.6
Adamkovic, A.7
Liu, Q.8
Harler, M.B.9
Hahn, C.10
Singh, A.11
-
27
-
-
79953311504
-
Risk factors associated with cytomegalovirus infection in heart transplant patients: A prospective, epidemiological study
-
Delgado JF, Manito N, Almenar L, et al. Risk factors associated with cytomegalovirus infection in heart transplant patients: a prospective, epidemiological study. Transpl Infect Dis 2011;13:136-44
-
(2011)
Transpl Infect Dis
, vol.13
, pp. 136-144
-
-
Delgado, J.F.1
Manito, N.2
Almenar, L.3
-
28
-
-
84861818332
-
CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages
-
Poglitsch M, Weichhart T, Hecking M, et al. CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages. Am J Transplant 2012;12:1458-68
-
(2012)
Am J Transplant
, vol.12
, pp. 1458-1468
-
-
Poglitsch, M.1
Weichhart, T.2
Hecking, M.3
-
29
-
-
79953242027
-
Paradoxical aspects of rapamycin immunobiology in transplantation
-
Ferrer IR, Araki K, Ford ML. Paradoxical aspects of rapamycin immunobiology in transplantation. Am J Transplant 2011;11:654-9
-
(2011)
Am J Transplant
, vol.11
, pp. 654-659
-
-
Ferrer, I.R.1
Araki, K.2
Ford, M.L.3
-
30
-
-
67650074206
-
MTOR regulates memory CD8 T-cell differentiation
-
Araki K, Turner AP, Shaffer VO, et al. mTOR regulates memory CD8 T-cell differentiation. Nature 2009;460:108-13
-
(2009)
Nature
, vol.460
, pp. 108-113
-
-
Araki, K.1
Turner, A.P.2
Shaffer, V.O.3
-
31
-
-
0742322206
-
Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation
-
DOI 10.1097/01.TP.0000101822.50960.AB
-
Azzola A, Havryk A, Chhajed P, et al. Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation. Transplantation 2004;77:275-80 (Pubitemid 38155758)
-
(2004)
Transplantation
, vol.77
, Issue.2
, pp. 275-280
-
-
Azzola, A.1
Havryk, A.2
Chhajed, P.3
Hostettler, K.4
Black, J.5
Johnson, P.6
Roth, M.7
Glanville, A.8
Tamm, M.9
-
32
-
-
33644856861
-
Everolimus versus azathioprine in maintenance lung transplant recipients: An international, randomized, double-blind clinical trial
-
DOI 10.1111/j.1600-6143.2005.01134.x
-
Snell GI, Valentine VG, Vitulo P, et al. Everolimus versus azathioprine in maintenance lung transplant recipients: an international, randomized, double-blind clinical trial. Am J Transplant 2006;6:169-77 (Pubitemid 43382215)
-
(2006)
American Journal of Transplantation
, vol.6
, Issue.1
, pp. 169-177
-
-
Snell, G.I.1
Valentine, V.G.2
Vitulo, P.3
Glanville, A.R.4
McGiffin, D.C.5
Loyd, J.E.6
Roman, A.7
Aris, R.8
Sole, A.9
Hmissi, A.10
Pirron, U.11
-
33
-
-
79551533169
-
Comparison of sirolimus with azathioprine in a tacrolimus-based immunosuppressive regimen in lung transplantation
-
Bhorade S, Ahya VN, Baz MA, et al. Comparison of sirolimus with azathioprine in a tacrolimus-based immunosuppressive regimen in lung transplantation. Am J Respir Crit Care Med 2011;183:379-87
-
(2011)
Am J Respir Crit Care Med
, vol.183
, pp. 379-387
-
-
Bhorade, S.1
Ahya, V.N.2
Ma, B.3
-
34
-
-
32844468996
-
Conversion to sirolimus and mycophenolate can attenuate the progression of bronchiolitis obliterans syndrome and improves renal function after lung transplantation
-
DOI 10.1097/01.tp.0000195781.02268.5e
-
Groetzner J, Wittwer T, Kaczmarek I, et al. Conversion to sirolimus and mycophenolate can attenuate the progression of bronchiolitis obliterans syndrome and improves renal function after lung transplantation. Transplantation 2006;81:355-60 (Pubitemid 43255719)
-
(2006)
Transplantation
, vol.81
, Issue.3
, pp. 355-360
-
-
Groetzner, J.1
Wittwer, T.2
Kaczmarek, I.3
Ueberfuhr, P.4
Strauch, J.5
Nagib, R.6
Meiser, B.7
Franke, U.8
Reichart, B.9
Wahlers, T.10
-
35
-
-
0029119711
-
Effect of pravastatin on outcomes after cardiac transplantation
-
Kobashigawa J, Katznelson S, Laks H, et al. Effect of pravastatin on outcomes after cardiac transplantation. N Engl J Med 1995;333:621-7
-
(1995)
N Engl J Med
, vol.333
, pp. 621-627
-
-
Kobashigawa, J.1
Katznelson, S.2
Laks, H.3
-
36
-
-
34547453885
-
Comparison of sirolimus and everolimus in their effects on blood lipid profiles and haematological parameters in heart transplant recipients
-
DOI 10.1111/j.1399-0012.2007.00686.x
-
Tenderich G, Fuchs U, Zittermann A, et al. Comparison of sirolimus and everolimus in their effects on blood lipid profiles and haematological parameters in heart transplant recipients. Clin Transplant 2007;21:536-43 (Pubitemid 47161833)
-
(2007)
Clinical Transplantation
, vol.21
, Issue.4
, pp. 536-543
-
-
Tenderich, G.1
Fuchs, U.2
Zittermann, A.3
Muckelbauer, R.4
Berthold, H.K.5
Koerfer, R.6
-
37
-
-
84885680591
-
Heart transplant recipients treated with everolimus have less increase in intimal thickness vs. MMF, irrespective of lipid values
-
Pauly D, Starling R, Kobashigawa J, et al. Heart transplant recipients treated with everolimus have less increase in intimal thickness vs. MMF, irrespective of lipid values. J Heart Lung Transplant 2011;30:57s
-
(2011)
J Heart Lung Transplant
, vol.30
-
-
Pauly, D.1
Starling, R.2
Kobashigawa, J.3
-
38
-
-
84870629320
-
Reduction of cardiac allograft vasculopathy with everolimus over mycophenolate mofetil: Intravascular ultrasound results of a randomized multicenter trial
-
Kobashigawa J, Pauly D, Ross H, et al. Reduction of cardiac allograft vasculopathy with everolimus over mycophenolate mofetil: intravascular ultrasound results of a randomized multicenter trial. J Heart Lung Transplant 2011;30:52S
-
(2011)
J Heart Lung Transplant
, vol.30
-
-
Kobashigawa, J.1
Pauly, D.2
Ross, H.3
-
39
-
-
79960305705
-
Effect of everolimus introduction on cardiac allograft vasculopathy-results of a randomized, multicenter trial
-
Arora S, Ueland T, Wennerblom B, et al. Effect of everolimus introduction on cardiac allograft vasculopathy-results of a randomized, multicenter trial. Transplantation 2011;92:235-43
-
(2011)
Transplantation
, vol.92
, pp. 235-243
-
-
Arora, S.1
Ueland, T.2
Wennerblom, B.3
-
40
-
-
19244366021
-
Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients
-
DOI 10.1056/NEJMoa022171
-
Eisen HJ, Tuzcu EM, Dorent R, et al. Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients. N Engl J Med 2003;349:847-58 (Pubitemid 37025404)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.9
, pp. 847-858
-
-
Eisen, H.J.1
Tuzcu, E.M.2
Dorent, R.3
Kobashigawa, J.4
Mancini, D.5
Valantine-Von Kaeppler, H.A.6
Starling, R.C.7
Sorensen, K.8
Hummel, M.9
Lind, J.M.10
Abeywickrama, K.H.11
Bernhardt, P.12
-
41
-
-
20844461132
-
Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: A randomized clinical trial
-
DOI 10.1161/01.CIR.0000136812.90177.94
-
Keogh A, Richardson M, Ruygrok P, et al. Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial. Circulation 2004;110:2694-700 (Pubitemid 39453021)
-
(2004)
Circulation
, vol.110
, Issue.17
, pp. 2694-2700
-
-
Keogh, A.1
Richardson, M.2
Ruygrok, P.3
Spratt, P.4
Galbraith, A.5
O'Driscoll, G.6
Macdonald, P.7
Esmore, D.8
Muller, D.9
Faddy, S.10
-
42
-
-
0038300674
-
Use of rapamycin slows progression of cardiac transplantation vasculopathy
-
DOI 10.1161/01.CIR.0000070421.38604.2B
-
Mancini D, Pinney S, Burkhoff D, et al. Use of rapamycin slows progression of cardiac transplantation vasculopathy. Circulation 2003;108:48-53 (Pubitemid 36859019)
-
(2003)
Circulation
, vol.108
, Issue.1
, pp. 48-53
-
-
Mancini, D.1
Pinney, S.2
Burkhoff, D.3
LaManca, J.4
Itescu, S.5
Burke, E.6
Edwards, N.7
Oz, M.8
Marks, A.R.9
-
43
-
-
37349072494
-
Conversion to sirolimus as primary immunosuppression attenuates the progression of allograft vasculopathy after cardiac transplantation
-
DOI 10.1161/CIRCULATIONAHA.107.692996
-
Raichlin E, Bae JH, Khalpey Z, et al. Conversion to sirolimus as primary immunosuppression attenuates the progression of allograft vasculopathy after cardiac transplantation. Circulation 2007;116:2726-33 (Pubitemid 350291245)
-
(2007)
Circulation
, vol.116
, Issue.23
, pp. 2726-2733
-
-
Raichlin, E.1
Bae, J.-H.2
Khalpey, Z.3
Edwards, B.S.4
Kremers, W.K.5
Clavell, A.L.6
Rodeheffer, R.J.7
Frantz, R.P.8
Rihal, C.9
Lerman, A.10
Kushwaha, S.S.11
-
44
-
-
84863173879
-
Sirolimus as primary immunosuppression attenuates allograft vasculopathy with improved late survival and decreased cardiac events after cardiac transplantation
-
Topilsky Y, Hasin T, Raichlin E, et al. Sirolimus as primary immunosuppression attenuates allograft vasculopathy with improved late survival and decreased cardiac events after cardiac transplantation. Circulation 2012;125:708-20
-
(2012)
Circulation
, vol.125
, pp. 708-720
-
-
Topilsky, Y.1
Hasin, T.2
Raichlin, E.3
-
45
-
-
80054122390
-
Proliferation signal inhibitors and post-transplant malignancies in heart transplantation: Practical clinical management questions
-
Epailly E, Albanell J, Andreassen A, et al. Proliferation signal inhibitors and post-transplant malignancies in heart transplantation: practical clinical management questions. Clin Transplant 2011;25:E475-86
-
(2011)
Clin Transplant
, vol.25
-
-
Epailly, E.1
Albanell, J.2
Andreassen, A.3
-
46
-
-
78650961986
-
Increased risk of venous thromboembolism with a sirolimus-based immunosuppression regimen in lung transplantation
-
Ahya VN, McShane PJ, Baz MA, et al. Increased risk of venous thromboembolism with a sirolimus-based immunosuppression regimen in lung transplantation. J Heart Lung Transplant 2011;30:175-81
-
(2011)
J Heart Lung Transplant
, vol.30
, pp. 175-181
-
-
Ahya, V.N.1
McShane, P.J.2
Ma, B.3
-
47
-
-
2942562298
-
Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy
-
DOI 10.1111/j.1432-2277.2004.tb00431.x
-
Dittrich E, Schmaldienst S, Soleiman A, et al. Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy. Transpl Int 2004;17:215-20 (Pubitemid 38758188)
-
(2004)
Transplant International
, vol.17
, Issue.4
, pp. 215-220
-
-
Dittrich, E.1
Schmaldienst, S.2
Soleiman, A.3
Horl, W.H.4
Pohanka, E.5
-
48
-
-
8644289235
-
Investigation of pediatric renal transplant recipients with heavy proteinuria after sirolimus rescue
-
DOI 10.1097/01.TP.0000140868.88149.63
-
Butani L. Investigation of pediatric renal transplant recipients with heavy proteinuria after sirolimus rescue. Transplantation 2004;78:1362-6 (Pubitemid 39507977)
-
(2004)
Transplantation
, vol.78
, Issue.9
, pp. 1362-1366
-
-
Butani, L.1
-
49
-
-
33644928466
-
Sirolimus-associated heavy proteinuria in a renal transplant recipient: Evidence for a tubular mechanism
-
DOI 10.1111/j.1600-6143.2005.01195.x
-
Straathof-Galema L, Wetzels JF, Dijkman HB, et al. Sirolimus-associated heavy proteinuria in a renal transplant recipient: evidence for a tubular mechanism. Am J Transplant 2006;6:429-33 (Pubitemid 43382183)
-
(2006)
American Journal of Transplantation
, vol.6
, Issue.2
, pp. 429-433
-
-
Straathof-Galema, L.1
Wetzels, J.F.M.2
Dijkman, H.B.P.M.3
Steenbergen, E.J.4
Hilbrands, L.B.5
-
50
-
-
34250815070
-
Sirolimus toxicity and vascular endothelial growth factor release from islet and renal cell lines
-
DOI 10.1097/01.tp.0000266555.06635.bf, PII 0000789020070627000018
-
Laugharne M, Cross S, Richards S, et al. Sirolimus toxicity and vascular endothelial growth factor release from islet and renal cell lines. Transplantation 2007;83:1635-8 (Pubitemid 46987917)
-
(2007)
Transplantation
, vol.83
, Issue.12
, pp. 1635-1638
-
-
Laugharne, M.1
Cross, S.2
Richards, S.3
Dawson, C.4
Ilchyshyn, L.5
Saleem, M.6
Mathieson, P.7
Smith, R.8
-
51
-
-
80051699035
-
Early prediction of new-onset diabetes mellitus by fifth-day fasting plasma glucose, pulse pressure, and proteinuria
-
Rodrigo E, Santos L, Pinera C, et al. Early prediction of new-onset diabetes mellitus by fifth-day fasting plasma glucose, pulse pressure, and proteinuria. Transplant Proc 2011;43:2208-10
-
(2011)
Transplant Proc
, vol.43
, pp. 2208-2210
-
-
Rodrigo, E.1
Santos, L.2
Pinera, C.3
-
52
-
-
0034789534
-
Rapamycin impairs recovery from acute renal failure: Role of cell-cycle arrest and apoptosis of tubular cells
-
Lieberthal W, Fuhro R, Andry CC, et al. Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol 2001;281:F693-706
-
(2001)
Am J Physiol Renal Physiol
, vol.281
-
-
Lieberthal, W.1
Fuhro, R.2
Andry, C.C.3
-
54
-
-
65549140131
-
Posttransplant proteinuria associated with everolimus
-
Bertoni E, Bruschi M, Candiano G, et al. Posttransplant proteinuria associated with everolimus. Transplant Proc 2009;41:1216-17
-
(2009)
Transplant Proc
, vol.41
, pp. 1216-1217
-
-
Bertoni, E.1
Bruschi, M.2
Candiano, G.3
-
55
-
-
77953911869
-
Sirolimus and everolimus reduce albumin endocytosis in proximal tubule cells via an angiotensin II-dependent pathway
-
Oroszlan M, Bieri M, Ligeti N, et al. Sirolimus and everolimus reduce albumin endocytosis in proximal tubule cells via an angiotensin II-dependent pathway. Transpl Immunol 2010;23:125-32
-
(2010)
Transpl Immunol
, vol.23
, pp. 125-132
-
-
Oroszlan, M.1
Bieri, M.2
Ligeti, N.3
-
56
-
-
0032949981
-
Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy
-
Serkova N, Litt L, James TL, et al. Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy. J Pharmacol Exp Ther 1999;289:800-6 (Pubitemid 29191234)
-
(1999)
Journal of Pharmacology and Experimental Therapeutics
, vol.289
, Issue.2
, pp. 800-806
-
-
Serkova, N.1
Litt, L.2
James, T.L.3
Sadee, W.4
Leibfritz, D.5
Benet, L.Z.6
Christians, U.7
-
57
-
-
58849117190
-
Safety and efficacy of statin therapy in patients switched from cyclosporine a to sirolimus after cardiac transplantation
-
Aliabadi AZ, Mahr S, Dunkler D, et al. Safety and efficacy of statin therapy in patients switched from cyclosporine a to sirolimus after cardiac transplantation. Transplantation 2008;86:1771-6
-
(2008)
Transplantation
, vol.86
, pp. 1771-1776
-
-
Aliabadi, A.Z.1
Mahr, S.2
Dunkler, D.3
-
58
-
-
65749105204
-
Absence of proteinuria predicts improvement in renal function after conversion to sirolimus-based immunosuppressive regimens in lung transplant survivors with chronic kidney disease
-
Stephany BR, Boumitri M, Budev M, et al. Absence of proteinuria predicts improvement in renal function after conversion to sirolimus-based immunosuppressive regimens in lung transplant survivors with chronic kidney disease. J Heart Lung Transplant 2009;28:564-71
-
(2009)
J Heart Lung Transplant
, vol.28
, pp. 564-571
-
-
Stephany, B.R.1
Boumitri, M.2
Budev, M.3
-
59
-
-
34548182861
-
Replacement of calcineurin-inhibitors with sirolimus as primary immunosuppression in stable cardiac transplant recipients
-
DOI 10.1097/01.tp.0000276959.56959.69, PII 0000789020070827000005
-
Raichlin E, Khalpey Z, Kremers W, et al. Replacement of calcineurin-inhibitors with sirolimus as primary immunosuppression in stable cardiac transplant recipients. Transplantation 2007;84:467-74 (Pubitemid 47312156)
-
(2007)
Transplantation
, vol.84
, Issue.4
, pp. 467-474
-
-
Raichlin, E.1
Khalpey, Z.2
Kremers, W.3
Frantz, R.P.4
Rodeheffer, R.J.5
Clavell, A.L.6
Edwards, B.S.7
Kushwaha, S.S.8
-
60
-
-
80052777477
-
A retrospective 12-month study of conversion to everolimus in lung transplant recipients
-
Roman A, Ussetti P, Zurbano F, et al. A retrospective 12-month study of conversion to everolimus in lung transplant recipients. Transplant Proc 2011;43:2693-8
-
(2011)
Transplant Proc
, vol.43
, pp. 2693-2698
-
-
Roman, A.1
Ussetti, P.2
Zurbano, F.3
-
61
-
-
79959830895
-
Surgical wound complications after heart transplantation
-
Zuckermann A, Barten MJ. Surgical wound complications after heart transplantation. Transpl Int 2011;24:627-36
-
(2011)
Transpl Int
, vol.24
, pp. 627-636
-
-
Zuckermann, A.1
Barten, M.J.2
-
62
-
-
80052397126
-
Impact of de novo everolimus-based immunosuppression on incisional complications in heart transplantation
-
Zuckermann A, Arizon JM, Dong G, et al. Impact of de novo everolimus-based immunosuppression on incisional complications in heart transplantation. Transplantation 2011;92:594-600
-
(2011)
Transplantation
, vol.92
, pp. 594-600
-
-
Zuckermann, A.1
Arizon, J.M.2
Dong, G.3
-
63
-
-
78649321650
-
Molecular pathology of wound healing
-
Kondo T, Ishida Y. Molecular pathology of wound healing. Forensic Sci Int 2010;203:93-8
-
(2010)
Forensic Sci Int
, vol.203
, pp. 93-98
-
-
Kondo, T.1
Ishida, Y.2
-
64
-
-
0028898108
-
Effects of rapamycin on growth factor-stimulated vascular smooth muscle cell DNA synthesis. Inhibition of basic fibroblast growth factor and platelet-derived growth factor action and antagonism of rapamycin by FK506
-
Cao W, Mohacsi P, Shorthouse R, et al. Effects of rapamycin on growth factor-stimulated vascular smooth muscle cell DNA synthesis. Inhibition of basic fibroblast growth factor and platelet-derived growth factor action and antagonism of rapamycin by FK506. Transplantation 1995;59:390-5
-
(1995)
Transplantation
, vol.59
, pp. 390-395
-
-
Cao, W.1
Mohacsi, P.2
Shorthouse, R.3
-
65
-
-
34248541017
-
Effect of rapamycin on wound healing: An experimental study
-
DOI 10.1016/j.transproceed.2007.04.013, PII S004113450700509X
-
Ekici Y, Emiroglu R, Ozdemir H, et al. Effect of rapamycin on wound healing: an experimental study. Transplant Proc 2007;39:1201-3 (Pubitemid 46764935)
-
(2007)
Transplantation Proceedings
, vol.39
, Issue.4
, pp. 1201-1203
-
-
Ekici, Y.1
Emiroglu, R.2
Ozdemir, H.3
Aldemir, D.4
Karakayali, H.5
Haberal, M.6
-
66
-
-
17844392656
-
The effect of rapamycin on the healing of the ureteric anastomosis and wound healing
-
DOI 10.1016/j.transproceed.2004.12.156
-
Kahn D, Spearman CW, Mall A, et al. The effect of rapamycin on the healing of the ureteric anastomosis and wound healing. Transplant Proc 2005;37:830-1 (Pubitemid 40590715)
-
(2005)
Transplantation Proceedings
, vol.37
, Issue.2
, pp. 830-831
-
-
Kahn, D.1
Spearman, C.W.2
Mall, A.3
Shepherd, E.4
Engelbrecht, G.5
Lotz, Z.6
Tyler, M.7
-
67
-
-
33845701788
-
Everolimus interferes with healing of experimental intestinal anastomoses
-
DOI 10.1097/01.tp.0000246078.09845.9c, PII 0000789020061215000018
-
van der Vliet JA, Willems MC, de Man BM, et al. Everolimus interveres with healing of experimental intestinal anastamoses. Transplantation 2006;82:1477-83 (Pubitemid 44967631)
-
(2006)
Transplantation
, vol.82
, Issue.11
, pp. 1477-1483
-
-
Van Der Vliet, J.A.1
Willems, M.C.M.2
De Man, B.M.3
Lomme, R.M.L.M.4
Hendriks, T.5
-
68
-
-
18844456534
-
Surgical-site infection after cardiac surgery: Incidence, microbiology, and risk factors
-
DOI 10.1086/502569
-
Lepelletier D, Perron S, Bizouarn P, et al. Surgical-site infection after cardiac surgery: incidence, microbiology, and risk factors. Infect Control Hosp Epidemiol 2005;26:466-72 (Pubitemid 40695280)
-
(2005)
Infection Control and Hospital Epidemiology
, vol.26
, Issue.5
, pp. 466-472
-
-
Lepelletier, D.1
Perron, S.2
Bizouarn, P.3
Caillon, J.4
Drugeon, H.5
Michaud, J.-L.6
Duveau, D.7
-
69
-
-
0034854991
-
Sternal wound infection after heart transplantation: Incidence and results with aggressive surgical treatment
-
DOI 10.1016/S0003-4975(01)02824-7, PII S0003497501028247
-
Carrier M, Perrault LP, Pellerin M, et al. Sternal wound infection after heart transplantation: incidence and results with aggressive surgical treatment. Ann Thorac Surg 2001;72:719-23 (Pubitemid 32846215)
-
(2001)
Annals of Thoracic Surgery
, vol.72
, Issue.3
, pp. 719-723
-
-
Carrier, M.1
Perrault, L.P.2
Pellerin, M.3
Marchand, R.4
Auger, P.5
Pelletier, G.B.6
White, M.7
Racine, N.8
Bouchard, D.9
-
70
-
-
33745288559
-
Wound healing complications with de novo sirolimus versus mycophenolate mofetil-based regimen in cardiac transplant recipients
-
DOI 10.1111/j.1600-6143.2006.01282.x
-
Kuppahally S, Al-Khaldi A, Weisshaar D, et al. Wound healing complications with de novo sirolimus versus mycophenolate mofetil-based regimen in cardiac transplant recipients. Am J Transplant 2006;6:986-92 (Pubitemid 44356648)
-
(2006)
American Journal of Transplantation
, vol.6
, Issue.5
, pp. 986-992
-
-
Kuppahally, S.1
Al-Khaldi, A.2
Weisshaar, D.3
Valantine, H.A.4
Oyer, P.5
Robbins, R.C.6
Hunt, S.A.7
-
71
-
-
0030816311
-
Early and late airway complications after lung transplantation: Incidence and management
-
DOI 10.1016/S0003-4975(97)83852-0, PII S0003497597003275
-
Kshettry VR, Kroshus TJ, Hertz MI, et al. Early and late airway complications after lung transplantation: incidence and management. Ann Thorac Surg 1997;63:1576-83 (Pubitemid 27321517)
-
(1997)
Annals of Thoracic Surgery
, vol.63
, Issue.6
, pp. 1576-1583
-
-
Kshettry, V.R.1
Kroshus, T.J.2
Hertz, M.I.3
Hunter, D.W.4
Shumway, S.J.5
Bolman III, R.M.6
-
72
-
-
2342456301
-
Airway anastomosis complications in de novo lung transplantation with sirolimus-based immunosuppression
-
DOI 10.1016/S1053-2498(03)00309-7, PII S1053249803003097
-
Groetzner J, Kur F, Spelsberg F, et al. Airway anastomosis complications in de novo lung transplantation with sirolimus-based immunosuppression. J Heart Lung Transplant 2004;23:632-8 (Pubitemid 38595752)
-
(2004)
Journal of Heart and Lung Transplantation
, vol.23
, Issue.5
, pp. 632-638
-
-
Groetzner, J.1
Kur, F.2
Spelsberg, F.3
Behr, J.4
Frey, L.5
Bittmann, I.6
Vogeser, M.7
Ueberfuhr, P.8
Meiser, B.9
Hatz, R.10
Reichart, B.11
-
73
-
-
0038586466
-
Airway anastomotic dehiscence associated with use of sirolimus immediately after lung transplantation
-
DOI 10.1097/01.TP.0000064083.02120.2C
-
King-Biggs MB, Dunitz JM, Park SJ, et al. Airway anastomotic dehiscence associated with use of sirolimus immediately after lung transplantation. Transplantation 2003;75:1437-43 (Pubitemid 36597273)
-
(2003)
Transplantation
, vol.75
, Issue.9
, pp. 1437-1443
-
-
King-Biggs, M.B.1
Dunitz, J.M.2
Park, S.J.3
Savik, S.K.4
Hertz, M.I.5
-
74
-
-
0038349667
-
The influence of the rapamycin-derivate SDZ RAD on the healing of airway anastomoses
-
DOI 10.1016/S1010-7940(03)00182-9
-
Dutly AE, Gaspert A, Inci I, et al. The influence of the rapamycin-derivate SDZ RAD on the healing of airway anastomoses. Eur J Cardiothorac Surg 2003;24:154-8 (Pubitemid 36802356)
-
(2003)
European Journal of Cardio-thoracic Surgery
, vol.24
, Issue.1
, pp. 154-158
-
-
Dutly, A.E.1
Gaspert, A.2
Inci, I.3
Schneiter, D.4
Korom, S.5
Weder, W.6
-
75
-
-
74549154398
-
Persistent effects of everolimus on strength of experimental wounds in intestine and fascia
-
Willems MC, van der Vliet JA, de Man BM, et al. Persistent effects of everolimus on strength of experimental wounds in intestine and fascia. Wound Repair Regen 2010;18:98-104
-
(2010)
Wound Repair Regen
, vol.18
, pp. 98-104
-
-
Willems, M.C.1
Van Der Vliet, J.A.2
De Man, B.M.3
-
76
-
-
25144441807
-
Sirolimus-associated interstitial pneumonitis in solid organ transplant recipients
-
DOI 10.1111/j.1399-0012.2005.00356.x
-
Garrean S, Massad MG, Tshibaka M, et al. Sirolimus-associated interstitial pneumonitis in solid organ transplant recipients. Clin Transplant 2005;19:698-703 (Pubitemid 41341705)
-
(2005)
Clinical Transplantation
, vol.19
, Issue.5
, pp. 698-703
-
-
Garrean, S.1
Massad, M.G.2
Tshibaka, M.3
Hanhan, Z.4
Caines, A.E.5
Benedetti, E.6
-
78
-
-
0035884304
-
Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients
-
Morelon E, Stern M, Israel-Biet D, et al. Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients. Transplantation 2001;72:787-90 (Pubitemid 32879846)
-
(2001)
Transplantation
, vol.72
, Issue.5
, pp. 787-790
-
-
Morelon, E.1
Stern, M.2
Israel-Biet, D.3
Correas, J.-M.4
Danel, C.5
Mamzer-Bruneel, M.-F.6
Peraldi, M.-N.7
Kreis, H.8
-
79
-
-
84859509360
-
Cavitatory lung disease in thoracic transplant recipients receiving sirolimus
-
Banerjee SK, Santhanakrishnan K, Tsui S, et al. Cavitatory lung disease in thoracic transplant recipients receiving sirolimus. J Heart Lung Transplant 2012;31:548-51
-
(2012)
J Heart Lung Transplant
, vol.31
, pp. 548-551
-
-
Banerjee, S.K.1
Santhanakrishnan, K.2
Tsui, S.3
-
80
-
-
33646545659
-
Patterns of pulmonary complications associated with sirolimus
-
DOI 10.1159/000087945
-
Chhajed PN, Dickenmann M, Bubendorf L, et al. Pattern of pulmonary complications associated with sirolimus. Resipration 2006;73:367-74 (Pubitemid 43725797)
-
(2006)
Respiration
, vol.73
, Issue.3
, pp. 367-374
-
-
Chhajed, P.N.1
Dickenmann, M.2
Bubendorf, L.3
Mayr, M.4
Steiger, J.5
Tamm, M.6
-
81
-
-
33745127767
-
Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate
-
DOI 10.1378/chest.129.6.1718
-
Howard L, Gopalan D, Griffiths M, Mahadexa R. Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate. Chest 2006;129:1718-21 (Pubitemid 43895005)
-
(2006)
Chest
, vol.129
, Issue.6
, pp. 1718-1721
-
-
Howard, L.1
Gopalan, D.2
Griffiths, M.3
Mahadeva, R.4
-
82
-
-
31544443523
-
Reversible sirolimus-associated pneumonitis after heart transplantation
-
DOI 10.1016/j.healun.2005.08.022, PII S1053249805006388
-
Hamour IM, Mittal TK, Bell AD, Banner NR. Reversible sirolimus-associated pneumonitis after heart transplantation. J Heart Lung Transplant 2006;25:241-4 (Pubitemid 43156379)
-
(2006)
Journal of Heart and Lung Transplantation
, vol.25
, Issue.2
, pp. 241-244
-
-
Hamour, I.M.1
Mittal, T.K.2
Bell, A.D.3
Banner, N.R.4
-
83
-
-
0037312008
-
Interstitial pneumonitis associated with sirolimus: A dilemma for lung transplantation
-
DOI 10.1016/S1053-2498(02)00564-8, PII S1053249802005648
-
McWilliams TJ, Levvey BJ, Russell PA, et al. Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation. J Heart Lung Transplant 2003;22:210-13 (Pubitemid 36173681)
-
(2003)
Journal of Heart and Lung Transplantation
, vol.22
, Issue.2
, pp. 210-213
-
-
McWilliams, T.J.1
Levvey, B.J.2
Russell, P.A.3
Milne, D.G.4
Snell, G.I.5
-
84
-
-
48249099224
-
Sirolimus-associated pneumonitis in heart transplant recipients
-
Garcia-Luque A, Cordero E, Torello J, et al. Sirolimus-associated pneumonitis in heart transplant recipients. Ann Pharmacother 2008;42:1143
-
(2008)
Ann Pharmacother
, vol.42
, pp. 1143
-
-
Garcia-Luque, A.1
Cordero, E.2
Torello, J.3
-
85
-
-
58149159562
-
Everolimus-associated pneumonitis in 3 heart transplant recipients
-
Otton J, Hayward CS, Keogh AM, et al. Everolimus-associated pneumonitis in 3 heart transplant recipients. J Heart Lung Transplant 2009;28:104-6
-
(2009)
J Heart Lung Transplant
, vol.28
, pp. 104-106
-
-
Otton, J.1
Hayward, C.S.2
Keogh, A.M.3
-
87
-
-
84885683081
-
Risk factors for pericardial and pleural effusions in heart transplant recipients exposed to everolimus, azathioprine, or MMF
-
Zuckermann A, Arizon J, Eisen H, et al. Risk factors for pericardial and pleural effusions in heart transplant recipients exposed to everolimus, azathioprine, or MMF. J Heart Lung Transplant 2011;30:244s
-
(2011)
J Heart Lung Transplant
, vol.30
-
-
Zuckermann, A.1
Arizon, J.2
Eisen, H.3
-
88
-
-
79953242027
-
Paradoxical aspects of rapamycin immunobiology in transplantation
-
Ferrer IR, Araki K, Ford ML. Paradoxical aspects of rapamycin immunobiology in transplantation. Am J Transplant 2011;11:654-9
-
(2011)
Am J Transplant
, vol.11
, pp. 654-659
-
-
Ferrer, I.R.1
Araki, K.2
Ford, M.L.3
-
89
-
-
34249284512
-
MTOR at the crossroads of T cell proliferation and tolerance
-
DOI 10.1016/j.smim.2007.02.008, PII S1044532307000140, Molecular Mechanisms Supporting Peripheral T cell Tolerance: Potential Therapeutic Approaches to Autoimmunity and Allograft Rejection
-
Mondino A, Mueller DL. mTOR at the crossroads of T cell proliferation and tolerance. Semin Immunol 2007;19:162-72 (Pubitemid 46810293)
-
(2007)
Seminars in Immunology
, vol.19
, Issue.3
, pp. 162-172
-
-
Mondino, A.1
Mueller, D.L.2
|