Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate

Chest

Volumn 129, Issue 6, 2006, Pages 1718-1721

  Howard, Luke ^a,c   Gopalan, Deepa ^b   Griffiths, Meryl ^b   Mahadeva, Ravi ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Hypersensitivity; Liver; Rapamycin; Sirolimus; Transplantation

Indexed keywords

AZATHIOPRINE; MEROPENEM; PREDNISOLONE; RAPAMYCIN; TACROLIMUS;

AGED; ARTICLE; CASE REPORT; CD4+ T LYMPHOCYTE; COUGHING; DIFFERENTIAL DIAGNOSIS; DRUG INDUCED DISEASE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DYSPNEA; FEMALE; HELPER CELL; HEPATITIS C; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; INTERSTITIAL PNEUMONIA; LIVER CIRRHOSIS; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LUNG INFILTRATE; LUNG LAVAGE; MALAISE; OPPORTUNISTIC INFECTION; ORGANIZING PNEUMONIA; POLYMERASE CHAIN REACTION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; THORAX RADIOGRAPHY; TRANSBRONCHIAL BIOPSY;

EID: 33745127767     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.129.6.1718     Document Type: Article

References (6)

1. Henry MT, Newstead CG. Sirolimus: another cause of drug-induced interstitial pneumonitis. Transplantation 2001; 72:773-774
2. Pham PT, Pham PC, Danovitch GM, et al. Sirolimus-associated pulmonary toxicity. Transplantation 2004; 77:1215-1220
3. Avitzur Y, Jimenez-Rivera C, Fecteau A, et al. Interstitial granulomatous pneumonitis associated with sirolimus in a child after liver transplantation. J Pediatr Gastroenterol Nutr 2003; 37:91-94
4. Morelon E, Stern M, Israel-Biet D, et al. Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients. Transplantation 2001; 72:787-790
5. Mahalati K, Murphy DM, West ML. Bronchiolitis obliterans and organizing pneumonia in renal transplant patients [letter]. Transplantation 2000; 69:1531
6. McWilliams TJ, Levvey BJ, Russell PA, et al. Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation. J Heart Lung Transplant 2003; 22:210-213