REGENT: A risk assessment and classification algorithm for genetic and environmental factors

European Journal of Human Genetics

Volumn 21, Issue 1, 2013, Pages 109-111

  Crouch, Daniel J M ^a   Goddard, Graham H M ^a   Lewis, Cathryn M ^a,b  

^a GUY S HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

environment; genetic association; risk estimation; SNPs; variability

Indexed keywords

ARTICLE; CLASSIFICATION ALGORITHM; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; HEREDITY; HUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; RISK ESTIMATION FOR GENETIC AND ENVIRONMENTAL TRAIT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ALGORITHMS; CARRIER PROTEINS; CONFIDENCE INTERVALS; CROHN DISEASE; ENVIRONMENT; GENE-ENVIRONMENT INTERACTION; HUMANS; NOD2 SIGNALING ADAPTOR PROTEIN; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN; RISK ASSESSMENT; SOFTWARE;

EID: 84871239707     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2012.107     Document Type: Article

References (7)

1. Manolio TA, Collins FS, Cox NJ et al: Finding the missing heritability of complex diseases. Nature 2009; 461: 747-753.
2. Goddard GH, Lewis CM: Risk categorization for complex disorders according to genotype relative risk and precision in parameter estimates. Genet Epidemiol 2010; 34: 624-632.
3. Frayling TM, Timpson NJ, Weedon MN et al: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894.
4. Franke A, McGovern DP, Barrett JC et al: Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010; 42: 1118-1125.
5. Calkins BM: A meta-analysis of the role of smoking in inflammatory bowel disease. Dig Dis Sci 1989; 34: 1841-1854.
6. Lewis CM, Whitwell SC, Forbes A, Sanderson J, Mathew CG, Marteau TM: Estimating risks of common complex diseases across genetic and environmental factors: the example of Crohn disease. J Med Genet 2007; 44: 689-694.
7. Stringer S, Wray NR, Kahn RS, Derks EM: Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes. PLoS One 2011; 6: e27964.