Unique genes identified in the epidemic extremely drug-resistant KPC-producing Klebsiella pneumoniae sequence type 258

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 1, 2013, Pages 74-83

  Chmelnitsky, I ^a   Shklyar, M ^a   Hermesh, O ^a,b   Navon Venezia, S ^a   Edgar, R ^a   Carmeli, Y ^a  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Epidemic clone ST258; K. pneumoniae; Subtractive library

Indexed keywords

CARBAPENEMASE; KLEBSIELLA PNEUMONIAE CARBAPENEMASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENETICS; BACTERIAL MEMBRANE; BACTERIOPHAGE; CELL MOTILITY; CONTROLLED STUDY; DNA MODIFICATION; DNA REPLICATION; DNA TRANSFER; GENE SEQUENCE; GENETIC SCREENING; HUMAN; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; NONHUMAN; PHYLOGENY; POLYMERASE CHAIN REACTION; PROTEIN DOMAIN; PROTEIN FUNCTION; SOUTHERN BLOTTING; SUPPRESSION SUBTRACTIVE HYBRIDIZATION;

BACTERIAL PROTEINS; BETA-LACTAMASES; CLONING, MOLECULAR; DRUG RESISTANCE, MULTIPLE, BACTERIAL; EPIDEMICS; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; PROSPECTIVE STUDIES;

EID: 84871238447     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks370     Document Type: Article

References (33)

1. Schwaber MJ, Carmeli Y. Carbapenem-resistant Enterobacteriaceae: a potential threat. JAMA 2008; 300: 2911-3.
2. Hidron AI, Edwards JR, Patel J et al. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008; 29: 996-1011.
3. ECDC. Antimicrobial Resistance Surveillance in Europe 2010. Annual Report of the European Antimicrobial Resistance Surveillance Network. http://www.ecdc.europa.eu/en/publications/Publications/1111_SUR_AMR_data.pdf (5 September 2012, date last accessed).
4. Woodford N, Turton JF, Livermore DM. Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance. FEMS Microbiol Rev 2011; 35: 736-55.
5. Kitchel B, Rasheed JK, Patel JB et al. Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258. Antimicrob Agents Chemother 2009; 53: 3365-70.
6. Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009; 9: 228-36.
7. Grundmann H, Livermore DM, Giske CG et al. Carbapenem-nonsusceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts. Euro surveillance 2010; 15: pii=19711.
8. Leavitt A, Carmeli Y, Chmelnitsky I et al. Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. Antimicrob Agents Chemother 2010; 54: 3002-6.
9. Schwaber MJ, Lev B, Israeli A et al. Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention. Clin Infect Dis 2011; 52: 848-55.
10. Leavitt A, Navon-Venezia S, Chmelnitsky I et al. Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. Antimicrob Agents Chemother 2007; 51: 3026-9.
11. Chmelnitsky I, Hermesh O, Navon-Venezia S et al. Detection of aac(6′)-Ib-cr in KPC-producing Klebsiella pneumoniae isolates from Tel Aviv, Israel. J Antimicrob Chemother 2009; 64: 718-22.
12. Liu S-L, Hessel A, Sanderson KE. Genomic mapping with I-Ceu I, an intron-encoded endonuclease specific for genes for ribosomal RNA, in Salmonella spp., Escherichia coli, and other bacteria. Proc Natl Acad Sci USA 1993; 90: 6874-8.
13. Marchler-Bauer A, Anderson JB, Chitsaz F et al. CDD: specific functional annotation with the Conserved Domain Database. Nucleic Acids Res 2009; 37: D205-10.
14. Nunez B, Avila P, de la Cruz F. Genes involved in conjugative DNA processing of plasmid R6K. Mol Microbiol 1997; 24: 1157-68.
15. Ishiwa A, Komano T. PilV adhesins of plasmid R64 thin pili specifically bind to the lipopolysaccharides of recipient cells. J Mol Biol 2004; 343: 615-25.
16. Moreira CG, Carneiro SM, Nataro JP et al. Role of type I fimbriae in the aggregative adhesion pattern of enteroaggregative Escherichia coli. FEMS Microbiol Lett 2003; 226: 79-85.
17. Chandler M, Mahillon J. Insertion sequences revisited. In: Craig NL, Craigie R, Gellert M. et al. eds. Mobile DNA II. Washington, DC: ASM Press, 2002; 305-66.
18. Goodman MF. Error-prone repair DNA polymerases in prokaryotes and eukaryotes. Annul Rev Biochem 2002; 71: 17-50.
19. Snider J, Houry WA. AAA+ proteins: diversity in function, similarity in structure. Biochem Soc Tran 2008; 36: 72-7.
20. Smith MC, Thorpe HM. Diversity in the serine recombinases. Mol Microbiol 2002; 44: 299-307.
21. Viard T, de la Tour CB. Type IA topoisomerases: a simple puzzle? Biochimie 2007; 89: 456-67.
22. Hansen S, Lewis K, Vulic M. Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli. Antimicrob Agents Chemother 2008; 52: 2718-26.
23. Taylor JE, Callow P, Swiderska A et al. Structural and functional analysis of the engineered type I DNA methyltransferase EcoR124I(NT). J Mol Biol 2010; 398: 391-9.
24. Riley MA, Pinou T, Wertz JE et al. Molecular characterization of the klebicin B plasmid of Klebsiella pneumoniae. Plasmid 2001; 45: 209-21.
25. Turlin E, Sismeiro O, Le Caer JP et al. 3-Phenylpropionate catabolism and the Escherichia coli oxidative stress response. Res Microbiol 2005; 156: 312-21.
26. Frey PA, Hegeman AD, Ruzicka FJ. The radical SAM superfamily. Crit Rev Biochem Mol Biol 2008; 43: 63-88.
27. Silver S. Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. FEMS Microbiol Rev 2003; 27: 341-53.
28. Ames GF. Bacterial periplasmic transport systems: structure, mechanism, and evolution. Ann Rev Biochem 1986; 55: 397-425.
29. Calderon MI, Vargas C, Rojo F et al. Complex regulation of the synthesis of the compatible solute ectoine in the halophilic bacterium Chromohalobacter salexigens DSM 3043T. Microbiology 2004; 150: 3051-63.
30. Abramson J, Smirnova I, Kasho V et al. Structure and mechanism of the lactose permease of Escherichia coli. Science 2003; 301: 610-5.
31. Richardson H, Puspurs A, Egan JB. Control of gene expression in the P2-related temperate coliphage 186. VI. Sequence analysis of the early lytic region. J Mol Biol 1989; 206: 251-5.
32. Garcia-Fernandez A, Villa L, Carta C et al. Klebsiella pneumoniae ST258 producing KPC-3 identified in Italy carries novel plasmids and OmpK36/OmpK35 porin variants. Antimicrob Agents Chemother 2012; 56: 2143-5.
33. Leavitt A, Chmelnitsky I, Ofek I et al. Plasmid pKpQIL encoding KPC-3 and TEM-1 confers carbapenem resistance in an extremely drug-resistant epidemic Klebsiella pneumoniae strain. J Antimicrob Chemother 2010; 65: 243-8.