Bone regeneration based on nano-hydroxyapatite and hydroxyapatite/chitosan nanocomposites: An in vitro and in vivo comparative study

Journal of Nanoparticle Research

Volumn 15, Issue 1, 2013, Pages

  Tavakol, S ^a   Nikpour, M R ^b   Amani, A ^a,e   Soltani, M ^c   Rabiee, S M ^b   Rezayat, S M ^a,d   Chen, P ^c   Jahanshahi, M ^b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b BABOL NOSHIRVANI UNIVERSITY OF TECHNOLOGY   (Iran)

^c UNIVERSITY OF WATERLOO   (Canada)

^d ISLAMIC AZAD UNIVERSITY   (Iran)

^e TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gene expression; Histomorphometry; Hydroxyapatite chitosan nanocomposites; Nano hydroxyapatite; Surface topography; Wettability

Indexed keywords

CHEMICAL BONDS; CHITOSAN; GENE EXPRESSION; HYDROXYAPATITE; NANOCOMPOSITES; PROTEINS; SIZE DISTRIBUTION; SURFACE MORPHOLOGY; SURFACE ROUGHNESS; SURFACE TOPOGRAPHY; TISSUE REGENERATION; TOPOGRAPHY; WETTING;

CELL DIFFERENTIATION; COMPARATIVE STUDIES; HISTOMORPHOMETRY; HYDROXYAPATITE/CHITOSAN NANOCOMPOSITES; IN-SITU HYBRIDIZATION; NANO-HYDROXYAPATITE; STRUCTURAL SIMILARITY; SURFACE WETTABILITY;

BONE;

CALCIUM; CHITOSAN; HYDROXYAPATITE; NANOCOMPOSITE; OSTEOCALCIN; OSTEONECTIN; TRANSCRIPTION FACTOR RUNX2;

ADSORPTION; ANIMAL TISSUE; ARTICLE; ATOMIC FORCE MICROSCOPY; BONE REGENERATION; CELL DIFFERENTIATION; COMPARATIVE STUDY; CONTACT ANGLE; DRUG ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; WETTABILITY;

EID: 84871219871     PISSN: 13880764     EISSN: 1572896X     Source Type: Journal    
DOI: 10.1007/s11051-012-1373-8     Document Type: Article

References (39)

1. Ahmed R, Faisal N, Paradowska A, Fitzpatrick M, Khor K (2011) Neutron diffraction residual strain measurements in nanostructured hydroxyapatite coatings for orthopaedic implants. J Mech Behav Biomed Mater 4(8):2043-2054
2. Ao Q, Fung C, Tsui A, Cai S, Zuo H, Chan Y, Shum D (2011) The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells. Biomaterials 32(3):787-796
3. Att W, Hori N, Iwasa F, Yamada M, Ueno T, Ogawa T (2009a) The effect of UV-photofunctionalization on the timerelated bioactivity of titanium and chromium-cobalt alloys. Biomaterials 30(26):4268-4276
4. Att W, Hori N, Takeuchi M, Ouyang J, Yang Y, Anpo M, Ogawa T (2009b) Time-dependent degradation of titanium osteoconductivity: an implication of biological aging of implant materials. Biomaterials 30(29):5352-5363
5. Bin L, Longnan H, Xinbo W, Jinhuan M, Fang X (2011) Biodegradation and compressive strength of phosphorylated chitosan/chitosan/hydroxyapatite bio-composites. Mater Des 32(8-9):4543-4547
6. Chen J, Nan K, Yin S, Wang Y, Wu T, Zhang Q (2010) Characterization and biocompatibility of nanohybrid scaffold prepared via in situ crystallization of hydroxyapatite in chitosan matrix. Colloids Surf B 81(2):640-647
7. Chen Y, Huang Z, Li X, Li S, Zhou Z, Zhang Y, Feng Q, Yu B (2012a) In vitro biocompatibility and osteoblast differentiation of an injectable chitosan/nano-hydroxyapatite/collagen scaffold. J Nanomater 1-6:Article ID 401084
8. Chen Y, Li S, Li X, Zhang Y, Huang Z, Feng Q, Zhou Z, Lin B, Yu B (2012b) Noninvasive evaluation of injectable chitosan/nano-hydroxyapatite/collagen scaffold via ultrasound. J Nanomater 1-7:Article ID 939821
9. Chesnutt BM, Yuan Y, Buddington K, Haggard WO, Bumgardner JD (2009) Composite chitosan/nano-hydroxyapatite scaffolds induce osteocalcin production by osteoblasts in vitro and support bone formation in vivo. Tissue Eng Part A 15(9):2571-2579
10. Clarke SA, Hoskins NL, Jordan GR, Henderson SA, Marsh DR (2007) In vitro testing of advanced JAX bone void filler system: species differences in the response of bone marrow stromal cells to β tri-calcium phosphate and carboxymethylcellulose gel. J Mater Sci Mater Med 18(12):2283-2290 (Pubitemid 350165595)
11. Dalby M, David M, Mary R, Hossein A, Duncan S, Stanley A, Richard O (2006) Osteoprogenitor response to semi-ordered and random nanotopographies. Biomaterials 27(15):2980-2987 (Pubitemid 43208923)
12. Fang L, Leng Y, Gao P (2005) Processing of hydroxyapatite reinforced ultrahigh molecular weight polyethylene for biomedical applications. Biomaterials 26(17):3471-3478 (Pubitemid 40038140)
13. Hassenkam T, Fantner G, Cutroni J, Weaver J, Morse D, Hansma P (2004) High-resolution AFM imaging of intact and fractured trabecular bone. Bone 35(1):4-10 (Pubitemid 38789142)
14. Huang Z, Yu B, Feng Q, Li S, Chen Y, Luo L (2011) In situ-forming chitosan/nano-hydroxyapatite/collagen gel for the delivery of bone marrow mesenchymal stem cells. Carbohydr Polym 85(1):261-267
15. Kim K, Dean D, Lu A, Mikos A, Fisher J (2011) Early osteogenic signal expression of rat bone marrow stromal cells is influenced by both hydroxyapatite nanoparticle content and initial cell seeding density in biodegradable nanocomposite scaffolds. Acta Biomater 7(3):1249-1264
16. Kong L, Gao Y, Cao W, Gong Y, Zhao N, Zhang X (2005) Preparation and characterization of nano-hydroxyapatite/chitosan composite scaffolds. J Biomed Mater Res Part A 75(2):275-282 (Pubitemid 41463895)
17. Kong L, Gao Y, Lu G, Gong Y, Zhang X (2006) A study on the bioactivity of chitosan/nano-hydroxyapatitecomposite scaffolds for bone tissue engineering. Eur Polym J 42:3171-3179 (Pubitemid 44708907)
18. Kumar M, Muzzarelli R, Muzzarelli C, Sashiwa H, Domb A (2004) Chitosan chemistry and pharmaceutical perspectives. Chem Rev 104(12):6017-6084 (Pubitemid 40025733)
19. Luo X, Zhang L, Morsi Y, Zou Q, Wang Y, Gao S, Li Y (2011) Hydroxyapatite/polyamide 66 porous scaffold with an ethylene vinyl acetate surface layer used for simultaneous substitute and repair of articular cartilage and underlying bone. Appl Surf Sci 257(23):9888-9894
20. Manjubala I, Scheler S, Bossert J, Jandt K (2006) Mineralisation of chitosan scaffolds with nano-apatite formation by double diffusion technique. Acta Biomater 2(1):75-78 (Pubitemid 43348747)
21. Mohamed K, M.El-Rashidy Z, Salamai A (2011) In-vitro properties of nano-hydroxyapatite/chitosan biocomposites. Ceram Int 37:3265-3271
22. Muzzarelli R (2011) Chitosan composites with inorganics, morphogenetic proteins and stem cells, for bone regeneration. Carbohydr Polym 83(4):1433-1445
23. Notodihardjo FZ, Kakudo N, Kushida S, Suzuki K, Kusumoto K (2012) Bone regeneration with BMP-2 and hydroxyapatite in critical-size calvarial defects in rats. J Craniomaxillofac Surg 40(3):287-291
24. Qiaoling H, Baoqiang L, Mang W, Jiacong S (2004) Preparation and characterization of biodegradable chitosan/hydroxyapatite nanocomposite rods via in situ hybridization: a potential material as internal fixation of bone fracture. Biomaterials 25(5):779-785 (Pubitemid 37376416)
25. Roy M, Bandyopadhyay A, Bose S (2011) Induction plasma sprayed nano hydroxyapatite coatings on titanium for orthopaedic and dental implants. Surf Coat Technol 205(8-9):2785-2792
26. Rusu V, Ng C, Wilke M, Tiersch B, Fratzl P, Peter M (2005) Size controlled hydroxyapatite nanoparticles as self-organized organic-inorganic composite materials. Biomaterials 26(26):5414-5426 (Pubitemid 40467572)
27. San Thian E, Huang J, Barber Z, Best S, Bonfield W (2011) Surface modification of magnetron-sputtered hydroxyapatite thin films via silicon substitution for orthopaedic and dental applications. Surf Coat Technol 205(11):3472-3477
28. Saravanan S, Nethala S, Pattnaik S, Tripathi A, Moorthi A, Selvamurugan N (2011) Preparation, characterization and antimicrobial activity of a bio-composite scaffold containing chitosan/nano-hydroxyapatite/nano-silver for bone tissue engineering. Int J Biol Macromol 49(2):188-193
29. Silva G, Czeisler C, Niece K, Beniash E, Harrington D, Kessler J et al (2004) Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science 303:1352-1355 (Pubitemid 38269424)
30. Tan F, Naciri M, Dowling D, Al-Rubeai M (2012) In-vitro and in-vivo bioactivity of CoBlast hydroxyapatite coating and the effect of impaction on its osteoconductivity. Biotechnol Adv 30(1):352-362
31. Tavakol S, Ragerdi Kashani I, Azami M, Khoshzaban A, Tavakol B, Kharrazi S, Ebrahimi S, Rezayat Sorkhabadi SM (2012) In vitro and in vivo investigations on bone regeneration potential of laminated hydroxyapatite/gelatin nanocomposite scaffold along with DBM. J Nanopart Res 14:1265
32. Teng S-H, Lee E-J, Yoon B-H, Shin D-S, Kim H-E, Oh J-S (2009) Chitosan/nanohydroxyapatite composite membranes via dynamic filtration for guided bone regeneration. J Biomed Mater Res A 88(3):569-580
33. Wei J, Igarashi T, Okumori N, Igarashi T, Maetani T, Liu B, Yoshinari M (2009) Influence of surface wettability on competitive protein adsorption and initial attachment of osteoblasts. Biomed Mater 4(4):045002
34. Xu H, Carl S (2005) Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility. Biomaterials 26(12):1337-1348 (Pubitemid 39336510)
35. Yim E, Pang S, Leong K (2007) Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. Exp Cell Res 313(9):1820-1829 (Pubitemid 46653872)
36. Zhang L, Ao Q, Wang A, Lu G, Kong L, Gong Y (2006) A sandwich tubular scaffold derived from chitosan for blood vessel tissue engineering. J Biomed Mater Res Part A 77(2):277-284 (Pubitemid 47233529)
37. Zhao F, Grayson W, Ma T, Bunnell B, Lu W (2006) Effects of hydroxyapatite in 3-D chitosan-gelatin polymer network on human mesenchymal stem cell constructs development. Biomaterials 27(9):1859-1867 (Pubitemid 41759480)
38. Zhao Y, Zhang Y, Ning F, Guo D, Xu Z (2007) Synthesis and cellular biocompatibility of two kinds of HAP with different nanocrystal morphology. J Biomed Mater Res Part B: Appl Biomater 83(1):121-126 (Pubitemid 47463204)
39. Zhou H, Lee J (2011) Nanoscale hydroxyapatite particles for bone tissue engineering. Acta Biomater 7(7):2769-2781