Radiation-induced neuropathy in cancer survivors

Radiotherapy and Oncology

Volumn 105, Issue 3, 2012, Pages 273-282

  Delanian, Sylvie ^a   Lefaix, Jean Louis ^b   Pradat, Pierre François ^c  

^a SAINT LOUIS HOSPITAL   (France)

^b GANIL   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Brachial plexopathy; Peripheral neuropathy; Radiation induced fibrosis

Indexed keywords

ANTICONVULSIVE AGENT; BENZODIAZEPINE; CARBAMAZEPINE; CLODRONIC ACID; CONNECTIVE TISSUE GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR; PENTOXIFYLLINE; QUININE; REACTIVE OXYGEN METABOLITE; TOCOPHEROL; TRANSFORMING GROWTH FACTOR BETA1; TRICYCLIC ANTIDEPRESSANT AGENT;

ACUTE TRANSIENT LUMBOSACRAL PLEXOPATHY; ANTERIOR ISCHEMIC OPTIC NEUROPATHY; AXONAL INJURY; BLOOD PRESSURE REGULATION; BLOOD VESSEL PERMEABILITY; BONE NECROSIS; BRACHIAL PLEXUS NEUROPATHY; BREAST CANCER; CANCER SURVIVOR; CELL DIFFERENTIATION; CHRONIC INFLAMMATION; COMORBIDITY; CRANIAL NERVE INJURY; DELAYED PROGRESSIVE LUMBOSACRAL RADICULOPLEXOPATHY; DEMYELINATION; DIABETES CONTROL; DIFFERENTIAL DIAGNOSIS; EARLY TRANSIENT RADIATION INDUCED BRACHIAL PLEXOPATHY; EXTRACELLULAR MATRIX; FACIAL NERVE PARALYSIS; FIBROGENESIS; FIBROSIS; HEAD AND NECK CANCER; HODGKIN DISEASE; HUMAN; HYPERBARIC OXYGEN; HYPOGLOSSAL NERVE PALSY; ISCHAEMIC RADIATION INDUCED BRACHIAL PLEXOPATHY; LUMBAR PUNCTURE; LYMPH NODE DISSECTION; MICROVASCULARIZATION; MUSCLE CRAMP; MYOKYMIA; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTIC NERVE INJURY; PAIN; PARESTHESIA; PATHOPHYSIOLOGY; PELVIS CANCER; PERIPHERAL NEUROPATHY; PHYSIOTHERAPY; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIATION DOSE FRACTIONATION; RADIATION INDUCED FIBROSIS; RADIATION INDUCED PERIPHERAL NEUROPATHY; RADIATION INJURY; REVIEW; RISK FACTOR; TRIGEMINUS NEURALGIA; TUMOR RECURRENCE;

ANTIOXIDANTS; BRACHIAL PLEXUS NEUROPATHIES; BREAST NEOPLASMS; DISEASE PROGRESSION; FEMALE; FRANCE; HODGKIN DISEASE; HUMANS; INCIDENCE; NEOPLASMS; PERIPHERAL NERVOUS SYSTEM DISEASES; QUALITY OF LIFE; RADIATION INJURIES; RADIOTHERAPY; SURVIVORS; TREATMENT OUTCOME;

EID: 84871213045     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2012.10.012     Document Type: Review

References (94)

1. S. Delanian, and J.-L. Lefaix The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway Radiother Oncol 73 2004 119 131 (Pubitemid 39470150)
2. P.F. Pradat, M. Poisson, and J.Y. Delattre Radiation-induced neuropathies. Experimental and clinical data Rev Neurol (Paris) 150 1994 664 677 (Pubitemid 24367776)
3. S. Delanian, and P.-F. Pradat A posteriori conformal radiotherapy using 3D dosimetric reconstitution in a survivor of adult-onset Hodgkin's disease for definitive diagnosis of a lower motor neuron disease J Clin Oncol 28 2010 e599 e601
4. F. Ducray, R. Guillevin, and D. Psimaras Post-radiation lumbosacral radiculopathy with spinal root cavernomas mimicking carcinomatous meningitis Neuro-oncol 10 2008 1035 1039
5. J.B. Cavanagh Effects of X-irradiation on the proliferation of cells in peripheral nerve during Wallerian degeneration in the rat Br J Radiol 41 1968 275 281
6. J. Denham, and M. Hauer-Jensen The radiotherapeutic injury - a complex wound Radiother Oncol 63 2002 129 145
7. S. Powell, J. Cooke, and C. Parsons Radiation-induced brachial plexus injury: follow-up of two different fractionation schedules Radiother Oncol 18 1990 213 220 (Pubitemid 20221782)
8. P. Westling, H. Svensson, and P. Hele Cervical plexus lesions following post-operative radiation therapy of mammary carcinoma Acta Radiol Ther Phys Biol 11 1972 209 216
9. J.T. Parsons, F. Bova, C. Fitzgerald, W. Mendenhall, and R. Million Radiation optic neuropathy after megavoltage external-beam irradiation: analysis of time-dose factors Int J Radiat Oncol Biol Phys 30 1994 755 763 (Pubitemid 24355922)
10. B.A. Stoll, and J.T. Andrews Radiation-induced peripheral neuropathy Br Med J 1 1966 834 837
11. J.G. Maier, R. Perry, W. Saylor, and M. Sulak Radiation myelitis of the dorsolumbar spinal cord Radiology 93 1969 153 160
12. S. Johansson, H. Svensson, and J. Denekamp Dose response and latency for radiation-induced fibrosis, edema, and neuropathy in breast cancer patients Int J Radiat Oncol Biol Phys 52 2002 1207 1219 (Pubitemid 34296481)
13. J.E. Thomas, T.L. Cascino, and J.D. Earle Differential diagnosis between radiation and tumor plexopathy of the pelvis Neurology 35 1985 1 7 (Pubitemid 15193612)
14. E.M. Ashenhurst, G. Quartey, and A. Starreveld Lumbo-sacral radiculopathy induced by radiation Can J Neurol Sci 4 1977 259 263 (Pubitemid 8233971)
15. G. Zadeh, C. Buckle, P. Shannon, E. Massicotte, S. Wong, and A. Guha Radiation induced peripheral nerve tumors: case series and review of the literature J Neurooncol 83 2007 205 212 (Pubitemid 46784995)
16. M. Salvatti, A. D'Elia, and G. Melone Radio-induced Gliomas: 20-year experience and critical review of the pathology J Neurooncol 89 2008 169 177
17. E.L. Gilette, P.A. Mahler, B.E. Powers, S.M. Gilette, and Z. Vujaskovic Late radiation injury to muscle and peripheral nerves (late effects consensus conference) Int J Radiat Oncol Biol Phys 31 1995 1309 1318
18. J.C. Flickinger Cranial nerves D.C. Shrieve, J.S. Loeffler, Human radiation injury 2011 Lippincott Williams Wilkins Philadelphia 210 216
19. P. Berger, and J.P. Bataïni Radiation-induced nerve palsy Cancer 48 1977 152 155
20. T. Takimoto, Y. Saito, M. Suzuki, and T. Nishimura Radiation induced cranial nerve palsy: hypoglossal nerve and vocal cord palsies J Laryngol Otol 105 1991 44 45
21. K. Westbrook, A. Ballantyne, M. Eckles, and G. Brown Breast cancer and vocal cord paralysis South Med J 67 1974 805 807
22. C. Lefevre-Houller, J.C. Willer, J.Y. Delattre, and N. Martin-Duverneuil Post-irradiation neuromyotonia of the messeter muscle Rev Neurol (Paris) 160 2004 1075 1077
23. R.B. Tishler, J.S. Loeffler, and L.D. Lunsford Tolerance of cranial nerves of the cavernous sinus to radiosurgery Int J Radiat Oncol Biol Phys 27 1993 215 221 (Pubitemid 23304445)
24. B.H. Malow, and D.M. Dawson Neuralgic amyotrophy in association with radiation therapy for Hodgkin disease Neurology 41 1991 440 441
25. A. Furby, A. Behin, and J.P. Lefaucheur Late-onset cervicoscapular muscle atrophy and weakness after radiotherapy for Hodgkin disease: a case series J Neurosurg 81 2010 101 104
26. D. Psimaras, T. Maisonobe, and S. Delanian Radiation-induced late onset camptocormia J Neurol 2011 10.1007/s00415-011-5997-x
27. E.K. Avila, A. Goenka, and S. Fontenla Bilateral phrenic nerve dysfunction: a late complication of mantle irradiation J Neurooncol 2010 [PMID 20838851]
28. A. Bajrovic, D. Rades, and F. Fehlauer Is there a life-long risk of brachial plexopathy after radiotherapy of supraclavicular lymph nodes in breast cancer patients? Radiother Oncol 71 2004 297 301 (Pubitemid 38686667)
29. N.K. Olsen, P. Pfeiffer, K. Mondrup, and C. Rose Radiation-induced brachial plexus neuropathy in breast cancer patients Acta Oncol 29 1990 885 890
30. N.K. Olsen, P. Pfeiffer, L. Johannsen, H. Schroder, and C. Rose Radiation-induced brachial plexopathy: neurological follow-up in 161 recurrence-free breast cancer patients Int J Radiat Oncol Biol Phys 26 1993 43 49 (Pubitemid 23137886)
31. S. Basso-Ricci, C. della Costa, G. Viganotti, V. Ventafridda, and R. Zanolla Report on 42 cases of postirradiation lesions of the brachial plexus and their treatment Tumori 66 1980 117 122 (Pubitemid 10111522)
32. G. Rawlings, R. Arriagada, F. Fontaine, H. Bouhnik, H. Mouriesse, and D. Sarrazin Radiation-induced brachial plexopathy: Institut Gustave Roussy experience Bull Cancer 70 1983 77 83 (Pubitemid 13061390)
33. J. Forquer, A. Fakiris, and R. Timmerman Brachial plexopathy from stereotaxic body radiotherapy in early-stage NSCLC: dose-limiting toxicity in apical tumor sites Radiother Oncol 93 2009 408 413
34. A.M. Chen, D. Lau, and M. Mathai Prospective clinical-dosimetric evaluation of normal tissue tolerance of the brachial plexus among patients treated by intensity modulated radiotherapy for head and neck cancer Int J Radiat Oncol Biol Phys 78 2010 S152 [abstr. 1028]
35. J.F. Pezzimenti, J.W. Bruckner, and R.C. De Couti Paralytic brachial neuritis in Hodgkin's disease Cancer 31 1973 626 629
36. S.H. Kori, K.M. Foley, and J.B. Posner Brachial plexus lesions in patients with cancer: 100 cases Neurology 31 1981 45 50 (Pubitemid 11217452)
37. H. Killer, and K. Hess Natural history of radiation-induced brachial plexopathy compared with surgically treated patients J Neurol 237 1990 247 250 (Pubitemid 20213310)
38. N.J. Wadd, and H.H. Lucraft Brachial plexus neuropathy following mantle radiotherapy Clin Oncol (R Coll Radiol) 10 1998 399 400 (Pubitemid 29015248)
39. J. Pritchard, P. Anand, and J. Broome Double-blind randomized phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy Radiother Oncol 58 2001 279 286 (Pubitemid 32181862)
40. E. Beglu, L. Kurland, D. Mulder, and A. Nicolosi Brachial plexus neuropathy in the population of Rochester, Minessota 1970-1981 Ann Neurol 18 1985 320 323 (Pubitemid 15023105)
41. G. Roth, M.R. Magistris, D. Le Fort, P. Desjacques, and D. Della Santa Post-radiation brachial plexopathy. Persistent conduction block. Myokymic discharges and cramps Rev Neurol (Paris) 144 1988 173 180 (Pubitemid 18098657)
42. P. Fardin, S. Lelli, P. Negrin, and S. Maluta Radiation-induced brachial plexopathy: clinical and electromyographical considerations in 13 cases Electromyogr Clin Neurophysiol 30 1990 277 282 (Pubitemid 20283558)
43. E. Fathers, and D. Trush Radiation-induced brachial plexopathy in women treated for carcinoma of the breast Clin Rehabil 16 2002 160 165 (Pubitemid 34187843)
44. K. Mondrup, N.K. Olsen, P. Pfeiffer, and C. Rose Clinical and electrodiagnostic findings in breast cancer patients with radiation-induced brachial plexus neuropathy Acta Neurol Scand 81 1990 153 158 (Pubitemid 20083660)
45. O. Soto Radiation-induced conduction block: resolution following anticoagulant therapy Muscle Nerve 31 2005 642 645 (Pubitemid 40577789)
46. R. Du, K. Auguste, and C. Chin Magnetic resonance neurography for the evaluation of peripheral nerve, brachial plexus and nerve roots disorders J Neurosurg 112 2010 362 371
47. K. Jaeckle Neurologic manifestations of neoplastic and radiation-induced plexopathies Semin Neurol 30 2010 254 262
48. A.L. Salner, L.E. Botnick, and A.G. Herzog Reversible brachial plexopathy following primary radiation therapy for breast cancer Cancer Treat Rep 65 1981 797 802 (Pubitemid 11050875)
49. S.M. Pierce, A. Recht, and T.I. Lingos Long-term radiation complications following conservative surgery (CS) and radiation therapy (RT) in patients with early stage breast cancer Int J Radiat Oncol Biol Phys 23 1992 915 923
50. M. Churn, V. Clough, and A. Slater Early onset of bilateral brachial plexopathy during mantle radiotherapy for Hodgkin's disease Clin Oncol 12 2000 289 291
51. F. Vega, L. Davila, and J.Y. Delattre Experimental carcinomatous plexopathy J Neurol 240 1993 54 58
52. J.M. Gerard, N. Franck, Z. Moussa, and J. Hildebrand Acute ischemic brachial plexus neuropathy following radiation therapy Neurology 39 1989 450 451 (Pubitemid 19094752)
53. A.V. Schiodt, and O. Kristensen Neurologic complications after irradiation of malignant tumors of the testis Acta Radiol Oncol Radiat Phys Biol 17 1978 369 378 (Pubitemid 9080747)
54. R. Grunewald, E. Chroni, C. Panayiotopoulos, and T. Enevoldson J Neurol Neurosurg Psychiatry 55 1992 741 742
55. O. Kristensen, B. Melgard, and A.V. Schiodt Radiation myelopathy of the lumbo-sacral spinal cord Acta Neurol Scand 56 1977 217 222 (Pubitemid 8185866)
56. M.M. Knap, S.M. Bentzen, and J. Overgaard Late neurological complications after irradiation of malignant tumors of the testis Acta Oncol 46 2007 497 503 (Pubitemid 46752247)
57. S.L. Horowitz, and J.D. Stewart Lower motor neuron syndrome following radiotherapy Can J Neurol Sci 10 1983 56 58 (Pubitemid 13160851)
58. H. Feistner, K. Weissenborn, T.F. Munte, H. Heinze, and J.P. Malin Post-irradiation lesions of the caudal roots Acta Neurol Scand 80 1989 277 281 (Pubitemid 19264755)
59. C. Lamy, J. Mas, B. Varet, M. Ziegler, and J. de Recondo Postradiation lower motor neuron syndrome presenting as monomelic amyotrophy J Neurol Neurosurg Psychiatry 54 1991 648 649
60. J. Bowen, R. Gregory, M. Squier, and M. Donaghy The post-irradiation lower motor neuron syndrome. Neuronopathy or radiculopathy? Brain 119 1996 1429 1439 (Pubitemid 26375715)
61. C.M. Tallaksen, V. Jetne, and S. Fosså Postradiation lower motorneuron syndrome - a case report and brief literature review Acta Oncol 36 1997 345 347
62. S. Mathis, P. Dumas, J.P. Neau, and R. Gil Pure motor neuropathy, an uncommon complication of radiotherapy: report of 3 cases and review of the literature Rev Med Interne 28 2007 377 387
63. M.M. Greenfield, and F.M. Stark Post-irradiation-induced neuropathy AJR Am J Roentgenol 60 1948 617 622
64. J.L. de Greve, M. Bruyland, J. de Keyser, G. Storme, and G. Ebinger Lower motor neuron disease in a patient with Hodgkin's disease treated with radiotherapy Clin Neurol Neurosurg 86 1984 43 46 (Pubitemid 14152995)
65. T. Lalu, B. Mercier, and N. Birouk Neuropathies motrices pures post-irradiation: 6 cas Rev Neurol 154 1998 40 44 (Pubitemid 28088437)
66. A.W. Hsia, J.S. Katz, S.L. Hancock, and K. Peterson Post-irradiation polyradiculopathy mimics leptomeningeal tumor on MRI Neurology 60 2003 1694 1696 (Pubitemid 36618107)
67. S. Delanian, J.L. Lefaix, T. Maisonobe, F. Salachas, and P.F. Pradat Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (PENTOCLO) J Neurol Sci 275 2008 164 166
68. K. Aho, and K. Sainio Late irradiation-induced lesions of the lumbosacral plexus Neurology 33 1983 953 955 (Pubitemid 13066704)
69. A. Georgiou, P. Grisby, and C. Perez Radiation induced lumbosacral plexopathy in gynecologic tumors: clinical findings and dosimetric analysis Int J Radiat Oncol Biol Phys 26 1993 479 482 (Pubitemid 23182343)
70. L.C. Pettigrew, J.P. Glass, M. Maor, and J. Zornoza Diagnosis and treatment of lumbosacral plexopathies in patients with cancer Arch Neurol 41 1984 1282 1285 (Pubitemid 15222600)
71. J.P. Glass, L. Pettigrew, and M. Maor Plexopathy induced by radiation therapy Neurology 35 1985 1261 [letter]
72. T. Saphner Neurologic complication of cervical cancer. A review of 2261 cases Cancer 64 1989 1147 1151 (Pubitemid 19208872)
73. J.A. Stryker, K. Sommerville, R. Perez, and D. Velky Sacral plexus injury after radiotherapy for carcinoma of cervix Cancer 66 1990 1488 1492 (Pubitemid 20355414)
74. G. Frykholm, K. Sintorn, A. Montelius, B. Jung, L. Pahlman, and B. Glimelius Acute lumbosacral plexopathy during and after preoperative radiotherapy of rectal adenocarcinoma Radiother Oncol 38 1996 121 130 (Pubitemid 26061033)
75. M. Dahele, P. Davey, and S. Reingold Radiation-induced lumbosacral plexopathy: an important enigma Clin Oncol 18 2006 427 428
76. R.S. Pieters, A. Niemierko, B.C. Fullerton, and J. Munzenrider Cauda equina tolerance to high-dose fractionated irradiation Int J Radiat Oncol Biol Phys 64 2006 251 257 (Pubitemid 41831234)
77. M. Brydoy, A. Storstein, and O. Dahl Transient neurological adverse effects following low dose radiation therapy for early stage testicular seminoma Radiother Oncol 82 2007 137 144 (Pubitemid 46275131)
78. P.D. Gikas, S. Hanna, and W. Aston Post-radiation sciatic neuropathy: a case report and review of the literature World J Surg Oncol 6 2008 130
79. P.F. Pradat, P. Bouche, and S. Delanian Sciatic nerve moneuropathy: an unusual late effect of radiotherapy Muscle Nerve 40 2009 872 874
80. M.J. Zelefsky, D. Nori, M. Shiu, and M. Brennan Limb salvage in soft tissue sarcomas involving neurovascular structures using combined surgical resection and brachytherapy Int J Radiat Oncol Biol Phys 19 1990 913 918 (Pubitemid 20345159)
81. T.J. Kinsella, W.F. Sindelar, and A.M. DeLuca Tolerance of peripheral nerve to intra-operative radiotherapy (IORT): clinical and experimental studies Int J Radiat Oncol Biol Phys 11 1985 1579 1585 (Pubitemid 15233619)
82. I. Azinovic, R. Martinez Monge, and J. Javier Aristu Intraoperative radiotherapy electron boost followed by moderate doses of external beam radiotherapy in resected soft-tissue sarcoma of the extremities Radiother Oncol 67 2003 331 337 (Pubitemid 36831088)
83. D. Mendes, R. Nawalkar, and S. Eldar Post irradiation femoral neuropathy J Bone Joint Surg 73A 1991 137 140
84. C. Laurent Femoral nerve compression syndrome with paresis of the quadriceps muscle a report of four cases Acta Orthop Scand 46 1975 804 808
85. S. Delanian, and J.-L. Lefaix Current management for late normal tissue injury: radiation-induced fibrosis and necrosis Semin Radiat Oncol 17 2007 99 107 (Pubitemid 46476864)
86. M. Evans, M. Graham, P. Mahler, and J. Rasey Use of steroids to suppress vascular response to radiation Int J Radiat Oncol Biol Phys 13 1987 563 567 (Pubitemid 17069652)
87. J.Y. Delattre, M. Rosenblum, H. Thaler, L. Mandell, W. Shapiro, and J. Posner A model of radiation myelopathy in the rat. Pathology, regional capillary changes and treatment with dexamethasone Brain 111 1988 1319 1336 (Pubitemid 19028456)
88. M. Bennett, J. Feldmeier, N. Hampson, R. Smee, and C. Milross Hyperbaric oxygen therapy for late radiation tissue injury Cochrane Database Syst Rev 20 2005 CD005005
89. U. Carl, J. Feldmeier, G. Schmitt, and K. Hartmann Hyperbaric oxygen therapy for late sequelae in women receiving radiation after breast-conserving surgery Int J Radiat Oncol Biol Phys 49 2001 1029 1031 (Pubitemid 32184609)
90. M. Glantz, P. Burger, A. Friedman, R. Radtke, E. Massey, and S. Schold Treatment of radiation-induced nervous system injury with heparin and warfarin Neurology 44 1994 2020 2027 (Pubitemid 24349499)
91. S. Delanian, R. Porcher, S. Balla-Mekias, and J.-L. Lefaix Randomized placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis J Clin Oncol 21 2003 2545 2550 (Pubitemid 46606336)
92. S. Hamama, M. Gilbert-Sirieix, M.-C. Vozenin, and S. Delanian Radiation-induced enteropathy: molecular basis of pentoxifylline-vitamin E antifibrotic effect involved TGF-β1 cascade inhibition Radiother Oncol 105 2012 305 312
93. R. Williamson, D. Kondziolka, H. Kanaan, L. Lunsford, and J. Flickinger Adverse radiation effects after radiosurgery may benefit from oral vitamin E and pentoxifylline therapy: a pilot study Stereotact Funct Neurosurg 86 2008 359 366
94. S. Delanian, C. Chatel, and R. Porcher Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial Int J Radiat Oncol Biol Phys 80 2011 832 839