The multimodal management of locally advanced N2 non-small cell lung cancer: Is there a role for surgical resection? A single institution's experience

Clinical and Translational Oncology

Volumn 14, Issue 11, 2012, Pages 835-841

  Bosch Barrera, Joaquim ^a   García Franco, Carlos ^a   Guillén Grima, Francisco ^a   Moreno Jiménez, Marta ^a   López Picazo, José María ^a   Gúrpide, Alfonso ^a   Pérez Gracia, José Luis ^a   Aristu, Javier ^a   Torre, Wenceslao ^a   García Foncillas, Jesús ^a   Gil Bazo, Ignacio ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Chemoradiation; Locally advanced lung cancer; Lung surgery; Multimodal treatment; N2; Non small cell lung cancer

Indexed keywords

CISPLATIN; PACLITAXEL;

ADULT; ARTICLE; ASTHENIA; CANCER CLASSIFICATION; CANCER GROWTH; CANCER PATIENT; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CHEMORADIOTHERAPY; COMPARATIVE EFFECTIVENESS; EMPYEMA; ESOPHAGITIS; FEMALE; FOLLOW UP; GASTROINTESTINAL DISEASE; HEMOPTYSIS; HUMAN; KAPLAN MEIER METHOD; LOBECTOMY; LUNG EMBOLISM; LUNG NON SMALL CELL CANCER; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; OUTCOME ASSESSMENT; PNEUMONIA; SKIN DISEASE; THORACOTOMY; TREATMENT DURATION;

CARCINOMA, NON-SMALL-CELL LUNG; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MALE; MIDDLE AGED;

EID: 84871185835     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-012-0874-3     Document Type: Article

References (24)

1. Ferlay J, Parkin DM, Steliarova-Foucher E (2010) Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer 46:765-781
2. Jemal A, Siegel R, Xu J et al (2010) Cancer Statistics, 2010. CA Cancer J Clin 60:277-300
3. Mountain CF (1997) Revisions in the international system for staging lung cancer. Chest 111:1710-1717
4. Shields TW (1990) The significance of ipsilateral mediastinal lymph node metastasis (N2 disease) in non-small cell carcinoma of the lung. A commentary. J Thorac Cardiovasc Surg 99:48-53
5. Rosell R, Gomez-Codina J, Camps C et al (1994) A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer. N Engl J Med 330:153-158
6. Stinchcombe TE, Lee CB, Moore DT et al (2008) Long-term follow-up of a phase I/II trial of dose escalating three-dimensional conformal thoracic radiation therapy with induction and concurrent carboplatin and paclitaxel in unresectable stage IIIA/B non-small cell lung cancer. J Thorac Oncol 3:1279-1285
7. Stinchcombe TE, Hodgson L, Herndon JE et al (2009) Treatment outcomes of different prognostic groups of patients on cancer and leukemia group B trial 39801: induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for unresectable stage III non-small cell lung cancer. J Thorac Oncol 4:1117-1125
8. Wang T, Nelson RA, Bogardus A et al (2010) Five-year lung cancer survival: which advanced stage nonsmall cell lung cancer patients attain long-term survival? Cancer 116:1518-1525
9. Albain KS, Swann RS, Rusch VW et al (2009) Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial. Lancet 374:379-386
10. van Meerbeeck JP, Kramer GW, Van Schil PE et al (2007) Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer. J Natl Cancer Inst 99:442-450
11. Eisenhauer EA, Therasse P, Bogaerts J et al (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45:228-247
12. Friedel G, Budach W, Dippon J et al (2010) Phase II trial of a trimodality regimen for stage III non-small-cell lung cancer using chemotherapy as induction treatment with concurrent hyperfractionated chemoradiation with carboplatin and paclitaxel followed by subsequent resection: a single-center study. J Clin Oncol 28:942-948
13. Ratto GB, Costa R, Maineri P et al (2009) Is there a subset of patients with preoperatively diagnosed N2 non-small cell lung cancer who might benefit from surgical resection? J Thorac Cardiovasc Surg 138:849-858
14. van Meerbeeck JP, Surmont VF (2009) Stage IIIA-N2 NSCLC: a review of its treatment approaches and future developments. Lung Cancer 65:257-267
15. Higgins K, Chino JP, Marks LB et al (2009) Preoperative chemotherapy versus preoperative chemoradiotherapy for stage III (N2) non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 75:1462-1467
16. Mansour Z, Kochetkova EA, Santelmo N et al (2008) Persistent N2 disease after induction therapy does not jeopardize early and medium term outcomes of pneumonectomy. Ann Thorac Surg 86:228-233
17. Mac Manus MP, Hicks RJ, Matthews JP et al (2003) Positron emission tomography is superior to computed tomography scanning for response-assessment after radical radiotherapy or chemoradiotherapy in patients with non-small-cell lung cancer. J Clin Oncol 21:1285-1292
18. Decaluwe H, De Leyn P, Vansteenkiste J et al (2009) Surgical multimodality treatment for baseline resectable stage IIIA-N2 non-small cell lung cancer. Degree of mediastinal lymph node involvement and impact on survival. Eur J Cardiothorac Surg 36:433-439
19. Stefani A, Alifano M, Bobbio A et al (2010) Which patients should be operated on after induction chemotherapy for N2 non-small cell lung cancer? Analysis of a 7-year experience in 175 patients. J Thorac Cardiovasc Surg 140:356-363
20. Friedel G, Hruska D, Budach W et al (2000) Neoadjuvant chemoradiotherapy of stage III non-small-cell lung cancer. Lung Cancer 30:175-185
21. Thibout Y, Guibert B, Bossard N et al (2009) Is pneumonectomy after induction chemotherapy for non-small cell lung cancer a reasonable procedure? A multicenter retrospective study of 228 cases. J Thorac Oncol 4:1496-1503
22. Vandenbroucke E, De Ryck F, Surmont V et al (2009) What is the role for surgery in patients with stage III non-small cell lung cancer? Curr Opin Pulm Med 15:295-302
23. Berghmans T, Van Houtte P, Paesmans M et al (2009) A phase III randomised study comparing concomitant radiochemotherapy as induction versus consolidation treatment in patients with locally advanced unresectable non-small cell lung cancer. Lung Cancer 64:187-193
24. Pottgen C, Eberhardt WE, Gauler T et al (2010) Intensified high-dose chemo-radiotherapy with induction chemotherapy in patients with locally advanced non-small-cell lung cancer-safety and toxicity results within a prospective trial. Int J Radiat Oncol Biol Phys 76:809-815