Preoperative Chemotherapy Versus Preoperative Chemoradiotherapy for Stage III (N2) Non-Small-Cell Lung Cancer

International Journal of Radiation Oncology Biology Physics

Volumn 75, Issue 5, 2009, Pages 1462-1467

  Higgins, Kristin ^a   Chino, Junzo P ^a   Marks, Lawrence B ^c   Ready, Neal ^b   D'Amico, Thomas A ^b   Clough, Robert W ^a   Kelsey, Chris R ^a  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

chemotherapy; induction therapy; Lung cancer; preoperative therapy; radiotherapy; surgery

Indexed keywords

CHEMORADIOTHERAPY; CHI-SQUARE TESTS; COX REGRESSION ANALYSIS; DISEASE FREE SURVIVAL; DUKE UNIVERSITY; INDUCTION THERAPY; KAPLAN-MEIER METHOD; LOCAL CONTROL; LUNG CANCER; LYMPH NODE; MULTI VARIATE ANALYSIS; NON SMALL CELL LUNG CANCER; OVERALL SURVIVAL; PATHOLOGIC COMPLETE RESPONSE (PCR); PREOPERATIVE THERAPY; RANK TEST; STATISTICALLY SIGNIFICANT DIFFERENCE;

BIOLOGICAL ORGANS; CHEMOTHERAPY; DECISION MAKING; FLUORINE CONTAINING POLYMERS; MULTIVARIANT ANALYSIS; RADIOTHERAPY; REGRESSION ANALYSIS; SURGERY;

DISEASE CONTROL;

CARBOPLATIN; NAVELBINE; PLATINUM DERIVATIVE;

ACUTE RESPIRATORY TRACT DISEASE; ADJUVANT THERAPY; ADULT; AGED; ARTICLE; BLOOD TOXICITY; BRONCHOPLEURAL FISTULA; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CANCER SURVIVOR; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DISEASE SEVERITY; DRUG FATALITY; FEMALE; FOLLOW UP; GASTROINTESTINAL TOXICITY; HUMAN; INTERMETHOD COMPARISON; LUNG NON SMALL CELL CANCER; LUNG RESECTION; LUNG TOXICITY; MAJOR CLINICAL STUDY; MALE; MEDIASTINUM LYMPH NODE; MULTIMODALITY CANCER THERAPY; OVERALL SURVIVAL; POSTOPERATIVE HEMORRHAGE; PREOPERATIVE RADIOTHERAPY; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RADIATION DOSE; RETROSPECTIVE STUDY; SEPSIS; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; COMBINED MODALITY THERAPY; FEMALE; HUMANS; LUNG NEOPLASMS; LYMPH NODES; MALE; MEDIASTINUM; MIDDLE AGED; NEOPLASM STAGING; NORTH CAROLINA; PREOPERATIVE PERIOD; REGRESSION ANALYSIS; REMISSION INDUCTION; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 71649104106     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.01.069     Document Type: Article

References (30)

1. Martini N., and Flehinger B.J. The role of surgery in N2 lung cancer. Surg Clin North Am 67 (1987) 1037-1049
2. Gilligan D., Nicolson M., Smith I., et al. Preoperative chemotherapy in patients with resectable non-small cell lung cancer: Results of the MRC LU22/NVALT 2/EORTC 08012 multicentre randomized trial and update of systematic review. Lancet 369 (2007) 1929-1937
3. Eberhardt W., Wilke H., Stamatis G., et al. Preoperative chemotherapy followed by concurrent chemoradiation therapy based on hyperfractionated accelerated radiotherapy and definitive surgery in locally advanced non-small-cell lung cancer: Mature results of a phase II trial. J Clin Oncol 16 (1998) 622-634
4. Thomas M., Rube C., Semik M., et al. Impact of preoperative bimodality induction including twice-daily radiation on tumor regression and survival in stage III non-small cell lung cancer. J Clin Oncol 17 (1999) 1185-1193
5. Rosell R., Gomez-Codina J., Camps C., et al. A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer. N Engl J Med 330 (1994) 153-158
6. Albain K.S., Rusch V.W., Crowley J.J., et al. Concurrent cisplatin/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small cell lung cancer: Mature results of Southwest Oncology Group phase II study 8805. J Clin Oncol 13 (1995) 1880-1892
7. Roth J.A., Fossella F., Komaki R., et al. A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer. J Natl Cancer Inst 86 (1994) 673-680
8. Garrido P., Gonzalez-Larriba J.L., Insa A., et al. Long-term survival associated with complete resection after induction chemotherapy in stage IIIA (N2) and IIIB (T4N0-1) non-small-cell lung cancer patients: The Spanish Lung Cancer Group Trial 9901. J Clin Oncol 25 (2007) 4736-4742
9. DePierre A., Milleron B., and Moro-Sibilot D. Preoperative chemotherapy followed by surgery compared with primary surgery in resectable stage I (except T1N0), II, and IIIa non-small-cell lung cancer. J Clin Oncol 20 (2001) 247-253
10. Betticher D.C., Schmitz S.H., Totsch M., et al. Mediastinal lymph node clearance after docetaxel-cisplatin neoadjuvant chemotherapy is prognostic of survival in patients with stage IIIA pN2 non-small-cell lung cancer: A multicenter phase II trial. J Clin Oncol 21 (2003) 1752-1759
11. Choi N.C., Carey R.W., Daly W., et al. Potential impact on survival of improved tumor downstaging and resection rate by preoperative twice-daily radiation and concurrent chemotherapy in Stage IIIA non-small-cell lung cancer. J Clin Oncol 15 (1997) 712-722
12. Pass H.I., Pogrebniak H.W., Steinberg S.M., et al. Randomized trial of neoadjuvant therapy for lung cancer: Interim analysis. Ann Thorac Surg 53 (1992) 992-998
13. Kaplan E.L., and Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 53 (1958) 457-481
14. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50 (1966) 163-170
15. Albain K.S. Phase III study of concurrent chemotherapy and radiotherapy (CT/RT) vs CT/RT followed by surgical resection for stage III A (pN2) non-small cell lung cancer (NSCLC): Outcomes update of North American Intergroup 0139 (RTOG 9309). [ASTRO Abstract]. J Clin Oncol 23 Suppl (2005) 7014
16. van Meerbeeck J.P., Gijs W.P.M., Kramer P.E.Y., et al. Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer. J Natl Cancer Inst 99 (2007) 442-450
17. Katakami N., Okazaki, Nishiuhi S., et al. Induction chemoradiotherapy for advanced stage III non-small cell lung cancer: Long-term follow-up in 42 patients. Lung Cancer 22 (1998) 127-137
18. Van Zandwijk N.V. Gemcitabine and cisplatin as induction regimen for patients with biopsy-proven stage IIIA N2 non-small-cell lung cancer: A phase II study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group (EORTC 08955). J Clin Oncol 18 (2000) 2658-2664
19. Rosell R., Gomez-Codina J., Camps C., et al. Preresectional chemotherapy in stage IIIA non-small-cell lung cancer: A 7-year assessment of a randomized controlled trial. Lung Cancer 47 (1999) 7-14
20. Roth J.A., Atkinson E.N., Fossella F., et al. Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer. Lung Cancer 21 (1998) 1-6
21. Thomas M., Rube C., Hoffknecht P., et al. Effect of preoperative chemoradiation in addition to preoperative chemotherapy: A randomised trial in stage III non-small cell lung cancer. Lancet Oncol 9 (2008) 636-648
22. O'Brien M.E.R., Splinter T., Smit E.F., et al. Carboplatin and paclitaxol (Taxol) as an induction regimen for patients with biopsy-proven IIIA N2 non-small cell lung cancer: An EORTC phase II study (EORTC 08958). Eur J Cancer 39 (2003) 1416-1422
23. Betticher D.C., Schmitz S.H., Totsch M., et al. Prognostic factors affecting long-term outcomes in patients with resected stage IIIA pN2 non-small-cell lung cancer: 5 year follow-up of a phase II study. Br J Cancer 94 (2006) 1099-1106
24. Faber L., Kittle C.F., Warren W.H., et al. Preoperative chemotherapy and irradiation for stage III non-small cell lung cancer. Ann Thorac Surg 47 (1989) 669-675
25. Boer R.H., Smith I.E., Pastorino U., et al. Pre-operative chemotherapy in early stage resectable non-small-cell lung cancer: A randomized feasibility study justifying a multicentre phase III trial. Br J Cancer 79 (1999) 1514-1518
26. Nagai K., Tsuchiya R., Mori T., et al. A randomized trial comparing induction chemotherapy followed by surgery with surgery alone for patients with Stage IIIA N2 non-small cell lung cancer (JCOG 9209). J Thorac Cardiovasc Surg 125 (2003) 254-260
27. Fleck J., Camargo J., Godoy D., et al. Chemoradiation therapy (CRT) versus chemotherapy (CT) alone as a neo-adjuvant treatment for stage III non-small cell lung cancer (NSCLC): Preliminary report of a phase III prospective randomized trial. Proc ASCO 12 (1993) 333
28. Sauvaget J., Rebischung J., and Vannetzel J. Phase III study of neo-adjuvant MVP versus MVP plus chemoradiotherapy in stage III NSCLC. Proc ASCO 19 (2000) 495a
29. Marks L.B., and Prosnitz L.R. Postoperative radiotherapy for lung cancer: The breast cancer story all over again?. Int J Radiat Oncol Biol Phys 48 (2000) 625-627
30. Andre F., Grunenwald D., and Pignon J.P. Survival of patients with resected N2 non small-cell lung cancer: Evidence for a subclassification and implications. J Clin Oncol 18 (2000) 2981-2989