Persistent N2 Disease After Induction Therapy Does Not Jeopardize Early and Medium Term Outcomes of Pneumonectomy

Annals of Thoracic Surgery

Volumn 86, Issue 1, 2008, Pages 228-233

  Mansour, Ziad ^a   Kochetkova, Evgenia A ^a   Santelmo, Nicola ^a   Ducrocq, Xavier ^a   Quoix, Elisabeth ^a   Wihlm, Jean Marie ^a   Massard, Gilbert ^a  

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CISPLATIN; DOCETAXEL; GEMCITABINE; NAVELBINE;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ARTICLE; BRONCHOPLEURAL FISTULA; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE SEVERITY; EARLY INTERVENTION; EMPYEMA; FEMALE; HUMAN; LUNG NON SMALL CELL CANCER; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; SMOKING; SURGICAL MORTALITY; TREATMENT OUTCOME; ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; CANCER INVASION; CANCER STAGING; COHORT ANALYSIS; FOLLOW UP; KAPLAN MEIER METHOD; LUNG TUMOR; METHODOLOGY; MIDDLE AGED; MORTALITY; NONPARAMETRIC TEST; PATHOLOGY; PROBABILITY; REMISSION; RETROSPECTIVE STUDY; RISK ASSESSMENT; SURVIVAL; TIME; TUMOR RECURRENCE;

AGED; CARCINOMA, NON-SMALL-CELL LUNG; CHEMOTHERAPY, ADJUVANT; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIERS ESTIMATE; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PNEUMONECTOMY; PROBABILITY; RADIOTHERAPY, ADJUVANT; REMISSION INDUCTION; RETROSPECTIVE STUDIES; RISK ASSESSMENT; STATISTICS, NONPARAMETRIC; SURVIVAL ANALYSIS; TIME FACTORS; TREATMENT OUTCOME;

EID: 47049117419     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2008.01.019     Document Type: Article

References (36)

1. Yukinori S., Miyamoto H., Yamazaki A., et al. Prognostic significance of metastasis to the highest mediastinal lymph node in nonsmall cell lung cancer. Ann Thorac Surg 81 (2006) 292-297
2. Martin L., Correa A., Hofstetter W., et al. The evolution of treatment outcomes for resected stage IIIA non-small lung cancer over 16 years at a single institution. J Thorac Cardiovasc Surg 130 (2005) 1601-1610
3. Inoue M., Sawabata N., Takeda S., Ohta M., Ohno Y., and Maeda H. Results of surgical intervention for p-stage IIIA (N2) non-small cell lung cancer: acceptable prognosis predicted by complete resection in patients with single N2 disease with primary tumor in the upper lobe. J Thorac Cardiovasc Surg 127 (2004) 1100-1106
4. Ichinose Y., Kato H., Koike T., et al. Completely resected stage IIIA non-small cell lung cancer: the significance of primary tumor location and N2 station. J Thorac Cardiovasc Surg 122 (2001) 803-808
5. Ichinose Y., Kato H., Koike T., et al. Overall survival and local recurrence of 406 completely resected stage IIIa-N2 non-small cell lung cancer patients: questionnaire survey of the Japan Clinical Oncology Group to plan for clinical trials. Lung Cancer 34 (2001) 29-36
6. Suzuki K., Nagai K., Yoshida J., Nishimura M., Takahashi K., and Nishiwaki Y. The prognosis of surgically resected N2 non-small cell lung cancer: the importance of clinical N status. J Thorac Cardiovasc Surg 118 (1999) 145-153
7. Asamura H., Nakayama H., Kondo H., Tsuchiya R., and Naruke T. Lobe-specific extent of systematic lymph node dissection for non-small cell lung carcinomas according to a retrospective study of metastasis and prognosis. J Thorac Cardiovasc Surg 117 (1999) 1102-1111
8. Vansteenkiste J., De Leyn P., Deneffe G., et al. Survival and prognostic factors in resected N2 non-small cell lung cancer: a study of 140 cases. Ann Thorac Surg 63 (1997) 1441-1450
9. Debevec M., Bitenc M., Vidmar S., et al. Postoperative radiotherapy for radically resected N2 non-small-cell lung cancer: randomized clinical study 1988-1992. Lung Cancer 14 (1996) 99-107
10. Goldstraw P., Mannam G., Kaplan D., and Michail P. Surgical management of non-small-cell lung cancer with ipsilateral mediastinal node metastasis (N2 disease). J Thorac Cardiovasc Surg 107 (1994) 19-28
11. Miller D., McManus K., Allen M., et al. Results of surgical resection in patients with N2 non-small cell lung cancer. Ann Thorac Surg 57 (1994) 1095-1101
12. Watanabe Y., Shimizu J., Oda M., et al. Aggressive surgical intervention in N2 non-small cell lung cancer of the lung. Ann Thorac Surg 51 (1991) 253-261
13. Régnard J., Magdeleinat P., Azoulay D., et al. Results of resection for bronchogenic carcinoma with mediastinal lymph node metastases in selected patients. Eur J Cardiothorac Surg 5 (1991) 583-587
14. Kawano R., Hata E., Ikeda S., and Sakaguchi H. Micrometastasis to lymph nodes in stage I left lung cancer patients. Ann Thorac Surg 73 (2002) 1558-1562
15. Nakanishi R., Osaki T., Nakanishi K., et al. Treatment strategy for patients with surgically discovered N2 stage IIIA non-small cell lung cancer. Ann Thorac Surg 64 (1997) 342-348
16. De Leyn P., Schoonooghe P., Deneffe G., et al. Surgery for non-small cell lung cancer with unsuspected metastasis to ipsilateral or subcarinal nodes (N2 disease). Eur J Cardiothorac Surg 10 (1996) 649-655
17. Van Klaveren R., Festen J., Otten H., Cox A., De Graaf R., and Lacquet L. Prognosis of unsuspected but completely respectable N2 non-small cell lung cancer. Ann Thorac Surg 56 (1993) 300-304
18. Ferguson M. Optimal management when unsuspected N2 nodal disease is identified during thoracotomy for lung cancer: cost-effectiveness analysis. J Thorac Cardiovasc Surg 126 (2003) 1935-1942
19. Riquet M., Assouad J., Bagan P., et al. Skip mediastinal lymph node metastasis and lung cancer: a particular N2 subgroup with a better prognosis. Ann Thorac Surg 79 (2005) 225-233
20. Prenzel K., Mönig S., Sinning J., et al. Role of skip metastasis to mediastinal lymph nodes in non-small cell lung cancer. J Surg Oncol 82 (2003) 256-260
21. Gunlunoglu Z., Solak O., Metin M., and Gurses A. The prognostic significance of skip mediastinal lymphatic metastasis in resected non-small cell lung cancer. Eur J Cardiothorac Surg 21 (2002) 595 (letter)
22. Yoshino I., Yokoyam H., Yano T., et al. Skip metastasis to the mediastinal lymph nodes in non-small cell lung cancer. Ann Thorac Surg 62 (1996) 1021-1025
23. Roth J., Atkinson E., Fossella F., et al. Long-term follow-up of patients enrolled on a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in respectable stage IIIA non-small-cell lung cancer. Lung Cancer 21 (1998) 1-6
24. Rosell R., Gómez-Codina J., Camps C., et al. A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer. N Engl J Med 330 (1994) 153-158
25. Pass H.I., Pogrebniak H.W., Steinberg S.M., Mulshine J., and Minna J. Randomized trial of neoadjuvant therapy for lung cancer: interim analysis. Ann Thorac Surg 53 (1992) 992-998
26. Depierre A., Milleran B., Maro-Sibilot D., et al. Preoperative chemotherapy followed by surgery compared with primary surgery in respectable stage I (except T1N0), II, and IIIa non-small-cell lung cancer. J Clin Oncol 20 (2001) 247-253
27. Bueno R., Richard W., Swanson S., et al. Nodal stage after induction therapy in stage IIIA lung cancer determines patient survival. Ann Thorac Surg 70 (2000) 1826-1831
28. Betticher D.C., Hsu Schmitz S.F., Tötsch M., et al. Mediastinal lymph node clearance after docetaxel-cisplatin neoadjuvant chemotherapy is prognostic of survival in patients with IIIA p N2 non-small-cell lung cancer: a multicenter phase II trial. J Clin Oncol 21 (2003) 1752-1759
29. Martin J., Ginsberg R., Abolhoda A., et al. Morbidity and mortality after neoadjuvant therapy for lung cancer: the risks of right pneumonectomy. Ann Thorac Surg 72 (2001) 1149-1154
30. Doddoli C., Barlesi F., Trousse D., et al. One hundred consecutive pneumonectomies after induction therapy for non-small lung cancer: an uncertain balance between risks and benefits. J Thorac Cardiovasc Surg 130 (2005) 416-425
31. Massard G., Ducrocq X., Kochetkova E.A., Riquet M., and Porhanov V. Sampling or node dissection for intraoperative staging of lung cancer: a multricentric cross-sectional study. Eur J Cardiothorac Surg 30 (2006) 164-167
32. Mansour Z., Kochetkova E.A., Ducrocq X., et al. Induction chemotherapy does not increase the operative risk of pneumonectomy!. Eur J Cardiothorac Surg 31 (2007) 181-185
33. Doddoli C., Aragon A., Barlesi F., et al. Does the extent of lymph node dissection influence outcome in patients with stage I non-small cell lung cancer?. Eur J Cardiothorac Surg 27 (2005) 680-685
34. Wu Y.L., Huan Z.F., Wang S.Y., Yang X.N., and Ou W. A randomized trial of systematic nodal dissection in respectable non-small cell lung cancer. Lung Cancer 36 (2002) 1-6
35. Keller S.M., Adak S., Wagner H., et al. Mediastinal lymph node dissection improves survival in patients with stages II and IIIa non-small cell lung cancer. Ann Thorac Surg 70 (2000) 358-366
36. Wright G., Manser R.L., Byrnes G., Hart D., and Campbell D.A. Surgery for non-small cell lung cancer: systematic review and metaanalysis of randomized controlled trials. Thorax 61 (2006) 597-603