Use of a green (bio) solvent - limonene - as extractant and immiscible diluent for large volume injection in the RPLC-tandem MS assay of statins and related metabolites in human plasma

Biomedical Chromatography

Volumn 27, Issue 1, 2013, Pages 48-57

  Medvedovici, Andrei ^a   Udrescu, Stefan ^b   David, Victor ^a  

^a UNIVERSITY OF BUCHAREST   (Romania)

^b LaborMed Pharma SA   (Romania)

Author keywords

Bioanalysis; Green solvents; Immiscible diluents; Large volume injection; Limonene; Statins

Indexed keywords

BIOMOLECULES; CARBOXYLIC ACIDS; DIRECT INJECTION; EXTRACTION; HYDROPHOBICITY; MASS SPECTROMETRY; MONOTERPENES; PHASE SEPARATION; PLASMA (HUMAN); SOLVENTS;

BIOANALYSIS; GREENER SOLVENTS; HYDROXY ACIDS; IMMISCIBLE DILUENT; LARGE VOLUME INJECTION; LIMONENE; LOVASTATIN; SIMVASTATIN; STATINS; TANDEM MS;

METABOLITES;

ACETONITRILE; DILUENT; DRUG METABOLITE; HYDROXYACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIMONENE; MEVINOLIN; SIMVASTATIN; SOLVENT;

ARTICLE; BIOEQUIVALENCE; CHEMICAL REACTION; COMPARATIVE STUDY; DRUG BLOOD LEVEL; DRUG ISOLATION; HUMAN; INJECTION; PROTEIN ANALYSIS; QUALITY CONTROL; REVERSED PHASE LIQUID CHROMATOGRAPHY; STANDARD; TANDEM MASS SPECTROMETRY; VOLUNTEER;

EID: 84871171696     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2747     Document Type: Article

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