Morphogenesis of the infectious HIV-1 virion

Frontiers in Microbiology

Volumn 2, Issue DEC, 2011, Pages

  Sakuragi, Jun Ichi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Gag; Hiv 1; Maturation; Morphology; Rna; Virion

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84871170170     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2011.00242     Document Type: Article

References (30)

1. Adamson, C. S., and Freed, E. O. (2011). Novel approaches to inhibiting HIV-1 replication. Antiviral Res. 85,119-141.
2. Adamson, C. S., Salzwedel, K., and Freed, E. O. (2009). Virus maturation as a new HIV-1 therapeutic target. Expert Opin. Ther. Targets 13, 895-908.
3. Briggs, J. A., and Krausslich, H. G. (2011). The molecular architecture of HIV. J. Mol. Biol. 410, 491-500.
4. Briggs, J. A., Simon, M. N., Gross, I., Krausslich, H. G., Fuller, S. D., Vogt, V M., and Johnson, M. C. (2004). The stoichiometry of Gag protein in HIV-1. Nat. Struct. Mol. Biol. 11, 672-675.
5. Bukrinskaya, A. G. (2004). HIV-1 assembly and maturation. Arch. Virol. 149, 1067-1082.
6. Carlson, L. A., de Marco, A., Oberwin-kler, H., Habermann, A., Briggs, J. A., Krausslich, H. G., and Grunewald, K. (2010). Cryo electron tomography of native HIV-1 budding sites. PLoS Pathog. 6, e1001173. doi:10.1371/journal.ppat.1001173
7. de Marco, A., Muller, B., Glass, B., Riches, J. D., Krausslich, H. G., and Briggs, J. A. (2010). Structural analysis of HIV-1 maturation using cryo-electron tomography. PLoS Pathog. 6, e1001215. doi:10.1371/journal.ppat.1001215
8. Frankel, A. D., and Young, J. A. (1998). HIV-1: fifteen proteins and an RNA. Annu. Rev. Biochem. 67, 1-25.
9. Ganser-Pornillos, B. K., Yeager, M., and Sundquist, W. I. (2008). The structural biology of HIV assembly. Curr. Opin. Struct. Biol. 18,203-217.
10. Hammarstedt, M., and Garoff, H. (2004). Passive and active inclusion of host proteins in human immunodeficiency virus type 1 gag particles during budding at the plasma membrane. J. Virol. 78, 5686-5697.
11. Kaplan, A. H., Manchester, M., and Swanstrom, R. (1994). The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency. J. Virol. 68, 6782-6786.
12. Keller, P. W., Adamson, C. S., Heymann, J. B., Freed, E. O., and Steven, A. C. (2011). HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice. J. Virol. 85, 1420-1428.
13. Lefebvre, E., and Schiffer, C. A. (2008). Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir. AIDS Rev. 10,131-142.
14. Li, F., Goila-Gaur, R., Salzwedel, K., Kil-gore, N. R., Reddick, M., Matallana, C., Castillo, A., Zoumplis, D., Martin, D. E., Orenstein, J. M., Allaway, G. P., Freed, E. O., and Wild, C. T. (2003). PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing. Proc. Natl. Acad. Sci. U.S.A. 100, 13555-13560.
15. Liu, J., Wright, E. R., and Winkler, H. (2010). 3D visualization of HIV virions by cryoelectron tomography. Meth. Enzymol. 483, 267-290.
16. Martin-Serrano, J., and Neil, S. J. (2011). Host factors involved in retrovi-ral budding and release. Nat. Rev. Microbiol. 9,519-531.
17. Ohishi, M., Nakano, T., Sakuragi, S., Shioda, T., Sano, K., and Sakuragi, J. I. (2011). The relationship between HIV-1 genome RNA dimerization, virion maturation and infectivity. Nucleic Acids Res. 39, 3404-3017.
18. Pearse, B. M. (1976). Clathrin: a unique protein associated with intracellu-lar transfer of membrane by coated vesicles. Proc. Natl. Acad. Sci. U.S.A. 73,1255-1259.
19. Peng, C., Ho, B. K., Chang, T. W., and Chang, N. T. (1989). Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity. J. Virol. 63, 2550-2556.
20. Perno, C. E (2011). The discovery and development of HIV therapy: the new challenges. Ann. Ist. Super. Sanita 47, 41-43.
21. Pertel, T., Hausmann, S., Morger, D., Zuger, S., Guerra, J., Lascano, J., Reinhard, C., Santoni, E A., Uchil, P. D., Chatel, L., Bisiaux, A., Albert, M. L., Strambio-De-Castillia, C., Mothes, W., Pizzato, M., Grutter, M. G., and Luban, J. (2011). TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature 472, 361-365.
22. Pettit, S. C., Moody, M. D., Wehbie, R. S., Kaplan, A. H., Nantermet, P. V., Klein, C. A., and Swanstrom, R. (1994). The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions. J. Virol. 68, 8017-8027.
23. Sakalian, M., McMurtrey, C. P., Deeg, E J., Maloy, C. W., Li, E, Wild, C. T., and Salzwedel, K. (2006).3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro. J. Virol. 80, 5716-5722.
24. Salzwedel, K., Martin, D. E., and Sakalian, M. (2007). Maturation inhibitors: a new therapeutic class targets the virus structure. AIDS Rev. 9, 162-172.
25. Seclen, E., Gonzalez Mdel, M., Corral, A., de Mendoza, C., Soriano, V., and Poveda, E. (2010). High prevalence of natural polymorphisms in Gag (CA-SP1) associated with reduced response to Bevirimat, an HIV-1 maturation inhibitor. AIDS 24, 467-469.
26. Verheyen, J., Verhofstede, C., Knops, E., Vandekerckhove, L., Fun, A., Brunen, D., Dauwe, K., Wens-ing, A. M., Pfister, H., Kaiser, R., and Nijhuis, M. (2010). High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates. AIDS 24, 669-673.
27. Wainberg, M. A., and Albert, J. (2010). Can the further clinical development of bevirimat be justified? AIDS 24, 773-774.
28. Weichsel, J., Herold, N., Lehmann, M. J., Krausslich, H. G., and Schwarz, U. S. (2010). A quantitative measure for alterations in the actin cytoskeleton investigated with automated high-throughput microscopy. Cytometry A 77, 52-63.
29. Zhang, F., Zang, T., Wilson, S. J., Johnson, M. C., and Bieniasz, P. D. (2011). Clathrin facilitates the morphogenesis of retrovirus particles. PLoS Pathog. 7, e1002119. doi:10.1371/journal.ppat. 1002119
30. Zhou, J., Huang, L., Hachey, D. L., Chen, C. H., and Aiken, C. (2005). Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles. J. Biol. Chem. 280,42149-42155.