Ischemic preconditioning in the younger and aged heart

Aging and Disease

Volumn 2, Issue 2, 2011, Pages 138-148

  Abete, Pasquale ^a   Testa, Gianluca ^a,b   Cacciatore, Francesco ^c   Della Morte, David ^a,d,e   Galizia, Gianluigi ^a,c   Langellotto, Assunta ^a   Rengo, Franco ^a,c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF MOLISE   (Italy)

^c IRCCS   (Italy)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^e IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

Aged; Caloric restriction; Heart; Ischemia; Preconditioning; Younger

Indexed keywords

EID: 84871163642     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: None     Document Type: Review

References (56)

1. Murry, C.E., Jennings, R.B. and Reimer, K.A. (1986). Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation, 74, 1124-36.
2. Kloner, R.A., Bolli, R., Marban, E., Reinlib, L. and Braunwald, E. (1998). Medical and cellular implications of stunning, hibernation and preconditioning. An NHLBI workshop. Circulation, 97, 1848-67.
3. Napoli, C., Pinto, A. and Cirino, G. (2000). Pharmacological modulation, preclinical studies, and new clinical features of myocardial ischemic preconditioning. Pharmacol Ther, 88, 311-31.
4. Yellon, D.M. and Downey, J.M. (2003). Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev, 83, 1113-51.
5. Vinten-Johansen, J., Zhao, Z.Q., Jiang, R., Zatta, A.J. and Dobson, G.P. (2007). Preconditioning and postconditioning: innate cardioprotection from ischemia-reperfusion injury. J Appl Physiol, 103, 1441-8.
6. Juhaszova, M., Rabuel, C., Zorov, D.B., Lakatta, E.G. and Sollott, S.J. (2005). Protection in the aged heart: preventing the heart-break of old age? Cardiovasc Res, 66, 233-44.
7. Downey, J.M., Davis, A.M., Cohen, M.V. (2007). Signaling pathways in ischemic preconditioning. Heart Fail Rev, 12, 181-8.
8. Heusch, G., Boengler, K. and Schulz, R. (2008). Cardioprotection: nitric oxide, protein kinases, and mitochondria. Circulation, 118, 1915-19.
9. Halestrap, A.P., Clarke, S.J. and Khaliulin, I. (2007). The role of mitochondria in protection of the heart by preconditioning. Biochim Biophys Acta, 1767, 1007-31.
10. Hausenloy, D.J. and Yellon, D.M. (2006). Survival kinases in ischemic preconditioning and postconditioning. Cardiovasc Res, 70, 240-53.
11. Zorov, D.B., Juhaszova, M., Yaniv, Y., Nuss, H.B., Wang, S. and Sollott, S.J. (2009). Regulation and pharmacology of the mitochondrial permeability transition pore. Cardiovasc Res, 83, 213-25
12. Kloner, R.A., Shook, T., Przyklenk, K., Davis, V.G., Junio, L., Matthews, R.V., Burstein, S., Gibson, C.M., Poole, W.K., Cannon, C.P., McCabe, C.H. and Braunwald, E. (1995). Previous angina alters in-hospital outcome in TIMI 4: a clinical correlate to preconditioning. Circulation, 91, 37-47.
13. Andreotti, F., Pasceri, V., Hackett, D.R., Davies, G.J., Haider, A.W. and Maseri, A. (1996). Preinfarction angina as a predictor of more rapid coronary thrombolysis in patients with acute myocardial infarction. N Engl J Med, 334, 7-12.
14. Tresch, D.D., Brady, W.J., Aufderheide, T.P., Lawrence, S.W. and Williams, K.J. (1996). Comparison of elderly and younger patients with out-of-hospital chest pain. Arch Intern Med, 156, 1089-93.
15. Berger, A.K., Radford, M.J., Wang, Y. and Krumholz, H.M. (2000). Thrombolytic therapy in older patients. J Am Coll Cardiol, 36, 366-74.
16. Boersma, E., Pieper, K.S., Steyerberg, E.W., Wilcox, R.G., Chang, W.C., Lee, K.L., Akkerhuis, K.M., Harrington, R.A., Deckers, J.W., Armstrong, P.W., Lincoff, A.M., Califf, R.M., Topol, E.J. and Simoons, M.L. (2000). Predictors of outcome in patients with acute coronary syndromes without persistent ST-segment elevation. Results from an international trial of 9461 patients. The PURSUIT Investigators. Circulation, 101, 2557-67.
17. Maggioni, A.P., Maseri, A., Fresco, C., Franzosi, M.G., Mauri, F., Santoro, E. and Tognoni, G. (1993). Age related increase in mortality among patients with first myocardial infarctions treated with thrombolysis. N Engl J Med, 329, 1442-8.
18. Gerstenblith, G., Frederiksen, J., Yin F.C., Fortuin, N.J., Lakatta, E.G. and Weisfeldt, M.L. (1977). Echocardiography assessment of a normal adult aging population. Circulation, 56, 672-9.
19. Tresch, D.D. and McGough, M.F. (1995). Heart failure with normal systolic function: a common disorder in older people. J Am Geriatr Soc, 43, 1035-42.
20. Rivard, A., Fabre, J.E., Silver, M., Chen, D., Murohara, T., Kearney, M., Magner, M., Asahara, T. and Isner, J.M. (1999). Age-dependent impairment of angiogenesis. Circulation, 99, 111-20.
21. Ataka, K., Chen, D., Levitsky, S., Jimenez, E. and Feinberg, H. (1992). Effect of aging on intracellular Ca2+, pHi, and contractility during ischemia and reperfusion. Circulation, 86(II), 371-76.
22. Abete, P., Cioppa, A., Ferrara, P., Caccese, P., Ferrara, N. and Rengo, F. (1995). Reduced aerobic metabolic efficiency in postischemic myocardium dysfunction in rats: role of aging. Gerontology, 41, 187-94.
23. Abete, P., Cioppa, A., Calabrese, C., Pascucci, I., Cacciatore, F., Napoli, C., Carnovale, V., Ferrara, N. and Rengo, F. (1999). Ischemic threshold and myocardial stunning in the aging heart. Experimental Gerontology, 34, 875-84.
24. Abete, P., Calabrese, C., Ferrara, N., Cioppa, A., Pisanelli, P., Cacciatore, F., Longobardi, G., Napoli, C. and Rengo, F. (1996). Preconditioning does not prevent post-ischemic dysfunction in aging heart. J Am Coll Cardiol, 27, 1777-86.
25. Tani, M., Suganuma, Y., Hasegawa, H., Shinmura, K., Hayashi, Y., Guo, X. and Nakamura, Y. (1997). Changes in ischemic tolerance and effects of ischemic preconditioning in middle-aged rat hearts. Circulation, 95, 2559-66.
26. Fenton, R.A., Dickson, E.W., Meyer, T.E. and Dobson, J.G. Jr. (2000). Aging reduces the cardioprotective effect of ischemic preconditioning in the rat heart. J Mol Cell Cardiol, 32, 1371-75.
27. Schulman, D., Latchman, D.S. and Yellon, D.M. (2001). Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol, 281, H1630-6.
28. Bartling, B., Friedrich, I., Silber, R.E. and Simm, A. (2003). Ischemic preconditioning is not cardioprotective in senescent human myocardium. Ann Thorac Surg, 76, 105-11.
29. Boengler, K., Konietzka, I., Buechert, A., Heinen, Y., Garcia-Dorado, D., Heusch, G., Schulz, R. et al. (2007). Loss of ischemic preconditioning's cardioprotection in aged mouse hearts is associated with reduced gap junctional and mitochondrial levels of connexin 43. Am J Physiol Heart Circ Physiol, 292, H1764-9.
30. Banerjee, A., Locke-Winter, C., Rogers, K.B. and Mitchell, M.B. (1993). Preconditioning against myocardial dysfunction after ischemia and reperfusion by an α1-adrenergic mechanism. Circ Res, 73, 656-70.
31. Mazzeo, R.S. and Horvarth, S.M. (1987). A decline in myocardial and hepatic norepinephrine turnover with age in Fisher 344 rats. Am J Physiol, 252, E762-4.
32. Dawson, R. and Meldrum, M.J. (1992). Norepinephrine content in cardiovascular tissue from the aged Fisher 344 rat. Gerontology, Vol. 38, 185-91.
33. Willems, L., Ashton, K.J. and Headrick, J.P. (2005). Adenosine-mediated cardioprotection in the aging myocardium. Cardiovasc Res, 66, 245-55.
34. Tani, M., Honma, Y., Hasegawa, H. and Tamaki, K. (2001). Direct activation of mitochondrial K [ATP] channels mimics preconditioning but protein kinase C activation is less effective in middle-aged rat hearts. Cardiovasc Res, 49, 56-68.
35. Przyklenk, K., Li, G., Simkhovich, B.Z. and Kloner, R.A. (2003). Mechanisms of myocardial ischemic preconditioning are age related: PKC-1 does not play a requisite role in old rabbits. Am J Physiol, 95, 2563-9.
36. Peart, J.N., Gross, E.R., Headrick, J.P. and Gross, G.J. (2007). Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection. J Mol Cell Cardiol, 42, 972-80.
37. Fenton, R.A., Dickson, E.W. and Dobson, J.G. Jr. (2005). Inhibition of phosphatase activity enhances preconditioning and limits cell death in the ischemic/reperfused aged rat heart. Life Sci, 77, 3375-88.
38. Przyklenk, K., Maynard, M., Darling, C.E. and Whittaker, P. (2008). Aging mouse hearts are refractory to infarct size reduction with post-conditioning. J Am Coll Cardiol, 51, 1393-8.
39. Abete, P., Ferrara, N., Cacciatore, F., Sagnelli, E., Manzi, M., Carnovale, V., Calabrese, C., De Santis, D., Testa, G., Longobardi, G., Napoli, C. and Rengo, F. (1997). Angina-induced protection against myocardial infarction in adult and senescent patients. A loss of preconditioning mechanism in aging heart. J Am Coll Cardiol, 30, 947-54.
40. Ishihara, M., Sato, H., Tateishi, H., Kawagoe, T., Shimatani, Y., Ueda, K., Noma, K., Yumoto, A. and Nishioka, K. (2000). Beneficial effect of prodromal angina pectoris is lost in elderly patients with acute myocardial infarction. Am Heart J, 139, 881-8.
41. Napoli, C., Liguori, A., Cacciatore, F., Rengo, F., Ambrosio, G. and Abete, P. (1999). Warm-up phenomenon detected by electrocardiographic ambulatory monitoring in adult and elderly patients. J Am Geriatr Soc, 47, 1-4.
42. Longobardi, G., Abete, P., Ferrara, N., Papa, A., Rosiello, R., Furgi, G., Calabrese, C., Cacciatore, F. and Rengo, F. (2000). Warm-up. Phenomenon in adult and elderly patients with coronary artery disease. Further evidence of the loss of.ischemic preconditioning. in the aging heart. J Gerontol, 55, M124-9.
43. Lee, T.M., Su, S.F., Chou, T.F., Lee, Y.T. and Tsai, C.H. (2002). Loss of preconditioning by attenuated activation of myocardial ATP-sensitive potassium channel in elderly patients undergoing coronary angioplasty. Circulation, 105, 334-40.
44. Masoro, E.J. (2000). Caloric restriction and aging: an update. Exp Gerontol, 35, 299-305.
45. McCay, C.M., Crowell, M.F. and Maynard, L.A. (1935). The effect of retarded growth upon the length of life span and upon the ultimate body size. J Nutr, 10, 63-79.
46. Weindruch, R. and Walford, R.L. (eds). (1988). The retardation of aging and disease by dietary restriction. Springfield, Il: Thomas.
47. Abete, P., Testa, G., Ferrara, N., De Santis, D., Capaccio, P., Viati, L., Calabrese, C., Cacciatore, F., Longobardi, G., Condorelli, M., Napoli, C. and Rengo, F. (2002). Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats. Am J Physiol, 282, H1978-87.
48. Holloszy, J.O. (1997). Mortality rate and longevity of food-restricted exercising male rats: a re-evaluation. J Appl Physiol, 82, 399-403.
49. Abete, P., Calabrese, C., Ferrara, N., Cioppa, A., Pisanelli, P., Cacciatore, F., Longobardi, G., Napoli, C. and Rengo, F. (2000). Exercise training restores ischemic preconditioning in the aging heart. J Am Coll Cardiol, 36, 643-50.
50. Crandall, D.L., Feirer, R.P. and Griffith, D.R. (1981). Relative role of caloric restriction and exercise training upon susceptibility to isoproterenol-induced myocardial infarction in male rats. Am J Clin Nutr, 34, 841-7.
51. Abete, P., Testa, G., Galizia, G., Mazzella, F., Della Morte, D., De Santis, D., Calabrese, C., Cacciatore, F., Gargiulo, G., Ferrara, N., Rengo, G., Sica, V., Napoli, C. and Rengo, F. (2005). Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart. Exp Gerontol, 40, 43-50.
52. Washburn, R.A., McAuley, E., Katula, J. et al. (1999). The Physical Activity for the Elderly (PASE): Evidence for validity. J Clin Epidemiol, 52, 643-51.
53. Abete, P., Ferrara, N., Cacciatore, F., Madrid, A., Bianco, S., Calabrese, C., Napoli, C., Scognamiglio, P., Bollella, O., Cioppa, A., Longobardi, G. and Rengo, F. (2001). High level of physical activity preserves the cardioprotective effect of preinfarction angina in elderly patients. J Am Coll Cardiol, 38, 1357-65.
54. Abete, P., Cacciatore, F., Ferrara, N., Calabrese, C., De Santis, D., Testa, G., Galizia, G., Del Vecchio, S., Leosco, D., Condorelli, M., Napoli, C. and Rengo, F. (2003). Body mass index and preinfarction angina in elderly patients with acute myocardial infarction. Am J Clin Nutr, 78, 796-801.
55. Abete, P., Cacciatore, F., Della Morte, D., Mazzella, F., Testa, G., Galizia, G., De Santis, D., Longobardi, G., Ferrara, N. and Rengo, F. (2009). Joint effect of physical activity and body mass index on mortality for acute myocardial infarction in the elderly: role of preinfarction angina as equivalent of ischemic preconditioning. Eur J Cardiovasc Prev Rehabil, 16, 73-9.
56. Abete, P., Cacciatore, F., Testa, G., Della Morte, D., Galizia, G., De Santis, D., Calabrese, C., Cioppa, A., Ferrara, N. and Rengo, F. (2010). Ischemic preconditioning in the aging heart: from bench to bedside. Ageing Res Rev, 9, 153-62.