Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding

Journal of Biological Chemistry

Volumn 285, Issue 23, 2010, Pages 17471-17478

  Derbyshire, Emily R ^a,c   Deng, Sarah ^b   Marletta, Michael A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORBANCES; BINDING PROTEINS; CYCLASES; DISTAL POCKET; ENZYME ACTIVATION; FULL-LENGTH ENZYMES; GUANYLATE CYCLASE; HEME COFACTOR; HEME POCKETS; HEME-BINDING DOMAINS; HEMOPROTEINS; HIGH AFFINITY; HYDROGEN BOND DONORS; HYDROGEN BONDING NETWORK; LIGAND BINDING; NO DISSOCIATION; OXYGEN AFFINITY; OXYGEN BINDING; SEQUENCE ANALYSIS; SOLUBLE GUANYLATE CYCLASE (SGC); STABLE COMPLEXES; TYROSINE RESIDUES;

AMINO ACIDS; CHEMICAL ACTIVATION; ENZYMES; HYDROGEN; HYDROGEN BONDS; LIGANDS; MAMMALS; NITRIC OXIDE; OXYGEN; PHOSPHATASES; PORPHYRINS;

HEMOGLOBIN;

GLUTAMINE; GUANYLATE CYCLASE; HEME; ISOLEUCINE; NITRIC OXIDE; OXYGEN; PHENYLALANINE; TYROSINE; VALINE;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; DROSOPHILA; ENZYME ANALYSIS; ENZYME BINDING; HYDROGEN BOND; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; GLUTAMINE; GUANOSINE TRIPHOSPHATE; GUANYLATE CYCLASE; HEME; KINETICS; MOLECULAR SEQUENCE DATA; NITRIC OXIDE; OXYGEN; PORPHYRINS; PROTEIN BINDING; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROPHOTOMETRY; TYROSINE;

MAMMALIA; RATTUS;

EID: 77952942728     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.098269     Document Type: Article

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