Differential lumbar spinal cord responses among wild type, CD4 knockout, and CD40 knockout mice in spinal nerve L5 transection-induced neuropathic pain

Molecular Pain

Volumn 8, Issue , 2012, Pages

  Cao, Ling ^a   Beaulac, Holly ^a   Eurich, Adriana ^a  

^a UNIVERSITY OF NEW ENGLAND   (United States)

Author keywords

CD4+ T cells; CD40; Microglia; Nerve injury; Neuopathic pain

Indexed keywords

CD11B ANTIGEN; CD40 ANTIBODY; CD40 ANTIGEN; CD45 ANTIGEN; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE INACTIVATION; HYPERALGESIA; INTRACELLULAR SIGNALING; LUMBAR SPINAL CORD; LYMPHOCYTIC INFILTRATION; MALE; MICROGLIA; MONONUCLEAR CELL; MOUSE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN FUNCTION; SPINAL CORD TRANSSECTION; SPINAL NERVE; WILD TYPE;

ANIMALS; ANTIGENS, CD40; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICROGLIA; NEURALGIA; SPINAL NERVES;

EID: 84871104378     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-8-88     Document Type: Article

References (30)

1. Jensen TS, et al. A new definition of neuropathic pain. Pain 2011, 152(10):2204-2205. 10.1016/j.pain.2011.06.017, 21764514.
2. DeLeo JA, Tanga FY, Tawfik VL. Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia. Neuroscientist 2004, 10(1):40-52. 10.1177/1073858403259950, 14987447.
3. Milligan ED, Watkins LR. Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 2009, 10(1):23-36. 10.1038/nrn2533, 2752436, 19096368.
4. Ren K, Dubner R. Interactions between the immune and nervous systems in pain. Nat Med 2010, 16(11):1267-1276. 10.1038/nm.2234, 3077564, 20948535.
5. Lindenlaub T, Sommer C. Cytokines in sural nerve biopsies from inflammatory and non-inflammatory neuropathies. Acta Neuropathol 2003, 105(6):593-602.
6. Cao L, DeLeo JA. CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain. Eur J Immunol 2008, 38(2):448-458. 10.1002/eji.200737485, 2963094, 18196515.
7. Grace PM, Rolan PE, Hutchinson MR. Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain Behav Immun 2011, 25(7):1322-1332. 10.1016/j.bbi.2011.04.003, 21496480.
8. Gordh T, Chu H, Sharma HS. Spinal nerve lesion alters blood-spinal cord barrier function and activates astrocytes in the rat. Pain 2006, 124(1-2):211-221.
9. Abbadie C, et al. Impaired neuropathic pain responses in mice lacking the Chemokine receptor CCR2. Proc Natl Acad Sci USA 2003, 100(13):7947-7952. 10.1073/pnas.1331358100, 164693, 12808141.
10. Gao YJ, Ji RR. Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Pharmacol Ther 2010, 126(1):56-68. 10.1016/j.pharmthera.2010.01.002, 2839017, 20117131.
11. White FA, Jung H, Miller RJ. Chemokines and the pathophysiology of neuropathic pain. Proc Natl Acad Sci USA 2007, 104(51):20151-20158. 10.1073/pnas.0709250104, 2154400, 18083844.
12. Matyszak MK, et al. Microglia induce myelin basic protein-specific T cell anergy or T cell activation, according to their state of activation. Eur J Immunol 1999, 29(10):3063-3076. 10.1002/(SICI)1521-4141(199910)29:10<3063::AID-IMMU3063>3.0.CO;2-G, 10540317.
13. Olson JK, Girvin AM, Miller SD. Direct activation of innate and antigen-presenting functions of microglia following infection with Theiler's virus. J Virol 2001, 75(20):9780-9789. 10.1128/JVI.75.20.9780-9789.2001, 114550, 11559811.
14. Dalpke AH, et al. Immunostimulatory CpG-DNA activates murine microglia. J Immunol 2002, 168(10):4854-4863.
15. Ponomarev ED, et al. Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J Neurosci Res 2005, 81(3):374-389. 10.1002/jnr.20488, 15959904.
16. Cao L, et al. Critical role of microglial CD40 in the maintenance of mechanical hypersensitivity in a murine model of neuropathic pain. Eur J Immunol 2009, 39(12):3562-3569. 10.1002/eji.200939657, 2810130, 19750482.
17. Becher B, et al. The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system. J Exp Med 2001, 193(8):967-974. 10.1084/jem.193.8.967, 2193406, 11304557.
18. Benveniste EN, Nguyen VT, O'Keefe GM. Immunological aspects of microglia: relevance to Alzheimer's disease. Neurochem Int 2001, 39(5-6):381-391.
19. Togo T, et al. Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases. Brain Res 2000, 885(1):117-121. 10.1016/S0006-8993(00)02984-X, 11121537.
20. D'Aversa TG, Weidenheim KM, Berman JW. CD40-CD40L Interactions induce Chemokine expression by human microglia: implications for human immunodeficiency virus encephalitis and multiple sclerosis. Am J Pathol 2002, 160(2):559-567. 10.1016/S0002-9440(10)64875-4, 1850648, 11839576.
21. Kotowicz K, et al. Biological function of CD40 on human endothelial cells: costimulation with CD40 ligand and interleukin-4 selectively induces expression of vascular cell adhesion molecule-1 and P-selectin resulting in preferential adhesion of lymphocytes. Immunology 2000, 100(4):441-448. 10.1046/j.1365-2567.2000.00061.x, 2327040, 10929070.
22. Faine LA, et al. Bioactivity of nitrolinoleate: effects on adhesion molecules and CD40-CD40L system. J Nutr Biochem 2010, 21(2):125-132. 10.1016/j.jnutbio.2008.12.004, 19195864.
23. Aloisi F, et al. Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells. J Immunol 2000, 164(4):1705-1712.
24. Raivich G, Banati R. Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease. Brain Res Brain Res Rev 2004, 46(3):261-281.
25. Sedgwick JD, et al. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system. Proc Natl Acad Sci USA 1991, 88(16):7438-7442. 10.1073/pnas.88.16.7438, 52311, 1651506.
26. Ford AL, et al. Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared. J Immunol 1995, 154(9):4309-4321.
27. Gabrusiewicz K, et al. Characteristics of the alternative phenotype of microglia/macrophages and its modulation in experimental gliomas. PLoS One 2011, 6(8):e23902. 10.1371/journal.pone.0023902, 3162015, 21901144.
28. Nikodemova M, Watters JJ. Efficient isolation of live microglia with preserved phenotypes from adult mouse brain. J Neuroinflammation 2012, 9:147. 10.1186/1742-2094-9-147, 3418565, 22742584.
29. Cao L, Tanga FY, Deleo JA. The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain. Neuroscience 2009, 158(2):896-903. 10.1016/j.neuroscience.2008.10.004, 2701510, 18976692.
30. Malon JT, et al. Involvement of calcitonin gene-related peptide and CCL2 production in CD40-mediated behavioral hypersensitivity in a model of neuropathic pain. Neuron Glia Biol 2012, 1-12. Epub ahead of print.