Delivery of medications by metered dose inhaler through a chamber/mask to young children with asthma

Pediatric, Allergy, Immunology, and Pulmonology

Volumn 25, Issue 4, 2012, Pages 236-239

  Elmallah, Mai K ^a   Hendeles, Leslie ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; FLUTICASONE; FLUTICASONE PROPIONATE; SALBUTAMOL; SALBUTAMOL SULFATE;

ARTICLE; ASTHMA; BRONCHOSPASM; DISEASE CONTROL; DISEASE EXACERBATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; HOSPITALIZATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; METERED DOSE INHALER; NEBULIZER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); TACHYCARDIA;

EID: 84871102788     PISSN: 2151321X     EISSN: 21513228     Source Type: Journal    
DOI: 10.1089/ped.2012.0197     Document Type: Article

References (32)

1. Castro-Rodriguez JA, Rodrigo GJ. Beta-agonists through metered-dose inhaler with valved holding chamber versus nebulizer for acute exacerbation of wheezing or asthma in children under 5 years of age: a systematic review with meta-analysis. J Pediatr 2004; 145:172-177. (Pubitemid 38993387)
2. Schuh S, Johnson DW, Stephens D, Callahan S, Winders P, Canny GJ. Comparison of albuterol delivered by a metered dose inhaler with spacer versus a nebulizer in children with mild acute asthma. J Pediatr 1999; 135:22-27. (Pubitemid 30180557)
3. Kerem E, Levison H, Schuh S, O'Brodovich H, Reisman J, Bentur L, Canny GJ. Efficacy of albuterol administered by nebulizer versus spacer device in children with acute asthma. J Pediatr 1993; 123:313-317. (Pubitemid 23221119)
4. Delgado A, Chou KJ, Silver EJ, Crain EF. Nebulizers vs metereddose inhalers with spacers for bronchodilator therapy to treat wheezing in children aged 2 to 24 months in a pediatric emergency department. Arch Pediatr Adolesc Med 2003; 157:76-80. (Pubitemid 36343422)
5. Leversha AM, Campanella SG, Aickin RP, Asher MI. Costs and effectiveness of spacer versus nebulizer in young children with moderate and severe acute asthma. J Pediatr 2000; 136: 497-502. (Pubitemid 30469591)
6. Hendeles L, Hatton RC, Coons TJ, Carlson L. Automatic replacement of albuterol nebulizer therapy by metered-dose inhaler and valved holding chamber. Am J Health-Syst Pharm 2005; 62:1053-1061. (Pubitemid 40676641)
7. Ploin D, Chapuis FR, Stamm D, Robert J, David L, Chatelain PG, Dutau G, Floret D. High-dose albuterol by metered-dose inhaler plus a spacer device versus nebulization in preschool children with recurrent wheezing: a double-blind, randomized equivalence trial. Pediatrics 2000; 106:311-317. (Pubitemid 30636401)
8. Mandelberg A, Tsehori S, Houri S, Gilad E, Morag B, Priel IE. Is nebulized aerosol treatment necessary in the pediatric emergency department? Chest 2000; 117:1309-1313.
9. Wexler MR, Rhame FS, Blumenthal MN, Cameron SB, Juni BA, Fish LA. Transmission of gram-negative bacilli to asthmatic children via home nebulizers. Ann Allergy 1991; 66:267-271.
10. Mallol J, Aguirre V, Barrueto L, Wandalsen G, Tepper R. Effect of inhaled fluticasone on lung function in infants with recurrent wheezing: a randomised controlled trial. Allergol Immunopathol (Madr) 2009; 37:57-62.
11. Bisgaard H, Gillies J, Groenewald M, Maden C. The effect of inhaled fluticasone propionate in the treatment of young asthmatic children: a dose comparison study. Am J Respir Crit Care Med 1999; 160:126-131. (Pubitemid 29326077)
12. Teper AM, Kofman CD, Szulman GA, Vidaurreta SM, Maffey AF. Fluticasone improves pulmonary function in children under 2 years old with risk factors for asthma. Am J Respir Crit Care Med 2005; 171:587-590. (Pubitemid 40365413)
13. Teper AM, Colom AJ, Kofman CD, Maffey AF, Vidaurreta SM, Bergadá I. Effects of inhaled fluticasone propionate in children less than 2 years old with recurrent wheezing. Pediatr Pulmonol 2004; 37:111-115. (Pubitemid 38120980)
14. Qaqundah PY, Sugerman RW, Ceruti E, Maspero JF, Kleha JF, Scott CA, Wu W, Mehta R, Crim C. Efficacy and safety of fluticasone propionate hydrofluoroalkane inhalation aerosol in preschool-age children with asthma: a randomized, double-blind, placebo-controlled study. J Pediatr 2006; 149:663-670.
15. Carlsen KC, Stick S, Kamin W, Cirule I, Hughes S, Wixon C. The efficacy and safety of fluticasone propionate in very young children with persistent asthma symptoms. Respir Med 2005; 99:1393-1402. (Pubitemid 41487497)
16. Newman SP. Spacer devices for metered dose inhalers. Clin Pharmacokinet 2004; 43:349-360. (Pubitemid 38594710)
17. Khan Y, Tang Y, Hochhaus G, Shuster JJ, Spencer T, Chesrown S, Hendeles L. Lung bioavailability of hydrofluoroalkane fluticasone in young children when delivered by an antistatic chamber/mask. J Pediatr 2006; 149:793-797. (Pubitemid 44816340)
18. Blake K, Mehta R, Spencer T, Kunka RL, Hendeles L. Bioavailability of inhaled fluticasone propionate via chambers/masks in young children. Eur Respir J 2012; 39:97-103.
19. Barry PW, O'Callaghan C. Inhalational drug delivery from seven different spacer devices. Thorax 1996; 51:835-840. (Pubitemid 26274087)
20. Doub WH, Adams WP, Wokovich AM, Black JC, Shen M, Buhse LF. Measurement of drug in small particles from aqueous nasal sprays by Andersen cascade impactor. Pharm Res 2012. [Epub ahead of print]; DOI:10.1007/s11095-012-0804-7.
21. Mitchell JP, Nagel MW, Wiersema KJ, Doyle CC. Aerodynamic particle size analysis of aerosols from pressurized metered-dose inhalers: comparison of Andersen 8-stage cascade impactor, next generation pharmaceutical impactor, and model 3321 Aerodynamic Particle Sizer aerosol spectrometer. AAPS PharmSci-Tech 2003; 4:E54.
22. Liang J, Asmus MJ, Hochhaus G, Chesrown S, Hendeles L. Differences in inhaled fluticasone bioavailability between holding chambers in children with asthma. Pharmacotherapy 2002; 22:947-953. (Pubitemid 34831289)
23. Dolovich MB, Ahrens RC, Hess DR, Anderson P, Dhand R, Rau JL, Smaldone GC, Guyatt G. Device selection and outcomes of aerosol therapy: evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and Immunology. Chest 2005; 127:335-371. (Pubitemid 41724594)
24. Bisgaard H, Anhøj J, Klug B, Berg E. A non-electrostatic spacer for aerosol delivery. Arch Dis Child 1995; 73:226-230.
25. Anhøj J, Bisgaard H, Lipworth BJ. Effect of electrostatic charge in plastic spacers on the lung delivery of HFA-salbutamol in children. Br J Clin Pharmacol 1999; 47:333-336. (Pubitemid 29131350)
26. Anhøj J, Thorsson L, Bisgaard H. Lung deposition of inhaled drugs increases with age. Am J Respir Crit Care Med 2000; 162:1819-1822.
27. Lipworth BJ, Lee DK, Anhøj J, Bisgaard H. Effect of plastic spacer handling on salbutamol lung deposition in asthmatic children. Br J Clin Pharmacol 2002; 54:544-547. (Pubitemid 35356883)
28. Elmallah MK, Khan Y, Hochhaus G, Shuster JJ, Hendeles L. Systemic exposure to fluticasone MDI delivered through antistatic chambers (letter). J Allergy Clin Immunol 2011; 128:1113-1115.
29. Prabhakaran S, Shuster J, Chesrown S, Hendeles L. Response to albuterol MDI delivered through an anti-static chamber during nocturnal bronchospasm. Respir Care 2012; 57:1291-1296.
30. Masoli M, Weatherall M, Holt S, Beasley R. Systematic review of the dose-response relation of inhaled fluticasone propionate. Arch Dis Child 2004; 89:902-907.
31. Kelly HW, Sternberg AL, Lescher R, Fuhlbrigge AL, Williams P, Zeiger RS, Raissy HH, Van Natta ML, Tonascia J, Strunk RC; CAMP Research Group. Effect of inhaled glucocorticoids in childhood on adult height. N Engl J Med 2012; 367:904-912.
32. Geller DE, Kesser KC. Effects of pretreatment of static and nonstatic holding chambers (HC) on the delivery of Flovent 110-HFA (F) in an infant airway model (abstract). Am J Respir Crit Care Med 2006; 3:A85.