The efficacy and safety of fluticasone propionate in very young children with persistent asthma symptoms

Respiratory Medicine

Volumn 99, Issue 11, 2005, Pages 1393-1402

  Carlsen, Karin C Lødrup ^a   Stick, Steve ^b   Kamin, Wolfgang ^c   Cirule, Ieva ^d   Hughes, Sara ^e   Wixon, Claire ^e  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^d CHILDREN'S CLINICAL UNIVERSITY HOSPITAL   (Latvia)

^e GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Asthma; Children; Cough; Fluticasone propionate; Wheeze

Indexed keywords

CREATININE; FLUTICASONE PROPIONATE; HYDROCORTISONE; PLACEBO;

AREA UNDER THE CURVE; ARTICLE; ASTHMA; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FEVER; DRUG SAFETY; DRUG TOLERABILITY; EAR INFECTION; FEMALE; FOREIGN BODY; HUMAN; MAJOR CLINICAL STUDY; MALE; METERED DOSE INHALER; MULTICENTER STUDY; NAUSEA AND VOMITING; NOSE INFECTION; PARALLEL DESIGN; PHARYNGITIS; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SLEEP DISORDER; SYMPTOMATOLOGY; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION; VIRUS INFECTION; WHEEZING;

EID: 27144529543     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2005.04.008     Document Type: Article

References (26)

1. M. Silverman Childhood asthma and other wheezing disorders 1995 Chapman and Hall London
2. B. Lundback Epidemiology of rhinitis and asthma Clin Exp Allergy 28 Suppl. 2 1995 3-10
3. F. Chedervergne M. Le Bourgeois J. de Blic et al. The role of inflammation in childhood asthma Arch Dis Child 82 Suppl II 2000 ii6-ii9
4. Global strategy for asthma management and prevention NHLBI/WHO workshop report. NIH publication No. 95-3659 2002 National Institute of Health Bethesda, MD
5. C. Maayan T. Itzhaki E. Bar-Yishay S. Gross A. Tal S. Godfrey The functional response of infants with persistent wheezing to nebulized beclomethasone dipropionate Pediatr Pulmonol 2 1986 9-14
6. K. Carlsen J. Leegaard S. Larsen I. Orstavik Nebulised beclomethasone dipropionate in recurrent obstructive episodes after acute bronchiolitis Arch Dis Child 63 1988 1428-1433
7. J. Storr C. Lenney W. Lenney Nebulised beclomethasone dipropionate in preschool asthma Arch Dis Child 61 1986 270-273
8. W. Pedersen P. Prahl Jet-nebulized beclomethasone dipropionate in the management of bronchial asthma. Topical steroids for asthmatic children younger than 4 years Allergy 42 1987 272-275
9. M. Mellon Efficacy of budesonide inhalation suspension in infants and young children with persistent asthma. Budesonide inhalation suspension study group J Allergy Clin Immunol 104 1999 191-199
10. J. de Blic C. Delacourt M. Le Bourgeois et al. Efficacy of nebulized budesonide in the treatment of severe infantile asthma: A double blind study J Allergy Clin Immunol 98 1996 14-20
11. B. Volovitz R. Soferman H. Blau M. Nussinovitch I. Varsano Rapid induction of clinical response with a short-term high-dose starting schedule of budesonide nebulizing suspension in young children with recurrent wheezing episodes J Allergy Clin Immunol 101 1998 464-469
12. P. Ilangovan S. Pedersen S. Godfrey K. Nikander N. Noviski J.O. Warner Treatment of severe steroid dependent preschool asthma with nebulised budesonide suspension Arch Dis Child 68 1993 356-359
13. G. Connett C. Warde E. Wooler W. Lenney Use of budesonide in severe asthmatics aged 1-3 years Arch Dis Child 69 1993 351-355
14. V. Noble N. Ruggins M. Everard A. Milner Inhaled budesonide for chronic wheezing under 18 months of age Arch Dis Child 67 1992 285-288
15. S. Pedersen Early use of inhaled steroids in children with asthma Clin Exp Allergy 27 1997 995-999
16. H. Bisgaard D. Allen J. Milanowski I. Kalev L. Willits P. Davies Twelve month safety and efficacy of inhaled fluticasone propionate in children aged 1-3 years old with recurrent wheezing Pediatrics 113 2 2004 e87-e94
17. R. Roorda G. Mezei H. Bisgaard C. Maden Response of preschool children with asthma symptoms to fluticasone propionate J Allergy Clin Immunol 108 2001 540-546
18. R. Chavasse Y. Bastian-Lee H. Richter T. Hilliard P. Seddon Persistent wheezing in infants with an atopic tendency responds to inhaled fluticasone Arch Dis Child 85 2001 143-148
19. H. Bisgaard J. Gillies M. Groenewald C. Maden The effect of inhaled fluticasone propionate in the treatment of young asthmatic children: A dose comparison study Am J Respir Crit Care Med 160 1999 126-131
20. C.S. Pao S.A. McKenzie Randomised controlled trial of fluticasone in preschool children with intermittent wheeze Am J Respir Crit Care Med 166 2002 945-949
21. Stein R, Jessop D. Functional status II(R): A measure of child health status. Med Care 28 A.D.; 11: 1041-55.
22. S. Vernon Urine collection from infants: A reliable method Pediatr Nursing J 7 1995 26-27
23. J. Gerritsen G. Koeter D. Postma J. Schouten K. Knol Prognosis of asthma from childhood to adulthood Am Rev Respir Dis 140 1989 1325-1330
24. A.E. Mackie A. Bye The relationship between systemic exposure to fluticasone propionate and cortisol reduction in healthy male volunteers Clin Pharmacokinet 39 Suppl. 1 2000 47-54
25. G. Todd C. Acerini J. Buck et al. Acute adrenal crisis in asthmatics treated with high-dose fluticasone propionate Eur Respir J 19 2002 1207-1209
26. A. Drake R. Howells J. Shield A. Prendeville P.S. Ward E.C. Crowne Symptomatic adrenal insufficiency presenting with hypoglycaemia in children with asthma receiving high dose inhaled fluticasone propionate Br Med J 324 2002 1081-1082