Effect of plastic spacer handling on salbutamol lung deposition in asthmatic children

British Journal of Clinical Pharmacology

Volumn 54, Issue 5, 2002, Pages 544-547

  Lipworth, Brian J ^a   Lee, Daniel K C ^a   Anhøj, Jacob ^b   Bisgaard, Hans ^b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b Rigshospitalet   (Denmark)

Author keywords

Asthma; Children; Electrostatics; Lung dose; Plastics; Salbutamol; Spacer

Indexed keywords

BENZALKONIUM CHLORIDE; SALBUTAMOL; VENTOLIN EVOHALER;

ARTICLE; ASTHMA; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DRUG BIOAVAILABILITY; ELECTRICITY; HUMAN; METERED DOSE INHALER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SINGLE BLIND PROCEDURE;

ADMINISTRATION, INHALATION; ALBUTEROL; ASTHMA; BRONCHODILATOR AGENTS; CHILD; CHILD, PRESCHOOL; CROSS-OVER STUDIES; HUMANS; LUNG; METERED DOSE INHALERS; NEBULIZERS AND VAPORIZERS; PLASTICS; SINGLE-BLIND METHOD;

EID: 0036432971     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2002.01675.x     Document Type: Article

References (12)

1. Bisgaard H. Delivery of inhaled medication to children. J Asthma 1997; 34: 443-467.
2. Zak M, Madsen J, Berg E, Bulow J, Bisgaard H. A mathematical model of aerosol holding chambers. J Aerosol Med 1999; 12: 187-196.
3. Bisgaard H, Anhoøj J, Klug B, Berg E. A non-electrostatic spacer for aerosol delivery. Arch Dis Child 1995; 73: 226-230.
4. Anhoøj J, Bisgaard H, Lipworth BJ. Effect of electrostatic charge in plastic spacers on the lung delivery of HFA-salbutamol in children. Br J Clin Pharmacol 1999; 47: 333-336.
5. Wildhaber JH, Janssens HM, Pierart F, Dore ND, Devadason SG, LeSouef PN. High-percentage lung delivery in children from detergent-treated spacers. Pediatr Pulmonol 2000; 29: 389-393.
6. Wildhaber JH, Devadason SG, Hayden MJ, et al. Electrostatic charge on a plastic spacer device influences the delivery of salbutamol. Eur Respir J 1996; 9: 1943-6.
7. Berg E, Madsen J, Bisgaard H. In vitro performance of three combinations of spacers and pressurized metered dose inhalers for treatment in children. Eur Respir J 1998; 12: 472-476.
8. Clark DJ, Lipworth BJ. Effect of multiple actuations, delayed inhalation and antistatic treatment on the lung bioavailability of salbutamol via a spacer device. Thorax 1996; 51: 981-984.
9. Zar HJ, Weinberg EG, Binns HJ, Gallie F, Mann MD. Lung deposition of aerosol - A comparison of different spacers. Arch Dis Child 2000; 82: 495-498.
10. Hindle M, Chrystyn H. Relative bioavailability of salbutamol to the lung following inhalation using metered dose inhalation methods and spacer devices. Thorax 1994; 49: 549-553.
11. Bisgaard H. A metal aerosol holding chamber devised for young children with asthma. Eur Respir J 1995; 8: 856-860.
12. Lipworth BJ, Clark DJ. Lung delivery of salbutamol by dry powder inhaler (Turbuhaler) and small volume antistatic metal spacer (Airomir CFC-free MDI plus NebuChamber). Eur Respir J 1997; 10: 1820-1823.