Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein S

Blood

Volumn 120, Issue 25, 2012, Pages 5059-5062

  Ahnström, Josefin ^a   Andersson, Helena M ^a   Hockey, Verity ^a   Meng, Yiran ^a   McKinnon, Thomas A J ^a   Hamuro, Tsutomu ^b   Crawley, James T B ^a   Lane, David A ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b Kaketsuken   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; PROTEIN S; THROMBIN; TISSUE FACTOR PATHWAY INHIBITOR;

ARTICLE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE;

EID: 84871080504     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-05-432005     Document Type: Article

References (15)

1. Wun TC, Kretzmer KK, Girard TJ, Miletich JP, Broze GJ, Jr. Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains. J Biol Chem. 1988;263(13):6001-6004.
2. Girard TJ, Warren LA, Novotny WF, et al. Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. Nature. 1989;338(6215):518-520. (Pubitemid 19107996)
3. Crawley JT, Lane DA. The haemostatic role of tissue factor pathway inhibitor. Arterioscler Thromb Vasc Biol. 2008;28(2):233-242. (Pubitemid 351161194)
4. Broze GJ Jr, Girard TJ. Tissue factor pathway inhibitor: structure-function. Front Biosci. 2012; 17:262-280.
5. Broze GJ Jr,Warren LA, Novotny WF, Higuchi DA, Girard JJ, Miletich JP. The lipoprotein-associated coagulation inhibitor that inhibits the factor VIItissue factor complex also inhibits factor Xa: insight into its possible mechanism of action. Blood. 1988;71(2):335-343. (Pubitemid 18089519)
6. Huang ZF, Wun TC, Broze GJ Jr. Kinetics of factor Xa inhibition by tissue factor pathway inhibitor. J Biol Chem. 1993;268(36):26950-26955.
7. Hackeng TM, Sere KM, Tans G, Rosing J. Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor. Proc Natl Acad Sci U S A. 2006;103(9):3106-3111. (Pubitemid 43346432)
8. Ndonwi M, Tuley EA, Broze GJ Jr. The Kunitz-3 domain of TFPI-alpha is required for protein S-dependent enhancement of factor Xa inhibition. Blood. 2010;116(8):1344-1351.
9. Ahnström J, Andersson HM, Canis K, et al. Activated protein C cofactor function of protein S: a novel role for a gamma-carboxyglutamic acid residue. Blood. 2011;117(24):6685-6693.
10. Andersson HM, Arantes MJ, Crawley JT, et al. Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain. Blood. 2010;115(23):4878-4885.
11. Mine S, Yamazaki T, Miyata T, Hara S, Kato H. Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor. Biochemistry. 2002;41(1):78-85. (Pubitemid 34049383)
12. Lindhout T, Willems G, Blezer R, Hemker HC. Kinetics of the inhibition of human factor Xa by full-length and truncated recombinant tissue factor pathway inhibitor. Biochem J. 1994;297(Pt 1):131-136. (Pubitemid 24025614)
13. Nordfang O, Bjorn SE, Valentin S, et al. The C-terminus of tissue factor pathway inhibitor is essential to its anticoagulant activity. Biochemistry. 1991;30(43):10371-10376.
14. Wesselschmidt R, Likert K, Girard T, Wun TC, Broze GJ Jr. Tissue factor pathway inhibitor: the carboxy-terminus is required for optimal inhibition of factor Xa. Blood. 1992;79(8):2004-2010.
15. Castoldi E, Simioni P, Tormene D, Rosing J, Hackeng TM. Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma. J Thromb Haemost. 2010;8(2):294-300.