Magnetic resonance imaging and joint outcomes in boys with severe hemophilia A treated with tailored primary prophylaxis in Canada

Journal of Thrombosis and Haemostasis

Volumn 10, Issue 12, 2012, Pages 2494-2502

  Kraft, J ^a   Blanchette, V ^b   Babyn, P ^c   Feldman, B ^b   Cloutier, S ^d   Israels, S ^e   Pai, M ^f   Rivard, G E ^g   Gomer, S ^h   Mclimont, M ^h   Moineddin, R ⁱ   Doria, A S ^b  

^a LEEDS GENERAL INFIRMARY   (United Kingdom)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c ROYAL UNIVERSITY HOSPITAL   (Canada)

^d LAVAL UNIVERSITY   (Canada)

^e UNIVERSITY OF MANITOBA   (Canada)

^f MCMASTER UNIVERSITY   (Canada)

^g UNIVERSITY OF MONTREAL   (Canada)

^h HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

ⁱ UNIVERSITY OF TORONTO   (Canada)

Author keywords

Arthropathy; Children; Hemophilia; Magnetic resonance imaging; Prophylaxis

Indexed keywords

HEMOSIDERIN; RECOMBINANT BLOOD CLOTTING FACTOR 8;

ANKLE; ARTICLE; CANADA; CHILD; CLINICAL ARTICLE; DISEASE SEVERITY; DRUG DOSE ESCALATION; ELBOW; HEMOPHILIA A; HEMOPHILIC ARTHROPATHY; HUMAN; KNEE; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRESCHOOL CHILD; PRIORITY JOURNAL; PROPHYLAXIS; SCHOOL CHILD; SOFT TISSUE DISEASE; TAILORED PRIMARY PROPHYLAXIS;

CANADA; CHILD; HEMOPHILIA A; HUMANS; JOINTS; MAGNETIC RESONANCE IMAGING; MALE; REPRODUCIBILITY OF RESULTS;

EID: 84871073400     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12025     Document Type: Article

References (23)

1. Arnold WD, Hilgartner MW. Hemophilic arthropathy. Current concepts of pathogenesis and management. J Bone Joint Surg Am 1977; 59: 287-305.
2. Fischer K, Valentino L, Ljung R, Blanchette V. Prophylaxis for severe haemophilia: clinical challenges in the absence as well as in the presence of inhibitors. Haemophilia 2008; 14(Suppl. 3): 196-201.
3. Fischer K, van der Bom JG, Mauser-Bunschoten EP, Roosendaal G, Prejs R, De Kleijn P, Grobbee DE, van den Berg M. The effects of postponing prophylactic treatment on long-term outcome in patients with severe hemophilia. Blood 2002; 99: 2337-41.
4. Feldman BM, Pai M, Rivard GE, Israels S, Poon MC, Demers C, Robinson S, Luke KH, Wu JK, Gill K, Lillicrap D, Babyn P, McLimont M, Blanchette VS. Tailored prophylaxis in severe hemophilia A: interim results from the first 5years of the Canadian Hemophilia Primary Prophylaxis Study. J Thromb Haemost 2006; 4: 1228-36.
5. Nilsson IM, Berntorp E, Lofqvist T, Pettersson H. Twenty-five years' experience of prophylactic treatment in severe haemophilia A and B. J Intern Med 1992; 232: 25-32.
6. Petrini P, Lindvall N, Egberg N, Blomback M. Prophylaxis with factor concentrates in preventing hemophilic arthropathy. Am J Pediatr Hematol Oncol 1991; 13: 280-7.
7. Manco-Johnson MJ, Abshire TC, Shapiro AD, Riske B, Hacker MR, Kilcoyne R, Ingram JD, Manco-Johnson ML, Funk S, Jacobson L, Valentino LA, Hoots WK, Buchanan GR, DiMichele D, Recht M, Brown D, Leissinger C, Bleak S, Cohen A, Mathew P, et al. Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. N Engl J Med 2007; 357: 535-44.
8. Nuss R, Kilcoyne RF, Geraghty S, Wiedel J, Manco-Johnson M. Utility of magnetic resonance imaging for management of hemophilic arthropathy in children. J Pediatr 1993; 123: 388-92.
9. Kilcoyne RF, Nuss R. Radiological evaluation of hemophilic arthropathy. Semin Thromb Hemost 2003; 29: 43-8.
10. Kilcoyne RF, Nuss R. Radiological assessment of haemophilic arthropathy with emphasis on MRI findings. Haemophilia 2003; 9(Suppl. 1): 57-63.
11. Gilbert MS. Prophylaxis: musculoskeletal evaluation. Semin Hematol 1993; 30: 3-6.
12. Pettersson H, Ahlberg A, Nilsson IM. A radiologic classification of hemophilic arthropathy. Clin Orthop Relat Res 1980; 149: 153-9.
13. Ota S, McLimont M, Carcao MD, Blanchette VS, Graham N, Paradis E, Feldman BM. Definitions for haemophilia prophylaxis and its outcomes: the Canadian consensus study. Haemophilia 2007; 13: 12-20.
14. Lundin B, Babyn P, Doria AS, Kilcoyne R, Ljung R, Miller S, Nuss R, Rivard GE, Pettersson H. Compatible scales for progressive and additive MRI assessments of haemophilic arthropathy. Haemophilia 2005; 11: 109-15.
15. Doria AS, Babyn PS, Lundin B, Kilcoyne RF, Miller S, Rivard GE, Moineddin R, Pettersson H. Reliability and construct validity of the compatible MRI scoring system for evaluation of haemophilic knees and ankles of haemophilic children. Expert MRI working group of the international prophylaxis study group. Haemophilia 2006; 12: 503-13.
16. Hacker MR, Funk SM, Manco-Johnson MJ. The Colorado Haemophilia Paediatric Joint Physical Examination Scale: normal values and interrater reliability. Haemophilia 2007; 13: 71-8.
17. Nuss R, Kilcoyne RF, Geraghty S, Shroyer AL, Rosky JW, Mawhinney S, Wiedel J, Manco-Johnson M. MRI findings in haemophilic joints treated with radiosynoviorthesis with development of an MRI scale of joint damage. Haemophilia 2000; 6: 162-9.
18. Fleiss JL. Statistical Methods for Rates and Proportions. New York: Wiley, 1981.
19. Altman D. Practical Statistics for Medical Research. London: Chapman and Hall, 1991.
20. Dietrich O, Reiser MF, Schoenberg SO. Artifacts in 3-T MRI: physical background and reduction strategies. Eur J Radiol 2008; 65: 29-35.
21. Nuss R, Kilcoyne RF, Rivard GE, Murphy J. Late clinical, plain X-ray and magnetic resonance imaging findings in haemophilic joints treated with radiosynoviorthesis. Haemophilia 2000; 6: 658-63.
22. Collins PW, Blanchette VS, Fischer K, Bjorkman S, Oh M, Fritsch S, Schroth P, Spotts G, Astermark J, Ewenstein B. Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A. J Thromb Haemost 2009; 7: 413-20.
23. Doria AS, Lundin B, Miller S, Kilcoyne R, Dunn A, Thomas S, Rivard G, Moineddin R, Babyn PS. Reliability and construct validity of the compatible MRI scoring system for evaluation of elbows in haemophilic children. Haemophilia 2008; 14: 303-14.