Blunted sympathetic vasoconstriction in contracting skeletal muscle of healthy humans: Is nitric oxide obligatory?

Journal of Physiology

Volumn 553, Issue 1, 2003, Pages 281-292

  Dinenno, Frank A ^a   Joyner, Michael J ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; CLONIDINE; N(G) METHYLARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; TYRAMINE; ALPHA ADRENERGIC RECEPTOR; PHENYLEPHRINE;

ADULT; ALPHA ADRENERGIC STIMULATION; ARTICLE; CALCULATION; CONTROLLED STUDY; DOPPLER FLOWMETRY; ENZYME INHIBITION; EVOKED RESPONSE; FOREARM; HAND GRIP; HUMAN; MALE; MUSCLE BLOOD FLOW; MUSCLE CONTRACTION; NORADRENALIN RELEASE; PRIORITY JOURNAL; SKELETAL MUSCLE; VASOCONSTRICTION; ALPHA ADRENERGIC RECEPTOR BLOCKING; BLOOD FLOW; BLUNTED SYMPATHETIC VASOCONSTRICTION; FOREARM VASCULAR CONDUCTANCE; HUMAN EXPERIMENT; NORMAL HUMAN; VASODILATATION;

ADENOSINE; ADULT; ENZYME INHIBITORS; FOREARM; HAND STRENGTH; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; NITRIC OXIDE; OMEGA-N-METHYLARGININE; REGIONAL BLOOD FLOW; SYMPATHETIC NERVOUS SYSTEM; TYRAMINE; VASOCONSTRICTION; VASODILATOR AGENTS;

EID: 0345327764     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.049940     Document Type: Article

References (44)

1. 2-adrenoceptor constriction to metabolic inhibition during rat skeletal muscle contraction. Circ Res 69, 178-184.
2. Boushel R, Langberg H, Gemmer C, Olesen J, Crameri R, Scheede C, Sander M & Kjaer M (2002). Combined inhibition of nitric oxide and prostaglandins reduces skeletal muscle blood flow during exercise. J Physiol 543, 691-698.
3. Buckwalter JB, Naik JS, Valic Z & Clifford PS (2001). Exercise attenuates alpha-adrenergic-receptor responsiveness in skeletal muscle vasculature. J Appl Physiol 90, 172-178.
4. Chavoshan B, Sander M, Sybert TE, Hansen J, Victor RG & Thomas GD (2002). Nitric oxide-dependent modulation of sympathetic neural control of oxygenation in exercising human skeletal muscle. J Physiol 540, 377-386.
5. Dietz NM, Rivera JM, Eggener ES, Fix RT, Warner DO & Joyner MJ (1994). Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans. J Physiol 480, 361-368.
6. Dinenno FA, Dietz NM & Joyner MJ (2002a). Aging and forearm postjunctional α-adrenergic vasoconstriction in healthy men. Circulation 106, 1349-1354.
7. Dinenno FA, Eisenach JH, Dietz NM & Joyner MJ (2002b). Post-junctional α-adrenoceptors and basal limb vascular tone in healthy men. J Physiol 540, 1103-1110.
8. Dyke CK, Proctor DN, Dietz NM & Joyner MJ (1995). Role of nitric oxide in exercise hyperaemia during prolonged rhythmic handgripping in humans. J Physiol 488, 259-265.
9. Eisenach JH, Clark ES, Charkoudian N, Dinenno FA, Atkinson JL, Fealey RD, Dietz NM & Joyner MJ (2002). Effects of chronic sympathectomy on vascular function in the human forearm. J Appl Physiol 92, 2019-2025.
10. Faber JE, Harris PD & Joshua IG (1982). Microvascular response to blockade of prostaglandin synthesis in rat skeletal muscle. Am J Physiol 243, H51-60.
11. Frandsen U, Bangsbo J, Sander M, Hoffner L, Betak A, Saltin B & Hellsten Y (2001). Exercise-induced hyperaemia and leg oxygen uptake are not altered during effective inhibition of nitric oxide synthase with N(G)-nitro-L-arginine methyl ester in humans. J Physiol 531, 257-264.
12. Frandsen U, Lopez-Figueroa M & Hellsten Y (1996). Localization of nitric oxide synthase in human skeletal muscle. Biochem Biophys Res Commun 227, 88-93.
13. Frewin DB & Whelan RF (1968). The mechanism of action of tyramine on the blood vessels of the forearm in man. Br J Pharmacol 33, 105-116.
14. Grange RW, Isotani E, Lau KS, Kamm KE, Huang PL & Stull JT (2001). Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles. Physiol Genomics 5, 35-44.
15. Hansen J, Sander M & Thomas GD (2000). Metabolic modulation of sympathetic vasoconstriction in exercising skeletal muscle. Acta Physiol Scand 168, 489-503.
16. Hansen J, Thomas GD, Jacobsen TN & Victor RG (1994). Muscle metaboreflex triggers parallel sympathetic activation in exercising and resting human skeletal muscle. Am J Physiol 266, H2508-2514.
17. Jie K, van Brummelen P, Vermey P, Timmermans PB & van Zwieten PA (1987). Postsynaptic alpha1 and alpha2-adrenoceptors in human blood vessels: interactions with exogenous and endogenous catecholamines. Eur J Clin Invest 17, 174-181.
18. Kobzik L, Reid MB, Bredt DS & Stamler JS (1994). Nitric oxide in skeletal muscle. Nature 372, 546-548.
19. Lautt WW (1989). Resistance or conductance for expression of arterial vascular tone. Microvasc Res 37, 230-236.
20. Lippton HL, Chapnick BM & Kadowitz PJ (1981). Influence of prostaglandins on vasoconstrictor responses in the hindquarters vascular bed of the cat. Prostaglandins Med 6, 183-202.
21. Malik KU & Sehic E (1990). Prostaglandins and the release of the adrenergic transmitter. Ann N Y Acad Sci 604, 222-236.
22. Marshall RJ, Schirger A & Shepherd JT (1961). Blood pressure during supine exercise in idiopathic orthostatic hypotension. Circulation 24, 76-81.
23. Nishigaki K, Faber JE & Ohyanagi M (1991). Interactions between α-adrenoceptors and adenosine receptors on microvascular smooth muscle. Am J Physiol 260, H1655-1666.
24. 2-adrenoceptors and endothelium-derived relaxing factor. Circ Res 71, 188-200.
25. O'Leary DS (1991). Regional vascular resistance vs. conductance: which index for baroreflex responses. Am J Physiol 260, H632-637.
26. Osanai T, Fujita N, Fujiwara N, Noakano T, Takahashi K, Guan W & Okumura K (2000). Cross talk of shear-induced production of prostacyclin and nitric oxide in endothelial cells. Am J Physiol Heart Circ Physiol 278, H233-238.
27. Joyner MJ & Proctor DN (1999). Muscle blood flow during exercise: the limits of reductionism. Med Sci Sports Exerc 31, 1036-1040.
28. Radegran G & Saltin B (1999). Nitric oxide in the regulation of vasomotor tone in human skeletal muscle. Am J Physiol 276, H1951-1960.
29. Remensnyder JP, Mitchell JH & Sarnoff SJ (1962). Functional sympatholysis during muscular activity. Circ Res 11, 370-380.
30. 2-adrenergic vasoconstriction is blunted in contracting human muscle. J Physiol 547, 971-976.
31. Rowell LB (1997). Neural control of muscle blood flow: importance during dynamic exercise. Clin Exp Pharmacol Physiol 24, 117-125.
32. Ruble SB, Valic Z, Buckwalter JB, Tschakovsky ME & Clifford PS (2002). Attenuated vascular responsiveness to noradrenaline release during dynamic exercise in dogs. J Physiol 541, 637-644.
33. Saltin B, Radegran G, Koskolou MD & Roach RC (1998). Skeletal muscle blood flow in humans and its regulation during exercise. Acta Physiol Scand 162, 421-436.
34. Sander M, Chavoshan B, Harris SA, Iannoccone ST, Stull JT, Thomas GD & Victor RG (2000). Functional muscle ischemia in neuronal nitric oxide synthase-deficient skeletal muscle of children with Duchenne muscular dystrophy. Proc Natl Acad Sci USA 97, 13818-13823.
35. Seals DR, Victor RG & Mark AL (1988). Plasma norepinephrine and muscle sympathetic discharge during rhythmic exercise in humans. J Appl Physiol 65, 940-944.
36. Shoemaker JK, Halliwill JR, Hughson RL & Joyner MJ (1997). Contributions of acetylcholine and nitric oxide to forearm blood flow at exercise onset and recovery. Am J Physiol 273, H2388-2395.
37. Strandell T & Shepherd JT (1967). The effect in humans of increased sympathetic activity on the blood flow to active muscles. Acta Med Scand 472, 146-167.
38. Thomas GD, Hansen J & Victor RG (1994). Inhibition of alpha2-adrenergic vasoconstriction during contraction of glycolytic, not oxidative, rat hindlimb muscle. Am J Physiol 266, H920-929.
39. Thomas GD, Hansen J & Victor RG (1997). ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle. J Clin Invest 99, 2602-2609.
40. Thomas GD, Sander M, Lau KS, Huang PL, Stull JT & Victor RG (1998). Impaired metabolic modulation of α-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle. Proc Natl Acad Sci USA 95, 15090-15095.
41. Thomas GD & Victor RG (1998). Nitric oxide mediates contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle. J Physiol 506, 817-826.
42. Tschakovsky ME, Sujirattanawimol K, Ruble SB, Valic Z & Joyner MJ (2002). Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle? J Physiol 541, 623-635.
43. VanTeeffelen JW & Segal SS (2003). Interaction between sympathetic nerve activation and muscle fibre contraction in resistance vessels of hamster retractor muscle. J Physiol 550, 563-574.
44. Wilson JR & Kapoor S (1993). Contribution of endothelium-derived relaxing factor to exercise-induced vasodilation in humans. J Appl Physiol 75, 2740-2744.