Stress-induced increase in skeletal muscle force requires protein kinase A phosphorylation of the ryanodine receptor

Journal of Physiology

Volumn 590, Issue 24, 2012, Pages 6381-6387

  Andersson, Daniel C ^a   Betzenhauser, Matthew J ^a   Reiken, Steven ^a   Umanskaya, Alisa ^a   Shiomi, Takayuki ^b   Marks, Andrew R ^a,b  

^a Clyde and Helen Wu Center for Molecular Cardiology   (United States)

^b College of Physicians and Surgeons of Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; RYANODINE RECEPTOR 1;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; EMBRYO; ENZYME PHOSPHORYLATION; IN VIVO STUDY; INOTROPISM; MOUSE; MUSCLE EXCITATION; MUSCLE STRENGTH; MUSCLE STRESS; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SKELETAL MUSCLE; WILD TYPE;

ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM SIGNALING; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ISOPROTERENOL; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE CONTRACTION; MUSCLE FIBERS, FAST-TWITCH; MUSCLE STRENGTH; PHOSPHORYLATION; POINT MUTATION; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SERINE; TIME FACTORS;

EID: 84871059886     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.237925     Document Type: Article

References (19)

1. Allen DG, Lamb GD & Westerblad H (2008). Skeletal muscle fatigue: cellular mechanisms. Physiol Rev 88, 287-332.
2. Andersson DC, Betzenhauser MJ, Reiken S, Meli AC, Umanskaya A, Xie W, Shiomi T, Zalk R, Lacampagne A & Marks AR (2011). Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab 14, 196-207.
3. 2+ in mitochondrial myopathy. Hum Mol Genet 18, 278-288.
4. Bellinger AM, Reiken S, Carlson C, Mongillo M, Liu X, Rothman L, Matecki S, Lacampagne A & Marks AR (2009). Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat Med 15, 325-330.
5. Bers DM (2001). Excitation-Contraction Coupling and Cardiac Contractile Force. Kluwer Academic Publishers.
6. Brown GL, Bülbring E & Burns BD (1948). The action of adrenaline on mammalian skeletal muscle. J Physiol 107, 115-128.
7. Cairns SP & Dulhunty AF (1993a). Beta-adrenergic potentiation of E-C coupling increases force in rat skeletal muscle. Muscle Nerve 16, 1317-1325.
8. Cairns SP & Dulhunty AF (1993b). The effects of beta-adrenoceptor activation on contraction in isolated fast- and slow-twitch skeletal muscle fibres of the rat. Br J Pharmacol 110, 1133-1141.
9. 2+]i during beta-adrenoceptor activation of single, intact fibres from mouse skeletal muscle. Pflugers Arch 425, 150-155.
10. Ha TN, Posterino GS & Fryer MW (1999). Effects of terbutaline on force and intracellular calcium in slow-twitch skeletal muscle fibres of the rat. Br J Pharmacol 126, 1717-1724.
11. Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M & Marks AR (2005). Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell 123, 25-35.
12. 2+ handling by phosphorylation status in mouse fast- and slow-twitch skeletal muscle fibers. Am J Physiol Cell Physiol 273, C1915-C1924.
13. Lynch GS & Ryall JG (2008). Role of beta-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease. Physiol Rev 88, 729-767.
14. Reiken S, Lacampagne A, Zhou H, Kherani A, Lehnart SE, Ward C, Huang F, Gaburjakova M, Gaburjakova J, Rosemblit N, Warren MS, He KL, Yi GH, Wang J, Burkhoff D, Vassort G & Marks AR (2003). PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure. J Cell Biol 160, 919-928.
15. Rockman HA, Koch WJ & Lefkowitz RJ (2002). Seven-transmembrane-spanning receptors and heart function. Nature 415, 206-212.
16. Shan J, Betzenhauser MJ, Kushnir A, Reiken S, Meli AC, Wronska A, Dura M, Chen BX & Marks AR (2010a). Role of chronic ryanodine receptor phosphorylation in heart failure and beta-adrenergic receptor blockade in mice. J Clin Invest.
17. Shan J, Kushnir A, Betzenhauser MJ, Reiken S, Li J, Lehnart SE, Lindegger N, Mongillo M, Mohler PJ & Marks AR (2010b). Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. J Clin Invest 120, 4388-4398.
18. Suko J, Maurer-Fogy I, Plank B, Bertel O, Wyskovsky W, Hohenegger M & Hellmann G (1993). Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase. Biochim Biophys Acta 1175, 193-206.
19. Ward CW, Reiken S, Marks AR, Marty I, Vassort G & Lacampagne A (2003). Defects in ryanodine receptor calcium release in skeletal muscle from post-myocardial infarct rats. FASEB J 17, 1517-1519.