Rational design of highly selective spleen tyrosine kinase inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 23, 2012, Pages 10414-10423

  Lucas, Matthew C ^a,c   Goldstein, David M ^a,d   Hermann, Johannes C ^a   Kuglstatter, Andreas ^a   Liu, Wenjian ^b   Luk, Kin Chun ^a   Padilla, Fernando ^a   Slade, Michelle ^a   Villaseñor, Armando G ^a   Wanner, Jutta ^a   Xie, Wenwei ^b   Zhang, Xiaohu ^b,e   Liao, Cheng ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b BioDuro(Beijing)Co Ltd   (China)

^c CUBIST PHARMACEUTICALS INC   (United States)

^d Principia BioPharma Inc   (United States)

^e SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FOSTAMATINIB; IMIDAZOPYRIDAZINE DERIVATIVE; PROTEIN KINASE SYK INHIBITOR; THIENOPYRIMIDINE DERIVATIVE; TRIAZOLOPYRIDINE; UNCLASSIFIED DRUG;

ARTICLE; ASTHMA; BINDING SITE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; PROTEIN INTERACTION; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; UNSPECIFIED SIDE EFFECT;

DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; SPLEEN;

EID: 84871023029     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301367c     Document Type: Article

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