Developmental toxicity associated with receptor tyrosine kinase ret inhibition in reproductive toxicity testing

Birth Defects Research Part A - Clinical and Molecular Teratology

Volumn 85, Issue 2, 2009, Pages 130-136

  Clemens, George R ^a   Schroeder, Raymond E ^b   Magness, Steven H ^b   Weaver, Elizabeth V ^c   Lech, Joseph W ^d   Taylor, Vanessa C ^a   Masuda, Esteban S ^a   Baluom, Muhammad ^a   Grossbard, Elliott B ^a  

^a RIGEL PHARMACEUTICALS INC   (United States)

^b MPI RESEARCH   (United States)

^c UK   (United States)

^d CHARLES RIVER LABORATORIES   (United States)

Author keywords

Developmental reproductive toxicity of Ret and Syk kinase inhibitors; Renal agenesis; Ret kinase inhibition; Subclavian artery abnormalities; Urogenital abnormalities

Indexed keywords

PROTEIN KINASE SYK INHIBITOR; PROTEIN RET; R 406; R 788; SUNITINIB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY MALFORMATION; ARTICLE; CARDIOVASCULAR MALFORMATION; CELL ASSAY; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG MEGADOSE; EMBRYOTOXICITY; ENZYME INHIBITION; EXPERIMENTAL RAT; FEMALE; GESTATIONAL AGE; KIDNEY AGENESIS; MALE; MORNING DOSAGE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RABBIT; RAT; REPRODUCTIVE TOXICITY; SKELETON MALFORMATION; SUBCLAVIAN ARTERY; TOXICITY TESTING; URETER MALFORMATION;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; CELLS, CULTURED; EMBRYONIC DEVELOPMENT; ENZYME INHIBITORS; FEMALE; INFERTILITY; MALE; OXAZINES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROTO-ONCOGENE PROTEINS C-RET; PYRIDINES; RABBITS; RATS; REPRODUCTION; TOXICITY TESTS;

MUS; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 62949223071     PISSN: 15420752     EISSN: 15420760     Source Type: Journal    
DOI: 10.1002/bdra.20505     Document Type: Article

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