Pattern recognition receptors and their role in invasive aspergillosis

Annals of the New York Academy of Sciences

Volumn 1273, Issue 1, 2012, Pages 60-67

  Gresnigt, Mark S ^a   Netea, Mihai G ^a   Van de Veerdonk, Frank L ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Aspergillus fumigatus; C type lectin receptors; Innate immune cells; NOD like receptors; Toll like receptors

Indexed keywords

BETA GLUCAN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CRYOPYRIN; DECTIN 1; GALACTOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 22; INTERLEUKIN 6; MANNOSE BINDING LECTIN; MYELOID DIFFERENTIATION FACTOR 88; PATTERN RECOGNITION RECEPTOR; PENTRAXIN 3; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA;

3' UNTRANSLATED REGION; ADAPTIVE IMMUNITY; ARTICLE; ASPERGILLUS FUMIGATUS; CD4+ T LYMPHOCYTE; CELL SURVIVAL; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVATION; FUNGAL COLONIZATION; FUNGUS HYPHAE; HUMAN; IMMUNOCOMPROMISED PATIENT; LUNG ASPERGILLOSIS; MACROPHAGE; MIXED INFECTION; MONOCYTE; MORTALITY; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TH1 CELL; TH17 CELL;

EID: 84870955007     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06759.x     Document Type: Article

References (58)

1. Meier, A. et al 2003. Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol. 5: 561-570.
2. Braedel, S. et al 2004. Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4. Br. J. Haematol. 125: 392-399.
3. Mambula, S.S. et al 2002. Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus. J. Biol. Chem. 277: 39320-39326.
4. Wang, J.E. et al 2001. Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae. Infect. Immun. 69: 2402-2406.
5. Netea, M.G. et al 2003. Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction. J. Infect. Dis. 188: 320-326.
6. Balloy, V. et al 2005. Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis. Infect. Immun. 73: 5420-5425.
7. Bellocchio, S. et al 2004. The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J. Immunol. 172: 3059-3069.
8. Rubino, I. et al 2012. Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6. J. Infect. Dis. 205: 944-954.
9. Carvalho, A. et al 2012. TLR3 essentially promotes protective class I-restricted memory CD8 T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients. Blood 119: 967-977.
10. Ramirez-Ortiz, Z.G. et al 2008. Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA. Infect. Immun. 76: 2123-2129.
11. Kasperkovitz, P.V., M.L. Cardenas & J.M. Vyas 2010. TLR9 is actively recruited to Aspergillus fumigatus phagosomes and requires the N-terminal proteolytic cleavage domain for proper intracellular trafficking. J. Immunol. 185: 7614-7622.
12. Chai, L.Y. et al 2009. Modulation of Toll-like receptor 2 (TLR2) and TLR4 responses by Aspergillus fumigatus. Infect. Immun. 77: 2184-2192.
13. Chai, L.Y. et al 2011. Aspergillus fumigatus cell wall components differentially modulate host TLR2 and TLR4 responses. Microbes. Infect. 13: 151-159.
14. Rodland, E.K. et al 2011. Toll like receptor 5 (TLR5) may be involved in the immunological response to Aspergillus fumigatus in vitro. Med. Mycol. 49: 375-379.
15. Bochud, P.Y. et al 2008. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N. Engl. J. Med. 359: 1766-1777.
16. de Boer, M.G. et al 2011. Influence of polymorphisms in innate immunity genes on susceptibility to invasive aspergillosis after stem cell transplantation. PLoS One 6: e18403.
17. Kesh, S. et al 2005. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Ann. N.Y. Acad. Sci. 1062: 95-103.
18. Steele, C. et al 2005. The beta-glucan receptor Dectin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog. 1: e42.
19. Gersuk, G.M. et al 2006. Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states. J. Immunol. 176: 3717-3724.
20. Hohl, T.M. et al 2005. Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display. PLoS Pathog 1: e30.
21. Werner, J.L. et al 2009. Requisite role for the Dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J. Immunol. 182: 4938-4946.
22. Chamilos, G. et al 2010. Generation of IL-23 producing dendritic cells (DCs) by airborne fungi regulates fungal pathogenicity via the induction of T(H)-17 responses. PLoS One 5: e12955.
23. Gessner, M.A. et al 2012. Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus. Infect. Immun. 80: 410-417.
24. Werner, J.L. et al 2011. Neutrophils produce interleukin 17A (IL-17A) in a Dectin-1- and IL-23-dependent manner during invasive fungal infection. Infect. Immun. 79: 3966-3977.
25. Romani, L. et al 2008. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature 451: 211-215.
26. Cunha, C. et al 2010. Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity. Blood 116: 5394-5402.
27. Chai, L.Y. et al 2011. The Y238X stop codon polymorphism in the human beta-glucan receptor Dectin-1 and susceptibility to invasive aspergillosis. J. Infect. Dis. 203: 736-743.
28. Sainz, J. et al 2012. Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection. PLoS One 7: e32273.
29. Serrano-Gomez, D. et al 2004. Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages. J. Immunol. 173: 5635-5643.
30. Park, S.J., M.D. Burdick & B. Mehrad 2012. Neutrophils mediate maturation and efflux of lung dendritic cells in response to Aspergillus germ tubes. Infect. Immun. 80: 1759-1765.
31. Chai, L.Y. et al 2010. Aspergillus fumigatus conidial melanin modulates host cytokine response. Immunobiology 215: 915-920.
32. Barrett, N.A. et al 2009. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J. Immunol. 182: 1119-1128.
33. Li, Z.Z. et al 2012. Role of NOD2 in regulating the immune response to Aspergillus fumigatus. Inflamm Res. 61: 643-648.
34. Ogura, Y. et al 2001. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411: 603-606.
35. Said-Sadier, N. et al 2010. Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase. PLoS One 5: e10008.
36. Madan, T. et al 2001. Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis. Infect. Immun. 69: 2728-2731.
37. Madan, T. et al 2010. Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis. Mol. Immunol. 47: 1923-1930.
38. Kaur, S. et al 2007. Protective role of mannan-binding lectin in a murine model of invasive pulmonary aspergillosis. Clin. Exp. Immunol. 148: 382-389.
39. Clemons, K.V. et al 2010. Resistance of MBL gene-knockout mice to experimental systemic aspergillosis. Immunol. Lett. 128: 105-107.
40. Lambourne, J. et al 2009. Association of mannose-binding lectin deficiency with acute invasive aspergillosis in immunocompromised patients. Clin. Infect. Dis. 49: 1486-1491.
41. Garlanda, C. et al 2002. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature 420: 182-186.
42. Moalli, F. et al 2010. Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus. Blood 116: 5170-5180.
43. D'Angelo, C. et al 2009. Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease. J. Immunol. 183: 4609-4618.
44. Lo Giudice, P. et al 2010. Efficacy of PTX3 in a rat model of invasive aspergillosis. Antimicrob. Agents Chemother. 54: 4513-4515.
45. Philippe, B. et al 2003. Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates. Infect. Immun. 71: 3034-3042.
46. Vethanayagam, R.R. et al 2011. Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense. PLoS One 6: e28149.
47. Bruns, S. et al 2010. Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA. PLoS Pathog. 6: e1000873.
48. McCormick, A. et al 2010. NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus. Microbes. Infect. 12: 928-936.
49. Bianchi, M. et al 2009. Restoration of NET formation by gene therapy in CGD controls aspergillosis. Blood 114: 2619-2622.
50. Bianchi, M. et al 2011. Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent. J. Allergy Clin. Immunol. 127: 1243-1252 e1247.
51. Ramirez-Ortiz, Z.G. et al 2011. A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatus. Cell Host Microbe 9: 415-424.
52. Rivera, A. et al 2011. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J. Exp. Med. 208: 369-381.
53. Rivera, A. et al 2011. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J. Exp. Med. 208: 369-381.
54. Rivera, A. et al 2006. Innate immune activation and CD4+ T cell priming during respiratory fungal infection. Immunity 25: 665-675.
55. Piggott, D.A. et al 2005. MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J. Clin. Invest. 115: 459-467.
56. Chignard, M. et al 2007. Role of Toll-like receptors in lung innate defense against invasive aspergillosis. Distinct impact in immunocompetent and immunocompromized hosts. Clin. Immunol. 124: 238-243.
57. von Bernuth, H. et al 2008. Pyogenic bacterial infections in humans with MyD88 deficiency. Science 321: 691-696.
58. Hsu, Y.M. et al 2007. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nature Immunol. 8: 198-205.