Metabonomic classification and detection of small molecule biomarkers of malignant pleural effusions

Analytical and Bioanalytical Chemistry

Volumn 404, Issue 10, 2012, Pages 3123-3133

  Zhou, Xian Mei ^a   He, Cui Cui ^b   Liu, Yu Mei ^b   Zhao, Yang ^a   Zhao, Dan ^b   Du, Yun ^b   Zheng, Wei Yi ^c   Li, Jian Xin ^b  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b NANJING UNIVERSITY   (China)

^c Nanjing High Tech Zone   (China)

Author keywords

1H NMR; Biomarkers; Discriminant function analysis (DFA); Lung cancer; Pleural effusions; Small molecules

Indexed keywords

CHEMICAL CONSTITUENTS; CLINICAL ANALYSIS; DISCRIMINANT FUNCTION ANALYSIS; LUNG CANCER; MEAN VALUES; METABOLIC PROFILES; METABONOMICS; NMR ANALYSIS; NMR SPECTRUM; PLEURAL EFFUSION; SIGNAL INTENSITIES; SMALL MOLECULES;

AMINO ACIDS; BIOMARKERS; CHEMICAL ANALYSIS; DISCRIMINANT ANALYSIS; DISEASES; FORECASTING; GLUCOSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

MOLECULES;

TUMOR MARKER;

ADULT; AGED; ARTICLE; FEMALE; HUMAN; MALE; MALIGNANT PLEURA EFFUSION; METABOLISM; METABOLOMICS; METHODOLOGY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; PLEURA CAVITY; VALIDATION STUDY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; MIDDLE AGED; PLEURAL CAVITY; PLEURAL EFFUSION, MALIGNANT; TUMOR MARKERS, BIOLOGICAL;

EID: 84870935520     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6432-6     Document Type: Article

References (41)

1. Oba Y, Abu-Salah T (2012) The prevalence and diagnostic significance of eosinophilic pleural effusions: a meta-analysis and systematic review. Respiration 83(3):198-208
2. Burgess LJ (2004) Biochemical analysis of pleural, peritoneal and pericardial effusions. Clin Chim Acta 343(1-2):61-84
3. McGrath EE, Blades Z, Needham J, Anderson PB (2009) A systematic approach to the investigation and diagnosis of a unilateral pleural effusion. Int J Clin Pract 63(11):1653-1659
4. Marel M, Zrustova M, Stasny B, Light RW (1993) The incidence of pleural effusion in a well-defined region. Epidemiologic study in central Bohemia. Chest 104(5):1486-1489
5. Johnston RF, Loo RV (1996) Hepatic hydrothorax. Studies to determine the source of fluid and report of 13 cases. Ann Intern Med 61(3):385-401
6. D'Souza R, Doshi A, Bhojraj S, Shetty P, Udwadia Z (2002) Massive pleural effusion as the presenting feature of a subarachnoid-pleural fistula. Respiration 69(1):96-99
7. Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P (2007) Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 18(3):581-592
8. Khurshid R, Shore N, Saleem M, Naz M, Zameer N (2009) Diagnostic significance of adenosine deaminase in pleural tuberculosis. J Ayub Med Coll Abbottabad 21(1):83-85
9. Porcel JM, Light RW (2008) Pleural effusions due to pulmonary embolism. Curr Opin Pulm Med 14(4):337-342
10. Hamm H, Light RW (1997) Parapneumonic effusion and empyema. Eur Respir J 10(5):1150-1156
11. Uzbeck MH, Almeida FA, Sarkiss MG, Morice RC, Jimenez CA, Eapen GA, Kennedy MP (2010) Management of malignant pleural effusions. Adv Ther 27(6):334-347
12. Porcel JM, Chorda J, Cao G, Esquerda A, Ruiz-Gonzalez A, Vives M (2007) Comparing serum and pleural fluid pro-brain natriuretic peptide (NT-proBNP) levels with pleural-to-serum albumin gradient for the identification of cardiac effusions misclassified by Light's criteria. Respirology 12:654-659
13. How SH, Liam CK, Chin SP, Med AZ (2005) The utility of tumor markers in the diagnosis of neoplastic pleural effusions. Int Med J 4(2):30-37
14. McGrath EE, Warriner D, Anderson PB (2010) The use of nonroutine pleural fluid analysis in the diagnosis of pleural effusion. Respir Med 104(8):1092-1100
15. Shitrit D, Zingerman B, Shitrit ABG, Shlomi D, Kramer MR (2005) Diagnostic value of CYFRA 21-1, CEA, CA 19-9, CA 15-3, and CA 125 assays in pleural effusions: analysis of 116 cases and review of the literature. Oncologist 10(7):501-507
16. Neragi-Miandoab S (2006) Malignant pleural effusion, current and evolving approaches for its diagnosis and management. Lung Cancer 54(1):1-9
17. Waters NJ, Waterfield CJ, Farrant RD, Holmes E, Nicholson JK (2005) Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity. Chem Res Toxicol 18(4):639-654
18. Nicholson JK, Connelly J, Lindon JC, Holmes E (2002) Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov 1(2):153-161
19. Garrod S, Humpher E, Connor SC, Connelly JC, Spraul M, Nicholson JK, Holmes E (2001) High-resolution 1H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue. Magn Reson Med 45(5):781-790
20. Holmes E, Nicholson JK, Nicholls AW, Lindon JC, Connor SC, Polley S, Connelly J (1998) The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine. Chemom Intell Lab Syst 44 (1-2):245-255
21. Shariff MIF, Ladep NG, Cox IJ, Williams HRT, Okeke E, Malu A, Thillainayagam AV, Crossey MME, Khan SA, Thomas HC, Taylor-Robinson SD (2010) Characterization of urinary biomarkers of hepatocellular carcinoma using magnetic resonance spectroscopy in a Nigerian population. J Proteome Res 9 (2):1096-1103
22. Tsutsui H, Maeda T, Toyo'oka T, Min JZ, Inagaki S, Higashi T, Kagawa Y (2010) Practical analytical approach for the identification of biomarker candidates in prediabetic state based upon metabonomic study by ultraperformance liquid chromatography coupled to electrospray ionization time-of-flight mass spectrometry. J Proteome Res 9(8):3912-3922
23. Wang CH, Gee MJ, Yang C, Su YC (2006) A new model for outcome prediction in intra-abdominal sepsis by the linear discriminant function analysis of IL-6 and IL-10 at different heart rates. J Surg Res 132(1):46-51
24. Sariyar-Akbulut B (2009) Rapid differentiation of new isolates with MALDI-TOF mass spectrometry via discriminant function analysis based on principal components. Korean J Chem Eng 26 (6):1645-1651
25. Tiziani S, Emwas AH, Lodi A, Ludwig C, Bunce CM, Viant MR, Günther UL (2008) Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopy. Ana Biochem 377(1):16-23
26. Nicholson JK, Lindon JC, Holmes E (1999) Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29(11):1181-1189
27. Holmes E, Foxall PJ, Nicholson JK, Neild GH, Brown SM, Beddell CR, Sweatman BC, Rahr E, Lindon JC, Spraul M (1994) Automatic data reduction and pattern recognition methods for analysis of 1H nuclear magnetic resonance spectra of human urine from normal and pathological states. Anal Biochem 220(2):284-296
28. LightMD (2002) Pleural effusion.NEngl JMed 346(25):1971-1977
29. Sturgeon C (2002) Practice guidelines for tumor marker use in the clinic. Clin Chem 48(8):1151-1159
30. Gedik GK, Kiratli PO, Tascioglu B, Aras T (2006) Comparison of bone scintigraphy with serum tumor markers of CA 15-3 and carcinoembryonic antigen in patients with breast carcinoma. Saudi Med J 27(3):317-322
31. Lai HS, Lee JC, Lee PH, Wang ST, Chen WJ (2005) Plasma free amino acid profile in cancer patients. Semin Cancer Biol 15 (4):267-276
32. Proenza AM, Oliver J, Palou A, Roca P (2003) Breast and lung cancer are associated with a decrease in blood cell amino acid content. J Nutr Biochem 14(3):133-138
33. Sauer LA, Dauchy RT (1998) Ketone body, glucose, lactic acid, and amino acid utilization by tumors in vivo in fasted rats. Cancer Res 43(8):3497-3503
34. Sauer LA, Blask DE, Dauchy RT (2007) Dietary factors and growth and metabolism in experimental tumors. J Nutr Biochem 18(10):637-649
35. Ferreira LMR (2010) Cancer metabolism: the Warburg effect today. Exp Mol Pathol 89(3):372-380
36. Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4(11):891-899
37. Sillos EM, Shenep JL, Burghen GA, Pui CH, Behm FG, Sandlund JT (2001) Lactic acidosis: a metabolic complication of hematologic malignancies: case report and review of the literature. Cancer 92 (9):2237-2246
38. Foxall PJD, Mellotte GJ, Bending MR, Lindon JC, Nicholson JK (1993) NMR spectroscopy as a novel approach to the monitoring of renal transplant function. Kidney Int 43(1):234-245
39. Kim KB, Yang JY, Kwack SJ, Park KL, Kim HS, Ryu DH, Kim YJ, Hwang GS, Lee BM (2010) Toxicometabolomics of urinary biomarkers for human gastric cancer in a mouse model. J Toxicol Environ Health A 73(21-22):1420-1430
40. Carrola J, Rocha CM, Barros AS, Gil AM, Goodfellow BJ, Carreira IM, Bernardo J, Gomes A, Sousa V, Carvalho L, Duarte IF (2011) Metabolic signatures of lung cancer in biofluids: NMRbased metabonomics of urine. J Proteome Res 10(1):221-230
41. Rocha CM, Carrola J, Barros AS, Gil AM, Goodfellow BJ, Carreira IM, Bernardo J, Gomes A, Sousa V, Carvalho L, Duarte IF (2011) Metabolic signatures of lung cancer in biofluids: NMRbased metabonomics of blood plasma. J Proteome Res 10 (9):4314-4324