Atrial remodeling: New pathophysiological mechanism of atrial fibrillation

Medical Hypotheses

Volumn 80, Issue 1, 2013, Pages 53-56

  Xu, Yanmin ^b   Sharma, Deepak ^a   Li, Guangping ^b   Liu, Yuzhi ^b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b Institute of Cardiovascular   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIAL; ARTICLE; CARDIOVASCULAR PARAMETERS; DEPOLARIZATION; HEART ATRIUM FIBRILLATION; HEART ATRIUM REMODELING; HEART CONDUCTION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY;

ATRIAL FIBRILLATION; ATRIAL FUNCTION; HEART ATRIA; HEART RATE; HUMANS; MODELS, CARDIOVASCULAR;

EID: 84870934402     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.10.009     Document Type: Article

References (62)

1. Murgatroyd F.D., Camm A.J. Atrial arrhythmias. Lancet 1993, 341:1317-1322.
2. Godtfredsen J. Etiology, course and prognosis. A follow-up study of 1212 cases. Copenhagen: University of Copenhagen. Thesis; 1975.
3. Wijffels M.C., Kirchhof C.J., Dorland R., Allessie M.A. Atrial fibrillaion begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation 1995, 92:1954-1968.
4. Brundel B.J.J.M., Van Gelder I.C., Henning R.H., Tuinenburg A.E., Tieleman R.G., Wietses M., et al. Ion channel remodeling is related to intra-operative atrial refractory periods in patients with paroxysmal and persistent atrial fibrillation. Circulation 2001, 103:684-690.
5. Ausma J., Wijffels M., Thone F., Wouters L., Allessie M., Borgers M. Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. Circulation 1997, 96:3157-3163.
6. Thijssen V.L.J.L., Ausma J., Liu G.S., Allessie M., Eys G.J.J.M., Borgers M. Structural changes of atrial myocardium during chronic atrial fibrillation. Cardiovasc Pathol 2000, 9:17-28.
7. Moe G.K., Abildskov J.A. Experimental and laboratory reports. Atrial fibrillation as a self-sustained arrhythmia independent of focal discharge. Am Heart J 1959, 58:59-67.
8. Nattel S., Maguy A., Le Bouter S., Yeh Y.H. Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev 2007, 87:425-456.
9. Yue L., Feng J., Gaspo R., Li G.-R., Wang Z., Nattel S. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ Res 1997, 81:512-525.
10. Cha T.J., Ehrlich J.R., Chartier D., Xiao L., Nattel S. Kir3-based inward rectifier potassium current: potential role in atrial tachycardia remodeling effects on atrial repolarization and arrhythmias. Circulation 2006, 113:1730-1737.
11. Velden H.M., Ausma J., Rook M.B., Hellemons A.J., vanVeen T.A., Allessie M.A., et al. Gap junctional remodeling in relation to stabilization of atrial fibrillation in the goat. Cardiovasc Res 2000, 46:476-486.
12. + current in a chronic dog model of atrial fibrillation. Circ Res 1997, 81:1045-1052.
13. Li D., Fareh S., Leung T.K., Nattel S. Promotion of atrial fibrillation by heart failure in dogs atrial remodeling of a different sort. Circulation 1999, 100:87-95.
14. Shinagawa K., Shi Y.F., Tardif J.C., Leung T.-K., Nattel S. Dynamic nature of atrial fibrillation substrate during development and reversal of heart Failure in dogs. Circulation 2002, 105:2672-2678.
15. Zou R., Kneller J., Leon L.J., Nattel S. Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atrium. Am J Physiol 2005, 289:H1002-H1012.
16. Shi Y., Ducharme A., Li D., Gaspo R., Nattel S., Tardif J.C. Remodeling of atrial dimensions and emptying function in canine models of atrial fibrillation. Cardiovasc Res 2001, 52:217-225.
17. Henry W.L., Morganroth J., Pearlman A.S., Clark C.E., Redwood D.R., Itscoitz S.B., et al. Relation between chocardiographically determined left atrial size and atrial fibrillation. Circulation 1976, 53:273-279.
18. f) channel mRNA in human atrial tissue: correlation with left atrial filling pressure and atrial fibrillation. Cardiovasc Electrophysiol 1999, 10:947-953.
19. Zicha S., Ferncndez-Velasco M., Lonardo G., Heureux N., Nattel S. Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model. Cardiovasc Res 2005, 66:472-481.
20. Stambler B.S., Fenelon G., Shepard R.K., Clemo H.F., Guiraudon C.M. Characterization of sustained atrial tachycardia in dogs with rapid ventricular pacing-induced heart failure. J Cardiovasc Electrophysiol 2003, 14:499-507.
21. Yeh Y.H., Wakili R., Qi X., Chartier D., Boknik P., Ravens U., et al. Calcium handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circ Arrhythmia Electrophysiol 2008, 1:293-302.
22. Chen Y.J., Chen S.A., Chen Y.C., Yeh H.I., Chan P., Chang M.S., et al. Effects of rapid atrial pacing on the arrhythmogenic activity of single cardiomyocytes from pulmonary veins: implication in initiation of atrial fibrillation. Circulation 2001, 104:2849-2854.
23. 2+-handling properties of canine pulmonary vein and left atrial cardiomyocytes. Am J Physiol 2006, 291:H2290-H2300.
24. Nattel S., Quantz M.A. Pharmacological response of quinidine induced early after depolarisations in canine cardiac Purkinje fibres: insights into underlying ionic mechanisms. Cardiovasc Res 1988, 22:808-817.
25. Satoh T., Zipes D.P. Cesium-induced atrial tachycardia degenerating into atrial fibrillation in dogs: atrial torsades de pointes?. J Cardiovasc Electrophysiol 1998, 9:970-975.
26. Burashnikov A., Antzelevitch C. Reinduction of atrial fibrillation immediately after termination of the arrhythmiais mediated by late phase 3 early after depolarization-induced triggered activity. Circulation 2003, 107:2355-2360.
27. Nattel S. New ideas about atrial fibrillation 50years on. Nature 2002, 415:219-226.
28. Wijffels M.C., Kirchhof C.J., Dorland R., Allessie M.A. Atrial fibrillation begets atrial fibrillation: a study in awake chronically instrumented goats. Circulation 1995, 92:1954-1968.
29. Burstein B., Qi X.Y., Yeh Y.H., Calderone A., Nattel S. Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling. Cardiovasc Res 2007, 76:442-452.
30. KACh and muscarinic receptor-mediated shortening of action potentials. Circulation 2001, 104:2551-2557.
31. KACh is constitutively active in patients with chronic atrial fibrillation. Circulation 2005, 112:3697-3706.
32. Sun H., Gaspo R., Leblanc N., Nattel S. Cellular mechanisms of atrial contractile dysfunction caused by sustained atrial tachycardia. Circulation 1998, 98:719-727.
33. Yue L., Melnyk P., Gaspo R., Wang Z., Nattel S. Molecular mechanisms Underlying ionic remodeling in a dog model of atrial fibrillation. Circ Res 1999, 84:776-784.
34. 2+ current density in chronic human atrial fibrillation isassociated with increased activity of protein phosphatases. Circulation 2004, 110:2651-2657.
35. Brundel B.J., Ausma J., vanGelder C., Vander W.J.J., vanGilst W.H., Crijns H.J., et al. Activation of proteolysis by calpains and structural changes in human paroxysmal and persistent atrial fibrillation. Cardiovasc Res 2002, 54:380-389.
36. 2+-handling by atrial tachycardia: evidence for a role in loss of rate-adaptation. Cardiovasc Res 2002, 54:416-426.
37. Brundel B.J., VanGelder I.C., Henning R.H., Tieleman R.G., Tuinenburg A.E., Wietses M., et al. Ion channel remodelling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation. Circulation 2001, 103:684-690.
38. 2+ channel subunits alpha1C and beta 2 are not down regulated in atrial myocardium of patients with chronic atrial fibrillation. J Mol Cell Cardiol 2003, 35:437-443.
39. Ca,L in patients with chronic atrial fibrillation. Naunyn Schmiedebergs Arch Pharmacol 2007, 375:383-392.
40. Gaborit N., Steenman M., Lamirault G., LeMeur N., LeBouter S., Lande G., et al. Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation 2005, 112:471-481.
41. to in rapid atrial pacing in rabbits. J Am Coll Cardiol 2003, 41:858-869.
42. Carnes C.A., Janssen P.M., Ruehr M.L., Nakayama H., Nakayama T., Haase H., et al. Atrial glutathione content, calcium current, and contractility. J Biol Chem 2007, 282:28063-28073.
43. Hara M., Shvilkin A., Rosen M.R., Danilo P.J., Boyden P.A. Steady-state and non steady-state action potentials in fibrillating canine atrium: abnormal rate adaptation and its possible mechanisms. Cardiovasc Res 1999, 42:455-469.
44. Kneller J., Zou R., Vigmond E.J., Wang Z., Leon L.J., Nattel S. Cholinergic atrial fibrillation in a computer model of a two-dimensional sheet of canine atrial cells with realistic ionic properties. Circ Res 2002, 90:E73-E87.
45. Yeh Y.-H., Lemola K., Nattel S. Vagal atrial fibrillation. Acta Cardiol Sin 2007, 23:1-12.
46. Ehrlich J.R., Cha T.J., Zhang L., Chartier D., Villeneuve L., Hébert T.E., et al. Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium. J Physiol 2004, 557:583-597.
47. K,ACH single channel activity with atrial tachycardia remodeling in canine atrial cardiomyocytes. Cardiovasc Res 2008, 77:35-43.
48. K,Ach channels in patients with chronic atrial fibrillation. Cardiovasc Res 2007, 74:426-437.
49. K,ATP current density and allosteric modulation during chronic atrial fibrillation. Chin Med J 2005, 118:1161-1166.
50. + current density during chronic human atrial fibrillation. J Mol Cell Cardiol 2003, 35:1399-1405.
51. + channels. J Am Coll Cardiol 2001, 37:926-932.
52. Goette A., Arndt M., Rocken C., Staack T., Bechtloff R., Reinhold D., et al. Calpains and cytokines in fibrillating human atria. Am J Physiol 2002, 283:H264-H272.
53. to transmural gradient in the mouse heart. Circ Res 2006, 98:1306-1313.
54. Bukowska A., Lendeckel U., Hirte D., Wolke C., Striggow F., Röhnert P., et al. Activation of the calcineurin signaling pathway induces atrial hypertrophy during atrial fibrillation. Cell Mol Life Sci 2006, 63:333-342.
55. Burstein B., Nattel S. Atrialfibrosis: mechanisms and clinical relevance in atrial fibrillation. J Am Coll Cardiol 2008, 51:802-809.
56. Katz A.M. Proliferative signaling and disease progression in heart failure. Circ J 2002, 66:225-231.
57. Xiao H.D., Fuchs S., Campbell D.J., Lewis W., Dudley S.C., Kasi V.S., et al. Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. Am J Pathol 2004, 165:1019-1032.
58. Hunyady L., Catt K.J. Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Mol Endocrinol 2006, 20:953-970.
59. Rosenkranz S. TGF-beta1 and angiotens in networking in cardiac remodeling. Cardiovasc Res 2004, 63:423-432.
60. Attisano L., Wrana J.L. Signal transduction by the TGF-beta superfamily. Science 2002, 296:1646-1647.
61. Verheule S., Sato T., Everett T.I.V., Engle S.K., Otten D., Rubart-vonder Lohe M., et al. Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibros is caused by over expression of TGF-beta1. Circ Res 2004, 94:1458-1465.
62. Burstein B., Libby E., Calderone A., Nattel S. Atrial fibroblasts are different from ventricular: a potential contributor to atrial-ventricular remodeling differences?. Circulation 2008, 117:1630-1641.