Evaluation of immunohistochemical markers to detect the genotoxic mode of action of fine and ultrafine dusts in rat lungs

Toxicology

Volumn 303, Issue , 2013, Pages 177-186

  Rittinghausen, Susanne ^a   Bellmann, Bernd ^a   Creutzenberg, Otto ^a   Ernst, Heinrich ^a   Kolling, Angelika ^a   Mangelsdorf, Inge ^a   Kellner, Rupert ^a   Beneke, Sascha ^b   Ziemann, Christina ^a  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Carbon black; Genotoxicity in vivo; Lungs; Nanoparticles; Oxidative DNA damage; Silica

Indexed keywords

8 HYDROXYGUANINE; AEROSIL; CARBON; DOUBLE STRANDED DNA; GLYCOSYLATED ALBUMIN; HISTONE H2AX; PARAFFIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); SILICON DIOXIDE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CELL NUCLEUS; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOPLASM; DISEASE MARKER; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DUST; GENOTOXICITY; IMMUNOHISTOCHEMISTRY; INHALATION; LUNG; LUNG ALVEOLUS; LUNG LAVAGE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN PHOSPHORYLATION; RAT; SCORING SYSTEM; TISSUE SECTION;

ANIMALS; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA GLYCOSYLASES; FEMALE; GUANOSINE; HISTONES; IMMUNOHISTOCHEMISTRY; LUNG; MUTAGENICITY TESTS; MUTAGENS; PARTICLE SIZE; PHOSPHOPROTEINS; POLY ADENOSINE DIPHOSPHATE RIBOSE; QUARTZ; RATS; RATS, WISTAR; SILICON DIOXIDE; SOOT;

RATTUS;

EID: 84870920591     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.11.007     Document Type: Article

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