Validation and clinical application of an UHPLC method for simultaneous analysis of total homocysteine and cysteine in human plasma

Journal of Separation Science

Volumn 35, Issue 24, 2012, Pages 3427-3433

  Valente, Ana ^a   Bronze, Maria Rosário ^b,c   Bicho, Manuel ^d,e   Duarte, Rui ^f   Costa, Helena Soares ^a  

^a NATIONAL INSTITUTE OF HEALTH DR RICARDO JORGE   (Portugal)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^c INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^d INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^e INSTITUTO DE INVESTIGAÇÃO CIENTÍFICA BENTO DA ROCHA CABRAL   (Portugal)

^f Portuguese Diabetes Association   (Portugal)

Author keywords

Cysteine; Homocysteine; Ultra HPLC; Validation

Indexed keywords

ANGIOPATHY; CARDIO-VASCULAR DISEASE; CLINICAL APPLICATION; CONCENTRATION RANGES; CYSTEINE; DERIVATIZATION REACTION; DIABETIC PATIENT; EPIDEMIOLOGICAL STUDIES; HOMOCYSTEINES; HPLC METHOD; HUMAN PLASMAS; HYPERHOMOCYSTEINEMIA; L-CYSTEINE; METHOD VALIDATIONS; MOBILE PHASE; OPTIMIZED CONDITIONS; PEAK SHAPES; RISK FACTORS; SIMULTANEOUS ANALYSIS; SOLVENT CONTENT; ULTRA HPLC; VALIDATED METHODS; VALIDATION; VALIDATION RESULTS;

ORGANIC SOLVENTS;

AMINO ACIDS;

CYSTEINE; HOMOCYSTEINE; ORGANIC SOLVENT;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ANALYTIC METHOD; ARTICLE; DERIVATIZATION; DIABETIC ANGIOPATHY; HUMAN; HYPERCYSTEINEMIA; HYPERHOMOCYSTEINEMIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PH; PLASMA; PREVALENCE; PRIORITY JOURNAL; REACTION TIME; SENSITIVITY ANALYSIS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; DIABETES MELLITUS, TYPE 2; HOMOCYSTEINE; HUMANS; HYDROGEN-ION CONCENTRATION; LIMIT OF DETECTION; REPRODUCIBILITY OF RESULTS;

EID: 84870914595     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201200672     Document Type: Article

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