Multiple signaling routes involved in the regulation of adenylyl cyclase and extracellular regulated kinase by dopamine D2 and D3 receptors

Pharmacological Research

Volumn 67, Issue 1, 2013, Pages 31-41

  Jin, Mingli ^a   Min, Chengchun ^a   Zheng, Mei ^a   Cho, Dong Im ^a   Cheong, Soo Jin ^a   Kurose, Hitosh ^b   Kim, Kyeong Man ^a  

^a Chonnam National University   (South Korea)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Angiotensin receptor; Pertussis toxin; Ubiquitination; Vasopressin receptor

Indexed keywords

ADENYLATE CYCLASE; BETA ARRESTIN; CYCLIC AMP; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL SPECIFICITY; CELL STRAIN COS7; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ANIMALS; ARRESTINS; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC AMP; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GTP-BINDING PROTEINS; HEK293 CELLS; HUMANS; PROTEIN SUBUNITS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; SIGNAL TRANSDUCTION;

EID: 84870902827     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.09.012     Document Type: Article

References (40)

1. E.S. Lander, L.M. Linton, B. Birren, C. Nusbaum, M.C. Zody, and J. Baldwin Initial sequencing and analysis of the human genome Nature 409 2001 860 921
2. J.C. Venter, M.D. Adams, E.W. Myers, P.W. Li, R.J. Mural, and G.G. Sutton The sequence of the human genome Science 291 2001 1304 1351
3. E.H. Hurowitz, J.M. Melnyk, Y.J. Chen, H. Kouros-Mehr, M.I. Simon, and H. Shizuya Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes DNA Research 7 2000 111 120
4. J.C. Mobarec, and M. Filizola Advances in the development and application of computational methodologies for structural modeling of G-protein coupled receptors Expert Opinion on Drug Discovery 3 2008 343 355
5. R.S. Ostrom, and P.A. Insel The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology British Journal of Pharmacology 143 2004 235 245
6. S.S. Ferguson, W.E. Downey 3rd, A.M. Colapietro, L.S. Barak, L. Menard, and M.G. Caron Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization Science 271 1996 363 366
7. T.A. Kohout, F.S. Lin, S.J. Perry, D.A. Conner, and R.J. Lefkowitz beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking Proceedings of the National Academy of Sciences of the United States of America 98 2001 1601 1606
8. S. Ahn, S.K. Shenoy, H. Wei, and R.J. Lefkowitz Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor Journal of Biological Chemistry 279 2004 35518 35525
9. S.J. Kim, M.Y. Kim, E.J. Lee, Y.S. Ahn, and J.H. Baik Distinct regulation of internalization and mitogen-activated protein kinase activation by two isoforms of the dopamine D2 receptor Molecular Endocrinology 18 2004 640 652
10. H. Lan, Y. Liu, M.I. Bell, V.V. Gurevich, and K.A. Neve A dopamine D2 receptor mutant capable of G protein-mediated signaling but deficient in arrestin binding Molecular Pharmacology 75 2009 113 123
11. W. Quan, J.H. Kim, P.R. Albert, H. Choi, and K.M. Kim Roles of G protein and beta-arrestin in dopamine D2 receptor-mediated ERK activation Biochemical and Biophysical Research Communications 377 2008 705 709
12. J.M. Beaulieu, T.D. Sotnikova, S. Marion, R.J. Lefkowitz, R.R. Gainetdinov, and M.G. Caron An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior Cell 122 2005 261 273
13. B. Giros, M.P. Martres, P. Sokoloff, and J.C. Schwartz Gene cloning of human dopaminergic D3 receptor and identification of its chromosome Comptes Rendus de l' Academie des Sciences. Serie III, Sciences de la Vie 311 1990 501 508
14. C. Missale, S.R. Nash, S.W. Robinson, M. Jaber, and M.G. Caron Dopamine receptors: from structure to function Physiological Reviews 78 1998 189 225
15. P. Sokoloff, B. Giros, M.P. Martres, M.L. Bouthenet, and J.C. Schwartz Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics Nature 347 1990 146 151
16. J. Diaz, C. Pilon, B. Le Foll, C. Gros, A. Triller, and J.C. Schwartz Dopamine D3 receptors expressed by all mesencephalic dopamine neurons Journal of Neuroscience 20 2000 8677 8684
17. E.V. Gurevich, and J.N. Joyce Distribution of dopamine D3 receptor expressing neurons in the human forebrain: comparison with D2 receptor expressing neurons Neuropsychopharmacology 20 1999 60 80
18. M.H. Ghahremani, P. Cheng, P.M. Lembo, and P.R. Albert Distinct roles for Galphai2, Galphai3, and Gbeta gamma in modulation offorskolin- or Gs-mediated cAMP accumulation and calcium mobilization by dopamine D2S receptors Journal of Biological Chemistry 274 1999 9238 9245
19. S. Beom, D. Cheong, G. Torres, M.G. Caron, and K.M. Kim Comparative studies of molecular mechanisms of dopamine D2 and D3 receptors for the activation of extracellular signal-regulated kinase Journal of Biological Chemistry 279 2004 28304 28314
20. K.Y. Kim, K.C. Choi, S.H. Park, N. Auersperg, and P.C. Leung Extracellular signal-regulated protein kinase, but not c-Jun N-terminal kinase, is activated by type II gonadotropin-releasing hormone involved in the inhibition of ovarian cancer cell proliferation Journal of Clinical Endocrinology and Metabolism 90 2005 1670 1677
21. R.H. Oakley, S.A. Laporte, J.A. Holt, M.G. Caron, and L.S. Barak Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors Journal of Biological Chemistry 275 2000 17201 17210
22. X. Zhang, F. Wang, X. Chen, Y. Chen, and L. Ma Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms Journal of Neurochemistry 106 2008 781 792
23. D. Cho, M. Zheng, C. Min, L. Ma, H. Kurose, and J.H. Park Agonist-induced endocytosis and receptor phosphorylation mediate resensitization of dopamine D(2) receptors Molecular Endocrinology 24 2010 574 586
24. M.G. Hearn, Y. Ren, E.W. McBride, I. Reveillaud, M. Beinborn, and A.S. Kopin A drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants Proceedings of the National Academy of Sciences of the United States of America 99 2002 14554 14559
25. A. Himmler, C. Stratowa, and A.P. Czernilofsky Functional testing of human dopamine D1 and D5 receptors expressed in stable cAMP-responsive luciferase reporter cell lines Journal of Receptor Research 13 1993 79 94
26. K.M. Kim, K.J. Valenzano, S.R. Robinson, W.D. Yao, L.S. Barak, and M.G. Caron Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins Journal of Biological Chemistry 276 2001 37409 37414
27. M. Rossi, A. Dimida, M.T. Dell'anno, M.L. Trincavelli, P. Agretti, and F. Giorgi The thyroid disruptor 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane appears to be an uncompetitive inverse agonist for the thyrotropin receptor Journal of Pharmacology and Experimental Therapeutics 320 2007 465 474
28. S. Ahn, H. Wei, T.R. Garrison, and R.J. Lefkowitz Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2 Journal of Biological Chemistry 279 2004 7807 7811
29. S.K. Shenoy, L.S. Barak, K. Xiao, S. Ahn, M. Berthouze, and A.K. Shukla Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation Journal of Biological Chemistry 282 2007 29549 29562
30. S.K. Shenoy, M.T. Drake, C.D. Nelson, D.A. Houtz, K. Xiao, and S. Madabushi Beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor Journal of Biological Chemistry 281 2006 1261 1273
31. A. Tohgo, E.W. Choy, D. Gesty-Palmer, K.L. Pierce, S. Laporte, and R.H. Oakley The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation Journal of Biological Chemistry 278 2003 6258 6267
32. K.M. Kim, and M.G. Caron Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction Biochemical and Biophysical Research Communications 366 2008 42 47
33. S.K. Shenoy, P.H. McDonald, T.A. Kohout, and R.J. Lefkowitz Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin Science 294 2001 1307 1313
34. S.K. Shenoy, A.S. Modi, A.K. Shukla, K. Xiao, M. Berthouze, and S. Ahn Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2 Proceedings of the National Academy of Sciences of the United States of America 106 2009 6650 6655
35. S.K. Shenoy, and R.J. Lefkowitz Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination Journal of Biological Chemistry 278 2003 14498 14506
36. R.J. Lefkowitz, K.L. Pierce, and L.M. Luttrell Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity Molecular Pharmacology 62 2002 971 974
37. M. Jiang, K. Spicher, G. Boulay, Y. Wang, and L. Birnbaumer Most central nervous system D2 dopamine receptors are coupled to their effectors by Go Proceedings of the National Academy of Sciences of the United States of America 98 2001 3577 3582
38. M.J. Millan, C. Mannoury la Cour, F. Novi, R. Maggio, V. Audinot, and A. Newman-Tancredi S33138 [N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]- benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent: I. Receptor-binding profile and functional actions at G-protein-coupled receptors Journal of Pharmacology and Experimental Therapeutics 324 2008 587 599
39. J.R. Lane, B. Powney, A. Wise, S. Rees, and G. Milligan G protein coupling and ligand selectivity of the D2L and D3 dopamine receptors Journal of Pharmacology and Experimental Therapeutics 325 2008 319 330
40. P.G. Zaworski, G.L. Alberts, J.F. Pregenzer, W.B. Im, J.L. Slightom, and G.S. Gill Efficient functional coupling of the human D3 dopamine receptor to G(o) subtype of G proteins in SH-SY5Y cells British Journal of Pharmacology 128 1999 1181 1188