Detection of Merkel cell polyomavirus in chronic lymphocytic leukemia T-cells

Experimental and Molecular Pathology

Volumn 94, Issue 1, 2013, Pages 40-44

  Cimino, Patrick J ^a   Bahler, David W ^b   Duncavage, Eric J ^a  

^a WASHINGTON UNIVERSITY   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Chronic lymphocytic leukemia; CLL; Merkel cell; Polyomavirus

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; B LYMPHOCYTE; CHRONIC LYMPHATIC LEUKEMIA; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; MERKEL CELL POLYOMAVIRUS; MERKEL CELL TUMOR; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; STEREOTYPY; T CELL LEUKEMIA; T LYMPHOCYTE; TROPISM; VIRUS DETECTION;

B-LYMPHOCYTES; DNA, VIRAL; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MERKEL CELL POLYOMAVIRUS; POLYOMAVIRUS INFECTIONS; T-LYMPHOCYTES; TUMOR VIRUS INFECTIONS;

POLYOMAVIRUS;

EID: 84870874981     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2012.09.019     Document Type: Article

References (23)

1. Chang Y., Moore P.S. Merkel cell carcinoma: a virus-induced human cancer. Annual Review of Pathology 2012, 7:123-144.
2. Comar M., et al. Merkel-cell polyomavirus (MCPyV) is rarely associated to B-chronic lymphocytic leukemia (1 out of 50) samples and occurs late in the natural history of the disease. Journal of Clinical Virology 2012, (Epub ahead of print).
3. Feng H., et al. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008, 319:1096-1100.
4. Haugg A.M., et al. Fluorescence in situ hybridization confirms the presence of Merkel cell polyomavirus in chronic lymphocytic leukemia cells. Blood 2011, 117:5776-5777.
5. Johnson T.A., et al. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. Journal of Immunology 1997, 158:235-246.
6. Kaae J., et al. Merkel cell carcinoma: incidence, mortality, and risk of other cancers. Journal of the National Cancer Institute 2010, 102:793-801.
7. Koljonen V., et al. Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma. British Journal of Cancer 2009, 101:1444-1447.
8. Koljonen V., et al. Second cancers following the diagnosis of Merkel cell carcinoma: a nationwide cohort study. Cancer Epidemiology 2010, 34:62-65.
9. Pancaldi C., et al. Merkel cell polyomavirus DNA sequences in the buffy coats of healthy blood donors. Blood 2011, 117:7099-7101.
10. Pantulu N.D., et al. Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cells. Blood 2010, 116:5280-5284.
11. Robles C., et al. Antibody response to merkel cell polyomavirus associated with incident lymphoma in the epilymph case-control study in Spain. Cancer Epidemiology, Biomarkers & Prevention 2012, 21:1592-1598.
12. Rosen A., et al. Antigens in chronic lymphocytic leukemia-implications for cell origin and leukemogenesis. Seminars in Cancer Biology 2010, 20:400-409.
13. Schrama D., et al. Merkel cell carcinoma: recent insights and new treatment options. Current Opinion in Oncology 2012, 24:141-149.
14. Shuda M., et al. Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. International Journal of Cancer 2009, 125:1243-1249.
15. Tadmor T., et al. Merkel cell carcinoma, chronic lymphocytic leukemia and other lymphoproliferative disorders: an old bond with possible new viral ties. Annals of Oncology 2011, 22:250-256.
16. Teman C.J., et al. Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma. Leukemia Research 2011, 35:689-692.
17. ter Brugge P.J., et al. A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood 2009, 114:119-127.
18. Tolstov Y.L., et al. Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. International Journal of Cancer 2009, 125:1250-1256.
19. Tolstov Y.L., et al. Lack of evidence for direct involvement of Merkel cell polyomavirus (MCV) in chronic lymphocytic leukemia (CLL). Blood 2010, 115:4973-4974.
20. Toracchio S., et al. Lymphotropism of Merkel cell polyomavirus infection, Nova Scotia, Canada. Emerging Infectious Diseases 2010, 16:1702-1709.
21. Touze A., et al. Merkel cell polyomavirus strains in patients with Merkel cell carcinoma. Emerging Infectious Diseases 2009, 15:960-962.
22. Touze A., et al. Generation of Merkel cell polyomavirus (MCV)-like particles and their application to detection of MCV antibodies. Journal of Clinical Microbiology 2010, 48:1767-1770.
23. Tsakou E., et al. Partial versus productive immunoglobulin heavy locus rearrangements in chronic lymphocytic leukemia: implications for B-cell receptor stereotypy. Molecular Medicine 2012, 18:138-145.