Erratum to: Partial versus Productive Immunoglobulin Heavy Locus Rearrangements in Chronic Lymphocytic Leukemia: Implications for B-Cell Receptor Stereotypy (Molecular Medicine, (2012), 18, 1, (138-145), 10.2119/molmed.2011.00216);Partial versus productive immunoglobulin heavylocus rearrangements in chronic lymphocytic leukemia: Implications for B-cell receptor stereotypy

Molecular Medicine

Volumn 18, Issue 1, 2012, Pages 138-145

  Tsakou, Eugenia ^a,b   Agathagelidis, Andreas ^c,d   Boudjoghra, Myriam ^e   Raff, Thorsten ^f   Dagklis, Antonis ^c   Chatzouli, Maria ^b   Smilevska, Tatjana ^d   Bourikas, George ^a   Merle Beral, Helene ^e   Manioudaki Kavallieratou, Eleni ^b   Anagnostopoulos, Achilles ^c   Brüggemann, Monika ^f   Davi, Frederic ^e   Stamatopoulos, Kostas ^c,d   Belessi, Chrysoula ^b  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b GENERAL HOSPITAL OF NIKEA   (Greece)

^c INFORMATION TECHNOLOGIES INSTITUTE   (Greece)

^d G PAPANICOLAOU HOSPITAL   (Greece)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^f UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; PEPTIDE DERIVATIVE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DEVELOPMENTAL STAGE; GENE FREQUENCY; GENE LOCUS; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROPHILICITY; IGHD GENE; IGHD3 3 GENE; IGHD6 19 GENE; IGHJ GENE; IGHV GENE; IMMUNOGLOBULIN HEAVY CHAIN GENE; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SEQUENCE ANALYSIS; STEREOTYPY; STOP CODON;

EID: 84856996868     PISSN: 10761551     EISSN: 15283658     Source Type: Journal    
DOI: 10.2119/molmed.2011.00216.erratum     Document Type: Erratum

References (43)

1. Lefranc MP, Lefranc G. (2001) The Immunoglobulin FactsBook. London: Academic Press. 457 pp.
2. Schissel MS. (2003) Regulating antigen-receptor gene assembly. Nat. Rev. Immunol. 3:890-9.
3. Schatz DG, Spanopoulou E. (2005) Biochemistry of V(D)J recombination. Curr. Top. Microbiol. Immunol. 290:49-85.
4. Zemlin M, et al. (2005) Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures. J. Mol. Biol. 334:733-49.
5. Chiorazzi N, Ferrarini M. (2011) Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood. 117:1781-91.
6. Darzentas N, et al. (2010) A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence. Leukemia. 241:125-32.
7. Lanemo Myhrinder A, et al. (2008) A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood. 111:3838-48.
8. Chu CC, et al. (2008) Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood. 112:5122-9.
9. Rosen A, Murray F, Evaldsson C, Rosenquist R. (2010) Antigens in chronic lymphocytic leukemia: implications for cell origin and leuke-mogenesis. Semin. Cancer Biol. 20:400-6.
10. Johnson TA, Rassenti LZ, Kipps TJ. (1997) Ig VH1 genes expressed in B cell chronic lympho-cytic leukemia exhibit distinctive molecular features. J. Immunol. 158:235-46.
11. Bertrad FE III, et al. (1997) Ig D(H) gene segment transcription and rearrangement before surface expression of the pan-B-cell marker CD19 in normal human bone marrow. Blood. 90:736-44.
12. Davi F, et al. (1997) Early onset of immunoglobu-lin heavy chain gene rearrangements in normal human bone marrow CD34+ cells. Blood. 90:4014-21.
13. Gu H, Kitamura D, Rajewsky K. (1991) B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound D mu protein and selection of DH element reading frames. Cell. 65:47-54.
14. Tinfata T, Tinfata R, Reth M. (1991) Cell surface expression of the short immunoglobulin mu chain (D mu protein) in murine pre-B cells is differently regulated from that of the intact mu chain. Eur. J. Immunol. 21:1359-63.
15. Shimizu T, Yamagishi H. (1992) Biased reading frames of pre-existing DH-JH coding joints and preferential nucleotide insertions at VH-DJH signal joints of excision products of immunoglob-ulin heavy chain gene rearrangements. EMBO J. 11:4869-75.
16. Cohn M. (2008) A hypothesis accounting for the paradoxical expression of the D gene segment in the BCR and the TCR. Eur. J. Immunol. 38:1779-87.
17. Ivanov II, Link J, Ippolito GC, Schroeder HW Jr. (2002) Constraints on the Hydropathicity and Sequence Composition of HCDR3 are Conserved Across Evolution. In: The Antibodies. Volume 7. Capra JD, Zanetti M (eds.) Taylor & Francis Inc, New York, pp. 43-67.
18. Zemlin M, et al. (2008) Regulation of repertoire development through genetic control of DH reading frame preference. J. Immunol. 181:8416-24.
19. Reth MG, Alt FW. (1984) Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells. Nature. 312:418-23.
20. Horne MC, Roth PE, DeFranco AL. (1996) Assembly of the truncated immunoglobulin heavy chain D mu into antigen receptor-like complexes in pre-B cells but not in B cells. Immunity. 4:145-58.
21. Szczepa-ski T, et al. (2001) Precursor-B-ALL with D(H)-J(H) gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14. Leukemia. 15:1415-23.
22. González D, et al. (2003) Incomplete DJH rearrangements of the IgH gene are frequent in multiple myeloma patients: immunobiological characteristics and clinical implications. Leukemia. 17:1398-403.
23. Martín-Jiménez P, et al. (2007) Molecular characterization of complete and incomplete im-munoglobulin heavy chain gene rearrangements in hairy cell leukemia. Clin. Lymphoma Myeloma. 7:573-9.
24. González D, et al. (2005) Molecular characteristics and gene segment usage in IGH gene rearrangements in multiple myeloma. Haematologica. 90:906-13.
25. Hallek M, et al. (2008) Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 111:5446-56.
26. van Dongen JJ, et al. (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 17:2257-317.
27. Stamatopoulos K, et al. (2007) Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood. 109:259-70.
28. Brochet X, Lefranc MP, Giudicelli V. (2008) IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res. 36:W503-8.
29. Lefranc MP, et al. (2009) IMGT, the international ImMunoGeneTics information system. Nucleic Acids Res. 37:D1006-12.
30. Murray F, et al. (2008) Stereotyped patterns of somatic hypermutation in infsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood. 111:1524-33.
31. Fais F, et al. (1998) Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J. Clin. Invest. 102:1515-25.
32. Tschumper RC, et al. (2008) Immunoglobulin diversity gene usage predicts unfavorable outcome in a infset of chronic lymphocytic leukemia patients. J. Clin. Invest. 118:306-15.
33. Agathaggelidis A, et al. (2010) The composition of the B cell receptor repertoire in 7428 cases of chronic lymphocytic leukemia: one third stereotyped, two third heterogeneous. What does this mean? Blood. 116:43.
34. Zemlin M, et al. (2003) Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures. J. Mol. Biol. 334:733-49.
35. Klein U, et al. (1998) Somatic hypermutation in normal and transformed human B cells. Immunol. Rev. 162:261-80.
36. Dörner T, Foster SJ, Farner NL, Lipsky PE. (1998) Somatic hypermutation of human immunoglob-ulin heavy chain genes: targeting of RGYW motifs on both DNA strands. Eur. J. Immunol. 28:3384-96.
37. Goossens T, Klein U, Küppers R. (1998) Frequent occurrence of deletions and duplications during somatic hypermutation: implications for onco-gene translocations and heavy chain disease. Proc. Natl. Acad. Sci. U.S.A. 95:2463-8.
38. Belessi C, et al. (2005) Analysis of expressed and non-expressed IGK locus rearrangements in chronic lymphocytic leukemia. Mol. Med. 11:52-8.
39. Sen R, Oltz E. (2006) Genetic and epigenetic regulation of IgH gene assembly. Curr. Opin. Immunol. 18:237-42.
40. Forconi F, et al. (2010) The normal IGHV1-69-de-rived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL. Blood. 115:71-7.
41. Raaphorst FM, Raman CS, Tami J, Fischbach M, Sanz I. (1997) Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences. Int. Immunol. 9:1503-15.
42. Ippolito GC, et al. (2006) Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production. J. Exp. Med. 203:1567-78.
43. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C. (1991) Sequences of Proteins of Immuno-logical Interest. 5th Edition. Bethesda (MD): U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health. NIH publ. no. 91-3242.