The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity

Journal of Neuroinflammation

Volumn 9, Issue , 2012, Pages

  Fang, Jie ^a   Han, Deping ^b   Hong, Jinsheng ^b   Tan, Qi ^c   Tian, Yeping ^c  

^a Tongji University School of Medicine   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Astrocyte; Chemokines; Glutamate transporter; Lipid rafts; MIP 2

Indexed keywords

CAVEOLIN 1; FLOTILLIN 1; LACTATE DEHYDROGENASE; MACROPHAGE INFLAMMATORY PROTEIN 2; MACROPHAGE INFLAMMATORY PROTEIN 2 GAMMA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXCITOTOXICITY; FLOW CYTOMETRY; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GLT1 GENE; IN VITRO STUDY; LIPID RAFT; MIP 2GAMMA GENE; MOUSE; NERVE CELL CULTURE; NEURONAL SENSITIVITY; NEUROPATHOLOGY; NEUROTOXICITY; NEUTROPHIL CHEMOTAXIS; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYSICAL SENSITIVITY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 84870861250     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-267     Document Type: Article

References (23)

1. Beart PM, O'Shea RD. Transporters for l-glutamate: an update on their molecular pharmacology and pathological involvement. Br J Pharmacol 2007, 150:5-17. 2013845, 17088867.
2. Kaul M, Garden GA, Lipton SA. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 2001, 410:988-994. 10.1038/35073667, 11309629.
3. Mitosek-Szewczyk K, Sulkowski G, Stelmasiak Z, Struzyńska L. Expression of glutamate transporters GLT-1 and GLAST in different regions of rat brain during the course of experimental autoimmune encephalomyelitis. Neuroscience 2008, 155:45-52. 10.1016/j.neuroscience.2008.05.025, 18572325.
4. Rossi DJ, Brady JD, Mohr C. Astrocyte metabolism and signaling during brain ischemia. Nat Neurosci 2007, 10:1377-1386. 10.1038/nn2004, 17965658.
5. Shigeri Y, Seal RP, Shimamoto K. Molecular pharmacology of glutamate transporters, EAATs and VGLUTs. Brain Res Brain Res Rev 2004, 45:250-265.
6. Halassa MM, Haydon PG. Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu Rev Physiol 2010, 72:335-355. 10.1146/annurev-physiol-021909-135843, 3117429, 20148679.
7. van Neerven S, Nemes A, Imholz P, Regen T, Denecke B, Johann S, Beyer C, Hanisch UK, Mey J. Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid. J Neurochem 2010, 114:1511-1526.
8. Carpentier PA, Begolka WS, Olson JK, Elhofy A, Karpus WJ, Miller SD. Differential activation of astrocytes by innate and adaptive immune stimuli. Glia 2004, 49:360-374.
9. McKimmie CS, Graham GJ. Astrocytes modulate the chemokine network in a pathogen-specific manner. Biochem Biophys Res Commun 2010, 394:1006-1011. 10.1016/j.bbrc.2010.03.111, 20331977.
10. Dhillon NK, Williams R, Callen S, Zien C, Narayan O, Buch S. Roles of MCP-1 in development of HIV-dementia. Front Biosci 2008, 13:3913-3918. 2715276, 18508485.
11. Fuhrmann M, Bittner T, Jung CK, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, Herms J. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat Neurosci 2010, 13:411-413. 10.1038/nn.2511, 20305648.
12. Hamann I, Zipp F, Infante-Duarte C. Therapeutic targeting of chemokine signaling in Multiple Sclerosis. J Neurol Sci 2008, 274:31-38. 10.1016/j.jns.2008.07.005, 18706659.
13. Cao X, Zhang W, Wan T, He L, Chen T, Yuan Z, Ma S, Yu Y, Chen G. Molecular cloning and characterization of a novel CXC chemokine macrophage inflammatory protein-2 gamma chemoattractant for human neutrophils and dendritic cells. J Immunol 2000, 165:2588-2595.
14. Han D, Tian Y, Zhang M, Zhou Z, Lu J. Prevention and treatment of experimental autoimmune encephalomyelitis with recombinant adeno-associated virus-mediated alpha-melanocyte-stimulating hormone-transduced PLP139-151-specific T cells. Gene Ther 2007, 14:383-395. 10.1038/sj.gt.3302862, 17066098.
15. Sui G, Soohoo C, Affar el B, Gay F, Shi Y, Forrester WC, Shi Y. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci U S A 2002, 16:5515-5520.
16. Poulsen CF, Schousboe I, Sarup A, White HS, Schousboe A. Effect of topiramate and dBcAMP on expression of the glutamate transporters GLAST and GLT-1 in astrocytes cultured separately, or together with neurons. Neurochem Int 2006, 48:657-661. 10.1016/j.neuint.2006.01.006, 16524645.
17. Skytt DM, Madsen KK, Paje{ogonek}cka K, Schousboe A, Waagepetersen HS. Characterization of primary and secondary cultures of astrocytes prepared from mouse cerebral cortex. Neurochem Res 2010, 35:2043-2052. 10.1007/s11064-010-0329-6, 21127969.
18. González MI, Krizman-Genda E, Robinson MB. Caveolin-1 regulates the delivery and endocytosis of the glutamate transporter, excitatory amino acid carrier 1. J Biol Chem 2007, 282:29855-29865. 10.1074/jbc.M704738200, 17715130.
19. Zschocke J, Bayatti N, Behl C. Caveolin and GLT-1 gene expression is reciprocally regulated in primary astrocytes: association of GLT-1 with non-caveolar lipid rafts. Glia 2005, 49:275-287. 10.1002/glia.20116, 15494979.
20. Lee ES, Sidoryk M, Jiang H, Yin Z, Aschner M. Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes. J Neurochem 2009, 110:530-544. 10.1111/j.1471-4159.2009.06105.x, 19453300.
21. Florio T, Schettini G. Chemokines, their receptors and significance in brain function. Immune Biol 2008, 6:242-273.
22. Rostène W, Guyon A, Kular L, Godefroy D, Barbieri F, Bajetto A, Banisadr G, Callewaere C, Conductier G, Rovère C, Mélik-Parsadaniantz S, Florio T. Chemokines and chemokine receptors: New actors in neuroendocrine regulations. Front Neuroendocrinol 2011, 32:10-24. 10.1016/j.yfrne.2010.07.001, 20624414.
23. Sanchez A, Tripathy D, Grammas P. RANTES release contributes to the protective action of PACAP38 against sodium nitroprusside in cortical neurons. Neuropeptides 2009, 43:315-320. 10.1016/j.npep.2009.05.002, 2726654, 19497618.