Polypharmacy in attention deficit hyperactivity disorder treatment: Current status, challenges and next steps

Current Psychiatry Reports

Volumn 14, Issue 5, 2012, Pages 447-449

  Bussing, Regina ^a   Winterstein, Almut G ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

ADHD; Alpha agonists; Antidepressants; Attention deficit hyperactivity disorder; Comorbidity; Pharmacoepidemiology; Polypharmacy; Quality of care; Second generation atypical antipsychotics; Side effects; Sleep disturbance; Stimulant medications; Treatment guidelines

Indexed keywords

ANTIDEPRESSANT AGENT; NEUROLEPTIC AGENT; PSYCHOSTIMULANT AGENT;

AGGRESSION; AMBULATORY CARE; ATTENTION DEFICIT DISORDER; CHILD HEALTH CARE; COMPARATIVE EFFECTIVENESS; DISRUPTIVE BEHAVIOR; DOCTOR PATIENT RELATION; DRUG EFFICACY; DRUG SAFETY; ELDERLY CARE; ELECTRONIC MEDICAL RECORD; EVIDENCE BASED MEDICINE; GEOGRAPHIC DISTRIBUTION; HEALTH CARE POLICY; HUMAN; MEDICAL DECISION MAKING; MENTAL HEALTH CARE; NOTE; PHARMACOEPIDEMIOLOGY; POLYPHARMACY; PRESCRIPTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK BENEFIT ANALYSIS; VULNERABLE POPULATION;

ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; DOPAMINE AGENTS; HUMANS; POLYPHARMACY;

EID: 84870799688     PISSN: 15233812     EISSN: 15351645     Source Type: Journal    
DOI: 10.1007/s11920-012-0295-6     Document Type: Note

References (23)

1. Lipton HL, Bero LA, Bird JA, McPhee SJ. The impact of clinical pharmacists' consultations on physicians' geriatric drug prescribing. A randomized controlled trial. Med Care. 1992;30:646-58.
2. Schmader K, Hanlon JT, Weinberger M, Landsman PB, Samsa GP, Lewis I, et al. Appropriateness of medication prescribing in ambulatory elderly patients. J Am Geriatr Soc. 1994;42:1241-7. (Pubitemid 24377524)
3. Schmader KE, Hanlon JT, Pieper CF, Sloane R, Ruby CM, Twersky J, et al. Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly. Am J Med. 2004;116:394-401. (Pubitemid 38299484)
4. Sergi G, De Rui M, Sarti S, et al. Polypharmacy in the elderly: Can comprehensive geriatric assessment reduce inappropriate medication use? Drugs Aging. 2011;28:509-18.
5. Hajjar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. Am J Geriatr Pharmacother. 2007;5:345-51.
6. Rochon PA, Gurwitz JH. Optimising drug treatment for elderly people: the prescribing cascade. BMJ. 1997;315:1096-9. (Pubitemid 27458409)
7. Viktil KK, Blix HS, Moger TA, Reikvam A. Polypharmacy as commonly defined is an indicator of limited value in the assessment of drug-related problems. Br J Clin Pharmacol. 2007;63:187-95. (Pubitemid 46072105)
8. Bhatara V, Feil M, Hoagwood K, Vitiello B, Zima B. National trends in concomitant psychotropic medication with stimulants in pediatric visits: practice versus knowledge. J Atten Disord. 2004;7:217-26. (Pubitemid 38891300)
9. Comer JS, Olfson M, Mojtabai R. National trends in child and adolescent psychotropic polypharmacy in office-based practice, 1996-2007. J Am Acad Child Adolesc Psychiatry. 2010;49:1001-10.
10. Mojtabai R, Olfson M. National trends in psychotropic medication polypharmacy in office-based psychiatry. Arch Gen Psychiatry. 2010;67:26-36.
11. Pliszka S. Practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2007;46:894-921.
12. Wolraich M, Brown L, Brown RT, DuPaul G, Earls M, Feldman HM, et al. ADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics. 2011;128:1007-22.
13. Olfson M, Gameroff MJ, Marcus SC, Jensen PS. National trends in the treatment of attention deficit hyperactivity disorder. Am J Psychiatry. 2003;160:1071-7. (Pubitemid 41070965)
14. Barner JC, Khoza S, Oladapo A. ADHD medication use, adherence, persistence and cost among Texas Medicaid children. Curr Med Res Opin. 2011;27 Suppl 2:13-22.
15. Martin A, Van Hoof T, Stubbe D, Sherwin T, Scahill L. Multiple psychotropic pharmacotherapy among child and adolescent enrollees in Connecticut Medicaid managed care. Psychiatr Serv. 2003;54:72-7. (Pubitemid 36043850)
16. Yanofski J. The dopamine dilemma: using stimulants and antipsychotics concurrently. Psychiatry (Edgmont). 2010;7:18-23.
17. Penzner JB, Dudas M, Saito E, Olshanskiy V, Parikh UH, Kapoor S, et al. Lack of effect of stimulant combination with secondgeneration antipsychotics on weight gain, metabolic changes, prolactin levels, and sedation in youth with clinically relevant aggression or oppositionality. J Child Adolesc Psychopharmacol. 2009;19:563-73.
18. Weiss M, Panagiotopoulos C, Giles L, Gibbins C, Kuzeljevic B, Davidson J, et al. A naturalistic study of predictors and risks of atypical antipsychotic use in an attention-deficit/hyperactivity disorder clinic. J Child Adolesc Psychopharmacol. 2009;19:575-82.
19. Chen CY, Gerhard T, Winterstein AG. Determinants of initial pharmacological treatment for youths with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2009;19:187-95.
20. Zima BT, Bussing R, Tang L, Zhang L, Ettner S, Belin TR, et al. Quality of care for childhood attention-deficit/hyperactivity disorder in a managed care medicaid program. J Am Acad Child Adolesc Psychiatry. 2010;49:1225-37, 1237.e1-11.
21. Constantine RJ, McPherson MA, Jones ME, Tandon R, Becker ER. Improving Psychotherapeutic Medication Prescribing in Florida: Implementation of the Florida Medicaid Drug Therapy Management Program (MDTMP). Community Ment Health J. 2012. doi: 10.1007/s10597-01209497.y.
22. Farmer CA, Arnold LE, Bukstein OG, Findling RL, Gadow KD, Li X, et al. The treatment of severe child aggression (TOSCA) study: Design challenges. Child Adolesc Psychiatry Ment Health. 2011;5:36.
23. Bussing R, Fernandez M, Harwood M, Wei H, Garvan CW, Eyberg SM, et al. Parent and teacher SNAP-IV ratings of attention deficit hyperactivity disorder symptoms: psychometric properties and normative ratings from a school district sample. Assessment. 2008;15:317-28.