The dopamine dilemma: Using stimulants and antipsychotics concurrently

Psychiatry (Edgemont)

Volumn 7, Issue 6, 2010, Pages 18-23

  Yanofski, Jason ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Adhd; Antipsychotics; Children; Dopamine; Dyskinesias; Psychotropic medications; Stimulants; Tics

Indexed keywords

ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; CENTRAL STIMULANT AGENT; DOPAMINE; DOPAMINE RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; NEUROLEPTIC AGENT; RISPERIDONE;

AGGRESSION; ANXIETY DISORDER; ATTENTION DEFICIT DISORDER; BIPOLAR MANIA; COMORBIDITY; DEPRESSION; DOPAMINERGIC SYSTEM; DRUG EFFICACY; DRUG INDICATION; DRUG USE; DYSTONIA; HUMAN; MOOD DISORDER; PRACTICE GUIDELINE; PSYCHOSIS; REVIEW; TIC;

EID: 77956103893     PISSN: 15505952     EISSN: 15555194     Source Type: Journal    
DOI: None     Document Type: Review

References (62)

1. Olfson M, Gameroff M, Marcus S, Jensen P. National trends in the treatment of attention deficit hyperactivity disorder. Am J Psychiatry. 2003;160:1071-1077.
2. Cooper WO, Arbogast PG, Ding H, et al. Trends in prescribing of antipsychotic medications for US children. Ambul Pediatr. 2006; 6(2):79-83.
3. Zuvekas SH, Vitiello B, Norquist GS. Recent trends in stimulant medication use among US children. Am J Psychiatry. 2006; 163(4):579-585.
4. Bhatara V, Feil M, Hoagwood K, Vitiello B, Zima B. National trends in concomitant psychotropic medication with stimulants in pediatric visits: practice versus knowledge. J Atten Disord. 2004;7(4):217-26.
5. Wonodi I, Reeves G, Carmichael D, et al. Tardive dyskinesia in children treated with atypical antipsychotic medications. Mov Disord. 2007;22:1777-1782.
6. Olfson M, Blanco C, Liu L, et al. National trends in the outpatient treatment of children and adolescents with antipsychotic drugs. Arch Gen Psychiatry. 2006;63(6):679-685.
7. Zito JM, Safer DJ, dosReis S, et al. Trends in the prescribing of psychotropic medications to preschoolers. JAMA. 2008;23;283(8):1025-1030.
8. Kutcher S, Aman M, Brooks SJ, et al. International consensus statement on attention-deficit/hyperactivity disorder (ADHD) and disruptive behaviour disorders (DBDs): clinical implications and treatment practice suggestions. Eur Neuropsychopharmacol. 2004;4(1):11-28.
9. Pliszka S, Crimson M, Hughes C, et al. The Texas Children's Medication Algorithm Project: revision of the algorithm for pharmacotherapy of attention-deficit/hyperactivity disorder. ACAP. 2006;45(6):642-657.
10. Stahl SM. Stahl's Essential Psychopharmacology. New York, NY: Cambridge University Press; 2008:878-879.
11. Moore KE. The actions of amphetamine on neurotransmitters: a brief review. Biol Psychiatry. 1977;12(3):451-462.
12. Pehek AE. Comparison of effects of Haloperidol administration on amphetamine-stimulated dopamine release in the rat medial prefrontal cortex and dorsal striatum. J Pharmacol Exp Therapeut. 1999;289(1):14-23.
13. Nakahra T, Kurokit, Hashimoto K, et al. Effect of atypical antipsychotics on phencyclidine-induced expression of arc in rat brain. Neuroreport. 2000;11(3):551-555.
14. Kargieman L, Santana N, Mengod G, et al. NMDA antagonist and antipsychotic actions in corticosubcortical circuits. Neurotox Res. 2008;14(2-3):129-140.
15. Volkow ND, Wang G-J, Fowler JS, et al. Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors. Am J Psychiatry. 1997;154:50-55.
16. Botly L, Burton CL, Rizos Z, Fletcher PJ. Characterization of methylphenidate self-adminstration and reinstatement in the rat. Psychopharmacology. 2008;199:55-56.
17. Owen R, Owen F, Poulter M, Crow TJ. Dopamine D2 receptors in substantia nigra in schizophrenia. Brain Res. 1994;7;299(1):152-154.
18. Fehr C, Yakushev I, Hohmann N, et al. Association of low striatal dopamine D2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse. Am J Psychiatry. 2008;165:507-514.
19. Laurelle M, Abi-Dargham A, van Dyck CH, et al. SPECT imaging of striatal dopamine release after amphetamine challenge. J Nucl Med. 1995;36:1182-1190.
20. Leite JV, Guimarães FS, Moreira FA. Aripiprazole, an atypical antipsychotic, prevents the motor hyperactivity induced by psychotomimetics and psychostimulants in mice. Eur J Pharmacol. 2008;14;578(2-3):222-227.
21. Rappley M. Attention deficithyperactivity disorder. N Engl J Med. 2005;352:2.
22. Cheng-Shannon J, McGough JJ, Pataki C, McCracken JT. Secondgeneration antipsychotic medications in children and adolescents. J Child Adolesc Psychopharmacol. 2004;14(3):372-394.
23. Werry JS, Aman MG. Methylphenidate and haloperidol in children. Effects on attention, memory, and activity. Arch Gen Psychiatry.1975;32(6):790-795.
24. Gittelman-Klein R, Klein DF, Katz S, et al. Comparative effects of methylphenidate and thioridazine in hyperkinetic children. Arch Gen Psychiatry. 1976;33(10):1217-1231.
25. Greenberg LM, Deem MA, McMahon S. Effects of dextroamphetamine, chlorpromazine, and hydroxyzine on behavior and performance in hyperactive children. Am J Psychiatry. 1972;129(5):532-539.
26. Biederman J, Hammerness P, Doyle R. Risperidone treatment for ADHD in children and adolescents with bipolar disorder. Neuropsychiatr Dis Treat. 2008;4(1):203-207.
27. Findling RL, Short EJ, Leskovec T, et al. Aripiprazole in children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2008;18(4):347-354.
28. Gualtieri CT, Hicks RE. Stimulants and neuroleptics in hyperactive children (letter). J Am Acad Child Psychiatry. 1985;24:363-364.
29. Weizman A, Weitz R, Szekely GA, et al. Combination of neuroleptic and stimulant treatment in attention deficit disorder with hyperactivity. J Am Acad Child Psychiatry. 1984;23(3):295-298.
30. Pliszka S. Practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2007;46(7):894-921.
31. Findling RL. Atypical antipsychotic treatment of disruptive behavior disorders in children and adolescents. J Clin Psychiatry. 2008;69(Suppl 4):9-14.
32. Pandina GJ, Aman MG, Findling RL. Risperidone in the management of disruptive behavior disorders. J Child Adolesc Psychopharmacol. 2006;16(4):379-392.
33. Gadow KD, Nolan EE, Sverd J, et al. Methylphenidate in aggressivehyperactive boys: effects on peer aggression in public school settings. J Am Acad Child Adolesc Psychiatry. 1990;29(5):710-718.
34. Connor DF, Glatt SJ, Lopez ID, et al. Psychopharmacology and aggression: A meta-analysis of stimulant effects on overt/covert aggression-related behaviors in ADHD. J Am Acad Child Adolesc Psychiatry. 2002;41:253-261.
35. Allen RP, Safer D, Covi L. Effects of psychostimulants on aggression. J Nerv Ment Dis. 1975;160:138-145.
36. Sharp B. CMAP ADHD and comorbid aggression algorithm: letter to the editor. ACAP. 2007;46(1):1-3.
37. Beller B, Zimerman B, Williams M, et al. DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J Am Acad Child Adolesc Psychiatry. 2002;12(1):11-25.
38. Trivedi MH, Thase ME, Fava M, et al. Adjunctive aripiprazole in major depressive disorder: analysis of efficacy and safety in patients with anxious and atypical features. J Clin Psychiatry. 2008;69(12):1928-1936.
39. Shajahan P, Taylor M. The uses and outcomes of quetiapine in depressive and bipolar mood disorders in clinical practice. J Psychopharmacol. 2010;24(4):565-572. Epub 2009 Jan 22.
40. Sajatovic M. Treatment for mood and anxiety disorders: quetiapine and aripiprazole. Curr Psychiatry Rep. 2003;5:320-326.
41. Hardy SE. Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults. Am J Geriatr Pharmacother. 2009;7(1):34-59.
42. Huang CC, Shiah IS, Chen HK, et al. Adjunctive use of methylphenidate in the treatment of psychotic unipolar depression. Clin Neuropharmacol. 2008;31(4):245-247.
43. Nandagopal JJ, DelBello MP, Kowatch R. Pharmacologic treatment of pediatric bipolar disorder. Child Adolesc Psychiatr Clin N Am. 2009;18(2):455-469.
44. Chang KD. The use of atypical antipsychotics in pediatric bipolar disorder. J Clin Psychiatry. 2008;69(Suppl 4):4-8.
45. Levin A. Kids with bipolar + ADHD respond to added stimulant. Psychiatr News. 2005;40(2):42.
46. Wingo AP, Ghaemi SN. Frequency of stimulant treatment and of stimulant-associated mania/hypomania in bipolar disorder patients. Psychopharmacol Bull. 2008;41(4):37-47.
47. Carlson PJ, Merlock MC, Suppes T. Adjunctive stimulant use in patients with bipolar disorder: treatment of residual depression and sedation. Bipolar Disord. 2004;6(5):416-420.
48. Ross RG. Psychotic and manic-like symptoms during stimulant treatment of attention deficit hyperactivity disorder. Am J Psychiatry. 2006;163(7):1149-1152.
49. Curran C, Byrappa N, McBride A. Stimulant psychosis: systematic review. Br J Psychiatry. 2004;185:196-204.
50. Aman MG, Binder C, Turgay A. Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ. J Child Adolesc Psychopharmacol. 2004;14(2):243-254.
51. Hollis CP, Thompson A. Acute dyskinesia on starting methylphenidate after risperidone withdrawal. Pediatr Neurol. 2007;37(4):287-288.
52. Connor DF, Benjamin S, Ozbayrak KR. Case study: neuroleptic withdrawal dyskinesia exacerbated by ongoing stimulant treatment. J Am Acad Child Adolesc Psychiatry. 1995;34(11):1490-1494.
53. Benjamin E, Salek S. Stimulantatypical antipsychotic interaction and acute dystonia. J Am Acad Child Adolesc Psychiatry. 2005;44(6):510-512.
54. Sabuncuoglu O. Risperidone-tomethylphenidate switch reaction in children: three cases. J Psychopharmacol. 2009;22(6):699.
55. Seeman P, Niznik HB, Guan H-C, et al. Link between D1 and D2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain. Proc Nat Acad Sci USA. 1989;86:10156-10160.
56. Volkow N, Swanson J. Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD. Am J Psychiatry. 2003;160:1909-1918.
57. Sikström S, Söderlund G. Stimulusdependent dopamine release in attention-deficit/hyperactivity disorder. Psychol Rev. 2007;114(4):1047-1075.
58. Goto Y, Otani S, Grace AA. The yin and yang of dopamine release: a new perspective. Neuropharmacology. 2007;53(5):583-587.
59. Grace AA. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience. 1991;41(1):1-24.
60. Braun AR, Laruelle M, Mouradian MM. Interactions between D1 and D2 dopamine receptor family agonists and antagonists: the effects of chronic exposure on behavior and receptor binding in rats and their clinical implications. J Neur Transmis. 1997;104:4-5.
61. Gianutsos G, Drawbaugh RB, Hynes MD, Lal H. Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol. Life Sci. 1974;14:887-898.
62. Samaha A, Seeman P, Steward J, et al. "Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time. J Neurosci. 2007;27(11):2979-2986.